Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 135

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

European Journal of Preventive Cardiology

Cardiac rehabilitation in adults with congenital heart disease: care situation, barriers, and patient-reported outcomes

Juliane Barth, Steffen Montenbruck, Robert Cesnjevar, Oliver Dewald, Helena Dreher, Peter Ewert, Annika Freiberger, Tobias Gampert, Jürgen Hörer, Michael Huntgeburth, Harald Kaemmerer, Detlef Koch, Christian Meierhofer, Fritz Mellert, Wolfgang Schmiedeberg, Mathieu N Suleiman, Fabian von Scheidt, Wolfgang Wagener, Frank Harig, Ann-Sophie Kaemmerer-Suleiman

Abstract Aims Cardiac rehabilitation (CR) is an essential component of long-term care for adults with congenital heart disease (ACHD). This study provides novel patient-reported data on barriers to cardiac rehabilitation in ACHD, a population that has so far been insufficiently studied in this respect. The objective was to investigate knowledge, sources of information, barriers to access, and expectations regarding CR in ACHD and to analyse age-specific and sex-specific differences. Methods and results A pragmatic …

11.08.2026journal-article

Journal of Cardiopulmonary Rehabilitation and Prevention

A Scoping Review of the Effects of E-Cigarette Use on Cardiorespiratory Fitness and Lung Function in Young Adults

Ximeng Zhao, Salvador Jaime, William Cooke, Taghrid Asfar, Wasim Maziak

Purpose: The surge in e-cigarette use among young people worldwide has become a major public health issue. However, its impact on outcomes important to young people, such as cardiorespiratory fitness, is still not fully understood. This review aims to determine the effects of e-cigarette use on cardiorespiratory fitness in young people. Review Methods: A systematic search was conducted across PubMed and Embase to identify relevant studies. Original articles assessing the effects of e-cigarettes on cardiorespiratory …

11.08.2026journal-article

Journal of Cell Biology

EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy delivery

Sergi Marco, Peter J. Walsh, Alexey S. Revenko, Tobias Schmidt, Peter A. Thomason, Lynn McGarry, A. Robert MacLeod, Sonam Ansel, Dina Tataran, Martin Bushell, Chiara Braconi, Jim C. Norman

The potential for using therapeutic antisense oligonucleotides (ASOs) has been hampered by a lack of understanding of how they enter cells and subsequently access their targets. Endocytosis contributes to ASO uptake, but the machinery mediating subsequent ASO trafficking to permit suppression of their target mRNAs has not been described. Here, we show that direct ASO engagement with a scavenger receptor (CD44) activates the ERK-RSK axis to promote serine phosphorylation of a receptor tyrosine kinase (EPHA2). Serine …

1 Zitationen
11.08.2026journal-article

Healthcare

Google Translate Voice App vs. Qualified Interpreters: An Exploratory Study of Clinical Accuracy in Real-World Speech/Voice Encounters

Iris Feinberg, Heewon Lee-Laminack, Elizabeth L. Tighe, Ifedola Owoeye

Background/Objectives: AI voice interpretation applications like Google Translate in speech/voice mode are increasingly used in clinical settings to address verbal language access challenges, yet evidence comparing their performance to qualified in-person medical interpreters in authentic clinical encounters remains limited. The aim of this study is to compare the linguistic and clinical accuracy of AI-based Google Translate in speech/voice mode and qualified in-person medical interpretation using spoken real-world …

11.08.2026journal-article

Journal of modern medicine

OCCUPATIONAL, CLINICAL, AND DEMOGRAPHIC RISK FACTORS FOR PELVIC ORGAN PROLAPSE IN FEMALE TEXTILE WORKERS

M.M. Butaboeva

<p>Pelvic organ prolapse is a common pelvic floor problem for women. Pelvic organ prolapse hurts women’s quality of life, hurts women’s productivity, and hurts women’s reproductive health. In recent years researchers have focused on job risk factors; but knowledge about how textile industry work conditions affect pelvic organ prolapse remains limited. Objective. The aim is to study job, medical, and demographic risk factors for pelvic organ prolapse in women who work in the textile industry. Materials and methods. …

11.08.2026journal-article

Counselling and Psychotherapy Research

Seeing the New Through the Familiar: How Previous Professional Training Shapes the Early Stages of Learning Mentalization‐Based Therapy in Child Mental Health Services in the UK

Yasmin Broersma Lamouini, Polly Casey, Nick Midgley

ABSTRACT Introduction Many mental health practitioners train in multiple psychotherapy modalities throughout their careers. However, research has largely ignored how prior training in one modality affects the learning of a new one. This gap leaves us with a limited understanding of how practitioners with prior training in other modalities experience learning a new psychotherapy modality and how to design and deliver training that optimises learning in light of prior training. Therefore, this qualitative study inves …

