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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Experimental Oncology

THERAPEUTIC ROLE OF siRNA IN GASTRIC CANCER: GENE SILENCING MECHANISMS AND NANOCARRIER-BASED DELIVERY STRATEGIES

Gheysar Seifollahnezhad, Berrin Erdağ

Gastric cancer (GC) continues to be a significant global contributor to cancer-related mortality, primarily due to late-stage diagnoses, tumor heterogeneity, and the frequent emergence of therapeutic resistance. Despite advancements in surgical techniques, chemotherapy, targeted therapies, and immunotherapy, long-term survival rates remain unsatisfactory, underscoring the need for innovative, molecularly driven approaches. SiRNA has emerged as a promising gene-silencing tool capable of selectively downregulating on …

21.08.2026journal-article

Cancers

Artificial Intelligence for Diagnostic and Prognostic Support in Breast Cancer: A Literature Overview

Diana Gina Poalelungi, Anca Iulia Neagu, Ana Fulga, Octavian Stefan Patrascanu, Iuliu Fulga

Artificial intelligence (AI) is increasingly being integrated into medical practice, offering promising tools to improve diagnostic accuracy and clinical efficiency. In the field of breast pathology, AI applications, particularly those based on deep learning (DL) and machine learning (ML), are emerging as decision-support tools in both diagnostic and prognostic workflows. This review provides a comprehensive overview of current AI-based approaches, with a focus on their clinical utility in tumor detection, histolog …

21.08.2026journal-article

Frontiers in Genetics

Identification of NETs and inflammation-related prognostic genes in breast cancer and PCR experimental validation

Zhihong Xu, Qian Ma, Qihua Jiang, Wensong Wei, Dan Tao

Background Neutrophil extracellular trap-driven necrosis-related genes (NRGs) and inflammation-related genes (IRGs) are crucial in mitigating or inhibiting cancer progression in breast cancer patients. The interaction between NRGs and IRGs in breast cancer remains unclear. Thus, identifying prognostic genes associated with NETosis and inflammation in breast cancer may offer a novel approach to improving the outcome of breast cancer. Methods Genes with statistically significant expression levels and correlations wit …

21.08.2026journal-article

The Oncologist

IUC26600-79 ‘State-of-the-Nation’ Study: Understanding the current NHS treatment pathway to identify opportunities to advance future care of patients with high-risk non-muscle invasive bladder cancer in the UK (SPAN-UK)

J Aning, J Catto, R Martin, K Chatterton, P Mariappan, S Mccormack, S Gill, B Szabados

Abstract Background Optimal outcomes in high-risk non-muscle-invasive bladder cancer (HR-NMIBC) depend on coordinated, adequately resourced Multidisciplinary Team (MDT) care and robust service-level quality performance indicators (QPIs). To date, the HR-NMIBC care pathway across all National Health Service (NHS) regions has not been mapped. This descriptive, cross-sectional study was therefore undertaken to characterise the evolving treatment pathway from diagnosis through to follow-up, identifying areas for optimi …

21.08.2026journal-article

Cancer Research

YAP1-Driven PLCβ1 Impairs MHC-I Antigen Presentation and Limits Anti-Tumor Immunity in Gastrointestinal Cancer

Yingjing Zhang, Pengfei Su, Tian Yu, Bowen Hou, Jianpeng Gao, Fenglin Liu, Yakai Huang

Abstract Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet its efficacy in gastrointestinal malignancies is often limited by an immunosuppressive tumor microenvironment. In this study, we identified phospholipase C beta 1 (PLCβ1) as a central driver of pathogenesis and ICB resistance in gastrointestinal cancer. Unlike classical oncogenes, PLCβ1 promoted tumor progression by fostering immune evasion rather than directly enhancing intrinsic tumor cell survival. Mechanistically, PLCβ1 interacte …

21.08.2026journal-article

British Journal of Haematology

Declining treatment‐related and overall mortality in children with newly diagnosed advanced‐stage non‐Hodgkin lymphoma treated in a paediatric cancer centre during 2013–2024, Shanghai, China

Xinyu Qiao, Yuejia Tang, Qiushi Yang, Qing Yuan, Jie Zhao, Anan Zhang, Xu Zhou, Ming Wang, Haishan Ruan, Jingyan Tang, Yijin Gao

Summary Little is known about overall and treatment‐related mortality (TRM) in children with non‐Hodgkin lymphoma (NHL) in upper‐middle‐income countries (UMICs). A retrospective cohort of children with advanced‐stage NHL diagnosed and treated in a large paediatric cancer centre in Shanghai, China, was analysed. The 3‐year overall mortality and TRM cumulative incidence were 11.20% ± 1.44% and 2.11% ± 0.65% respectively. Patients diagnosed in the late period (2020–2024) had lower overall mortality (7.18% ± 1.88% vs. …

