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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Clinical Case Reports

Clinical Benefit of Pembrolizumab in Lynch Syndrome‐Associated Advanced Ovarian Cancer With Germline MSH6 Variant: A Case Report

Tomomi Yokozawa, Sayako Nakagawa, Yukio Suzuki, Aya Tokinaga‐Uchiyama, Katsuyuki Konnai, Hiroto Narimatsu, Yukihiko Hiroshima, Haruya Saji

ABSTRACT This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first‐line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.

31.08.2026journal-article

Acute and Critical Care

Peripheral administration of 11.7% hypertonic saline and phlebitis risk in acute ischemic stroke requiring hyperosmolar therapy in South Korea

Beom-Seok Seo, Hyesuk Hong, Jong Hwa Hong, Jisu Jung, Hyunsoo Kim

Background: Hypertonic saline (HTS) is used for hyperosmolar therapy in acute ischemic stroke (AIS) but is traditionally administered via central venous catheter to minimize vascular complications. Procedural burden and urgency often necessitate peripheral administration in practice. We investigated phlebitis risk associated with peripheral 11.7% HTS in AIS patients requiring hyperosmolar therapy.Methods: This retrospective study included 200 AIS patients receiving hyperosmolar therapy with mannitol (January 2022–D …

31.08.2026journal-article

Frontiers in Pharmacology

A new era in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD): clinical breakthroughs and challenges

Zhifu You, Linglong Yang, Yuanhao Long, Dongye You, Qian Zhao

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting nearly one-third of adults worldwide, encompasses a spectrum from steatosis to steatohepatitis (MASH), advanced fibrosis, cirrhosis, and hepatocellular carcinoma, with fibrosis stage as the primary determinant of liver-related outcomes and cardiovascular disease as the leading cause of mortality. Despite robust evidence that lifestyle interventions achieving ≥10% weight loss induce fibrosis regression in many patients, sustained success in …

31.08.2026journal-article

Frontiers in Medicine

Urine inflammatory protein levels decrease following kidney transplantation

Elizabeth Spiwak, Corina Nailescu, David S. Hains, Marah Kolner, Samual Arregui, Andrew L. Schwaderer

Background Kidney transplant recipients are subjected to several types of immunosuppressants in order to prevent rejection of the graft. Over-immunosuppression increases the risk of infectious complications and thesepatients require a delicate balance. Inflammatory profiles from the urine can help identify which biomarkersmay guide clinicians in balancing over vs. under-immunosuppression. Methods Urine samples were obtained from 10 complete kidney donor-recipient pairs at a pre-operative visit ~1 weekprior to or at …

31.08.2026journal-article

Journal of Science Research and Reviews

Artificial Intelligence for Medical Imaging Diagnosis: From Accuracy to Clinical Reliability through Multimodal Fusion, Validation, and Regulatory Perspectives

Enoch Jacob Dodo, Amos Takai Yayock, Gregory Onwodi, Ruth Tukuluku

Artificial intelligence (AI)-based medical imaging diagnosis has demonstrated remarkable performance across multiple clinical domains, with deep learning models frequently reporting diagnostic accuracy, sensitivity, and specificity exceeding 90% under controlled experimental conditions. However, translating these results into clinically reliable, regulatory-compliant systems remains a critical challenge. As a narrative survey rather than an original benchmark study, this paper reports no new experimental results; i …

31.08.2026journal-article

Environmental Geochemistry and Health

Distribution, mobility and exposure risk of rare earth elements, uranium and thorium in soils impacted by illegal cassiterite–monazite mining in the southeastern Amazon, Brazil

Antonia Andreyna Pereira Rodrigues, José Tasso Felix Guimarães, Gabriel Caixeta Martins, Luiza Santos Reis, Edna Santos de Souza, Roberto Dall’Agnol, Sílvio Junior Ramos

Abstract Illegal cassiterite and monazite mining in the Taboca district of São Félix do Xingu, southeastern Amazonia, Brazil, reworks alluvial materials developed on the Paleoproterozoic Antônio Vicente Granite. This A-type granite is naturally rich in the REE-, Th- and U-bearing minerals monazite, xenotime and zircon, so mining further concentrates rare earth elements (REE), thorium and uranium whose concentrations are already raised by lithology. We sampled 130 surface horizons (34 native soils, 96 tailing residu …

