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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Frontiers in Oncology

Pretreatment prognostic nutritional index and immune status for response to preoperative neoadjuvant chemotherapy in cervical squamous cell carcinoma: an exploratory retrospective study

Zhou-Le Li, Jian-Bin He, Xue Liu, Hui-Ting Hao, Han-Xiao Zhu, Min Wang, Xiao-Ming Wu, Chun-Qiang Lu

Introduction Pretreatment nutritional and immune status may be associated with response to preoperative neoadjuvant chemotherapy (NACT) in cervical squamous cell carcinoma (CSCC), but its clinical utility remains uncertain. Methods This exploratory retrospective study evaluated the association of pretreatment immunonutritional and tumor-related factors with short-term radiologic response to NACT. Ninety-two patients with histopathologically confirmed CSCC who received paclitaxel plus platinum-based NACT followed by …

21.08.2026journal-article

MD-Onco

Robot-assisted retroperitoneal lymph node dissection for stage IIA–IIB testicular germ cell tumor

E. M. Mamizhev, R. V. Orlova, D. I. Rumyantseva, R. A. Melikov, N. F. Krotov, P. M. Gorlin, A. K. Nosov

Background. For a long time, open retroperitoneal lymph node dissection remained the gold standard for the treatment of testicular germ cell tumors. A minimally invasive approach using endoscopic technologies made it possible to solve a number of problems reducing surgical risks for the patient and the perioperative burden for the operating team. Due to the widespread use of robotic surgery in urology, robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has been gaining popularity since its introduction …

21.08.2026journal-article

World Journal of Gastroenterology

Spatiotemporal trends in pancreatic cancer incidence from 2013 to 2023 in Gansu Province, Northwest China: A regional study

Yan-Mei Gu, Jie Liu, Ying-Ying Wang, Gang-Li Liu, Yuan-Yuan Li, Xiao-Mei Li, Yang Zhao, Hui-Juan Cheng, Jun Zhao, Yu-Min Li

BACKGROUND Pancreatic cancer (PC) is a malignant neoplasm with a rising incidence, yet long-term provincial trends in China remain unclear. AIM To comprehensively analyze the spatiotemporal distribution of, and trends in, PC incidence in Gansu Province from 2013 to 2023. METHODS Data on PC cases were gathered from 262 hospitals in Gansu Province, focusing on age-standardized incidence rates (ASIRs) stratified by county, gender, and climate. Moran’s I was employed for spatial autocorrelation analysis to detect clust …

21.08.2026journal-article

Endoscopy

Risk of lymph node metastasis in T1 colorectal cancer with isolated deep submucosal invasion: a multicenter European study

Lucas Barthet, Felix Corre, Thomas Lambin, Stanislas Chaussade, Vincent Lépilliez, Sarah Leblanc, Jérémie Jacques, Thimothée Wallenhorst, Jean-Philippe Ratone, Jean-Baptiste Chevaux, Marion Schaefer, Yann Le Baleur, Gabriel Rahmi, Eukene Rojo, Elena De Cristofaro, Arthur Berger, Arnaud Lemmers, Sohaib Ouazzani, Thibault Degand, Philippe Leclercq, Valerie Hervieu, Jérôme Rivory, Romain Legros, Jérémie Albouys, David Karsenti, Romain Gerard, Nicolas Etchepare, João Santos-Antunes, Henri Lubret, Fabien Subtil, Laura Gerard, Clara Yzet, Tanguy Fenouil, Mathieu Pioche

Background Advances in colorectal cancer (CRC) screening and endoscopic techniques have led to increased detection of T1 CRC. Patient management relies on histopathological criteria predicting lymph node metastasis (LNM), including submucosal invasion depth (SID) >1000 µm. However, the independent prognostic value of isolated deep invasion remains unclear. Methods We performed a retrospective multicenter study of patients treated at 18 European centers between 2009 and 2022. Patients with T1 CRC endoscopically rese …