11.08.2026journal-article

Clinical Cancer Research

Nonarmored GCC-Targeting CAR T-cell Therapy Demonstrates Significant Efficacy in Patients with Advanced Colorectal Cancer

Qianyu Zhang, Lin Lin, Wei Wang, Ling He, Lin Wang, Wenjuan Li, Qiujun Zhang, Dandan Hu, Sheng Wu, Wenyu Li, Shoubing Zhou, Wei Jin, Jing Pan, Yabei Liu, Yueyin Pan, Xiaohu Fan, Hu Liu

Abstract Purpose: This phase I clinical trial aims to evaluate the safety, expansion kinetics, and preliminary efficacy of nonarmored, nanobody-derived guanylyl cyclase 2C (GCC)–targeted chimeric antigen receptor (CAR) T cells in patients with heavily pretreated metastatic colorectal cancer. Patients and Methods: In this single-arm, open-label, phase I clinical trial, 24 patients who received at least 2 prior lines of treatment received GCC-targeted CAR T cells across 4 dose levels: 0.5 × 105, 1 × 106, 2 × 106, and …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Perception of Synthesized Mandarin Speech Based on a Large-Scale Language Model Among Deaf Adults With Cochlear Implants

Ju Zhang, Zhao Zhang, Yu Bai, Yu Chen

Purpose: This study investigated the intelligibility and processing characteristics of Mandarin sentences synthesized based on a large-scale language model (LLM), compared to natural speech, specifically for deaf adults with cochlear implants (CIs). Method: Fifty participants, 25 Mandarin-speaking deaf adults with CIs and 25 Mandarin-speaking adults with normal hearing (NH), were enrolled in the study. Sentence recognition rates and reaction times were measured using sentences from the Mandarin speech perception da …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Temperament Profiles and Their Association With Stuttering-Related Outcomes in a Clinical Cohort

Iris Heselmans, Sarah Delpeche, Elaine Kelman, Sharon Millard, Kurt Eggers

Purpose: Previous research on temperament in developmental stuttering has primarily treated emotional reactivity and self-regulation as separate constructs. Examining their interaction is likely to yield more comprehensive insights into their joint influence on stuttering-related outcomes. Therefore, this study examined how the interplay between emotional reactivity and self-regulation is reflected in differences in stuttering severity, speech attitude, levels of anxiety and depression, and the impact of stuttering …

11.08.2026journal-article

Scientific Reports

Effects of lower limb exoskeleton-assisted rehabilitation training on ischemic stroke patients with ICU-acquired weakness

Mengyi Ren, Kui Wang, Zhaoxiang Meng, Xibin Zhang, Jibin Wang, Yifeng Quan, Zhiping Xue, Wenyu Zhang, Xiaojia Tang, Daejung Yang, Xing Jin

Abstract To evaluate the effectiveness of lower limb exoskeleton robots in improving musculoskeletal function in ischemic stroke patients with ICU-acquired weakness (ICU-AW), compare its therapeutic efficacy with conventional rehabilitation, and explore the underlying physiological and biomechanical mechanisms. A total of 72 eligible patients were randomly divided into the experimental group (exoskeleton robot-assisted rehabilitation) and control group (conventional rehabilitation). Both groups received routine reh …

11.08.2026journal-article

Journal of Orofacial Innovation and Science

Predictability and oral health in clear aligner therapy for mixed dentition

Daniel Neves, Desire Cassilha Neves, Giselle Machado Gurek, Waleska Trovisco Caldas Furquim, Guilherme Fantini Ferreira, Larissa Carvalho Trojan

Objective:This prospective clinical study evaluated the predictability of dental movement and oral health outcomes in children with mixed dentition treated with clear aligners. Methods: Orthodontic treatment was delivered using ClearCorrect® aligners. Standardized clinical documentation was obtained at pre-treatment (T1) and immediately post treatment (T2). Digital models were used to measure changes in arch perimeter, transverse dental movement at the cusp and gingival levels of the intercanine, first and second p …

11.08.2026journal-article

Communications of International Proceedings

Financial Crises and Psychological Distress: The Role of Solution-Focused Brief Therapy (SFBT) as a Clinical Intervention

Jacek WINIARSKI, Aleksandra KOŹLAK

Individual financial crises – including personal debt, income loss, and unemployment – represent one of the strongest psychosocial risk factors for mental disorders in adult populations, yet clinical practice lacks validated interventions specifically designed for this context. This article addresses three convergent gaps: the absence of integrated theoretical frameworks explaining the pathway from financial to psychological crisis; clinical interventions not tailored to chronic financial stress; and the complete a …

11.08.2026journal-article

International Journal of Medical Science and Dental Health

Digital Prosthetic Rehabilitation for A Paediatric Patient Using CAD-CAM Fabricated PMMA Crown- A Case Report.

