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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

European Journal of Preventive Cardiology

Oral anticoagulant monotherapy vs. combination therapy in patients with chronic coronary syndrome: a systematic review and meta-analysis of randomized trials

Anastasios Tsarouchas, David Mutschlechner, Maximilian Tscharre, Christodoulos E Papadopoulos, Thomas Gremmel

Abstract Aims In patients on long-term oral anticoagulation (OAC), the optimal antithrombotic strategy in the setting of concomitant chronic coronary syndrome (CCS) remains unclear. We therefore performed a systematic review and meta-analysis of randomized controlled trials comparing OAC monotherapy vs. OAC plus single antiplatelet therapy (combination therapy) in patients with CCS and any indication for long-term OAC. Methods and results We systematically searched PubMed/MEDLINE and Embase through February 2026 to …

11.08.2026journal-article

Journal of Endovascular Therapy

Rotational Percutaneous Mechanical Thrombectomy for Acute and Subacute Limb Ischaemia: A Systematic Review and Proportional Meta-Analysis

Benedict Stanberry, Koen Deloose, Yann Gouëffic, Gilles Goyault, Giacomo Isernia, Ralph Jackson, Nils Kucher, Michael Lichtenberg, James McCaslin, Bruno Migliara, Mark Portou, Christos Rammos, Caren Randon, Refaat Salman, Marc Sirvent

Objective: Rotational percutaneous mechanical thrombectomy with adjunctive angioplasty, stenting or limited thrombolysis (rPMT+) has become commonplace in the treatment of acute and subacute limb ischaemia (SLI). This systematic review and proportional meta-analysis synthesises the available evidence on its safety and efficacy. Data Sources: MEDLINE, Embase and the Cochrane Library. Review Methods: We searched for studies (≥10 patients) published since January 1, 2012 (PROSPERO protocol CRD420251015846). Risk of bi …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Examination of the Words-in-Noise Test Signal-to-Noise Ratio Thresholds From the National Institutes of Health Toolbox for Children and Adults

Larry E. Humes, Sumitrajit Dhar

Purpose: The purpose of this study was to establish and evaluate normative values for the Words-in-Noise (WIN) test from the National Institutes of Health (NIH) Toolbox for children and adults. Method: NIH Toolbox conducted a large national standardization study of the WIN test, in both English and Spanish languages, in 2011 to allow for normative comparisons in a nationally representative sample of children and adults, ages 3–85 years. Clinical and university centers at 10 sites around the United States participat …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Increasing Word Learning Efficiency in Deaf and Hard of Hearing Children Through Retrieval Practice

Jena McDaniel

Purpose: Despite decades of attempts to “close the gap” between spoken language skills of deaf and hard of hearing (DHH) children and their hearing peers, this goal remains elusive. Retrieval practice is an empirically validated approach that could improve the acquisition and retention of language skills for DHH children. This study evaluates the effectiveness and efficiency of two key features of retrieval practice (feedback and spacing) for learning and retaining novel words. Method: Using a single-case adapted a …

11.08.2026journal-article

Signal Transduction and Targeted Therapy

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression

Egon J. Jacobus, Véronique N. Lafleur, Kerry D. Fisher, David R. Mole, Leonard W. Seymour

Abstract Hypoxia, a hallmark of solid tumors, poses a significant challenge in cancer therapy due to its association with poor prognosis and resistance to conventional treatments. Oncolytic viruses represent a promising treatment strategy, as they selectively replicate within cancer cells and lyse them, potentially including those in hypoxic tumor regions. Here, we examined how hypoxic conditions influence the activity of enadenotucirev (EnAd), a clinically relevant group B oncolytic adenovirus previously detected …

11.08.2026journal-article

Ijtimoiy-gumanitar sohada ilmiy-innovatsion tadqiqotlar

NUTQIY AKTLARNING BADIIY DISKURSDAGI FUNKSIONAL-PRAGMATIK XUSUSIYATLARI: ANTROPOSENTRIK YONDASHUV

Surayo Akramova

This article explores the functional and pragmatic characteristics of speech acts in literary discourse from an anthropocentric perspective. The study examines the role of speech acts in expressing communicative intentions, shaping interpersonal relationships between literary characters, and constructing artistic images within literary texts. It argues that the meaning of speech units is determined not only by their linguistic form but also by the speaker’s communicative intention, the speech situation, and the hum …

11.08.2026journal-article

Oxygen

Home Oxygen Therapy Utilization in a Newborn Intensive Care Unit Population at Altitude

