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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

Diseases of the Esophagus

PD09.09. Post-Recurrence Survival After Esophagectomy for Esophageal Cancer: Impact of Timing and Anatomic Site

Ofek Zemer, Ran Orgad, Hila Merin, Moran Michaeli Rotshtein, Hila Shmilovich, Nikolai Menasherov, Idan Carmeli, Hanoch Kashtan, Daniel Solomon

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Recurrent disease remains the leading cause of mortality following esophagectomy for esophageal carcinoma. While patterns of recurrence have been previously described, the prognostic impact of recurrence timing and site on post-recurrence survival (PRS) remains unclear. This study evaluated the impact of disease-free survival (DFS) duration and first recurrence site on PRS. Methods A multicentric retrospective …

22.08.2026journal-article

Diseases of the Esophagus

P1.166. Preoperative Geriatric Nutritional Risk Index (GNRI) as a Predictor of Intraoperative Hypothermia in Esophageal Cancer Surgery

Weiming Chen, Xiamei Chen, Sufang Ye, Huangxiang Chen, Hui Jiang, Weimin Fang, Weikun Su

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophageal cancer is life-threatening, and esophagectomy patients have a high incidence of intraoperative hypothermia (linked to adverse postoperative outcomes), with no stable predictive indicator available. The Geriatric Nutritional Risk Index (GNRI), a validated tool for predicting cancer prognosis/complications, has not been studied for its association with intraoperative hypothermia in esopha …

22.08.2026journal-article

Diseases of the Esophagus

P1.212. Sarcopaenia in Gastrooesophageal Cancer Surgery: Application in Surgical Risk Calculators

Samuel Cathie, Indran Mukherjee, Ashwin Rajagopalan, Isabelle Vincenzion, Ashwin Subramaniam, Geraldine Ooi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Sarcopaenia is prevalent among gastrooesophageal patients and is associated with postoperative complications. Despite the association, no surgical risk calculators have incorporated sarcopaenia as a parameter. This study evaluates the prognostic significance of the preoperative skeletal muscle index (SMI) and assess whether adding SMI into risk calculators increases their accuracy. Methods The ret …

22.08.2026journal-article

Diseases of the Esophagus

P1.118. Delaying the Treatment Schedule in First-Line Chemotherapy Including ICIs for Esophageal Cancer Does Not Affect Survival Outcomes

Takeshi Toyozumi, Masaya Uesato, Akira Nakano, Yoshihiro Kurata, Tadashi Shiraishi, Nobufumi Sekino, Koichi Hayano, Yasunori Matsumoto, Yukiko Yamaguchi, Hideki Hayashi, Hisahiro Matsubara, Michihiro Maruyama

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Cancer immunotherapy has dramatically changed the management of esophageal cancer. However, the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal squamous cell carcinoma (ESCC) including immune checkpoint inhibitors (ICIs) remains unclear. This study aimed to clarify the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal cancer including ICIs. Method …

22.08.2026journal-article

Cells

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Jiani Dai, Yufei Wang, Chunna Jin, Liuguang Song, Yao Xie, Liangliang Jia, Meixiang Xiang

Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution …

22.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Unmet Needs of Adolescent and Young Adult Cancer Survivors Treated in West Virginia: A Qualitative Analysis of Open-Ended Survey Responses

Konstantinos Sdrimas, Bei Jiang, Laurel Lyckholm, Nicole L. Stout

Purpose: To characterize unmet supportive care needs among adolescent and young adult (AYA) cancer survivors in rural West Virginia. Methods: We conducted a cross-sectional survey of individuals diagnosed with cancer at ages 15–39 and treated within the West Virginia University Health System from 2012–2023. The questionnaire included the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) Survey, the Veterans RAND 12-Item Health Survey (VR-12), and optional open-ended questions. This report …

22.08.2026journal-article

International Journal of Medical Sciences And Clinical Research

Patients’ Beliefs Regarding the Causes of Hypertension and Treatment Adherence as Predisposing Factors for Complications and Uncontrolled Blood Pressure

