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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Genes

Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities

Quanyou Wu, Kai Gui

Alternative pre-mRNA splicing is a central layer of gene regulation that enables a limited number of genes to generate a far larger and more context-dependent transcriptome and proteome. In cancer, splicing is disrupted by mutations in cis-regulatory sequences, recurrent lesions in spliceosome components, altered abundance or activity of RNA-binding proteins, and changes in transcription, chromatin, RNA modification, metabolism and stress signalling. These alterations are not merely by-products of malignant transfo …

22.08.2026journal-article

Current Oncology

Preoperative Immunonutritional Indices in Colorectal Cancer: The Contribution of Albumin, Time-Dependence of Effect, and Threshold Transportability in a Saudi Cohort

Moaz W. Abulfaraj, Ali H. M. Farsi

Preoperative immunonutritional indices are widely reported to predict survival after colorectal cancer (CRC) resection, yet their independence varies across cohorts and no data exist from the Arab Gulf. In this retrospective cohort study we analyzed 316 patients undergoing curative resection for stage I–III colorectal adenocarcinoma at a Saudi tertiary center between 2013 and 2022, of whom 48 (15.2%) presented as emergencies. The prognostic nutritional index (PNI) and a composite albumin–neutrophil-to-lymphocyte ra …

22.08.2026journal-article

Journal of Pharmaceutical and Sciences

Global Research Trends in Three-Dimensional Breast Cancer Models: A Bibliometric Analysis (2007–2025)

Amalia Amalia, Nur Ismiyati, Didi Nurhadi Illian, Agustina Setiawati, Adam Hermawan

Background: Three-dimensional (3D) culture models have emerged as a promising preclinical platform for breast cancer research because they better mimic the tumor microenvironment (TME) of conventional two-dimensional cultures. With advances in tissue engineering, research related to 3D models has grown rapidly, necessitating a comprehensive evaluation of global research trends. Methods: A bibliometric analysis was performed using the Scopus database covering publications from 2007 to 2025, and only original researc …

22.08.2026journal-article

Journal of Evolutionary Biology

Symbiotic cancer cell-stroma crosstalk in the acidic tumor microenvironment

Emma R Downey, Ana M Forero Pinto, Abigail L Booth, Joel Brown, Katarzyna A Rejniak, Mehdi Damaghi

Abstract The acidic microenvironment (AME) is a defining metabolic feature of solid tumors that fundamentally reshapes tumor–stroma interactions. Tumor acidosis arises from multiple metabolic processes, including hypoxia-driven glycolysis in poorly vascularized regions, the Warburg Effect (WE) in well-perfused areas, and carbon dioxide accumulation from tumor respiration. As a sustained ecological stress distinct from physiological pH (∼7.4), extracellular acidosis imposes powerful selective pressures within the tu …

22.08.2026journal-article

Diseases of the Esophagus

P1.170. Circulating Biomarkers of Angiogenesis in Esophageal Cancer Patients Undergoing Laparoscopic Gastric Ischemic Preconditioning: A Pilot Study

Stefan Marasligiller, Sumaya Ghaffar, Andrii Khomiak, Mythili Vigneshwar, Martin McCarter, Robert Meguid, John Mitchell, Elizabeth David, Sachin Wani, Mohammad Bilal, Sunnie Kim, Daysha Ferrer-Torres, Alison Mungo, Benedetto Mungo

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Laparoscopic gastric ischemic preconditioning (LGIP = ligation of the left gastric and short gastric vessels) aims to promote gastric conduit neovascularization and reduce anastomotic leak, a major complication following esophagectomy for esophageal cancer. The feasibility of measuring systemic peri-LGIP angiogenic biomarkers as a potential signal of preconditioning response was evaluated. Methods Twenty-three patients with resecta …

