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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

Cardiovascular Therapy and Prevention

Project activities (project work) in teaching medical students professional communication in a foreign language

N. V. Varshaver, V. V. Gavrilova, S. V. Plotnova, A. A. Shalavina, Yu. V. Shevtsova

Aim . To rationale the effectiveness of project activities in overcoming the language barrier and immersing medical students in a professional environment. Material and methods . This study surveyed students from the Privolzhsky Research Medical University, Lobachevsky State University of Nizhny Novgorod, and the Kstovo branch of the Arzamas Medical College. The main aim was to identify factors (according to students) that hinder free professional communication, as well as to assess the level of interest of future …

11.08.2026journal-article

Journal of Parkinson’s Disease

Cognitive-behavioral therapy in people with Parkinson's disease and caregivers: A mixed method systematic review on clinical applications and therapeutic outcomes

Francesca Proietti, Simone Migliore, Chiara Longo, Francesca Lea Saibene, Giuseppe Curcio, Maria Chiara Malaguti, Mario Meloni, Edoardo Bianchini, Massimo Marano

Background Cognitive behavioral therapy (CBT) has emerged as a promising intervention in Parkinson's disease (PD), although the available evidence remains heterogeneous in design and quality. Objective The present mixed method systematic review aims to synthesize the evidence on CBT in people with PD (PwPD) and caregivers, focusing on clinical applications and therapeutic outcomes across symptom domains. Methods A systematic search of PubMed, Web of Science, Scopus and Cochrane databases was conducted for studies p …

11.08.2026journal-article

Journal of the American Chemical Society

Stereospecific Peptide–Polysaccharide Conjugates Enable Noninvasive Therapy of Neovascular Age-Related Macular Degeneration

Yachao Li, Bingyan Li, Dongzhe Zou, Zenan Zeng, Beiling Guo, Wensheng Gong, Kefurong Deng, Zicong Wang, Haixiang Zhou, Yedi Zhou, Xianghui Xu

Abstract Therapeutic interventions for posterior segment ocular diseases, including neovascular age-related macular degeneration (nAMD), remain constrained by poor intraocular bioavailability and the need for repeated intravitreal injections. Here, we introduce a noninvasive therapeutic strategy based on stereospecific peptide–polysaccharide conjugates (PPC) for efficient nAMD treatment. A controllable synthetic strategy was established to generate stereospecific L-PPC and D-PPC, among which D-PPC displayed pronoun …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Optimization and Device-Level Validation of the i-Phagia Surface Electromyography Submental Sensor Patch for Swallowing Monitoring: A Randomized Crossover Design Study

Georgia A. Malandraki, Ching-Hsuan Peng, Kevin Berry, Macy Griffis, Arica Rusco, Bruce A. Craig

Purpose: Surface electromyography (sEMG) is a promising biofeedback method for swallowing intervention. Current sensors are either costly rigid platforms or short-lived wearables. We developed a second-generation flexible wearable sEMG patch (i-Phagia) designed to record submental muscle activity. This study validated the signal quality and preclinical performance of i-Phagia against conventional sensors in two age groups. Method: A randomized crossover study involved 30 young (17 women, 13 men; aged 18–29 years) a …

1 Zitationen
11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Psychophysical and Psychometric Properties of Visual Analog Scales: An Auditory-Perceptual Study Applied to Hypokinetic Dysarthria

Deepthi Crasta, Kaila L. Stipancic, Supraja Anand, Inyong Choi, Shawn Goodman, Mili Kuruvilla-Dugdale

Purpose: Despite the widespread use of visual analog scales (VASs), their psychophysical and psychometric properties for rating dysarthria remain largely untested. Using a scale whose measurement properties, reliability, and validity are unknown undermines the comparison of findings across studies and clinical contexts. Therefore, we investigated these properties of VAS using samples of hypokinetic dysarthria. Method: Thirty-seven nonexperts and three dysarthria experts evaluated 85 speech samples from individuals …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Effect of Acupuncture Combined With Computer-Assisted Cognitive Training on Language and Cognitive Functions in Poststroke Aphasia: A Randomized Controlled Trial

Lifang Qiu, Honghe Ma, Wanqing Lin, Xiao-Bin Wang, JinJing Xiao, Dezhong Zheng, Li-Qun Yao

Background: Poststroke aphasia (PSA) significantly impairs language and cognitive functioning, yet few interventions comprehensively address both domains. This study evaluated the efficacy of an intervention combining acupuncture and computer-assisted cognitive rehabilitation using the RehaCom cognitive training system (hereinafter, ACR) on language and nonverbal cognitive function in individuals with PSA. Method: A single-center randomized controlled trial was conducted at a tertiary rehabilitation hospital in Fuj …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