Joshua Reddish, Daniella Rodriguez, Alyssa Aragon, Jessica Gross, Jessie R. Maxwell

Neonates born at higher altitudes may be at increased risk for adverse outcomes due to lower ambient oxygen availability. Despite frequent use of home oxygen therapy following neonatal intensive care unit (NICU) discharge, evidence-based guidelines assessing discharge readiness and oxygen prescribing in high-altitude settings remains limited. This study aimed to identify factors associated with adverse events following discharge and characterize infants discharged with home oxygen therapy in New Mexico. A retrospec …

11.08.2026journal-article

Exploration of Cardiology

Cardiotoxicity of pembrolizumab therapy: narrative review

Jas Virk

Pembrolizumab, a programmed cell death protein 1 inhibitor, has had a substantial impact on cancer treatment across multiple malignancies, but is associated with immune-related cardiovascular toxicities that pose significant clinical challenges. Complications such as myocarditis, arrhythmias, and cardiomyopathy are emerging as significant entities with high morbidity and mortality. This article is a narrative review and was not designed or conducted as a systematic review. No formal systematic review protocol was f …

11.08.2026journal-article

Clinical Cancer Research

Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-line Therapy for Advanced Colorectal Adenocarcinoma: The Phase II DeFianCe Trial

Zev A. Wainberg, Keun-Wook Lee, Jong Gwang Kim, Craig Devoe, John H. Strickler, Jason Baum, Calvin Jia, Michael H. Kagey, Cynthia A. Sirard, Alexander Stein, Aaron James Scott, Meredith Pelster, Markus Moehler, Sae-Won Han

Abstract Purpose: DeFianCe was a randomized phase II study evaluating sirexatamab, a Dickkopf-related protein 1 (DKK1)–neutralizing antibody, plus chemotherapy and bevacizumab as second-line therapy for metastatic colorectal cancer (mCRC). Patients and Methods: Patients with mCRC and progression, during or after 1 prior systemic therapy line, were randomized 1:1 to investigator-choice folinic acid, 5-fluorouracil, and irinotecan (FOLFIRI) or folinic acid, 5-fluorouracil, and oxaliplatin (mFOLFOX6) plus bevacizumab, …

11.08.2026journal-article

Exploring Science Academic Conference Series

Research Progress and Clinical Challenges of Precision Targeted Therapy for Autoimmune Diseases

Mengyang He

The treatment of autoimmune diseases is undergoing a paradigm shift from “broad -spectrum immunosuppression” toward “precision targeted intervention.” Although conventional synthetic disease - modifying antirheumatic drugs (such as methotrexate) remain the cornerstone of therapy, their efficacy ceiling and cumulative toxicity limit long-term use, and clinical practice still has safety gaps, such as inadequate folic acid supplementation. The advent of targeted biologic agents (e.g., TNF -α inhibitors, IL-6R antagoni …

11.08.2026journal-article

BMC Psychiatry

Individualized hybrid electroconvulsive therapy (i-HECT) shows rapid anti-depressant effect in young patients with depression

Lun Zeng, Jing-ya Zhang, Jia Li, Mian-mian Chen, Shu-xian Xu, Chen-long Gu, Bai-jian Tan, Xin-hui Xie

Abstract Background For young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new individualized hybrid electroconvulsive therapy (i-HECT) combines ECT with low-charge electrotherapy (LCE) and individual symptom monitoring to reduce cognitive impairments. Methods i-HECT comprised two treatments: ECT and LCE. ECT utilized an energy set of 1.5 times the seizure threshold (ST), while LCE was set at 0.5 ST. The initial session employed …

01.09.2026journal-article

Hepatology Communications

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Angie Molina, Laia Trigueros-Motos, Manuela Molina, Javier Martínez-García, Laura Palomo, Guiomar Pérez, Leticia Odriozola, Cristina Gázquez, Blanche Tamarit, Martjin Van Faassen, Henkjan J. Verkade, Céline Bouquet, Jean Philippe Combal, Gloria González-Aseguinolaza, Cristian Smerdou

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatomegaly, and often fibrosis and end-stage hepatic disease. Treatments include ileal BA transporter inhibitors, surgical bile diversion, or ultimately, liver transplantation. Our aim was to develop a PFIC2 gene therapy approach based on the re …

11.08.2026journal-article

Cardiovascular Therapy and Prevention

Development of higher medical education in the context of primary care physician training

G. N. Shemetova, G. V. Gubanova, N. V. Krasnikova, M. E. Balashova, Yu. N. Belyaeva, A. I. Ryaboshapko, V. A. Suraeva, E. E. Sedelkova, E. M. Shebalova