21.08.2026journal-article

International Journal of Health Management Review

TREATMENT STRATEGIES AND MULTIDISCIPLINARY APPROACH TO DELIRIUM IN ELDERLY PATIENTS

Fernando Malachias de Andrade Bergamo, Bruno Henrique Monteiro de Barros, Rebeca Aniela Sandri Pozza, Carla Luzia Ganzala, Brenda Jeiliane Dantas Alves, Maria Eduarda Trindade Monteiro, Hanniel Gomes Silva, Fernando Soares Santos, Renata Paula Morais dos Santos, Izabella Cristiny Santiago Rodrigues, Debora Denyse Rodrigues Pereira Cruz, Raquel Manzan Miranda, Amanda Anne de Jesus Batista Bôa-Morte, Thamires Villas Boas de Amorim

Delirium is an acute, fluctuating neuropsychiatric syndrome with a high prevalence among hospitalized elderly patients; it is associated with increased mortality, functional and cognitive decline, and institutionalization. This integrative review synthesizes evidence regarding the prevention and treatment of the condition, highlighting that multicomponent non-pharmacological interventions constitute the most robust preventive strategy, reducing incidence by 27% to 54%. In the perioperative setting, modulating anest …

21.08.2026journal-article

International Journal of Cancer

Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study

Jorine Arnouts, Léon C. van Kempen, Senada Koljenović, Helena Oliveres, Pieterjan Vanclooster, Hans Prenen, Caro De Weerdt, Siddharth Chhajlani, Geert Roeyen, Laure Sorber, Koen De Winne, Jonas Dahnoun, Greetje Vanhoutte, Timon Vandamme, Karen Zwaenepoel

ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited. This retrospective cohort study characterized the molecular landscape of BTCs in a Belgian real‐practice setting and evaluated its prognostic relevance. Patients with BTC who underwent informative molecular tes …

21.08.2026journal-article

Frontiers in Nutrition

Longitudinal relationships of malnutrition risk, sleep disturbance, and fear of cancer recurrence in thyroid cancer patients: a cross-lagged panel model

Qixin Lian, Qiang Wu, Wenjun Jia, Lei Meng, Mengqian Zhou, Chengzhi Liang, Xiao Chen, Qi Zhang

Background Although papillary thyroid carcinoma (PTC) is generally associated with favorable survival, postoperative recovery often involves persistent nutritional, psychological, and behavioral challenges. Malnutrition risk, fear of cancer recurrence (FCR), and sleep disturbance are all clinically relevant in thyroid cancer survivorship, yet their temporal interrelationships remain unclear. This study aimed to examine the longitudinal reciprocal relationships among malnutrition risk, FCR, and sleep disturbance in …

21.08.2026journal-article

Frontiers in Nutrition

Appetite measures during ketamine administration in treatment-resistant mood disorders: a naturalistic study

Agnieszka Mechlińska, Mariusz Wiglusz, Jakub Słupski, Krzysztof Pastuszak, Wiesław Jerzy Cubała

This study evaluated the acute and short-term effects of repeated ketamine treatment on appetite in adult inpatients with treatment-resistant mood disorders, including major depressive disorder and bipolar disorder. Appetite, hunger, and desire to eat were assessed using the Visual Analog Scales (VAS) and the Simplified Nutritional Appetite Questionnaire (SNAQ) at baseline and at multiple time points up to 7 days following ketamine administration. No significant changes were observed over the course of treatment, a …

21.08.2026journal-article

The Oncologist

IUC26672-88 Treatment beyond progression in primary refractory mRCC during 1L systemic therapy (Meet-Uro 33)

D Aspden, D Bimbatti, A Dalla Volta, G Roviello, R Iacovelli, G Bozza, M G Vitale, E Fantinel, A Guida, F M Deppieri, C Nasso, S Scagliarini, E Cocorocchio, B Maiorano, C Caserta, A Cavo, F Paolieri, F La Russa, L Fratino, S E Rebuzzi