Dr. Kola Srikanth Reddy, Dr. Alekhya Achanta, Dr. Bhuvana C. M., Dr. Korakoppula Alekya, Bhavani Sukka, Dr. V. Nagakishore

Aim: Crowns apply to primary teeth with extensive caries, cervical decalcification, developmental defects, interproximal caries extending beyond line angles, and following pulpotomy or pulpectomy. Background description: 3D-milled polymethylmethacrylate (P-PMMA) crowns, which offer apperceptive and marginal adaptation. Advancements in CAD/CAM glass-ceramic crowns have expanded their use in Aesthetic dentistry. Case description: This case report illustrates a clinical use of computer-aided design and manufacturing t …

11.08.2026journal-article

Frontiers in Rehabilitation Sciences

Embodied robots in rehabilitation-oriented interventions for older adults with disability or cognitive impairment: a scoping review

Wen Xu, Xian Zhou, Yu Zeng, Sixuan Han, Yanyan Hong

Background Robots are increasingly used in later-life care. However, existing reviews often combine applications such as companionship, telepresence, medication support, monitoring, psychosocial support, traditional AI, and rehabilitation within a single body of evidence. This conceptual overlap makes it difficult to interpret the rehabilitation-specific evidence base. Objective This study aimed to map empirical studies on embodied robots used in rehabilitation-oriented interventions for older adults with disabilit …

11.08.2026journal-article

Oncogenesis

Disruption of the AR/ZNF217/PROM2 axis sensitizes prostate cancer to ferroptosis and enzalutamide therapy

Wenjun Hao, Peng Liang, Wanglong Zheng, Minglu Sheng, Yulin Peng, Xiang Gao, Haolin Zhao, Yuyan Zhu, Yanlong Wang, Bo Fan, Zhihong Dai, Xu Sun, Liang Wang, Huan Qi, Ying Wang, Yan Wang, Zhenlong Yu, Zhiyu Liu

Abstract Dysregulation of androgen receptor (AR) signaling is a key molecular driver of prostate cancer development and its transition to castration-resistant disease. Although emerging evidence indicates that AR may influence ferroptosis by modulating lipid peroxidation and antioxidant systems, the complete transcriptional network through which AR regulates ferroptosis remains incompletely defined. In this study, we identify the transcription factor ZNF217 as a direct downstream target of AR, which is aberrantly u …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Social–Emotional Development of Young Children Who Stutter: An Overview of Empirical Studies

Amir Hossein Rasoli Jokar, Hamed Fattahian Tehran, Holly E. Brophy-Herb, J. Scott Yaruss

Purpose: Developmental stuttering typically emerges between 2.5 and 6 years, the period during which emotion processes, peer competence, and self-system processes also become more consolidated. This scoping review synthesized evidence on how social–emotional development (SED) intersects with stuttering in early childhood and how the literature conceptualizes their associations. Method: Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, PubMed, APA PsycInf …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Understanding How Older Adults Comprehend Simple Comparative Sentences in a Predicate-Final Language

Jimin Park, Seunghun J. Lee, Jee Eun Sung

Purpose: This study examined the effects of aging on the comprehension of simple comparative sentences in a predicate-final language. Additionally, we explored individual variability among older adults by categorizing them based on chance-level performance. Method: A total of 221 participants completed a sentence–picture matching task involving simple comparative constructions, which were manipulated by word order (comparee-first, standard-first). Response accuracy and response time (RT) were analyzed across age gr …

11.08.2026journal-article

Blood Cancer Discovery

Predictive Models for Toxicities after CAR T-cell Therapy: Challenges and Opportunities

Julie Ma, August Culbert, Tian-Gen Chang, Mark L. Solter, Eytan Ruppin, Kai Rejeski, Nirali N. Shah

Abstract Chimeric antigen receptor (CAR) T-cell therapy is increasingly utilized with expanding indications beyond hematologic malignancies. Here, we review existing models developed for predicting toxicities in the CAR T-cell setting and identify both strengths and challenges emerging with their application. Predictive modeling approaches offer potential to guide risk stratification and inform clinical decision-making, but small sample sizes, overfitting, and poor data quality have limited model reproducibility an …