This article is devoted to defining the role of the Outpatient Medicine and General Practice departments in the training of primary care specialists. The article highlights and describes the specifics of training general practitioners, internists, and family doctors in the modern period. An overview of key challenges and unresolved issues in the field of medical staff training is presented. The authors of the article analyzed the experience of the Department of Outpatient Medicine, General Practice, and Preventive …

11.08.2026journal-article

Cardiovascular Therapy and Prevention

Project activities (project work) in teaching medical students professional communication in a foreign language

N. V. Varshaver, V. V. Gavrilova, S. V. Plotnova, A. A. Shalavina, Yu. V. Shevtsova

Aim . To rationale the effectiveness of project activities in overcoming the language barrier and immersing medical students in a professional environment. Material and methods . This study surveyed students from the Privolzhsky Research Medical University, Lobachevsky State University of Nizhny Novgorod, and the Kstovo branch of the Arzamas Medical College. The main aim was to identify factors (according to students) that hinder free professional communication, as well as to assess the level of interest of future …

11.08.2026journal-article

Journal of Parkinson’s Disease

Cognitive-behavioral therapy in people with Parkinson's disease and caregivers: A mixed method systematic review on clinical applications and therapeutic outcomes

Francesca Proietti, Simone Migliore, Chiara Longo, Francesca Lea Saibene, Giuseppe Curcio, Maria Chiara Malaguti, Mario Meloni, Edoardo Bianchini, Massimo Marano

Background Cognitive behavioral therapy (CBT) has emerged as a promising intervention in Parkinson's disease (PD), although the available evidence remains heterogeneous in design and quality. Objective The present mixed method systematic review aims to synthesize the evidence on CBT in people with PD (PwPD) and caregivers, focusing on clinical applications and therapeutic outcomes across symptom domains. Methods A systematic search of PubMed, Web of Science, Scopus and Cochrane databases was conducted for studies p …

11.08.2026journal-article

Journal of the American Chemical Society

Stereospecific Peptide–Polysaccharide Conjugates Enable Noninvasive Therapy of Neovascular Age-Related Macular Degeneration

Yachao Li, Bingyan Li, Dongzhe Zou, Zenan Zeng, Beiling Guo, Wensheng Gong, Kefurong Deng, Zicong Wang, Haixiang Zhou, Yedi Zhou, Xianghui Xu

Abstract Therapeutic interventions for posterior segment ocular diseases, including neovascular age-related macular degeneration (nAMD), remain constrained by poor intraocular bioavailability and the need for repeated intravitreal injections. Here, we introduce a noninvasive therapeutic strategy based on stereospecific peptide–polysaccharide conjugates (PPC) for efficient nAMD treatment. A controllable synthetic strategy was established to generate stereospecific L-PPC and D-PPC, among which D-PPC displayed pronoun …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Optimization and Device-Level Validation of the i-Phagia Surface Electromyography Submental Sensor Patch for Swallowing Monitoring: A Randomized Crossover Design Study

Georgia A. Malandraki, Ching-Hsuan Peng, Kevin Berry, Macy Griffis, Arica Rusco, Bruce A. Craig

Purpose: Surface electromyography (sEMG) is a promising biofeedback method for swallowing intervention. Current sensors are either costly rigid platforms or short-lived wearables. We developed a second-generation flexible wearable sEMG patch (i-Phagia) designed to record submental muscle activity. This study validated the signal quality and preclinical performance of i-Phagia against conventional sensors in two age groups. Method: A randomized crossover study involved 30 young (17 women, 13 men; aged 18–29 years) a …

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11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Psychophysical and Psychometric Properties of Visual Analog Scales: An Auditory-Perceptual Study Applied to Hypokinetic Dysarthria

Deepthi Crasta, Kaila L. Stipancic, Supraja Anand, Inyong Choi, Shawn Goodman, Mili Kuruvilla-Dugdale

Purpose: Despite the widespread use of visual analog scales (VASs), their psychophysical and psychometric properties for rating dysarthria remain largely untested. Using a scale whose measurement properties, reliability, and validity are unknown undermines the comparison of findings across studies and clinical contexts. Therefore, we investigated these properties of VAS using samples of hypokinetic dysarthria. Method: Thirty-seven nonexperts and three dysarthria experts evaluated 85 speech samples from individuals …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Effect of Acupuncture Combined With Computer-Assisted Cognitive Training on Language and Cognitive Functions in Poststroke Aphasia: A Randomized Controlled Trial

