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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

ANGII Initiated HSF2 Trans‐Activating HIF ‐1α Through Induction of ER Stress to Promote Cardiac Hypertrophy

Renchuang Cao, Qingying Meng, Gengyuan Li, Shumei Yuan, Chunmei Li, Xin Zhao, Dongmei Zhang

ABSTRACT Heat shock factor 2 (HSF2) and hypoxia‐inducible factor 1α are activated by angiotensin II (ANGII) in cardiomyocytes. The endoplasmic reticulum (ER) stress plays a critical role in cardiac hypertrophy. Moreover, HIF‐1α is known to be regulated by HSF2 in tumour cells. In this study, we hypothesised and clarified whether HSF2 trans‐activated HIF‐1α through initiation of ER stress in hypertrophic cardiomyocytes. Myocardial hypertrophy was induced by the treatment of ANGII. Expression of the gene or protein w …

30.08.2026journal-article

Malaysian Journal of Paediatrics and Child Health

Congenital Anterior Staphyloma in a Paediatric Patient: Clinical Presentation and Management Challenges

Nurhafizatul Akma Hasan, Noor Atikah Saini, Akmal Haliza Zamli, Wan Norliza Wan Muda, Norra Harun, Liza Sharmini Ahmad Tajudin

Congenital anterior staphyloma is a scarce condition characterised by the outpouching of anterior wall of the globe, typically involving both the cornea and sclera, leading to significant visual impairment. We report a seven-year-old boy, born prematurely at 34 weeks, who was diagnosed with congenital anterior staphyloma at birth. He had been monitored from an infant age and advised to undergo surgical intervention. However, surgery was delayed due to ongoing systemic illness, which required multiple hospital admis …

30.08.2026journal-article

Journal of Clinical Apheresis

Predicting Non‐Target Neutrophil Collection During HPC (A): Implications for Research Protocols in Apheresis

Yandy Marx Castillo‐Aleman, Carlos Agustin Villegas‐Valverde, Yendry Ventura‐Carmenate, Shinnette Lumame, Jay Mary Rose‐Roque, Marlene Cato, Hamda Ali, Ruaa Mousa Ali, Rachely Hernandez‐Corrales, Anil Sarode, Yaima Zuñiga‐Rosales, Vianed Marsan‐Suarez, Antonio Alfonso Bencomo‐Hernandez

ABSTRACT Neutrophils are unintentionally co‐collected during HPC(A) procedures using mononuclear cell collection protocols. Although non‐target granulocyte co‐collection is generally clinically acceptable, excessive neutrophil content may compromise certain translational research applications. This study aimed to develop a predictive model for neutrophil yield during routine HPC(A). A retrospective single‐center analysis of 377 HPC(A) procedures performed between January 2023 and April 2026 was conducted. Donor dem …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

A non-invasive method for verification of acute mesenteric blood flow disorder

Magomed D. Dibirov, Rasul U. Gadzhimuradov, Igor P. Parfenov, Darya I. Sidorova, Vladimir S. Fomin

Acute mesenteric perfusion disorder (AMP) is a critical emergency condition characterized by a sudden reduction in blood flow through the mesenteric vessels to the intestine, leading to inadequate perfusion of the small intestine. Mortality from this pathology ranges from 50% to 97% and is primarily due to its rapid progression and subsequent development of intestinal necrosis. Diagnosis of AMP and intestinal ischemia remains a challenge for clinicians due to the lack of pathogmonic symptoms of the disease. In the …