Abstract Background The optimal management of metastatic renal cell carcinoma (mRCC) patients (pts) experiencing progressive disease (PD) at the 1st radiological assessment during 1st line therapy (primary refractory pts) remains undefined. While treatment beyond progression (TBP) may be appropriate for selected pts with clinical benefit, evidence on pts selection and survival outcomes in this setting is limited. Methods Meet-Uro 33 is an ongoing Italian multicenter retrospective/prospective observational study of …

21.08.2026journal-article

Clinical Journal of Gastroenterology

A case of rectal mixed neuroendocrine-non-neuroendocrine neoplasm diagnosed only after radical surgery: implications of diagnostic timing for therapeutic decision-making

Ryoma Yokoi, Keita Matsumoto, Ryuichi Asai, Jesse Yu Tajima, Masahiro Fukada, Yuta Sato, Itaru Yasufuku, Yoshihiro Tanaka, Tatsuhiko Miyazaki, Nobuhisa Matsuhashi

Abstract Colorectal mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare and aggressive tumors in which accurate preoperative diagnosis remains difficult because of marked intratumoral heterogeneity. A 75-year-old man presented with locally advanced rectal cancer with inguinal lymph node metastasis. Routine biopsy demonstrated moderately to poorly differentiated adenocarcinoma, while retrospective immunohistochemical analysis revealed focal neuroendocrine differentiation insufficient for a diagnosis …

21.08.2026journal-article

Frontiers in Oncology

A rare case of multi-segmental lumbar intradural ependymoma: clinical presentation and surgical management: a case report

Tao Chen, Jianfeng Chen, Bin Wu, Weijin Li, Fan Zhang, Jie Lin

Background Intradural extramedullary(IDEM)-type Ependymoma is a rare clinicalentity belonging to the broader category of uncommon glial neoplasms. To date, most published studies have focused predominantly on classic anatomical locations—particularly the filum terminale, whereas the present case arose from an atypical spinal site, highlighting the pronounced anatomical heterogeneity characteristic of this tumor subtype. Moreover, its neuroimaging features demonstrate considerable overlap with those of more common i …

21.08.2026journal-article

Endoscopic Ultrasound

Novel use of synthetic peptide hemostatic gel in conjunction with EUS-guided coil injection for the treatment of gastric varices: A single-center experience

Christina S. Gainey, Andrew Canakis, Todd H. Baron

Background and Objectives: Bleeding from gastric varices (GV) is severe and associated with high mortality. The standard endoscopic therapy, EUS-guided coil injection with cyanoacrylate glue (EUS-COIL + glue), is highly effective but carries a risk of systemic embolization. This study investigates the safety and efficacy of PuraStat, a synthetic peptide hemostatic gel that promotes clot formation without embolization risk, as an alternative injectate in conjunction with EUS-COIL. Methods: This was a single-center, …

21.08.2026journal-article

Cancer Research

Motherhood’s Sentinels: Pregnancy Induces Tissue-Resident Memory T Cells to Curb Breast Cancer Growth

Meenakshi Sudhakaran, Kelly Kersten

Women who carry a pregnancy to term have long been known to have a reduced lifetime risk of breast cancer, yet the mechanisms underlying this protection remain poorly understood. Although parity-induced differentiation and hormonal remodeling of the mammary epithelium have been considered primary drivers of breast cancer protection, the contribution of immune adaptation has remained largely unexplored. In a recent issue of Nature Immunology, Hussain and colleagues identify pregnancy-induced tissue-resident memory–l …

21.08.2026journal-article

Medicine

Analyzing structural and temporal dynamics of the Drosophila cancer studies

Megan McCabe, Qian Tang, Daylon Douglas, Ava Negahdar, Alaina Godbee, Tyrel Ray, Manyun Liu, Kunie Yoshinaga-Sakurai, Andrew Punkay, Dongyu Jia