21.08.2026journal-article

International Journal of Health Management Review

TREATMENT STRATEGIES AND SURGICAL APPROACH FOR OBSTRUCTIVE URETERAL LITHIASIS

Laura Cristina Queiroz de Castro, Arthur Brachini Calegario, Leticia Galli de Aguiar, Ana Luíza Walter de Melo, Maria Eduarda Scheeren Xavier, Antonella Chiacchio Cagnani, Henrique Hamann Aita, Manuela Coradini Moglia, André Bolivar São Clemente, Pedro Henrique Ramos Guimaraes, Felipe Luiz Primon, Felipe Makcemiuk Dagios, Genilson Figueiredo de Oliveira Júnior, Luzia Conz Agostinetto

Obstructive ureteral lithiasis is a prevalent condition in urological practice, ranging from intense renal colic to severe complications such as hydronephrosis, urosepsis, and acute kidney injury, with a risk of progressive renal impairment if the obstruction is prolonged. This narrative review, based on PubMed searches using the terms "Ureteral Calculi" and "Therapeutics," discusses key emergency management strategies, ranging from conservative care to minimally invasive endourological approaches. Non-contrast com …

21.08.2026journal-article

Medicine

Role of mutant p53 and autophagy on precancerous lesions of gastric cancer progression

Qiuyue Wang, Yutao Wu, Wenrong Wang

Precancerous lesions of gastric cancer (PLGC) represent a critical stage in the development of gastric cancer. Multiple complex factors working together can increase the risk of cancer progression. Relevant published papers were collected through a search of the PubMed, Google Scholar, and Web of Science databases. Recent studies have shown that mutant p53 can impede processes like cell cycle arrest, cell apoptosis, and DNA damage repair, which promotes the proliferation of cancer cells and influences the transitio …

21.08.2026journal-article

Nano Research

Development of multi-lineage differentiated liver ductal organoids in suspension culture that generates therapeutic extracellular vesicles for sclerosing cholangitis treatment

Senyi Gong, Yu Liu, Xingyu Luo, Yuwen Hu, Qinbiao Yan, Zhe Yang, Shusen Zheng, Meijin Guo, Ali Mohsin

Abstract Organoid-based therapy, as an approach in regenerative medicine, offers new options for previously untreatable diseases. However, the limitations of organoid transplantation, such as immunogenicity, tumorigenic potential, and ethical issues, restrict its clinical translation. For the first time, a novel three-dimension matrigel-free suspension culture system is developed to generate liver ductal organoid-derived extracellular vesicles (3D OEVs) for primary sclerosing cholangitis (PSC) treatment. The result …

21.08.2026journal-article

Life

Integrated Mendelian Randomization and Single-Cell Transcriptomics Reveal T Cell Immune Mechanisms in Systemic Lupus Erythematosus–Bladder Cancer Comorbidity

Desheng Zhang, Huan Ren, Yunjin Bai, Ping Han

Objective: Patients with systemic lupus erythematosus (SLE) exhibit elevated malignancy risk, with increased bladder cancer incidence. This study integrated Mendelian randomization (MR) with single-cell sequencing (scRNA-seq) to nominate exploratory prioritized candidate genes in SLE–bladder cancer comorbidity and their T cell regulatory roles. Methods: Single-cell datasets for SLE (GSE266852) and bladder cancer (GSE222315) were retrieved from GEO. Quality control, clustering, and annotation were performed using Se …

21.08.2026journal-article

Frontiers in Oncology

Can risk scoring systems (R.E.N.A.L, PADUA and (MC)2 scoring systems) and related risk factors predict complications of renal ablation? a meta-analysis

Zhiqiang Zeng, Peng Ji, Yang He, Yubo Zhou, Tao Li, Lunhong Zou, Tao Zhou, Huan Zhao, Xionglin Hu, Wangbing Chen, Wubin Chen

Objective To evaluate the predictive value of the R.E.N.A.L., PADUA, and (MC) 2 scoring systems for complications after renal tumor ablation. Method This systematic review and meta-analysis was reported in accordance with PRISMA and registered in PROSPERO. PubMed, Embase, the Cochrane Library, and Web of Science were searched from inception to May 1, 2025. The primary outcomes were overall, major, and minor complications after renal ablation in relation to the R.E.N.A.L., PADUA, or (MC) 2 scoring systems. Results A …

