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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Pakistan Journal of Clinical Research

Frequency of Peripheral Neuropathy in Diabetic Patients with and Without Anemia: An Analytical Comparative Cross-Sectional Study

Farhat Ullah Bakhsh, Shamaila Burney

Background: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss, pain, gait impairment, ulcers, and amputation. Its substantial burden in Pakistan warrants systematic screening, while anemia and vitamin B12 deficiency may further contribute to neuropathic clinical manifestations. To evaluate the DPN frequency in patients with and without anemia in diabetic patients to determine the independent predictors. Methods: 192 adults type 2 diabetes were studied using an analytic …

30.08.2026journal-article

Nephrology

Clinical Predictors of Non‐Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic‐Range Proteinuria

Sittipath Tirasattayapitak, Kanin Thammavaranucupt, Kavee Limbutara, Nitcha Suphatheerawatr, Wanjak Pongsittisak, Chutima Chavanisakun, Nontawat Benjakul, Solos Jaturapisanukul

ABSTRACT Aim Nephrotic‐range proteinuria in patients with Type 2 diabetes mellitus (T2DM) may result from diabetic nephropathy or non‐diabetic glomerular disease (NDGD). Kidney biopsy risks and limited accessibility complicate patient selection. We aimed to identify predictors of NDGD and develop a score to guide biopsy decisions. Methods We conducted a single‐center retrospective study of T2DM patients undergoing native kidney biopsy for nephrotic‐range proteinuria at a tertiary hospital in Thailand between 2014 a …

30.08.2026journal-article

International Journal of Molecular Sciences

Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations

Kiran R. Ebrahimi, Stephen M. Ostrowski, David E. Fisher

Cutaneous melanoma is the most lethal skin cancer, and risk is strongly shaped by pigmentary phenotype. The red-hair color phenotype, marked by red hair, fair skin, freckling, and poor tanning, carries elevated melanoma risk driven largely by loss-of-function variants in the melanocortin 1 receptor gene (MC1R). This risk is not explained by reduced ultraviolet protection alone. Impaired MC1R signaling shifts melanogenesis from photoprotective eumelanin toward pheomelanin, a pigment associated with oxidative stress …

30.08.2026journal-article

International Journal of Human and Health Sciences (IJHHS)

Clinical Features and Outcomes of Dengue Fever in a Tertiary Paediatric Hospital in Dhaka, Bangladesh

Md Aktaruzzaman, Sharmin Afroze, Farhana Ahmed, Mostafizur Rahman, Gazi Abdul Bari, Kiriti Kumar Dhali

Globally, children, adolescents, and young adults constitute the largest burden of Dengue. Early diagnosis is crucial for timely intervention and better outcome. This cross-sectional study was conducted among 51 children with dengue fever admitted in the Department of Paediatrics, Dr. M R Khan Shishu Hospital & Institute, Dhaka, Bangladesh, between April and September of 2025, to assess the clinical features of the dengue infection in children and to evaluate the outcomes. The most common age of presentation was be …

30.08.2026journal-article

JCPP Advances

Ecological momentary assessment of targeted and non‐targeted symptom changes in clinical anxiety and irritability among children and adolescents receiving cognitive behavioral therapy

Lauren M. Henry, Meghan E. Byrne, Julia Modell, Lili Massac, Krystal Lewis, Simone Haller, Reut Naim, Katharina Kircanski, Daniel S. Pine, Melissa A. Brotman

Abstract Background Decades of youth psychotherapy research have demonstrated the efficacy of cognitive behavioral therapy (CBT) on targeted symptoms using standardized, retrospective clinician‐, child‐, and parent‐report. Advancements in digital technologies can be leveraged to capture granular symptom change in patients' natural environments. While CBT is tailored to treat specific diagnosis‐perpetuating mechanisms, it remains unknown whether such effects may carry over to non‐targeted symptoms, which could have …

30.08.2026journal-article

Cancer Medicine

Target‐Specific Dermatological Adverse Event Reporting With T‐Cell–Engaging Bispecific Antibodies: A Pharmacovigilance Analysis of FAERS and Canada Vigilance, 2016–2026

Saikat Mandal, Manideepa Maji, Arkadeep Dhali

ABSTRACT Background T‐cell–engaging bispecific antibodies are increasingly utilised in haematological malignancies and are beginning to be adopted in solid‐tumour treatment protocols. Cytokine release syndrome and neurotoxicity are well recognised, but target‐specific dermatological adverse event reporting patterns remain poorly defined. Methods We analysed 12,333,305 deduplicated FAERS reports from 2016Q1 to 2026Q1, including 23,386 reports exposed to ten T‐cell–engaging bispecific antibodies grouped by target: CD …