11.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

ECONOMIC IMPACT OF THE REGIS SCALE™ ON OPTIMIZING THERAPY FREQUENCY IN HOME-BASED NEUROLOGICAL REHABILITATION

Régis Ferraz Cornélio Goiana Novaes

Background: Determining the appropriate frequency of home-based physical therapy for patients with neurological disorders remains a major clinical and operational challenge. Decisions are frequently based on individual clinical judgment, which may result in variability in treatment intensity and inefficient allocation of healthcare resources. The Régis Scale™ was developed as a standardized clinical decision-support tool to optimize therapy frequency according to patients' rehabilitation needs. Objective: To evalua …

11.08.2026journal-article

Acta Epileptologica

Vagus nerve stimulation as an add-on therapy in patients with epilepsy: a prospective, multicenter, real-world study in China

Chenyang Zhao, Enhui Zhang, Hesheng Zhang, Raowei Yan, Zhijun Le, Yujie Chen, Wenyu Liu, Weixi Xiong, Xintong Wu, Dong Zhou

Abstract Background Vagus nerve stimulation (VNS) has been proven as an effective and safe adjunct therapy for epilepsy, but real-world evidence is limited. This study aimed to evaluate outcomes of VNS and its cumulative effect through a prospective, multicenter, real-world survey in China, with dynamic follow-up. Methods A total of 83 sites in China participated and 124 epilepsy patients enrolled. Visits were scheduled at 1, 3, 6, 9, and 12 months after VNS. Primary outcomes included seizure response rate (≥ 50% f …

11.08.2026journal-article

Inverge Journal of Social Sciences

Socioeconomic Determinants of Women's Occupational Choices in Pakistan

Dr. Samrana Afzal, Sara Noreen, Farwa, Sabiha Abid

This study examines the socioeconomic determinants of women's occupational choices in Pakistan. Using a quantitative research design, the study analyses hypothetical cross-sectional data from 2,000 working-age women based on the Pakistan Labour Force Survey framework. Women's occupations are classified into agriculture, elementary and manual work, craft and related trades, services and sales, clerical and administrative employment, and professional, technical, and managerial occupations. A multinomial logistic regr …

11.08.2026journal-article

Annals of Otology, Rhinology & Laryngology

Swallowing Rehabilitation with Motor Imagery in Patients Undergoing Radiation for Head & Neck Cancer: A Prospective Study

Rishi Kondapaneni, Safa Shaikh, Kaitlyn Florence, Naiwei Chen, Laura Dooley, Gregory Biedermann, Stephanie Knollhoff

Objectives: Radiation therapy (RT) for head and neck cancer (HNC) commonly causes dysphagia. Swallowing rehabilitation programs (SRPs) during RT improve functional outcomes, but adherence remains low due to RT-related pain. Motor imagery (MI) incorporated into SRPs may provide a low-burden adjunct to improve participation and outcomes. The purpose of this prospective pilot study is to evaluate adherence and clinical outcomes of an MI-based SRP for HNC patients undergoing RT. Methods: Between April 2021 and November …

11.08.2026journal-article

Revista NUPEM

Partejar Potiguaras: um relato de vivências com mulheres Potiguaras da Paraíba

Nathália Jorge Novais, Juliana Sampaio, Isabella Chianca Bessa Ribeiro do Valle, Luziana Marques da Fonseca Silva, Waglânia de Mendonça Faustino

Este artigo resulta de vivências com mulheres Potiguaras no âmbito do projeto de pesquisa-extensão “Partejar Potiguara”, desenvolvido em aldeias localizadas nos municípios de Rio Tinto, Marcação e Baía da Traição, no estado da Paraíba. O projeto teve como objetivo conhecer, mapear e dar visibilidade às práticas e aos saberes das parteiras potiguara, bem como compreender suas formas de inserção nos campos da educação, da religião, da saúde e da representação política. A pesquisa foi realizada por meio de visitas qui …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Quality of Life in Children With Cochlear Implants: A Systematic Review and Meta-Analysis of Different Quality of Life Domains

Ghaida E. Alharbi, Rozan M. Alabdali, Lujain A. Bukhari, Reem O. Nughays, Enar A. Almazroy, Shahad K. Elyas, Muhnnad Abdulaziz AlGhamdi, Lama N. Alghamdi, Moayyad Malas, Dakheelallah M. Almutairi

Abstract: Purpose: The primary objective of this study was to assess the quality of life (QoL) in children with cochlear implants (CIs) from the children's and parents' perspectives through utilizing the Pediatric Quality of Life Inventory (PedsQL) and KINDL questionnaires. A secondary objective was to compare the QoL of children with CIs to those using hearing aids and to children with normal hearing (NH). Method: A total of 1,830 records were obtained since the search was systematically carried out across databas …