31.08.2026journal-article

Nursing Philosophy

Active Learning and Professional Citizenship in Nursing Education: A Structural Account

Maria Efstathiou, Mary Gouva, Elena Dragioti

ABSTRACT Active learning and professional citizenship are widely discussed in nursing education, yet the conditions under which they converge have not been theoretically specified. In this paper, we advance a structural account of that relation, drawing on deliberative theory, philosophy of education, and nursing scholarship. The relation we describe is one of shared enabling conditions rather than causal production: active learning and professional citizenship converge not because one produces the other, but becau …

31.08.2026journal-article

Izmir Katip Celebi University Faculty of Medicine

Altered Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index in Children with Breath-Holding Spells: A Retrospective Comparative Study

Günce Başarır, Rıdvan Avcı

Objective: To evaluate whether complete blood count (CBC)-derived hematological and inflammatory indices differ between children with breath-holding spells (BHS) and a control group without neurological or chronic systemic disease, and whether laboratory parameters can contribute to distinguishing cyanotic and pallid subtypes. Materials and Methods: This retrospective, single-center comparative study included 47 children diagnosed with BHS (22 cyanotic, 25 pallid) and 50 controls without neurological, hematological …

31.08.2026journal-article

Research and Theory for Nursing Practice

Volunteerism in Nursing During Disasters: A Concept Analysis

Bilge Kalanlar

Background and Purpose: Understanding the factors that influence nurses’ willingness to volunteer during disasters is essential for fostering their active and sustained involvement in disaster preparedness efforts. The aim of the study is to conduct a concept analysis on nurses’ volunteerism in disaster situations. Methods: Walker and Avant’s concept analysis method was used to examine the concept of volunteering. Literature search was conducted in Web of Science, PubMed, ProQuest, ScienceDirect, and CINAHL (Cumula …

31.08.2026journal-article

Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics

Development of the Self-Voice Program for the Digital Transformation of Voice-Related Patient-Reported Outcome Measures

Chang Yoon Lee, Soo-Youn An, Hee Young Son

Background and Objectives To develop Self-Voice, a browser-based platform for administration, scoring, visualization, longitudinal tracking, and export of voice-related patient-reported outcome measures (PROMs).Materials and Method Self-Voice was developed as a static client-side web application in which patient and assessment data are stored in the user’s browser. The platform implements the Korean Voice Handicap Index (K-VHI)-30, K-VHI-10, Korean Voice Fatigue Index (K-VFI), and Korean Voice-Related Quality of Li …

31.08.2026journal-article

International Journal Of Community Medicine And Public Health

Menstrual hygiene practices and WASH practices among women residing in an urban slum in Delhi: a community-based study

Sahdev Santra, Nitin Panwar, Sahil Dhama, Abin K. Rajan, Parth Singhal, Anita Verma

Background: Menstrual hygiene management (MHM) is a vital component of women’s health, yet it remains a neglected issue in low-resource settings. Despite improved product availability, women in urban slums continue to face challenges related to sanitation, privacy, and hygiene. This study aimed to assess menstrual hygiene practices among women in an urban slum of Delhi and examine their association with WASH (water, sanitation, and hygiene) behaviours. Methods: A community-based cross-sectional study was conducted …

31.08.2026journal-article

International Journal Of Community Medicine And Public Health

Urolithin A-induced mitophagy: a mitochondrial therapeutic axis for decelerating musculoskeletal aging and modulating knee osteoarthritis pain

Aavrati Rastogi, Roop B. Kalia, Mukesh Bairwa

Knee osteoarthritis (OA) is a disease characterized by cellular energy dysregulation, in which structural joint deterioration and chronic pain are caused by mitochondrial dysfunction. OA is now recognized as a multifactorial condition caused by disturbed cellular homeostasis, metabolic imbalance, and typical biological processes of aging, notably mitochondrial dysfunction. However, it was once thought to be caused by mechanical wear and cartilage degradation