30.08.2026journal-article

Cancer Medicine

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma ( NPC ) Differs by Somatostatin Receptor 2 ( SSTR2 ) Expression

Dara Bracken‐Clarke, Elisabetta Xue, Harris Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor E. Steuer, Nabil F. Saba, Daniel J. Lubin, Nyall R. London, James L. Gulley, Charalampos S. Floudas

ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 ( SSTR2 ) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV‐positive) to 35.79 TPM (Q4, 82.9% EBV‐positive). PIK3CA (20.51%) and CYLD …

30.08.2026journal-article

Journal of Applied Clinical Medical Physics

Quantifying variation in DLP‐ to‐ effective‐dose conversion factors in CT using a Monte Carlo‐based dose‐estimation software

Jelena M. Mihailovic, Renxin Chu, Da Zhang, Andrew M. Hernandez, Kai Yang, Lifeng Yu

Abstract Background A common method to estimate the effective dose in CT is to multiply the dose length product in a CT scan by a conversion factor (k). The k‐factors are determined by dividing the effective dose (calculated using a weighted summation of organ doses) by the dose length product (DLP) for specific digital phantoms. The k‐factors determined in this way may vary substantially depending on the effective dose calculation methods and phantom models used. Purpose The purpose of this study was to estimate v …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress of Xuefu Zhuyu Decoction and Its Single Herbs in the Treatment of Coronary Heart Disease

Huan Zhang, Junru Zhang, Yiman Zhang, Danlei Mao

Coronary atherosclerotic heart disease, abbreviated as coronary heart disease (CHD), is a chronic cardiovascular disease and one of the major diseases threatening the life and health of populations worldwide. Its morbidity and mortality rates are on the rise. In recent years, CHD has also shown a trend of affecting younger individuals, making long-term treatment and management critically important. In traditional Chinese medicine (TCM), CHD falls under the category of “chest stuffiness and heart pain” (xiongbi xint …

30.08.2026journal-article

Revista Científica de la Facultad de Ciencias Veterinarias

Ketamine-Medetomidine-Midazolam and Ketamine- Dexmedetomidine-Midazolam anesthesia in gerbils: a clinical comparison of subcutaneous and intraperitoneal administration

Nimet Kılıç, Nuh Kılıç, Burak Baydoğan

This study investigated the anesthetic performance and cardiopulmonary effects of ketamine-medetomidine-midazolam and ketamine-dexmedetomidine-midazolam combinations administered by subcutaneous or intraperitoneal routes in gerbils. Thirty-two clinically healthy male gerbils were allocated to four experimental groups according to the anesthetic protocol and route of administration. All protocols produced satisfactory sedation and surgical anesthesia without mortality. Induction was achieved in all animals within a …

30.08.2026journal-article

Journal of Hospital Medicine

Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study

Krystal S. Jin, Naoko Kono, Jonathan D. Cogen, Sarah Hofman DeYoung, Catherine S. Forster, Andrea Hahn, Margaret Rush, John M. Morrison, Joanna E. Thomson, Sukhada V. Mairal, Michael N. Neely, Wendy J. Mack, Tamara D. Simon, Christopher J. Russell

Abstract We conducted a multicenter prospective cohort study to identify factors associated with discharge on higher respiratory support in children with tracheostomy hospitalized for bacterial tracheostomy‐associated infections (bTRAINs). We included children 0–21 years with tracheostomy hospitalized for bTRAIN at six freestanding children's hospitals between 2020 and 2024. The primary outcome was discharge on higher respiratory support compared to pre‐hospital baseline. Generalized linear mixed‐effects regression …

30.08.2026journal-article

Malaysian Journal of Paediatrics and Child Health

Congenital Anterior Staphyloma in a Paediatric Patient: Clinical Presentation and Management Challenges

Nurhafizatul Akma Hasan, Noor Atikah Saini, Akmal Haliza Zamli, Wan Norliza Wan Muda, Norra Harun, Liza Sharmini Ahmad Tajudin

Congenital anterior staphyloma is a scarce condition characterised by the outpouching of anterior wall of the globe, typically involving both the cornea and sclera, leading to significant visual impairment. We report a seven-year-old boy, born prematurely at 34 weeks, who was diagnosed with congenital anterior staphyloma at birth. He had been monitored from an infant age and advised to undergo surgical intervention. However, surgery was delayed due to ongoing systemic illness, which required multiple hospital admis …