Lifang Qiu, Honghe Ma, Wanqing Lin, Xiao-Bin Wang, JinJing Xiao, Dezhong Zheng, Li-Qun Yao

Background: Poststroke aphasia (PSA) significantly impairs language and cognitive functioning, yet few interventions comprehensively address both domains. This study evaluated the efficacy of an intervention combining acupuncture and computer-assisted cognitive rehabilitation using the RehaCom cognitive training system (hereinafter, ACR) on language and nonverbal cognitive function in individuals with PSA. Method: A single-center randomized controlled trial was conducted at a tertiary rehabilitation hospital in Fuj …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

A Scalable Approach for Estimating Employee Commuting Emissions at U.S. Healthcare Facilities

Melanie Marino, Matthew J. Eckelman

Objective: This study aims to develop a standardized method to estimate employee commuting greenhouse gas (GHG) emissions for healthcare facilities across the U.S. Current methods can be laborious, time-consuming, and difficult to scale – relying heavily on survey participation or manual data extraction. Methods: Quantitative data analysis was used to spatially join healthcare facility locations with EPA Smart Location Calculator data and estimate per-worker commuting GHG emissions for U.S. healthcare facilities. R …

11.08.2026journal-article

Small

A Redox‐Responsive Nanoplatform Modulating the Treg/Th17 Balance Through LAT1‐ and PPARγ‐Related Pathways for Psoriasis Therapy

Xinyu Jiang, Yingyi Zhao, Zihao Huang, Yuqi Han, Zihao Tao, Belquis Dakhane, Yinhao Lin, Dingchao Shen, Yanxian Hou, Shisheng Chen, Qing Yao, Helin Xu, Ruijie Chen, Longfa Kou

ABSTRACT Psoriasis is a chronic autoimmune skin disease affecting 2%–3% of the global population. Existing therapies, including topical agents, systemic immunosuppressants, and phototherapy, often suffer from limited efficacy, skin irritation, or serious side effects, highlighting the urgent need for more effective and safer alternatives. Notably, restoring the dynamic balance between regulatory T (Treg) cells and T helper 17 (Th17) cells has emerged as a promising strategy for halting psoriatic progression. Here, …

11.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Corticosteroid Dose and Efficacy in Shoulder Impingement Syndrome

Yihang Qin, Hana H. Kim, Donna Gao, Seungjae Cho, Yi (David) Diao, Ahilraj Siva

To evaluate whether corticosteroid dose affects pain and functional outcomes in shoulder impingement syndrome (SIS) treated with subacromial injection. Systematic review and meta-analysis. Six databases (CINAHL, EMBASE, Ovid MEDLINE, Ovid HealthSTAR, PubMed, Web of Science) were searched from inception to July 2025. Outcomes were pooled using random-effects meta-analysis with meta-regression to assess association between dose and treatment effect. Twenty-three studies comprising 739 patients were included. Seven st …

11.08.2026journal-article

International Journal of Molecular Sciences

T-Cell Engagers Targeting BCMA, GPRC5D, or FcRH5 in Relapsed/Refractory Multiple Myeloma: The Landscape Beyond CAR-T Cell Therapy-A Systematic Review and Network Meta-Analysis

Shreya Shambhavi, Aksa Alina Joy, Harmanjeet Singh, Terence Amonica, Astha Grover, Tanya Singh, Sharon Susan Paul, Tiffany Pompa

Relapsed/refractory multiple myeloma is marked by frequent triple-class refractoriness and poor survival, whereas bispecific antibodies targeting BCMA, GPRC5D, or FcRH5 show meaningful activity even in heavily pretreated and post-BCMA disease. This meta-analysis evaluates and compares the efficacy and safety of these agents in RRMM using direct and indirect evidence. We manually searched seven databases and identified 44 studies for quantitative analysis. Forest plots were created using R 4.1.1 software. Compared t …

11.08.2026journal-article

Journal of modern medicine

INDIVIDUALIZED SELECTION OF ORAL AND INTRAVENOUS IRON THERAPY IN WOMEN OF REPRODUCTIVE AGE WITH IRON DEFICIENCY ANEMIA

G.M. Ruzimatova

<p>Iron deficiency anemia (IDA) is highly prevalent among women of reproductive age because menstrual blood loss, pregnancy, childbirth, dietary insufficiency, and gastrointestinal disorders may coexist. The objective of this re­view was to synthesize current evidence on the individualized selection of oral and intravenous iron preparations, with emphasis on efficacy, tolerability, speed of hematologic response, and safety. A structured narrative review of peer-reviewed randomized trials, systematic reviews, and in …