31.08.2026journal-article

The Australian Journal of Anthropology

What ethnography sees that diagnosis misses: A clinical commentary on borderline personality disorder and ‘structures of care and credibility’

Shaun Halovic

Abstract In their recent article in The Australian Journal of Anthropology , Ira Parker Vaughan (2025) presents a rich ethnographic account of Anika and Milan that raises broader questions about how complex forms of suffering are recognised and interpreted. This commentary argues that the significance of Vaughan's article extends beyond the particulars of the case itself. Rather than treating Anika as a subject for retrospective psychiatric diagnosis, I suggest that the ethnography illustrates why certain forms of …

31.08.2026journal-article

Journal of Community Service and Empowerment

Comprehensive mentoring in developing Deep Learning-based instructional materials for public junior high school mathematics teachers

Umi Farihah, Mohammad Kholil, Siti Khikmatul Munawwaroh, Faishal Tamim, Muhammad Suwignyo Prayogo

Teachers of the MGMP Mathematics at Public Junior High Schools in the Western Region of Jember Regency experience difficulties in developing Deep Learning-based instructional materials. This mentoring program aims to describe teachers’ challenges, formulate mentoring strategies, and explain the outcomes of the implemented strategies. The community service method involved preparation, planning, coordination, implementation, reflection, evaluation, and follow-up. Data were collected through interviews, observations, …

31.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

CONTAMINAÇÃO ALIMENTAR POR LISTERIA MONOCYTOGENES: PATOGÊNESE, FORMAÇÃO DE BIOFILMES E IMPACTOS NA SAÚDE PÚBLICA

Jaqueline Santos Teles Bahia, Felipe Teles Bahia

A listeriose é uma grave infecção de origem alimentar ocasionada pela bactéria Listeria monocytogenes, um patógeno intracelular facultativo de distribuição ubiquitária. O presente estudo objetiva analisar o processo patogênico da bactéria, suas manifestações clínicas em grupos de risco e os desafios impostos à segurança alimentar na indústria. Trata-se de uma revisão bibliográfica de natureza qualitativa e descritiva, abrangendo publicações das últimas duas décadas. Os resultados evidenciam que a capacidade da bact …

31.08.2026journal-article

Contemporary Public Administration Review

Policy Communication Model Based on Collaborative Governance for Hydrometeorological Disaster Mitigation in West Sumatra Province

Rafeyfa Asyla Sururi, Rani Jelita Sinaga, Reni Juwita Sinaga, Sabrina Matanari Tampubulon

Hydrometeorological disasters constitute the dominant category of disasters in Indonesia, and West Sumatra is particularly exposed because of its geographical characteristics, environmental pressures, and changing climate conditions. Existing disaster-management arrangements involve multiple actors, yet the literature indicates continuing challenges related to fragmented coordination, one-way communication, and limited integration of local and scientific knowledge. This study aims to synthesize concepts, previous s …

31.08.2026journal-article

Nursing Edição Brasileira

Divertículo de Uretra Feminina: Diagnóstico por Rm e Técnicas de Reparo

Jennifer Favaretti Silva, Luíza Amâncio Nogueira de Sousa

O divertículo de uretra feminina é uma condição urológica caracterizada pela dilatação sacular da parede uretral, frequentemente subdiagnosticada devido à sua sintomatologia inespecífica, que mimetiza outras afecções do trato urinário inferior. O diagnóstico preciso é fundamental para a seleção da estratégia terapêutica, sendo a ressonância magnética (RM) atualmente considerada o padrão-ouro para a avaliação anatômica detalhada e o planejamento cirúrgico. O objetivo deste estudo foi realizar uma revisão sistemática …

31.08.2026journal-article

International Review of Administrative Sciences

Innovating public service delivery in Germany: What drives digital transformation at the local level?

