Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 149

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Medicine

Cervical cancer screening predictors in Tanzania: a variance component models’ approach of national survey 2022

Jovin R. Tibenderana, Sanun Ally Kessy, Jomo Gimonge, Innocent Peter, Fabiola Moshi

Despite the potential for prevention through early detection and treatment, cervical cancer remains the most prevalent cancer among women of reproductive age (WRA). There is a paucity of evidence on the predictors influencing cervical cancer screening nationwide. Thus, this study aimed to determine the predictors associated with cervical cancer screening among WRA in Tanzania using the 2022 Tanzania Demographic and Health Surveys. This study was an analytical cross-sectional study that utilized nationally represent …

21.08.2026journal-article

Molecules

Amphiphilic Covalent Organic Framework for Efficient DHT Adsorption and Androgenetic Alopecia Treatment via Spectral Technology

Jiahui Wei, Fanqiang Bu, Bing Zhao, Qi Liu, Jinqiang Wu

Androgenetic alopecia (AGA) is a prevalent clinical disorder, and the key pathogenic factor is dihydrotestosterone (DHT) present in the pilosebaceous unit. Current clinical therapeutic options are often associated with notable adverse effects, highlighting the urgent need for safer and more effective interventions. Herein, a novel amphiphilic covalent organic framework (amCOF) is designed and synthesized. By simultaneously incorporating hydrophilic functional groups and lipophilic alkyl chains into the covalent org …

21.08.2026journal-article

International Journal of Molecular Sciences

Lactate as a Master Regulator of Immune Suppression: From Metabolic Waste to Epigenetic Checkpoint in Colorectal Cancer

Beiyan Chen, Shuang Gao, Xin Chen, Qingping Shi, Mingli Shen, Jieru Han

Colorectal cancer, especially the microsatellite-stable subtype, which accounts for 85% to 95% of cases, resists immune checkpoint inhibitors largely due to metabolic reprogramming in the tumor microenvironment. Lactate has evolved from a waste product into a central immunosuppressive regulator. Oncogenic KRAS and BRAF mutations drive aerobic glycolysis, causing glucose deprivation and massive lactate accumulation in the tumor microenvironment. Lactate suppresses immunity through three parallel mechanisms. It signa …

21.08.2026journal-article

Journal of Applied Membrane Science & Technology

Machine Learning in Membrane Distillation for Pulp and Paper Wastewater Treatment: A Review

N. S. N. Shahrudin, N. Septari, N. Mokhtar, S. A. Rahman

Membrane distillation (MD) is a promising thermally driven separation technology for treating high-strength industrial wastewater, particularly from the pulp and paper industry. However, its performance is constrained by complex and nonlinear interactions among operating conditions, feed characteristics, and membrane properties, leading to challenges such as fouling, membrane wetting, and flux decline. Conventional modelling approaches are often inadequate in capturing these dynamic behaviours, resulting in limited …

21.08.2026journal-article

Cancer Science

TRIM59 Drives Bladder Cancer Progression Through E3 Ligase‐Dependent K48 ‐Linked Degradation of PTRF

Junlin Gan, Xuesong Bai, Aijie Zhang, Fei Lin, Hang Tong, Tinghao Li, Ning Xu, Xinyuan Li, Zhou Yu, Hubin Yin

ABSTRACT Tripartite motif‐containing 59 (TRIM59) is an E3 ubiquitin ligase implicated in multiple malignancies, but its role in bladder cancer (BLCA) remains incompletely understood. In this study, we identified TRIM59 as a clinically relevant oncogenic driver in BLCA through integrated transcriptomic, clinical, and functional analyses. TRIM59 was significantly upregulated in BLCA tissues and cell lines, and high TRIM59 expression was associated with advanced stage, higher grade, recurrence, and poor prognosis. Fun …

21.08.2026journal-article

The Oncologist

IUC26696-94 Enfortumab Vedotin Plus Pembrolizumab Outcomes in Advanced Urothelial Cancer: Real-World Data

S Peroos, A Saeed, S Jenkinson, A Clifford, M Prentice, S Mansukhani

Abstract Background Enfortumab vedotin plus pembrolizumab (EV-P) is the new standard first-line treatment with EV302/KeynoteA39 demonstrating OS, PFS and ORR benefit for locally advanced or metastatic urothelial carcinoma (la/mUC) compared with platinum-based regimes. We analysed real-world data to review the impact of EV-P on patient age-stratified outcomes. Methods Retrospective analysis was performed on patients with histologically confirmed la/mUC treated with EV-P at Royal Free London Trust (RFL) between June …