21.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of traditional Chinese medicine herbal hand-foot bath combined with arnebia oil for chemotherapy-induced hand-foot syndrome refractory to standard treatment: a single-arm prospective interventional pilot study of 30 cases

Ying Chen, Yuqi Jin, Linglin Fu, Ping Song, Ziyan Shao, Yinuo Tan

Background Chemotherapy-induced hand-foot syndrome (HFS) is a common dose-limiting cutaneous adverse reaction associated with cytotoxic agents such as capecitabine and small-molecule targeted drugs. Severe HFS may lead to dose reduction or interruption of antitumor treatment, significantly impairing patients' quality of life and treatment compliance. Current standard treatments (urea ointment, vitamin B6, topical corticosteroids, etc.) show limited efficacy for some patients with moderate-to-severe HFS, creating an …

21.08.2026journal-article

Frontiers in Psychiatry

Association of social restrictions with fear of cancer recurrence in hematopoietic stem cell transplantation patients: an exploratory analysis of the potential chain mediation role of illness perception and cognitive emotion regulation

Shurong Ran, Chunmei Zhang, Mingyan Liao

Objective To explore the potential association between social restrictions and FCR in patients who underwent HSCT, and preliminarily investigate whether examine whether illness perception and cognitive emotion regulation mediate this association using an exploratory cross-sectional design. Methods We retrospectively collected clinical data from 328 patients who underwent HSCT at the Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, between January 2020 and December 2024. After …

21.08.2026journal-article

Alcoholism & Drug Abuse Weekly

Combination of psychedelic, CBT shows promise in AUD treatment

Gary Enos

Participants in a Phase 2a trial of a single‐dose psychedelic in combination with cognitive‐behavioral therapy (CBT) for alcohol use disorder (AUD) used terms such as “cleansing” and “rebirth” to describe the impact of their study experience. All but two of the study's 10 interviewed participants reported eliminating or reducing drinking over a 12‐week follow‐up, though several described their overall experience as challenging.

21.08.2026journal-article

The International Journal of Health Planning and Management

Planning and Sustaining Breast Cancer Patient Navigation Programs: A CFIR‐Informed Scoping Review of Implementation Determinants

Siti Nurhafizah Saharudin, Nazirul Munir Abu Hassan, Mohd Fittri Fahmi Fauzi, Ahmad Zulfahmi Sha'ari, Mohd Faiz Mohd Ghazali, Afiq Izzudin A. Rahim

ABSTRACT Background Patient Navigation Programs (PNPs) address fragmentation and socioeconomic barriers in breast cancer care, but sustainable implementation is complex and context dependent. This scoping review systematically maps and synthesises multilevel determinants of breast cancer PNPs to inform strategic planning and health system management for sustainable service delivery across diverse public health contexts. Methods Guided by the Arksey and O'Malley methodology framework and reported in accordance with …

21.08.2026journal-article

ACS Pharmacology & Translational Science

Fibrinogen–Drug Nanoparticles Achieve Durable Responses in Pancreatic and Breast Cancer Murine Models

Rose Razavi, Michael O’Connor, James F. Hainfeld

Abstract Inadequate targeting, short-lived therapeutic exposure, drug resistance, and toxicities limit effective cancer treatments. We developed a strategy that redirects an evolutionarily optimized clotting cascade to achieve selective, sustained drug deposition within solid tumors. A vascular disrupting agent induces tumor-specific endothelial injury, activating platelets and exposing fibrinogen-binding sites. Systemically administered fibrinogen–drug nanoparticles (FDNs) bind activated platelets with multivalent …

21.08.2026journal-article

Medicine

Incremental prognostic value of a preoperative immune-metabolic-inflammatory score for disease-free survival in endometrial cancer

Shuhuan Li, Juan Li, Yuer Sun, Jiayu Chen, Jing Yan, Miaomiao Nie, Mei Wu, Yawen Shao, Zhenzhen Wu

The systemic immune-inflammation index, fibrinogen, triglyceride/high-density lipoprotein cholesterol ratio, and prognostic nutritional index have each been linked to endometrial cancer outcomes, but their optimal combination is uncertain. We compared alternative formulations and evaluated incremental prognostic value for disease-free survival (DFS). This single-center cohort included 853 surgically treated patients. Four biomarkers and 3 risk-aligned, equally weighted scores were compared: the 4-component immune-m …

21.08.2026journal-article

Journal of Clinical Medicine

Comparison of Perioperative, Oncologic, and Functional Outcomes Following Robotic and Laparoscopic Intersphincteric Resection for Low Rectal Cancer: A Systematic Review and Meta-Analysis