30.08.2026journal-article

JAMA

124 I-Evuzamitide Positron Emission Tomography/Computed Tomography for Diagnosing Cardiac Amyloidosis

Sharmila Dorbala, Mathew S. Maurer, Sarah A. M. Cuddy, Omar F. AbouEzzeddine, Marcelo F. Di Carli, Vasken Dilsizian, Angela Dispenzieri, Cesia Gallegos-Kattán, Spencer Guthrie, Brian Mangal, Mazen Hanna, Michel G. Khouri, Saurabh Malhotra, Joshua D. Mitchell, Ravi K. Narra, Cesare Orlandi, Julie L. Rosenthal, Frederick L. Ruberg, Dia Smiley, Brett W. Sperry, James E. Udelson, Richard L. Weinberg, Jonathan S. Wall, Ahmad Masri, REVEAL Study Investigators, Mouaz H Al-Mallah, Kevin M Alexander, Sabahat Bokhari, Paco E Bravo, Panithaya Chareonthaitawee, Philip H Kuo, Wesley T O'Neal, Ashutosh Wechalekar, Bryan A, Whittle, Benjamin Auer, Marie Foley Kijewski, Olivier F Clerc

Importance Diagnosing cardiac amyloidosis remains challenging because current imaging approaches are limited to transthyretin amyloidosis. A noninvasive test capable of directly imaging cardiac amyloidosis from various amyloid types and in multiple organs could address an important unmet diagnostic need. Objective To evaluate the sensitivity and specificity of 124 I-evuzamitide positron emission tomography (PET)/computed tomography (CT) for diagnosing cardiac amyloidosis. Design, Setting, and Participants Prospecti …

30.08.2026journal-article

Precision Radiation Oncology

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: from immune mechanisms to clinical practice

Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen

Abstract As a core modality for local control of thoracic tumors, including lung and esophageal cancers, radiotherapy (RT) shows synergistic effects with immunotherapy, fundamentally reshaping the landscape of cancer treatment. Given the rapid advancements in immunotherapy, this review explores the critical role of precise delineation of radiotherapy targets in achieving synergistic effects between RT and immunotherapy. It elucidates the dual‐edged nature of RT, which can both activate antitumor immune responses an …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

From Diagnosis to Treatment: Advances in Clinical Research on Severe Pneumonia

Sheng Wang, Xiaoli Wu, Xiaoshuai Wu

Severe pneumonia is a life-threatening infectious disease associated with high mortality and is frequently complicated by acute respiratory distress syndrome, septic shock, and multiple organ dysfunction. The current diagnostic and therapeutic paradigm is shifting from empirical broad-spectrum treatment toward individualized management based on precise pathogen identification and assessment of the host response. The pathogenesis of severe pneumonia involves a broad range of bacterial, viral, and fungal pathogens, t …

30.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

Anders Hviid, Anna Laksafoss, Elisabeth O'Regan, Poul Videbech, Ingrid Bech Svalgaard

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast milk, but characterisations better capturing the heterogeneity of this exposure are lacking. We aimed to identify distinct postpartum psychotropic treatment patterns using hierarchical clustering accounting for medication type, timing and pol …

30.08.2026journal-article

Applied System Innovation

Intelligent Fault Diagnosis and Maintenance Decision Support in Electrical Induction Generators Using Multi-CNN Extreme Ensemble Learning

Majida Khaleel Ahmed, Ahmed Mohammed Mohsin Alzubaidi, Zeashan Hameed Khan, Ahmed Ali Farhan Ogaili, Alaa Abdulhady Jaber, Luttfi A. Al-Haddad

Electrical induction generators are vulnerable to winding faults that can degrade operational reliability and lead to unplanned maintenance. This study proposes a multiple-convolutional neural network (Multi-CNN) extreme ensemble learning framework for intelligent fault diagnosis and maintenance decision support using three-phase current and voltage measurements. Experimental recordings representing healthy operation, inter-turn faults, and inter-winding faults were segmented into non-overlapping 200-sample windows …

30.08.2026journal-article

EJNMMI Physics

Virtual-patient nonlinear mixed-effects modelling for data-driven optimisation of single-time-point dosimetry: a proof-of-concept study in [177Lu]Lu-PSMA-617 therapy