A Scalable Approach for Estimating Employee Commuting Emissions at U.S. Healthcare Facilities

Melanie Marino, Matthew J. Eckelman

Objective: This study aims to develop a standardized method to estimate employee commuting greenhouse gas (GHG) emissions for healthcare facilities across the U.S. Current methods can be laborious, time-consuming, and difficult to scale – relying heavily on survey participation or manual data extraction. Methods: Quantitative data analysis was used to spatially join healthcare facility locations with EPA Smart Location Calculator data and estimate per-worker commuting GHG emissions for U.S. healthcare facilities. R …

11.08.2026journal-article

Small

A Redox‐Responsive Nanoplatform Modulating the Treg/Th17 Balance Through LAT1‐ and PPARγ‐Related Pathways for Psoriasis Therapy

Xinyu Jiang, Yingyi Zhao, Zihao Huang, Yuqi Han, Zihao Tao, Belquis Dakhane, Yinhao Lin, Dingchao Shen, Yanxian Hou, Shisheng Chen, Qing Yao, Helin Xu, Ruijie Chen, Longfa Kou

ABSTRACT Psoriasis is a chronic autoimmune skin disease affecting 2%–3% of the global population. Existing therapies, including topical agents, systemic immunosuppressants, and phototherapy, often suffer from limited efficacy, skin irritation, or serious side effects, highlighting the urgent need for more effective and safer alternatives. Notably, restoring the dynamic balance between regulatory T (Treg) cells and T helper 17 (Th17) cells has emerged as a promising strategy for halting psoriatic progression. Here, …

11.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Corticosteroid Dose and Efficacy in Shoulder Impingement Syndrome

Yihang Qin, Hana H. Kim, Donna Gao, Seungjae Cho, Yi (David) Diao, Ahilraj Siva

To evaluate whether corticosteroid dose affects pain and functional outcomes in shoulder impingement syndrome (SIS) treated with subacromial injection. Systematic review and meta-analysis. Six databases (CINAHL, EMBASE, Ovid MEDLINE, Ovid HealthSTAR, PubMed, Web of Science) were searched from inception to July 2025. Outcomes were pooled using random-effects meta-analysis with meta-regression to assess association between dose and treatment effect. Twenty-three studies comprising 739 patients were included. Seven st …

11.08.2026journal-article

International Journal of Molecular Sciences

T-Cell Engagers Targeting BCMA, GPRC5D, or FcRH5 in Relapsed/Refractory Multiple Myeloma: The Landscape Beyond CAR-T Cell Therapy-A Systematic Review and Network Meta-Analysis

Shreya Shambhavi, Aksa Alina Joy, Harmanjeet Singh, Terence Amonica, Astha Grover, Tanya Singh, Sharon Susan Paul, Tiffany Pompa

Relapsed/refractory multiple myeloma is marked by frequent triple-class refractoriness and poor survival, whereas bispecific antibodies targeting BCMA, GPRC5D, or FcRH5 show meaningful activity even in heavily pretreated and post-BCMA disease. This meta-analysis evaluates and compares the efficacy and safety of these agents in RRMM using direct and indirect evidence. We manually searched seven databases and identified 44 studies for quantitative analysis. Forest plots were created using R 4.1.1 software. Compared t …

11.08.2026journal-article

Journal of modern medicine

INDIVIDUALIZED SELECTION OF ORAL AND INTRAVENOUS IRON THERAPY IN WOMEN OF REPRODUCTIVE AGE WITH IRON DEFICIENCY ANEMIA

G.M. Ruzimatova

<p>Iron deficiency anemia (IDA) is highly prevalent among women of reproductive age because menstrual blood loss, pregnancy, childbirth, dietary insufficiency, and gastrointestinal disorders may coexist. The objective of this re­view was to synthesize current evidence on the individualized selection of oral and intravenous iron preparations, with emphasis on efficacy, tolerability, speed of hematologic response, and safety. A structured narrative review of peer-reviewed randomized trials, systematic reviews, and in …

11.08.2026journal-article

Exploring Science Academic Conference Series

Advances in Systemic Therapy for Advanced Hepatocellular Carcinoma: Paradigm Evolution from Single-Agent Chemotherapy to Targeted Therapy Combined with Immunotherapy