30.08.2026journal-article

JAMA

124 I-Evuzamitide Positron Emission Tomography/Computed Tomography for Diagnosing Cardiac Amyloidosis

Sharmila Dorbala, Mathew S. Maurer, Sarah A. M. Cuddy, Omar F. AbouEzzeddine, Marcelo F. Di Carli, Vasken Dilsizian, Angela Dispenzieri, Cesia Gallegos-Kattán, Spencer Guthrie, Brian Mangal, Mazen Hanna, Michel G. Khouri, Saurabh Malhotra, Joshua D. Mitchell, Ravi K. Narra, Cesare Orlandi, Julie L. Rosenthal, Frederick L. Ruberg, Dia Smiley, Brett W. Sperry, James E. Udelson, Richard L. Weinberg, Jonathan S. Wall, Ahmad Masri, REVEAL Study Investigators, Mouaz H Al-Mallah, Kevin M Alexander, Sabahat Bokhari, Paco E Bravo, Panithaya Chareonthaitawee, Philip H Kuo, Wesley T O'Neal, Ashutosh Wechalekar, Bryan A, Whittle, Benjamin Auer, Marie Foley Kijewski, Olivier F Clerc

Importance Diagnosing cardiac amyloidosis remains challenging because current imaging approaches are limited to transthyretin amyloidosis. A noninvasive test capable of directly imaging cardiac amyloidosis from various amyloid types and in multiple organs could address an important unmet diagnostic need. Objective To evaluate the sensitivity and specificity of 124 I-evuzamitide positron emission tomography (PET)/computed tomography (CT) for diagnosing cardiac amyloidosis. Design, Setting, and Participants Prospecti …

30.08.2026journal-article

Journal of Clinical Apheresis

Predicting Non‐Target Neutrophil Collection During HPC (A): Implications for Research Protocols in Apheresis

Yandy Marx Castillo‐Aleman, Carlos Agustin Villegas‐Valverde, Yendry Ventura‐Carmenate, Shinnette Lumame, Jay Mary Rose‐Roque, Marlene Cato, Hamda Ali, Ruaa Mousa Ali, Rachely Hernandez‐Corrales, Anil Sarode, Yaima Zuñiga‐Rosales, Vianed Marsan‐Suarez, Antonio Alfonso Bencomo‐Hernandez

ABSTRACT Neutrophils are unintentionally co‐collected during HPC(A) procedures using mononuclear cell collection protocols. Although non‐target granulocyte co‐collection is generally clinically acceptable, excessive neutrophil content may compromise certain translational research applications. This study aimed to develop a predictive model for neutrophil yield during routine HPC(A). A retrospective single‐center analysis of 377 HPC(A) procedures performed between January 2023 and April 2026 was conducted. Donor dem …

30.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

ANGII Initiated HSF2 Trans‐Activating HIF ‐1α Through Induction of ER Stress to Promote Cardiac Hypertrophy

Renchuang Cao, Qingying Meng, Gengyuan Li, Shumei Yuan, Chunmei Li, Xin Zhao, Dongmei Zhang

ABSTRACT Heat shock factor 2 (HSF2) and hypoxia‐inducible factor 1α are activated by angiotensin II (ANGII) in cardiomyocytes. The endoplasmic reticulum (ER) stress plays a critical role in cardiac hypertrophy. Moreover, HIF‐1α is known to be regulated by HSF2 in tumour cells. In this study, we hypothesised and clarified whether HSF2 trans‐activated HIF‐1α through initiation of ER stress in hypertrophic cardiomyocytes. Myocardial hypertrophy was induced by the treatment of ANGII. Expression of the gene or protein w …

30.08.2026journal-article

Precision Radiation Oncology

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: from immune mechanisms to clinical practice

Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen

Abstract As a core modality for local control of thoracic tumors, including lung and esophageal cancers, radiotherapy (RT) shows synergistic effects with immunotherapy, fundamentally reshaping the landscape of cancer treatment. Given the rapid advancements in immunotherapy, this review explores the critical role of precise delineation of radiotherapy targets in achieving synergistic effects between RT and immunotherapy. It elucidates the dual‐edged nature of RT, which can both activate antitumor immune responses an …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

A non-invasive method for verification of acute mesenteric blood flow disorder

Magomed D. Dibirov, Rasul U. Gadzhimuradov, Igor P. Parfenov, Darya I. Sidorova, Vladimir S. Fomin

Acute mesenteric perfusion disorder (AMP) is a critical emergency condition characterized by a sudden reduction in blood flow through the mesenteric vessels to the intestine, leading to inadequate perfusion of the small intestine. Mortality from this pathology ranges from 50% to 97% and is primarily due to its rapid progression and subsequent development of intestinal necrosis. Diagnosis of AMP and intestinal ischemia remains a challenge for clinicians due to the lack of pathogmonic symptoms of the disease. In the …

30.08.2026journal-article

Indian Journal of Psychological Medicine

Assessing Suicidal Ideation in a Community of Bangladesh: Validation of a Suicidal Ideation Scale