Yeni Pertiwi, Indra Budiansah, Jaja Muhamad Jabar, Muchtaridi Muchtaridi, Freddy Haryanto, Idam Arif, Deni Hardiansyah, Gerhard Glatting

Abstract Background Robust single-time-point (STP) dosimetry critically depends on selecting an imaging time that yields reliable estimates of the time-integrated activity coefficient (TIAC). This study developed and evaluated a virtual-patient nonlinear mixed-effects modelling (NLMEM) framework to optimise STP imaging schedules for renal TIAC estimation, using [¹⁷⁷Lu]Lu-PSMA-617 therapy as a proof of concept. Methods A previously published NLMEM (sum-of-exponentials structure and parameter distributions) describin …

30.08.2026journal-article

Scientific Reports

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Agata Galas, Robert Morawiec, Iwona Gorczyca-Głowacka, Agata Tymińska, Katarzyna Byczkowska, Jarosław D. Kasprzak, Aleksander Siniarski, Marek Kuch, Beata Wożakowska-Kapłon, Adrian Stefański, Witold Furmanek, Paweł Krzesiński

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringent GDMT target in patients with HFrEF undergoing scheduled hospitalization. The analysis included 287 patients with reduced left ventricular ejection fraction (LVEF), which is a subset of the 1422 participants of the HEROES study, a prospec …

30.08.2026journal-article

Frontiers on Healthcare Research

Inpatient Clinical Profile and Mortality Patterns at a Tertiary Referral Hospital in Indonesia: A Descriptive Study at RSUP Dr. M. Djamil Padang

Department of Statistics, Universitas Negeri Padang, Padang, Indonesia, Viora Antasya Viora, Dodi Vionanda Dodi, Dr. M. Djamil General Hospital, Padang, Indonesia, Alfitri Alfitri Alfitri

<p style="font-weight: 400;"><strong>Background:</strong> Hospital electronic medical records contain morbidity and mortality data that can be analyzed to provide a comprehensive picture of health profiles. However, most studies using inpatient data are limited in scope and do not integrate the distribution of diagnoses, mortality patterns, and case fatality rates into a single analytical framework. This study aimed to describe the characteristics of inpatients at Dr. M. Djamil General Hospital in Padang in 2025, i …

30.08.2026journal-article

Urologia Journal

Andrological emergencies in current emergency medicine: A narrative overview of clinical, psychological, and worldwide implications

Ghada Farouk Mohammed, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Ahmed Mohammed Al-Dhubaibi, Sameh Saad Aziz, Yasser Salem N. Saleh

Background: Andrological emergencies (AEs) constitute a critical subset of acute urogenital conditions requiring urgent recognition and intervention to preserve sexual and reproductive function while preventing long-term morbidity. Common AEs include testicular torsion, ischemic priapism, penile fracture, paraphimosis, Fournier’s gangrene, penile strangulation, and acute urinary retention. Aim: To provide a comprehensive synthesis of current knowledge on the clinical presentation, diagnostic approaches, therapeutic …

30.08.2026journal-article

Judi Clinical Journal

Vertebral Mass Mimicking Thoracic Outlet Syndrome: A Case Report with Literature Review

Fahmi H. Kakamad, Shakew S. Mohammed, Razan Babarasul Jalal, Azad S. Hattam, Saywan K. Asaad, Abdullah K. Ghafour, Lawand A. Sharif, Huzaifa Hamid Ahmed, Hadeel A. Yasseen, Miran I. Hassan, Hiwa S. Namiq, Harun Amanj Ahmed

Abstract Introduction: Neurogenic thoracic outlet syndrome is the most common subtype of thoracic outlet syndrome and can be readily mimicked and misdiagnosed. This report presents a rare cervical vertebral lesion mimicking neurogenic thoracic outlet syndrome, highlighting an important diagnostic pitfall. Case presentation: Presenting with two years of left shoulder pain and immobility following heavy labor, a 17-year-old male underwent provocative testing and nerve conduction studies suggesting left neurogenic tho …