22.08.2026journal-article

Diseases of the Esophagus

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Ryo Ishida, Shuhei Komatsu, Hajime Kamiya, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Hiroshi Arakawa, Masateru Yamauchi, Satoshi Hamada, Hiroyuki Kanazawa, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Hitoshi Fujiwara, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remains unclear. Methods We aimed to identify a PD-L1–targeting tumor-suppressor microRNA downregulated in esophageal squamous cell carcinoma (ESCC). Four tumor-suppressor microRNAs (miR-5193, miR-3117-3p, miR-802, and miR-651-3p) predicted to t …

22.08.2026journal-article

Diseases of the Esophagus

PD04.05. First-Line Treatment Strategies Considering Quality of Life in Unresectable or Recurrent Esophageal Cancer

Akiyuki Wakita, Yusuke Sato, Yushi Nagaki, Takatoshi Yoneya, Yusuke Minamizuka, Tsukasa Takahashi, Kazuhiro Imai

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Immune checkpoint inhibitors (ICIs) are established as standard treatments for unresectable or recurrent esophageal cancer. Nevertheless, a substantial proportion of patients experience severe dysphagia and malnutrition, which significantly impairs quality of life. The optimal first-line treatment strategy that addresses both therapeutic efficacy and symptom relief has yet to be determined. Methods From February 2022 to Decembe …

22.08.2026journal-article

Diseases of the Esophagus

P1.182. Development of Difficulty Prediction Method for Mediastinoscopic Esophagectomy in Esophageal Cancer

Hirotaka Konishi, Hitoshi Fujiwara, Hiroyuki Inoue, Keiji Nishibeppu, Toshiyuki Kosuga, Hiroki Shimizu, Tomohiro Arita, Yusuke Yamamoto, Ryo Morimura, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Mediastinoscopic esophagectomy is a minimally invasive procedure for esophageal cancer, but no established method exists to predict surgical difficulty. This study aimed to identify a difficulty factor of this technique and develop a novel scoring system to predict the difficulty of mediastinoscopic esophagectomy for esophageal cancer. Methods A total of 192 patients who underwent radical mediastinoscopic esophagectomy between 2019 …

22.08.2026journal-article

Urology Herald

Premature ejaculation: surgical treatment and its impact on reproductive function

M. Kh. Shaipov, T. V. Shatylko, S. I. Gamidov, D. E. Kalinkin, A. V. Beloborodova, I. V. Gulin, E. T. Zakaryaev

Introduction. Sexual dysfunctions, including erectile dysfunction and ejaculatory disorders, are highly prevalent among men and can adversely affect reproductive potential, making timely diagnosis and effective treatment essential. Objective. To evaluate the efficacy of surgical treatment for premature ejaculation and its impact on reproductive function. Materials & methods. The study included 116 men with premature ejaculation who expressed a strong desire to preserve and realise their reproductive potential. The …

22.08.2026journal-article

Techniques in Coloproctology

Salvage surgery after total neoadjuvant therapy and watch-and-wait in rectal cancer: a systematic review and proposed minimum outcome set

J. R. Burke, I. Samuel, R. Clifford, P. Sutton, C. Arthur, A. G. Renehan

Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporting. This methodological review proposes a structured minimum outcome set (MOS) to distinguish intra-operative technical complexity from surgery-related morbidity and evaluates current reporting against this framework. Methods A predefined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

Diseases of the Esophagus

PD09.09. Post-Recurrence Survival After Esophagectomy for Esophageal Cancer: Impact of Timing and Anatomic Site

Ofek Zemer, Ran Orgad, Hila Merin, Moran Michaeli Rotshtein, Hila Shmilovich, Nikolai Menasherov, Idan Carmeli, Hanoch Kashtan, Daniel Solomon

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Recurrent disease remains the leading cause of mortality following esophagectomy for esophageal carcinoma. While patterns of recurrence have been previously described, the prognostic impact of recurrence timing and site on post-recurrence survival (PRS) remains unclear. This study evaluated the impact of disease-free survival (DFS) duration and first recurrence site on PRS. Methods A multicentric retrospective …

22.08.2026journal-article

Diseases of the Esophagus

P1.166. Preoperative Geriatric Nutritional Risk Index (GNRI) as a Predictor of Intraoperative Hypothermia in Esophageal Cancer Surgery