21.08.2026journal-article

Frontiers in Medicine

Challenges in managing ruptured ectopic pregnancy complicated by hemorrhagic shock in an Ebola treatment unit in DR Congo: first reported case

Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Rigo Fraterne-Muhayangabo, Alfred Ombeni-Musimwa, Zacharie Tsongo-Kibendelwa, Olivier Nyakio-Ngeleza, Richard Kitenge-Omasumbu, Théophile Barhwamire-Kabesha, Dieudonné Sengey-Mushengezi-Amani, Placide Mbala-Kingebeni, Richard Bitwe-Mihanda, Juakali Sihali-Kyolov, Mija Ververs

Background Ectopic pregnancy (EP) is an obstetric emergency; early diagnosis is critical for maternal survival. In resource-limited settings, such as Ebola treatment units (ETU), delayed diagnosis or management of EP often leads to rupture and life-threatening hemorrhagic shock. Case presentation We report the case of a pregnant woman in her 30s who was admitted to the ETU with suspected Ebola virus disease in the Democratic Republic of Congo (DRC). Her clinical presentation included fever and abdominal pain, which …

21.08.2026journal-article

Diseases of the Colon & Rectum

Defining Volume Thresholds for Colorectal Cancer Surgery Using Stratum Specific Likelihood Ratios

Alexa Hughes, Kristen Kaiser, Brian Ruedinger, Adam Wilk, Katie Ross-Driscoll, Rachel E. Patzer, Sanjay Mohanty, Ryan Ellis

BACKGROUND: Higher procedure volume correlates with improved surgical outcomes, yet recent literature has questioned whether this relationship persists in modern times. Reports of an attenuated volume-outcome association may reflect the limitations of a single, static, cutoff rather than true weakening of the underlying relationships. Stratum-specific likelihood ratios generate multiple empirically derived volume strata that may detect persistent gradients that are obscured by binary threshold approaches. OBJECTIVE …

21.08.2026journal-article

Scientific Reports

Cell line-specific modulation of colorectal cancer cell behavior following SGLT2 inhibition via empagliflozin

Vincent Lučanský, Ivana Baranová, Jakub Šofranko, Roman Eibner, Angel Cid-Arregui, Eva Lukáčová, Monika Péčová, Katarína Dibdiaková, Radovan Murín, Renata Péčová, Marek Samec, Martin Péč

Abstract Colorectal cancer (CRC) is a major global health problem, with type 2 diabetes mellitus (T2DM) and obesity among its significant risk factors. Empagliflozin (EMPA), a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used in the treatment of T2DM, has also demonstrated potential anticancer effects. However, reports of possible adverse effects in certain oncological contexts have raised concerns. We established several in vitro assays to evaluate the effects of EMPA on different colon cancer …

21.08.2026journal-article

Journal of Clinical Medicine

Explainable Multimodal Machine Learning Predicts 90-Day Treatment Failure in Older Patients with Fragility Fractures of the Pelvis

Kangwei Wang, Yulin Cao, Nan Gao, Cong Ma, Jianwen Wang, Zishen Xia, Aiwen Gui, Yong Liu, Yuxiong Weng

Background: Fragility fractures of the pelvis (FFP) are increasingly encountered in older adults, yet early deterioration is difficult to anticipate because fracture instability interacts with frailty and systemic vulnerability. We developed and validated an admission-based multimodal framework to predict 90-day treatment failure (TF90) before definitive management. Methods: This multicentre retrospective prediction study included 1684 consecutive patients aged ≥65 years with FFP treated at five tertiary hospitals. …

21.08.2026journal-article

Journal of Clinical Medicine

Reprogramming the Evolution of High-Risk Prostate Cancer: Multidisciplinary Strategies to Delay Castration Resistance

Younghun Sim, Jae Won Choi, Dong Seob Kim, Jeong Hyun Kim, Sung Goo Yoon, Jung Ki Jo

Background/Objectives: High-risk prostate cancer is a biologically heterogeneous group of tumors carrying a substantial risk of progression to lethal, castration-resistant disease. Although androgen deprivation therapy (ADT) remains the therapeutic backbone, nearly all advanced disease eventually progresses to castration-resistant prostate cancer (CRPC) through Darwinian clonal evolution under sustained therapeutic pressure. This narrative review reframes high-risk prostate cancer management as an effort to reprogr …