Konstantinos Kossenas, Maximos Frountzas, Athanasios Syllaios, Nikolaos Pararas, Panagiotis Kokoropoulos, Dimosthenis Michelakis, Konstantinos Tsimogiannis, Dimitrios Symeonidis, Dimitrios Schizas

Background: Intersphincteric resection (ISR) is a technically demanding sphincter-preserving procedure for low rectal cancer. While robotic surgery may offer technical advantages, evidence comparing robotic ISR (R-ISR) and laparoscopic ISR (L-ISR) remains limited. This study aimed to compare perioperative, oncologic, and functional outcomes between R-ISR and L-ISR. Methods: A systematic review and meta-analysis was conducted in accordance with PRISMA 2020. PubMed, Scopus, and Cochrane Library were searched up to 1 …

21.08.2026journal-article

The Ukrainian Journal of Clinical Surgery

Neoadjuvant Hormone Therapy for Hormone-Receptor-Positive, HER2-Negative Breast Cancer: Experience of the Transcarpathian Anticancer Center

F. M. Pavuk, K. Ye. Rumyantsev, S. M. Chobei, M. F. Rishko

Objective. To summarize the experience of using neoadjuvant hormone therapy for hormone-receptor-positive, HER2-negative breast cancer in the real-world clinical practice of the Transcarpathian Cancer Center and to evaluate its impact on the frequency of breast-conserving surgery, long-term oncological outcomes, and patients’ quality of life.Materials and Methods. This retrospective study included 1,612 patients with hormone-receptor-positive, HER2-negative breast cancer who received treatment between 2010 and 2024 …

21.08.2026journal-article

Endocrine-Related Cancer

Succinate dehydrogenase germline mutation carriers: before tumours develop

Eugenie S. Lim, Jean-Pierre Bayley, Anne-Paule Gimenez-Roqueplo, Roderick J. Clifton-Bligh, Susan Richter

Abstract Succinate dehydrogenase (SDH) is an enzyme complex that plays a major role in cellular metabolism, as it sits at the interface between carbon metabolism in the Krebs cycle and oxidative phosphorylation for energy production. The precursor and product of the enzymatic reaction, succinate and fumarate, respectively, are regulators of various cellular and biological processes such as epigenetic status, hypoxia responses and angiogenesis, metabolic reprogramming, tumorigenesis, and immune responses. Succinate …

21.08.2026journal-article

Cancers

Variations in Autophagy-Related Genes ATG5, ATG10 and ATG16L1 Correlate with Tumor Burden, Inflammatory Biomarkers and Clinical Course in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors

Milica Ćućuz Jokić, Bojana Cikota-Aleksić, Jovana Pavlica, Branko Dujović, Igor Salatić, Tijana Stanojković, Tatjana Bollhorn, Lidija Kandolf

Background/Objectives: This study assessed the impact of variations in autophagy-related genes (ATG) on baseline characteristics of cutaneous melanoma, laboratory parameters (including inflammatory biomarkers), response to therapy, and survival in patients treated with immune checkpoint inhibitors (ICIs) as first-line therapy. Methods: DNA was extracted from blood samples of 144 melanoma patients. Genotyping of ATG5 (rs2245214 and rs510432), ATG10 (rs1864183 and rs1864182), and ATG16L1 (rs2241880) was performed usi …

21.08.2026journal-article

Materials

Effects of Solution Treatment on the Microstructure and Properties of Al0.4Co0.5V0.2FeNi High-Entropy Alloys

Hongbo Duan, Wei Yang, Zhijun Ma, Yuan Li

This work explores V-alloyed Al0.4Co0.5V0.2FeNi high-entropy alloys that are solution-treated at 1000–1200 °C for five hours and water-quenched. Solidification of this high-entropy alloy follows the sequence face-centered cubic (FCC) → ordered L12 → body-centered cubic (BCC) → ordered B2. All treated alloys maintain dual FCC–BCC-B2 microstructures, with temperature altering only morphological features. At 1000 and 1100 °C, coherent spinodal decomposition takes place in FCC matrices to form rodlike precipitates with …

21.08.2026journal-article

International Journal of Surgery Case Reports

Multicentric metachronous giant cell tumor of the femur: a rare case report and review of the literature

Christopher Paul, Jimmy Olomi

Background: Giant cell tumor of bone (GCTB) is a benign but locally aggressive osteolytic neoplasm that most commonly presents as a solitary lesion in long bones. Multicentric GCTB is rare, comprising fewer than 1% of all cases, and metachronous involvement of two distinct regions within the same bone is exceptionally uncommon. Case presentation: We report the case of a 22-year-old man who initially presented with a 2-year history of right knee pain. Radiologic and histopathologic evaluation confirmed a Campanacci …