Background: Cancer is the 2nd leading cause of human death, and thus an extensive and fast-evolving research field aimed at understanding and curing this disease has developed. Basic science researchers frequently utilize various model organisms to decipher the secrets of cancer, including Drosophila melanogaster . Methods: In this bibliometric analysis study, we extracted and filtered publication data related to Drosophila cancer research from Clarivate’s Web of Science Core Collection from 1990 to 2024, then util …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

Microtubule regulation in cancer cells

Alexandre Matov

Introduction The notion of microtubule (MT) dynamics relates to the changes in the length of MT polymers in living cells. They are governed by a stochastic process related to the rates and chances of adding or removing tubulin dimers at the ends of MT polymers, termed dynamic instability. The ability of each MT to swiftly switch between stages of adding or removing dimers at the tip of its lattice is critical for the overall success of the mitotic spindle, a molecular machinery built dynamically by MTs and associat …

21.08.2026journal-article

Obstetric Anesthesia Digest

Impact of a Maternal Early Warning System and Severe Hypertension Safety Bundle on Timely Treatment of Hypertensive Emergencies: A Quality Improvement and Health Equity Initiative

TD Sims, L Shubert, S Denning, L Shay, C Green, C Davidson

( BJOG 2025;132:2160–2167. doi:10.1111/1471-0528.18273) Hypertensive disorders during pregnancy remain a major contributor to maternal illness and death in the United States. Prompt management of severe hypertension (≥160 mm Hg systolic blood pressure and/or ≥110 mm Hg diastolic blood pressure persistent for 15 minutes or more) is critical, as delays in treatment can lead to complications such as stroke, organ damage and death. Clinical guidelines recommend initiating antihypertensive therapy within 30 to 60 minute …

21.08.2026journal-article

Medicina

Outcomes and Predictive Factors for Gynecologic Organ Involvement in Radical Cystectomy for Female Bladder Cancer Patients: A Multicenter Retrospective Cohort Study

Mehmet Gürkan Arikan, Ersan Arda, Volkan İzol, Hasan Yilmaz, Evren Suer, Murat Akgul, Sertac Yazici, Deniz Bolat, Guven Aslan, Serkan Akan, Levent Turkeri

Background and Objectives: Radical cystectomy (RC) is standard treatment for muscle-invasive bladder cancer, but the role of gynecologic organ preservation in women remains uncertain. We primarily evaluated the prevalence and predictors of pathological gynecologic organ involvement and secondarily assessed survival and developed a prediction model. Materials and Methods: This multicenter retrospective study included 232 women undergoing RC at 13 tertiary centers. Of the 232 women, 182 had clinical T2 disease and 50 …

21.08.2026journal-article

Current Oncology Reports

Periodontitis as a Modulator of Malignant Transformation in Oral Potentially Malignant Disorders: A Narrative Review of Biological Mechanisms and Clinical Implications

Giorgia Pieretto, Martina Sansavini, Arthur Rodriguez Gonzalez Cortes, Christian Bacci

Abstract Purpose of Review Oral potentially malignant disorders (OPMDs) comprise a heterogeneous group of lesions with a variable risk of progression to oral squamous cell carcinoma (OSCC). Although conventional risk assessment relies primarily on clinical and histopathological features, increasing evidence suggests that the local oral microenvironment may also influence malignant transformation. This narrative review examines the potential role of periodontitis as a modulator of OPMD progression, with particular e …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

Mechanistic biomarkers for cancer vaccine development: from cancer cell biology to neoantigen-guided precision immunotherapy

Dario Rusciano

Cancer vaccines have resurged in oncology because they address a central question in precision medicine: whether the molecular identity of a tumor can be converted into an immune target that is both specific and clinically useful. Preventive vaccines against oncogenic viruses have already shown that immune intervention can reduce the burden of virus-associated cancers. Therapeutic cancer vaccines face a more difficult task, because established tumors arise from self-tissues, change over time, and often acquire mech …