30.08.2026journal-article

Journal of Clinical Medicine

Effects of Exercise Interventions on Peripheral Brain-Derived Neurotrophic Factor: An Umbrella Meta-Analysis Across Clinical and Healthy Populations

Mesut Süleymanoğulları, Cemre Didem Eyipınar, Raul Ioan Muntean, Halil İbrahim Ceylan

Background and Objectives: Brain-derived neurotrophic factor (BDNF) supports neuronal function and plasticity, but exercise meta-analyses may reuse primary studies and combine distinct outcomes. We evaluated review-level evidence while preventing direct reuse of the same primary-study evidence within pooled syntheses in this umbrella review and meta-analysis. Methods: Thirty-nine systematic reviews with quantitative syntheses of peripheral BDNF were assessed. Review–primary-study links were normalized, methodologic …

30.08.2026journal-article

Journal of Clinical Medicine

Gender Differences in Diabetes Technology: Adherence and Outcomes—A Systematic Review

Sandro La Vignera, Aldo E. Calogero, Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Giuseppe Papa, Vincenzo Provenzano, Francesca Provenzano, Rosita A. Condorelli

Background/Objectives: Diabetes management technologies—including continuous glucose monitors (CGM), insulin pumps (CSII), advanced hybrid closed-loop (AHCL) systems, and mobile health applications—have transformed diabetes care, yet gender-specific differences in ad-herence, clinical outcomes, and patient-reported outcomes remain inadequately char-acterised. Methods: We conducted a systematic literature review following PRISMA 2020 guide-lines, searching SciSpace, Google Scholar, and PubMed databases. From 852 ide …

30.08.2026journal-article

Scientific Reports

Heritability, pregnancy determination, and clinical follow-up in fetal copy number variation: an eight-year single-center retrospective study

Meiying Cai, Wenqi Chen, Meimei Fu, Liangpu Xu, Na Lin, Hailong Huang

Abstract Copy number variation (CNV) is defined as a > 1-kb-long DNA fragment copy number increase or decrease, with fetal CNV judgment and genetic counseling posing difficulties. We tested and retrospectively analyzed fetuses using chromosomal microarray analysis (CMA), 169 with abnormal CNV being completely verified and followed up for pregnancy and postnatal outcomes. Among the 169 fetuses, 103 and 66 exhibited inherited and de novo CNV. Of the former, 50, 34, and 19 displayed hereditary pathogenic CNV (P-CNV) [ …

30.08.2026journal-article

Journal of Translational Medicine

The role of lipid metabolism in immune thrombocytopenia: new perspectives from immune inflammation and thrombopoiesis

Dan Li, Luer Qiu, Ying Zhang, Li Hong, Sai Zhou, Weiying Feng

Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune condition defined by increased immune-driven platelet destruction and inadequate platelet generation. Emerging research highlights that global alterations in lipid metabolism are closely associated with immune dysfunction and suppressed thrombopoiesis in ITP, offering a new metabolic framework for understanding disease mechanisms. Main body This review provides a comprehensive analysis of the pivotal role played by lipid metabolic pathways i …

30.08.2026journal-article

Malaysian Journal of Paediatrics and Child Health

Navigating the Challenges of Oesophageal Atresia With Tracheo-Oesophageal Fistula: A Case-Based Review From Diagnosis to Recovery

Harridas Manickam, Azliana Aziz, Mohd Shahrulsalam Mohd Shah

Oesophageal atresia with distal tracheo-oesophageal fistula (Type C EA/TEF) is the most common anatomical subtype of EA/TEF and requires early diagnosis and surgical management. Delayed recognition increases the risk of aspiration-related complications. This report describes the presentation, multidisciplinary management and early postoperative outcomes of two neonates with Type C EA/TEF treated at a tertiary referral centre. Two neonates presented after birth with respiratory distress, excessive oral secretions or …