Weiming Chen, Xiamei Chen, Sufang Ye, Huangxiang Chen, Hui Jiang, Weimin Fang, Weikun Su

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophageal cancer is life-threatening, and esophagectomy patients have a high incidence of intraoperative hypothermia (linked to adverse postoperative outcomes), with no stable predictive indicator available. The Geriatric Nutritional Risk Index (GNRI), a validated tool for predicting cancer prognosis/complications, has not been studied for its association with intraoperative hypothermia in esopha …

22.08.2026journal-article

Diseases of the Esophagus

P1.212. Sarcopaenia in Gastrooesophageal Cancer Surgery: Application in Surgical Risk Calculators

Samuel Cathie, Indran Mukherjee, Ashwin Rajagopalan, Isabelle Vincenzion, Ashwin Subramaniam, Geraldine Ooi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Sarcopaenia is prevalent among gastrooesophageal patients and is associated with postoperative complications. Despite the association, no surgical risk calculators have incorporated sarcopaenia as a parameter. This study evaluates the prognostic significance of the preoperative skeletal muscle index (SMI) and assess whether adding SMI into risk calculators increases their accuracy. Methods The ret …

22.08.2026journal-article

Diseases of the Esophagus

P1.118. Delaying the Treatment Schedule in First-Line Chemotherapy Including ICIs for Esophageal Cancer Does Not Affect Survival Outcomes

Takeshi Toyozumi, Masaya Uesato, Akira Nakano, Yoshihiro Kurata, Tadashi Shiraishi, Nobufumi Sekino, Koichi Hayano, Yasunori Matsumoto, Yukiko Yamaguchi, Hideki Hayashi, Hisahiro Matsubara, Michihiro Maruyama

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Cancer immunotherapy has dramatically changed the management of esophageal cancer. However, the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal squamous cell carcinoma (ESCC) including immune checkpoint inhibitors (ICIs) remains unclear. This study aimed to clarify the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal cancer including ICIs. Method …

22.08.2026journal-article

Cells

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Jiani Dai, Yufei Wang, Chunna Jin, Liuguang Song, Yao Xie, Liangliang Jia, Meixiang Xiang

Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution …

22.08.2026journal-article

International Journal of Medical Sciences And Clinical Research

Patients’ Beliefs Regarding the Causes of Hypertension and Treatment Adherence as Predisposing Factors for Complications and Uncontrolled Blood Pressure

Nidhal Awad Obaid Alibraheemi

Background: Hypertension is a highly prevalent non-communicable disease and a leading risk factor for cardiovascular morbidity and mortality. Despite effective treatments, blood pressure control remains suboptimal globally, partly due to patient beliefs and poor adherence, which contribute to the development of complications. Misconceptions about the causes and management of hypertension are particularly common in low- and middle-income countries. Aim of the study: To identify patients’ misconceptions about hyperte …

22.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Unmet Needs of Adolescent and Young Adult Cancer Survivors Treated in West Virginia: A Qualitative Analysis of Open-Ended Survey Responses

Konstantinos Sdrimas, Bei Jiang, Laurel Lyckholm, Nicole L. Stout

Purpose: To characterize unmet supportive care needs among adolescent and young adult (AYA) cancer survivors in rural West Virginia. Methods: We conducted a cross-sectional survey of individuals diagnosed with cancer at ages 15–39 and treated within the West Virginia University Health System from 2012–2023. The questionnaire included the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) Survey, the Veterans RAND 12-Item Health Survey (VR-12), and optional open-ended questions. This report …

22.08.2026journal-article

Supportive Care in Cancer

Photobiomodulation to minimize talquetamab-associated dysgeusia and xerostomia in multiple myeloma: a brief report of four cases

Mariana Henriques Ferreira, Fernanda de Paula Eduardo, Luiza Deitos Menti, Isabela Vieira Nasser de Morais, Nelson Hamerschlak, Mariana Nassif Kerbauy, Gabriela Rocco de Sá, Letícia Mello Bezinelli