Nidhal Awad Obaid Alibraheemi

Background: Hypertension is a highly prevalent non-communicable disease and a leading risk factor for cardiovascular morbidity and mortality. Despite effective treatments, blood pressure control remains suboptimal globally, partly due to patient beliefs and poor adherence, which contribute to the development of complications. Misconceptions about the causes and management of hypertension are particularly common in low- and middle-income countries. Aim of the study: To identify patients’ misconceptions about hyperte …

22.08.2026journal-article

Supportive Care in Cancer

Photobiomodulation to minimize talquetamab-associated dysgeusia and xerostomia in multiple myeloma: a brief report of four cases

Mariana Henriques Ferreira, Fernanda de Paula Eduardo, Luiza Deitos Menti, Isabela Vieira Nasser de Morais, Nelson Hamerschlak, Mariana Nassif Kerbauy, Gabriela Rocco de Sá, Letícia Mello Bezinelli

Abstract Background Talquetamab, a GPRC5D-targeting bispecific antibody, produces high response rates in relapsed/refractory multiple myeloma (RRMM) but is frequently associated with oral adverse effects, most commonly dysgeusia and xerostomia, which can impair nutrition and quality of life. No evidence-based supportive-care intervention has been established for these effects. Methods We describe four adults with RRMM who received photobiomodulation (PBM) concomitantly with talquetamab, using a dual-wavelength (660 …

22.08.2026journal-article

Diseases of the Esophagus

PD04.03. SMYD2 as a Novel Molecular Regulator of Immune Evasion and Immunosuppression in Esophagogastric Junction Cancer

Satoshi Hamada, Shuhei Komatsu, Taisuke Imamura, Takuma Ohashi, Keiji Nishibeppu, Jun Kiuchi, Hirotaka Konishi, Hitoshi Fujiwara, Hitoshi Tsuda, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Immune checkpoint inhibitors targeting PD-1/PD-L1 have caused a paradigm shift in esophageal and gastric cancer treatment; however, oncogenic mechanisms regulating immune evasion and Treg-mediated immunosuppression remain unclear. We investigated the role of SMYD2 in tumor immunity. Methods SCC, EAC, and GC cell lines and clinical specimens from 101 patients with esophagogastric junction adenocarcinoma who underwent curative resection were ana …

22.08.2026journal-article

Diseases of the Esophagus

P1.137. Baseline Skeletal Muscle Depletion Stratifies Treatment Feasibility and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Neoadjuvant Immunochemotherapy

Yizhou Huang, Maohui Chen, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Physiological reserve plays a pivotal role in determining the capacity of patients to tolerate intensive multimodal therapy. In locally advanced esophageal squamous cell carcinoma (ESCC), neoadjuvant immunochemotherapy (nICT) has become increasingly adopted; however, the prognostic and therapeutic implications of preexisting skeletal muscle depletion in this context remain insufficiently elucidated. Methods In this multicenter real-world cohort, consecutive patient …

22.08.2026journal-article

Diseases of the Esophagus

P1.126. Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma Treatment Experience From CMUH

Cheng Chi

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal squamous cell carcinoma account for 53% of esophageal tumor has high mortality due to exposure of carcinogens in Asian country. Head and neck cancer had high synchronous association with esophageal cancer due to “field-cancerization” to the upper aerodigestive tract. 15–20% of patients with HNC (head and neck squamous cell carcinoma had a secondary EC (esophageal squamous cell carcinoma) in Taiwan. Treatment choice and outcomes of sy …

22.08.2026journal-article

Diseases of the Esophagus

P1.087. Advancing Immunotherapy in Oesophagogastric Cancer: A Systematic Review of CLDN18.2-Targeted CAR T-Cell and T-Cell Engager Strategies

Sachin Shenoy, Unaiza Waheed, Ayesha Noorani, Kiran Purushothaman

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Conventional immunotherapy strategies have shown limited efficacy in oesophagogastric adenocarcinomas compared to other solid tumours. CLDN18.2-targeted chimeric antigen receptor T cells (CAR-T) and bispecific T-cell engagers (TCEs) represent emerging therapeutic strategies for advanced oesophagogastric cancers, yet their safety profiles and efficacy remain poorly characterized. This systematic review integrates early-phase outcomes ac …

22.08.2026journal-article

Diseases of the Esophagus

PD09.01. Impact of Sarcopenia, Myosteatosis and Cachexia on Surgical and Oncological Outcomes in Patients With Esophageal Cancer