21.08.2026journal-article

Experimental Oncology

SULFORAPHANE SUPPRESSES HEPATOCELLULAR CARCINOMA IN MICE VIA ACTIVATING p53, MITIGATING OXIDATIVE STRESS, AND INHIBITING ANGIOGENESIS

Kholoud A. Omran, Yomna I. Mahmoud, Asmaa A. Mahmoud, Nagui H. Fares

Background. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Sulforaphane (SF) is a natural isothiocyanate that exhibits anticarcinogenic activity against various cancer cells in vivo and in vitro, with no observed side effects. It also has a prophylactic effect against early stages of some cancer models, including HCC. The study aimed to assess the therapeutic anticarcinogenic effect of SF in experimental murine HCC in vivo and to estimate possible underlying mechanisms of its effects on …

21.08.2026journal-article

Journal of Prosthodontics

Multidisciplinary dental treatment planning by artificial intelligence: A comparative evaluation

Sohil A. Kazim, Bashaer A. Alnoman, Razan M. Hashim, Charles J. Goodacre

Abstract Purpose The purpose of this study was to evaluate and compare four AI software programs—ChatGPT‐5, Microsoft Copilot, Google Gemini (V 2.5), and OpenEvidence—in generating comprehensive dental treatment plans for minimally destructed and severely mutilated teeth using identical clinical inputs. Material and Methods Ten anonymized clinical cases, each consisting of 1 intraoral photograph and 1 corresponding periapical radiograph, were independently submitted to each AI software program using a standardized …

21.08.2026journal-article

Düzce Tıp Fakültesi Dergisi

Silent Corticotroph Pituitary Neuroendocrine Tumor: A Case Report

Merve Şimşek Dilli, Fettah Acıbucu, Zübeyde Şebnem Aktaran, Şekure Demet Küçük

Silent corticotroph pituitary neuroendocrine tumors are a rare subtype of non-functioning pituitary neuroendocrine tumors that lack the clinical and biochemical manifestations of Cushing disease. These tumors are associated with an aggressive clinical course because of a tendency for rapid progression and invasive growth, as well as a high recurrence rate. We present a 41-year-old woman without Cushingoid symptoms who presented with headache, bitemporal hemianopia, and diplopia. MRI revealed a mass extending into t …

21.08.2026journal-article

MD-Onco

Clinical, pathological and molecular aspects of meningiomas and treatment options

A. Y. Rynda, V. E. Olyushin, D. M. Rostovtsev, Y. M. Zabrodskaya, O. A. Pavlov

Meningiomas are the most common primary intracranial tumors in adults, accounting for over 35 % of all intracranial tumors. Moreover, meningiomas occurring in children account for only 0.64 % of all meningiomas, and among intracranial tumors in children, meningiomas account for 1.42–5.00 % of cases. Because the risk of developing meningioma increases significantly with age, the proportion of healthcare costs associated with meningiomas in developed countries will continue to increase as the demographics shift towar …

21.08.2026journal-article

Frontiers in Oncology

Case Report: Fibromatosis-like metaplastic breast cancer: a case with detection of three genetic alterations, accompanied by local recurrence, lymph node metastasis, and distant metastasis

Xin Zhang, Xiaoqing Cheng, Yue Shi, Yufan Xu

Fibromatosis-like metaplastic carcinoma (FLMC) is defined as a rare histologic subtype of metaplastic carcinoma within the 2019 World Health Organization (WHO) classification framework for breast tumors. We present a case of FLMC demonstrating a notably atypical clinical presentation. A 73-year-old woman presented with a self-detected breast mass. Radiological and pathological evaluations both indicated potential malignancy. Histological examination showed a lesion composed predominantly of spindle cells and displa …

21.08.2026journal-article

Cancers

Surgical Complexity and Perioperative Feasibility Following Neoadjuvant Chemotherapy, Chemoradiotherapy, or Chemoimmunotherapy in Stage II–III Non-Small Cell Lung Cancer: A Retrospective Single-Institution Study

Hiroki Sakai, Takayuki Hatakeyama, Takahiro Homma, Kanji Otsubo, Norifumi Kakizaki, Hideki Marushima, Koji Kojima, Kei Morikawa, Naoki Furuya, Masamichi Mineshita, Yoshiya Sugiura, Junki Koike, Hisashi Saji