Liz Marla Wehmeier, Philipp Gräfe

Digital transformation is widely seen as a key dimension of public sector innovation, expected to reshape and improve service delivery. Yet, empirical developments often fall short of these expectations, particularly in local and decentralised public administrations. We employ a mixed methods design to investigate the state of digitalisation and implementation dynamics in selected areas of German public administration and to identify key drivers shaping substantive digital transformation. Specifically, we employ qu …

31.08.2026journal-article

AFRICAN JOURNAL OF REPRODUCTIVE HEALTH

Emergency obstetric and newborn care: A priority measure to achieve rapid decline in maternal and newborn mortality in sub-Saharan Africa

Friday Okonofua, Lorretta Favour Chizomam Ntoimo

For more than three decades, sub-Saharan Africa has invested heavily in the five WHO pillars of safe motherhood.1,2 Governments, development partners, professional associations and civil society organizations have promoted family planning, strengthened antenatal care, expanded skilled birth attendance, improved postnatal care, and, where permitted by law, advocated for safe abortion services. These interventions have undoubtedly contributed to improved maternal and newborn health and have saved countless lives. Yet …

31.08.2026journal-article

Africa’s Public Service Delivery & Performance Review

Financial sector regulation reforms in South Africa: Post-adoption review of Socio-Economic Impact Assessment System that justified the Twin Peaks Regulatory model

Edward W. Khumalo, Jan van Romburgh, Jacqui-Lyn McIntyre

Background: The Twin Peaks Regulatory (TPR) model was adopted by the government to serve as a prudential and market conduct oversight tool for South Africa’s financial sector. Since its implementation, the country has faced challenges in inadequate social cohesion, financial security and inclusion, economic growth and development. Aim: To assess the validity of the Socio-Economic Impact Assessment System’s (SEIAS) findings and the tool that rationalised regulatory reforms within the financial sector in South Africa …

31.08.2026journal-article

Korean Association of Health and Medical Sociology

Village-Based Community Health Promotion in Rural Public Health Posts: Clinical and Behavioral Changes and Factors

Korean Association of Health and Medical Sociology, Mi Sook Jung, Sun Suk Bhin, Hyun Mi Park

This study aimed to examine changes in clinical indicators, health behaviors, and health status following participation in a village-based health promotion program, to assess variation in these changes across public health posts (PHPs), and to identify individual-level factors contributing to variability in change trajectories. A multi-site pre-post observational study was conducted using data from 247 participants across seven PHPs in Sejong city. Multidomain outcomes were assessed at baseline and post-interventio …

31.08.2026journal-article

Holistik Analisis Nexus

Analysis of Financial Statement Preparation Based on Financial Accounting Standards for Entities Without Public Accountability (SAK ETAP) at CV Saudagar Jaya Sukses

Isnaini Isnaini, Darno Darno

The financial information presented in the financial statements serves to evaluate company performance, control costs, and plan future business strategies. In addition to internal parties, financial statements are also used by external parties such as creditors, investors, and government agencies. Financial statements in accordance with SAK ETAP can increase company transparency and accountability. This financial transparency and accountability will increase external parties' trust in the company. Therefore, an ana …

31.08.2026journal-article

Natural and Life Sciences Communications

Occupational Health Risks from Pesticide Exposure: Evidence from Thai Farmers

Pronrumpa Kanjanasingh, Thittaya Ngamsang, Preechaya Tajai

Several pesticides are widely used in agriculture, yet many farmers lack adequate knowledge and protective practices, increasing risk of exposure and related health effects. This study aimed to screen health risks and analyze the factors affecting pesticide exposure among farmers in Chachoengsao Province, Thailand. Cross-sectional study was performed. Data were collected from 177 farmers who volunteered to participate. For pesticide exposure, 81.92% of farmers currently use pesticides, 57.25% sprayed pesticides the …

31.08.2026journal-article

Frontiers in Microbiology

Antifungal resistance and poor clinical outcome rates of Candida auris in mainland China: A systematic review and meta-analysis

Tao Xu, Rui Wang, Yufang Gao, Lei Yang

Objective This study systematically evaluated the antifungal resistance profile of Candida auris ( C. auris ) to five antifungal agents in mainland China, and analyzed clinical outcomes in a combined cohort of patients with C. auris colonization or infection. It aims to provide evidence-based references for clinical antifungal management and nosocomial infection prevention and control. Methods Six databases, including PubMed, Web of Science, and Embase, were systematically searched to identify observational studies …