Irene Sole Zuin, Elisa Sefora Pierobon, Giovanni Capovilla, Gianpietro Zanchettin, Lucia Moletta, Simone Corradin, Shady Attar, Alberto Ponzoni, Alessia Scarton, Sandra Zampieri, Roberta Sartori, Marco Sandri, Michele Valmasoni, Matteo Pittacolo

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Alterations in body composition, including sarcopenia, myosteatosis and cachexia, are increasingly recognized as negative prognostic factors in oncologic patients. However, the correlation between body composition, biochemical markers, and surgical and oncological outcomes in esophageal cancer remains incompletely defined. This study aimed to evaluate the association between CT-derived body composition paramete …

22.08.2026journal-article

Veterinary and Comparative Oncology

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Csilla Fejös, Felicitas Czichon, Maureen Griffin, Natalie Grillo, Quentin Fournier, Michelle L. Oblak, Mikaela Eng‐Toogood, Michael Kent, Isabelle Desmas‐Bazelle, Miriam Kleiter, Laura Marconato, Katie McNaught, Simona Vincenti, Carmit Chalfon, Petros Odatzoglou, Carla Rohrer Bley

ABSTRACT Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcoma. Seventy‐four dogs with cytologically or histologically diagnosed pelvic osteosarcoma were included in this multicentre retrospective study (2007–2025). The median progression‐free survival (PFS) and overall survival (OS) were es …

22.08.2026journal-article

Diseases of the Esophagus

P1.172. Comparison of Intraoperative Complications in Obese vs Non-Obese in Oesophageal Cancer Surgery

Raelene Tan, Amos Liew, Varun Jahagirdar, Eleazar Leong, Paul Cashin, Geraldine Ooi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Obesity is a substantial public health issue. A high body mass index (BMI) can increase surgical technical challenges, resulting in higher rates of intraoperative and postoperative complications. We aimed to assess whether intraoperative complication rates, using the the ClassIntra classification, differed between BMI categories in patients undergoing oesophageal cancer surgery. Methods Retrospective review was conducted of all oes …

22.08.2026journal-article

Diseases of the Esophagus

V-27. Right Recurrent Nerve Node Dissection (Station 106r)in Lateral Decubitus Esophagectomy for Cancer Esophagus Post Chemoradiation (Cross Regime)

Abhishek Jain

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Video Description THIS VIDEO SHOWS THE TECHNIQUE OF CAREFULLY DISSECTING RIGHT RECURRENT LARYNGEAL NERVE NODE DISSECTION ( STATION 106R) IN LATERAL DECUBITUS POSITION FOR A VATS ESOPHAGECTOMY FOR CANCER ESOPHAGUS ( POST NEOADJUVANT CHEMORADIATION)

22.08.2026journal-article

Urology Herald

Endovascular embolization in the surgical treatment of renal angiomyolipoma

D. S. Luzhanskiy, I. A. . Aboyan, S. P. Semitko, Yа. V. Kulikovskikh, S. M. Pakus, T. Yu. Luneva, S. V. Ten

Introduction. Angiomyolipoma (AML) is the most common benign renal tumor. Selective arterial embolization of AML-feeding vessels is currently regarded as an effective organ-preserving treatment. However, the absence of unified criteria for predicting procedural success limits its widespread adoption. Objective. To evaluate the outcomes of endovascular embolization of renal AML according to tumor angioarchitectonic type. Materials & methods. This retrospective study included 30 patients with renal AML who underwent …

22.08.2026journal-article

Journal of Clinical Medicine

A Composite Histopathologic Invasion Score Predicts Lymph Node Metastasis in Gastric Cancer

Ebru Karcı, Mahya Ahmadpour Youshanlui, Ferhat Ozden, Ozgur Acikgoz, Ömer Fatih Ölmez, Ozcan Yildiz, Hafize Uzun, Ahmet Bilici

Background: Lymph node metastasis (LNM) is a major determinant of prognosis in gastric adenocarcinoma. Although lymphovascular invasion (LVI) and perineural invasion (PNI) are established markers of aggressive tumor behavior, their combined association with nodal dissemination has not been systematically evaluated. This study investigated the relationship between invasive histopathologic features and LNM and developed a composite invasion score. Methods: This retrospective study included 395 patients with gastric a …