Abstract Background Talquetamab, a GPRC5D-targeting bispecific antibody, produces high response rates in relapsed/refractory multiple myeloma (RRMM) but is frequently associated with oral adverse effects, most commonly dysgeusia and xerostomia, which can impair nutrition and quality of life. No evidence-based supportive-care intervention has been established for these effects. Methods We describe four adults with RRMM who received photobiomodulation (PBM) concomitantly with talquetamab, using a dual-wavelength (660 …

22.08.2026journal-article

Veterinary and Comparative Oncology

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Csilla Fejös, Felicitas Czichon, Maureen Griffin, Natalie Grillo, Quentin Fournier, Michelle L. Oblak, Mikaela Eng‐Toogood, Michael Kent, Isabelle Desmas‐Bazelle, Miriam Kleiter, Laura Marconato, Katie McNaught, Simona Vincenti, Carmit Chalfon, Petros Odatzoglou, Carla Rohrer Bley

ABSTRACT Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcoma. Seventy‐four dogs with cytologically or histologically diagnosed pelvic osteosarcoma were included in this multicentre retrospective study (2007–2025). The median progression‐free survival (PFS) and overall survival (OS) were es …

22.08.2026journal-article

Diseases of the Esophagus

P1.087. Advancing Immunotherapy in Oesophagogastric Cancer: A Systematic Review of CLDN18.2-Targeted CAR T-Cell and T-Cell Engager Strategies

Sachin Shenoy, Unaiza Waheed, Ayesha Noorani, Kiran Purushothaman

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Conventional immunotherapy strategies have shown limited efficacy in oesophagogastric adenocarcinomas compared to other solid tumours. CLDN18.2-targeted chimeric antigen receptor T cells (CAR-T) and bispecific T-cell engagers (TCEs) represent emerging therapeutic strategies for advanced oesophagogastric cancers, yet their safety profiles and efficacy remain poorly characterized. This systematic review integrates early-phase outcomes ac …

22.08.2026journal-article

Diseases of the Esophagus

P1.126. Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma Treatment Experience From CMUH

Cheng Chi

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal squamous cell carcinoma account for 53% of esophageal tumor has high mortality due to exposure of carcinogens in Asian country. Head and neck cancer had high synchronous association with esophageal cancer due to “field-cancerization” to the upper aerodigestive tract. 15–20% of patients with HNC (head and neck squamous cell carcinoma had a secondary EC (esophageal squamous cell carcinoma) in Taiwan. Treatment choice and outcomes of sy …

22.08.2026journal-article

Diseases of the Esophagus

PD04.03. SMYD2 as a Novel Molecular Regulator of Immune Evasion and Immunosuppression in Esophagogastric Junction Cancer

Satoshi Hamada, Shuhei Komatsu, Taisuke Imamura, Takuma Ohashi, Keiji Nishibeppu, Jun Kiuchi, Hirotaka Konishi, Hitoshi Fujiwara, Hitoshi Tsuda, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Immune checkpoint inhibitors targeting PD-1/PD-L1 have caused a paradigm shift in esophageal and gastric cancer treatment; however, oncogenic mechanisms regulating immune evasion and Treg-mediated immunosuppression remain unclear. We investigated the role of SMYD2 in tumor immunity. Methods SCC, EAC, and GC cell lines and clinical specimens from 101 patients with esophagogastric junction adenocarcinoma who underwent curative resection were ana …

22.08.2026journal-article

Diseases of the Esophagus

P1.137. Baseline Skeletal Muscle Depletion Stratifies Treatment Feasibility and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Immunochemotherapy

Yizhou Huang, Maohui Chen, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Physiological reserve plays a pivotal role in determining the capacity of patients to tolerate intensive multimodal therapy. In locally advanced esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has become increasingly adopted; however, the prognostic and therapeutic implications of preexisting skeletal muscle depletion in this context remain insufficiently elucidated. Methods In this multicenter real-world cohort, consecutive patient …