Chang Zhao

Primary liver cancer, particularly hepatocellular carcinoma (HCC), represents a significant global public health burden with persistently high incidence and mortality rates. The systemic treatment of advanced HCC has undergone a paradigm evolution from traditional cytotoxic chemotherapy to molecular targeted therapy, and now to the current era centered on the combination of targeted therapy and immunotherapy. Traditional chemotherapy has shown limited efficacy due to tumor insensitivity and substantial toxicity. Si …

11.08.2026journal-article

Exploring Science Academic Conference Series

Advances in Molecular Subtype-Based Precision Therapy and Strategies to Overcome Resistance in Breast Cancer

Yeyao Lu

Breast cancer is a leading cause of cancer -related morbidity and mortality, characterized by significant biological and molecular heterogeneity. Molecular subtypes —including luminal A, luminal B, HER2 - enriched, and triple -negative—inform prognosis and guide prec ision therapies. Despite advances with endocrine agents, HER2-targeted therapies, PARP inhibitors, and immune checkpoint inhibitors, therapeutic resistance remains a major challenge, driven by intratumoral heterogeneity, cancer stem cell plasticity, an …

11.08.2026journal-article

Quality in Sport

Preserving Skeletal Muscle and Function During GLP-1 Receptor Agonist Therapy: An Evidence-Informed Exercise Prescription Framework

Michał Adamczak, Marcel Majewski, Bogumił Libura, Martyna Lazar, Łukasz Szkaradowski, Szymon Baranowski, Julia Lewańska, Krzysztof Bogdański, Zuzanna Kruszyńska, Anastasiya Aleshchyk

Background & Aim: GLP-1 RAs (e.g., semaglutide) and dual GIP/GLP-1 RAs (tirzepatide) induce substantial weight loss, but ~25% derives from fat-free mass (FFM). Whether this threatens skeletal muscle remains contested. Standard guidelines offer generic resistance training advice, ignoring the drugs' gastrointestinal and behavioral side effects. This narrative review aims to synthesize mechanisms of GLP-1 RA-associated lean mass loss, critique DXA-derived FFM as a clinical endpoint, shift focus to muscle quality/func …

11.08.2026journal-article

International Journal of Current Science Research and Review

Job Demands, Resources, Occupational Burnout, And Individual Work Performance Among Commune-Level Civil Servants: Evidence from Gia Lai, Vietnam

Lê Huỳnh Lai, MSc

The operation of Vietnam’s two-tier local government system, comprising the provincial and commune levels, has heightened the requirements placed upon commune-level civil servants in relation to initiative, coordination, digital casework, and accountability for outputs. This study examines the associations among personal resources, the work environment, job demands, new-task demands, occupational burnout, and individual work performance. Data were collected in 2026 from 563 non-managerial professional civil servant …

11.08.2026journal-article

Mindfulness

“Facing What’s There”: A Qualitative Study of Therapists’ Experiences with Integrating Mindfulness in Individual Therapy

Ragnhild Heldal, Maren Skredsvig, Frida Galtung Døsvig Hoff, Jon Vøllestad

Abstract Objectives Although mindfulness has been widely studied in group-based interventions, less is known about how therapists integrate mindfulness into individual psychotherapy. This is a critical gap, given the differences in therapeutic dynamics and the increased flexibility required in one-to-one formats. The aim of this study was to investigate how therapists think about and apply mindfulness in individual therapy, using a qualitative approach to provide a rich and detailed picture of this process of integ …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Vocabulary Breadth and Depth in Adults With Developmental Language Disorder

Tingting Wang, Charlotte Hilker, Dawna Duff, Kristi Hendrickson

Purpose: Developmental language disorder (DLD) affects approximately 7%–11% of children and often persists into adulthood, contributing to long-term challenges in education, employment, and health. Although vocabulary challenges are well-documented in children with DLD, relatively little is known about how these difficulties manifest in adulthood. The current study examines vocabulary knowledge in adults with DLD along two dimensions: breadth (the number of words for which an individual can retrieve a meaning) and …

1 Zitationen
11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Patterns of Mother, Father, and Child Code-Switching and Links With Child Language Development

Ines Juhee Sohn, Bonnie K. Lau, Sara T. Kover, Amy Pace

Purpose: Code-switching, the practice of alternating between languages within a conversation or utterance, is common among bilingual speakers. However, many aspects of its role in language acquisition and the association between parent and child code-switching remain unclear. This study examined code-switching between Spanish–English toddlers and their mothers and fathers. We tested whether the amount of mother and father code-switching was associated with toddlers' code-switching and whether parent and child code- …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Acoustic and Perceptual Characteristics of Compressed Dysarthric Speech: Implications for Teleassessment