Md Omar Faruk, Md Abdul Awal, Kamal Uddin Ahmed Chowdhury

Background: Surpassing the global and Bangladesh averages, Jhenaidah, a southwestern region in Bangladesh, remains one of the most prone districts for suicidal ideation and suicide rates. However, despite the higher prevalence, there is no psychometric measure available to assess the degree of suicidal ideation in this region. The present study aimed to validate the Bangla version of the Suicidal Ideation Scale (B-SIS) in Jhenaidah. Methods: We recruited 300 participants (male 50.87% and female 45.13%) via purposiv …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

From Diagnosis to Treatment: Advances in Clinical Research on Severe Pneumonia

Sheng Wang, Xiaoli Wu, Xiaoshuai Wu

Severe pneumonia is a life-threatening infectious disease associated with high mortality and is frequently complicated by acute respiratory distress syndrome, septic shock, and multiple organ dysfunction. The current diagnostic and therapeutic paradigm is shifting from empirical broad-spectrum treatment toward individualized management based on precise pathogen identification and assessment of the host response. The pathogenesis of severe pneumonia involves a broad range of bacterial, viral, and fungal pathogens, t …

30.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

Anders Hviid, Anna Laksafoss, Elisabeth O'Regan, Poul Videbech, Ingrid Bech Svalgaard

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast milk, but characterisations better capturing the heterogeneity of this exposure are lacking. We aimed to identify distinct postpartum psychotropic treatment patterns using hierarchical clustering accounting for medication type, timing and pol …

30.08.2026journal-article

Applied System Innovation

Intelligent Fault Diagnosis and Maintenance Decision Support in Electrical Induction Generators Using Multi-CNN Extreme Ensemble Learning

Majida Khaleel Ahmed, Ahmed Mohammed Mohsin Alzubaidi, Zeashan Hameed Khan, Ahmed Ali Farhan Ogaili, Alaa Abdulhady Jaber, Luttfi A. Al-Haddad

Electrical induction generators are vulnerable to winding faults that can degrade operational reliability and lead to unplanned maintenance. This study proposes a multiple-convolutional neural network (Multi-CNN) extreme ensemble learning framework for intelligent fault diagnosis and maintenance decision support using three-phase current and voltage measurements. Experimental recordings representing healthy operation, inter-turn faults, and inter-winding faults were segmented into non-overlapping 200-sample windows …

30.08.2026journal-article

EJNMMI Physics

Virtual-patient nonlinear mixed-effects modelling for data-driven optimisation of single-time-point dosimetry: a proof-of-concept study in [177Lu]Lu-PSMA-617 therapy

Yeni Pertiwi, Indra Budiansah, Jaja Muhamad Jabar, Muchtaridi Muchtaridi, Freddy Haryanto, Idam Arif, Deni Hardiansyah, Gerhard Glatting

Abstract Background Robust single-time-point (STP) dosimetry critically depends on selecting an imaging time that yields reliable estimates of the time-integrated activity coefficient (TIAC). This study developed and evaluated a virtual-patient nonlinear mixed-effects modelling (NLMEM) framework to optimise STP imaging schedules for renal TIAC estimation, using [¹⁷⁷Lu]Lu-PSMA-617 therapy as a proof of concept. Methods A previously published NLMEM (sum-of-exponentials structure and parameter distributions) describin …

30.08.2026journal-article

Scientific Reports

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Agata Galas, Robert Morawiec, Iwona Gorczyca-Głowacka, Agata Tymińska, Katarzyna Byczkowska, Jarosław D. Kasprzak, Aleksander Siniarski, Marek Kuch, Beata Wożakowska-Kapłon, Adrian Stefański, Witold Furmanek, Paweł Krzesiński

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringent GDMT target in patients with HFrEF undergoing scheduled hospitalization. The analysis included 287 patients with reduced left ventricular ejection fraction (LVEF), which is a subset of the 1422 participants of the HEROES study, a prospec …

30.08.2026journal-article

Frontiers on Healthcare Research

Inpatient Clinical Profile and Mortality Patterns at a Tertiary Referral Hospital in Indonesia: A Descriptive Study at RSUP Dr. M. Djamil Padang

Department of Statistics, Universitas Negeri Padang, Padang, Indonesia, Viora Antasya Viora, Dodi Vionanda Dodi, Dr. M. Djamil General Hospital, Padang, Indonesia, Alfitri Alfitri Alfitri

<p style="font-weight: 400;"><strong>Background:</strong> Hospital electronic medical records contain morbidity and mortality data that can be analyzed to provide a comprehensive picture of health profiles. However, most studies using inpatient data are limited in scope and do not integrate the distribution of diagnoses, mortality patterns, and case fatality rates into a single analytical framework. This study aimed to describe the characteristics of inpatients at Dr. M. Djamil General Hospital in Padang in 2025, i …