22.08.2026journal-article

Journal of Health Psychology

Understanding bowel cancer screening behaviour and intention across British, Indian, and Indian-Immigrant populations: A qualitative cross-cultural comparison

Soumya Shetty, Mark Conner, Chris Keyworth

Bowel cancer screening reduces mortality, yet uptake remains suboptimal across many populations. While disparities in participation are well documented, limited qualitative research has explored how cultural and healthcare contexts shape attitudes towards screening and preventive healthcare. This study examined beliefs, experiences, and screening-related decision-making among White British individuals, Indian immigrants living in the UK, and individuals residing in India. A cross-cultural qualitative design was emp …

22.08.2026journal-article

Diseases of the Esophagus

OA05.3. Gastrointestinal Symptoms, and Symptoms of Delayed Gastric Conduit Emptying, One Year After Diagnosis of Cancer in the Esophagus

Magnus Konradsson, Fredrik Klevebro, Magnus Nilsson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Comprehensive studies on long-term gastrointestinal functional results including DGCE after gastric conduit reconstruction are lacking. The aim of this study is to describe GI symptoms and symptoms of DGCE in relation to risk factors and global quality of life 1 year after diagnosis of esophageal cancer, in a large cohort. Methods Diagnostic, surgical and follow up data including EORTC QLQ-c30 and QLQ-OG25 pati …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.03. Non-Cisplatin-Based Preoperative Chemotherapy for Cisplatin-Unfit Esophageal Cancer: A Multicenter Retrospective Study in Japan

Yasunobu Ishizuka, Toru Kadono, Akitoshi Hakoda, Shun Yamamoto, Taisuke Hosokai, Motoo Nomura, Masahiro Fukuoka, Takeshi Yamashita, Kunihiro Fushiki, Kazuhiro Shiraishi, Yuta Sato, Kohei Kanamori, Yohei Ozawa, Atsushi Takeno, Masaaki Iwatsuki, Yuta Itohki, Yusuke Amanuma, Kazuma Sato, Ryoma Haneda, Hisahiro Matsubara, Takeo Bamba, Hiroki Hiratsuka, Naoshi Fujiwara, Takashi Ogata, Yoshito Komatsu, Hiroshi Ichikawa, Takashi Ohta, Hiroaki Nagano, Hiroya Takeuchi, Ken Kato

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Although cisplatin-based neoadjuvant chemotherapy is the standard for resectable esophageal squamous cell carcinoma in Japan, some patients are unfit due to age, renal, or cardiac dysfunction. No established treatment option exists for cisplatin-unfit patients. We compared the efficacy between non-cisplatin-based preoperative chemotherapy (noCDDP) followed by surgery and surgery alone (Sx). Methods This multicenter retrospective study …

22.08.2026journal-article

Diseases of the Esophagus

P1.129. Predictive Value of Baseline Bioelectrical Impedance Analysis(BIA) for Chemoradiotherapy Completion in Locally Advanced Esophageal Cancer: Implications for Prehabilitation

Panpanit Sukwarodwat, Somjai Nokdee, Wilawan Tapalad

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Locally advanced esophageal cancer requires toxic chemoradiotherapy, yet no established pretreatment body composition thresholds exist to predict completion. Traditional assessment relies on subjective performance status, often overlooking occult sarcopenia. This study evaluates BIA markers against BMI to define objective cut-offs for guiding targeted prehabilitation and optimizing therapeutic resilience. Methods A retrospective cohort study an …

22.08.2026journal-article

Diseases of the Esophagus

P1.159. Long-Term and Perioperative Outcomes of Ivor-Lewis Single-Incision Minimally Invasive Esophagectomy (SIMIE) for Esophageal Cancer: Comparison With McKeown MIE

Jang-Ming Mail, Pei-Ming Huang, Shuenn-Wen Kuo, Ke-Cheng Chen, Mong-Wei Lin

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally invasive esophagectomy has been gradually adopted as an effective surgical option for the treatment of esophageal cancer. However, the optimal surgical approach, including port placement and anastomotic site, remains to be determined. Methods In the present study, we evaluated the perioperative and long-term survival outcomes of single-incision Ivor Lewis minimally invasive esophagectomy with intrathoracic esophagogastros …