21.08.2026journal-article

Light: Science & Applications

A single-chip, dual-gain color–NIR camera for fluorescence-guided lung and breast cancer surgery

Zhongmin Zhu, Brianna Hajek, Yifei Jin, Sinisha Stojanovski, Anamarija Jankulovska, Darko Angjushev, Igor Djikovski, Nexhati Jakupi, Risto Colanceski, Imran Ferati, Borce Antevski, Ilir Vela, Despot Despotovski, Natasha Tolevska Dimitrovska, Magdalena Bogdanovska Todorovska, Goran Kondov, Borislav Kondov, Shuming Nie, Sunil Singhal, Viktor Gruev

Abstract Near infrared (NIR) fluorescence guided surgery can highlight tumors and sentinel lymph nodes, but most clinical fluorescence imaging systems use multi-camera architectures in which residual color–NIR misregistration can mislocalize fluorescence relative to anatomy, and weak signals often require dimming operating room lights. We developed a single-chip dual-gain scientific CMOS (sCMOS) sensor with red, green, blue (RGB), and NIR channels that provides intrinsically coregistered color reflectance and NIR f …

21.08.2026journal-article

Advanced Science

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye

ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance. PHB2 was consistently upregulated in resistant tumors and associated with poor clinical outcomes. Mechanistically, PHB2 binds the lipid‐metabolic enzyme ACSL3 through a defined AMP‐bi …

21.08.2026journal-article

International Journal of Clinical Oncology

Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender–age–physiology staging system

Yoshito Imamura, Keita Nakanishi, Heng Huang, Minoru Sugihara, Taiki Ryo, Yasuhisa Ichikawa, Tatsuya Masuda, Hirofumi Takenaka, Yuta Kawasumi, Hiroki Watanabe, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

Abstract Background Selecting the optimal surgical strategy for lung cancer patients with interstitial lung disease (ILD) remains difficult. This study evaluated the prognostic value of a newly proposed surgical indicator—the predicted ILD Gender–Age–Physiology (GAP) stage—which incorporates predicted postoperative pulmonary function into the conventional ILD-GAP stage. Methods This study retrospectively analyzed 125 patients with clinical stage 1 lung cancer and ILD who underwent surgery during 2011–2023. Postoper …

21.08.2026journal-article

International Journal of Health Management Review

GUIDELINES FOR THE TREATMENT AND EPIDEMIOLOGICAL CONTROL OF LEISHMANIASIS

Aíssa Rodrigues Ramos, Caren Andrigheti Grazziotin, Lucas Andre Gauer, Helena Duani, Claudia Aparecida Fernandes Cordeiro, Elisa Fioreze Dal Bó, Debora Denyse Rodrigues Pereira Cruz, Rafael Martins da Silva Figueiredo, Camilla Bastos Motta de Lacerda, Eduardo de Lacerda Aguiar, Alexandra Borja Mancheno, Lívia Ugikawa Fujiwara, Letícia Prado Ribeiro, Sandra Regina Silva de Moura, Emilly Guimarães dos Santos, Allana Moura de Araújo

Leishmaniasis is an endemic parasitic disease with significant global impact; World Health Organization (WHO) estimates indicate that over 12 million people are infected, predominantly in underdeveloped and developing tropical countries. The disease is caused by protozoa of the genus *Leishmania*, transmitted by female phlebotomine sandflies. Clinically, it manifests in three main forms: cutaneous (the most prevalent), mucocutaneous, and visceral (associated with high fatality rates). Conventional therapies face cr …

21.08.2026journal-article

Clinical Pharmacology & Therapeutics

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis

Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear. This target trial emulation, analyzing US commercial claims (2013–2023), evaluated these safety outcomes under gabapentin–opioids initiation vs. opioids only during the first postoperative month following breast cancer surgery, with su …