30.08.2026journal-article

Autism Research

Sex and Cognitive Ability‐Based Stratification of Social Attention in Autism

Jason W. Griffin, Frederick Shic, Adam Naples, Kelsey Dommer, Geraldine Dawson, Susan Faja, Shafali Jeste, Natalia Kleinhans, James Dziura, Catherine Sugar, Damla Senturk, Gerhard Hellemann, Sara Jane Webb, James C. McPartland, the Autism Biomarkers Consortium for Clinical Trials

ABSTRACT Reduced social attention (SA) is a hallmark feature of autism that is foundational to social communication and interaction. However, emerging evidence suggests that reduced SA may not be uniformly expressed across the autism spectrum. Sex and cognitive ability (IQ) have been identified as relevant stratification variables, potentially moderating SA in autistic children. We examined differential patterns of SA stratified by sex and cognitive ability in a large, longitudinal sample of autistic and neurotypic …

30.08.2026journal-article

JAMA

Anticoagulation Monotherapy vs Antiplatelet Monotherapy After Transcatheter Aortic Valve Implant

Christopher S. Dodgson, Jon Herstad, Sophie F. Kløve, Malin Flygel, Mehdi Akhavi, Sverre Høie, Jan Otto Beitnes, Christian H. Eek, Kaspar Broch, Céline Cunen, Lars Gullestad, Lars Aaberge, Ketil Lunde, Bjørn Bendz, Øyvind H. Lie

Importance Transcatheter aortic valve implant (TAVI) is increasingly being performed in younger and healthier patients with severe aortic valve stenosis. Antithrombotic therapy after TAVI is a key element of optimizing valve durability and clinical outcomes. Objective To evaluate the safety and efficacy of a factor Xa inhibitor non–vitamin K antagonist oral anticoagulant (NOAC) monotherapy strategy vs an acetylsalicylic acid (ASA) monotherapy strategy after TAVI. Design, Setting, and Participants Between December 2 …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Pharmacological Effects and Clinical Applications of Shouhui Tongbian Capsules: A Systematic Review

Xi Yan, Na Li, Lei Wang, Peini Sun, Ru Ma, Xu Ren

Shouhui Tongbian Capsules (SHTB) is a commonly used Chinese patent medicine for treating functional constipation. Recent studies have shown that its effects go beyond relieving constipation, with potential benefits in improving heart failure, reducing obesity, repairing intestinal injury, and slowing atherosclerosis. This review systematically summarizes 25 studies published between 2020 and 2026, covering clinical trials, pharmacological mechanisms, gut microbiota, and chemical composition. The main topics include …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress of Traditional Chinese Medicine on Diarrhea-predominant Irritable Bowel Syndrome

Xuemei Yang, Hui Ding

Irritable bowel syndrome (IBS) is a common functional disorder of the digestive system, characterized by recurrent abdominal pain and bloating accompanied by changes in stool consistency and bowel habits. The symptoms often recur or persist and are difficult to resolve. In clinical practice, diarrhea-predominant irritable bowel syndrome (IBS-D) is the most common subtype. This article mainly reviews internal and external treatment methods of traditional Chinese medicine for this disease, summarizes their advantages …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Clinical Study on Qinghuo Qibi Decoction Combined with Rehabilitation Training in the Treatment of Autism Spectrum Disorder of Heart-liver Fire Hyperactivity Pattern

Jiangwei Yang, Yaxiong Guo

Objective: To observe the clinical efficacy of Qinghuo Qibi Decoction combined with rehabilitation training in the treatment of autism spectrum disorder (ASD) of heart-liver fire hyperactivity pattern and its effects on inflammatory cytokines. Methods: A randomized controlled trial (RCT) was conducted. A total of 140 children with ASD of heart-liver fire hyperactivity pattern who attended our hospital and the Affiliated Hospital of Shaanxi University of Chinese Medicine between February 2022 and February 2025 were …