Kelvin Tran, Rene L. Utianski, Visar Berisha, Julie M. Liss

Purpose: This study aimed to evaluate how speech signal compression algorithms affect the acoustic and perceptual characteristics of dysarthric speech. As telepractice becomes more common in speech-language pathology, particularly in the assessment of dysarthria, understanding the impact of telecommunication compression on speech fidelity is essential for clinical decision making. Method: Speech samples were collected from 15 individuals with dysarthria, recorded locally and simultaneously via Zoom (Version 6.2.11) …

11.08.2026journal-article

Advanced Science

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Nina Sang, Eijiro Miyako

ABSTRACT Triple‐negative breast cancer (TNBC) remains highly lethal due to aggressive metastasis and profound immunosuppression by regulatory T cells (Tregs). Here, we present a biomimetic liquid metal (LM)‐based photothermal immunotherapeutic nanoplatform exploiting gallium‐based LMs to orchestrate cascade amplification of antitumor immunity. The engineered nanoplatform (B–LM–DMX–αCD25) integrates an LM photothermal core with dual immunomodulatory components—anti‐CD25 antibody for Treg depletion and stimulator of …

11.08.2026journal-article

BMC Cancer

Trials in progress: CARMAN – study protocol of a randomized controlled, international, multicenter, open-label phase II trial evaluating early treatment intensification in patients with high-risk mantle cell lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with rituximab and ibrutinib and 6 months ibrutinib maintenance as compared to standard of care induction and maintenance

Marie-Kristin Tilch, Christian Schmidt, Marek Trneny, Eva Giné, Olivier Hermine, Anke Ohler, Stephanie Herold, Eva Hoster, Linmiao Jiang, Christiane Pott, Martin Dreyling, Georg Hess

Abstract Background Brexucabtagene-autoleucel (brexu-cel) is an anti-CD19 chimeric antigen receptor T-cell (CAR-T) product approved for relapsed/refractory Mantle Cell Lymphoma (MCL) after two prior treatment lines, including Bruton tyrosine kinase inhibitors (BTKi). Patients with high-risk (hr) disease—defined by high-intermediate or high-risk MIPI-c, p53 overexpression, or TP53 alterations—have a poor prognosis, underscoring the need for improved first-line strategies. The European Mantle Cell Lymphoma Network th …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Validity of the Cepstral Spectral Index of Dysphonia in the Persian Language in Sustained Vowel, Sentence, and All-Voiced Sentence Contexts

Saeed Saeedi, Shaheen N. Awan, Samira Aghadoost, Christopher R. Watts, Mahshid Aghajanzadeh, Ben Barsties v. Latoszek

Purpose: Cepstral Spectral Index of Dysphonia (CSID) characterizes and objectively quantifies characteristics of voice quality. The findings of CSID's impact in determining dysphonia characteristics in different languages, however, are unclear but important if this tool is to be used cross-linguistically. Therefore, the purpose of the study was to determine the validity of CSID in Persian speakers. Method: Persian-speaking participants were assigned to two groups: patients with voice disorders ( n = 102) and vocall …

11.08.2026journal-article

Engineering, Technology & Applied Science Research

STOI-Optimized Fixed-Point Speech Enhancement Architecture with Verilog Verification for Hearing Aid ASICs

Vinodakumar M. Sonar, Srinivasarao Udara

This paper presents a fixed-point speech enhancement architecture optimized for intelligibility and designed for low-power hearing aid deployment. The system integrates a perceptual post-filtering pipeline guided by the Short-Time Objective Intelligibility (STOI) metric, enabling dynamic gain control across frequency bands. The algorithmic model, developed in MATLAB using Q-format arithmetic, is mapped precisely to synthesizable Verilog Register-Transfer Level (RTL), ensuring bit-accurate correspondence and reprodu …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Factors Associated with Burnout and Stress Symptoms in Brazilian Workers: Evidence from a Prospective Longitudinal Study from 2020 to 2023

Gabriel Eduardo Domingues, Maria Isabel Triches, Tatiana de Oliveira Sato

Objectives: This prospective study aims to identify factors associated with burnout and stress symptoms. Methods: 1,211 Brazilian workers were included at baseline and 467 at follow-up. A sociodemographic and occupational questionnaire, Copenhagen Psychosocial Questionnaire II-Br (COPSOQ II-Br), and Work Ability Index (WAI) were used to collect data. Multivariate logistic regression was applied. Results: Age was a protective factor for stress (OR=0.97, 95%CI=0.95-0.99) and burnout (OR=0.96, 95%CI=0.93-0.98); as wel …