Background: Neoadjuvant chemoimmunotherapy has emerged as a standard option for resectable stage II–III non-small cell lung cancer (NSCLC); however, its impact on surgical feasibility, operative complexity, and perioperative outcomes remains incompletely characterized. We compared surgical feasibility, complexity, and perioperative outcomes across different neoadjuvant strategies. Methods: This single-center retrospective study included patients with stage II–III NSCLC who underwent curative-intent resection follow …

21.08.2026journal-article

Biomedicines

Comparative Treatment Response to Intermittent Theta Burst Stimulation in Long COVID-Associated Depression Versus Major Depressive Disorder: A Propensity Score-Matched Retrospective Cohort Study

Yoshihiro Noda, Ryota Osawa, Yuya Takeda, Ryosuke Kitahata

Background: Long COVID has emerged as a global health challenge characterized by persistent neuropsychiatric symptoms, including depression, fatigue, and cognitive impairment. Growing evidence indicates that sustained neuroinflammation, endothelial dysfunction, and fronto-limbic network disruption may underlie these symptoms, representing pathophysiological features distinct from major depressive disorder (MDD). Although repetitive transcranial magnetic stimulation (rTMS) is an established treatment for MDD, its th …

21.08.2026journal-article

Medicina

Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study

Denis Gruber, Anca Mihaela Bina, Ahmed Abu-Awwad, Octavia Valentina Tinei, Simona-Alina Abu-Awwad, Cosmin Citu, Adrian Ratiu, Bianca Huidu, Sergiu Costescu, Zoran Laurentiu Popa

Background and Objectives: Ovarian cancer remains the most lethal gynecologic malignancy, largely due to late diagnosis and the limitations of currently available diagnostic tools. Systemic inflammatory markers derived from routine blood tests have emerged as potential low-cost biomarkers, reflecting the interaction between tumor biology and the host immune response. This study aimed to evaluate the association and diagnostic value of preoperative inflammatory markers in distinguishing malignant from non-malignant …

21.08.2026journal-article

Hereditas

Epigenetic upregulation of PAPSS2 drives proliferation, migration, angiogenesis, and M2 macrophage infiltration in gastric cancer

Yi Wu, Weiwei He, Fangjian Li, Lin Wu, Mengyi Xie, Jingdong Li, He Zhou

Abstract Objective 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) synthase 2 (PAPSS2) catalyzes the rate-limiting step in sulfation metabolism by generating the universal sulfate donor PAPS. However, its biological and clinical significance in gastric cancer (GC) remains poorly understood. Methods We analyzed PAPSS2 expression, prognostic value, immune infiltration correlates, promoter methylation, and histone acetylation patterns using public databases. Expression levels were validated by qRT-PCR and western blottin …

21.08.2026journal-article

Journal of Psychiatry and Neuroscience

Fronto-Cingulate Gamma Synchrony Predicts Deep Brain Stimulation Response in Treatment-Resistant Depression: Preliminary Evidence

Fatemeh Gholamali Nezhad, Ishaan Tailor, Sina Chegini, Ilya Demchenko, Alice Rueda, Sridhar Krishnan, Mohammad A Kamaleddin, Wendy Lou, Milad Lankarany, Robert Chen, Andres M Lozano, Venkat Bhat

Background: Gamma-band activity has been linked to cognitive-affective processing in depression. However, its role in deep brain stimulation (DBS) response in treatment-resistant depression (TRD) remains unclear. This exploratory study investigated whether ventral capsule/ventral striatum DBS (VCVS-DBS) modulates gamma activity during cognitive-affective processing and whether DBS-related gamma changes are associated with improvement in depressive symptoms. Methods: Seven participants with TRD completed an affectiv …

21.08.2026journal-article

Medicine

Durable response to olaparib plus continued PD-1 blockade in germline PALB2-mutated triple-negative breast cancer with leptomeningeal metastasis

Yulei Wang, Jiali Lin, Yi Zhang, Bo Liang, Xin Lin, Xiangqing Chen, Lijuan Guo, Yifang Zhang, Yuxia Chen, Guochun Zhang

Rationale: Triple-negative breast cancer (TNBC) with germline PALB2 (gPALB2 ) mutations represents a rare but actionable subset sensitive to poly(ADP-ribose) polymerase (PARP) inhibition. However, clinical evidence supporting PARP inhibition combined with programmed cell death protein 1 (PD-1) blockade after progression on prior immunotherapy remains limited, particularly in central nervous system-involved disease. Patient concerns: A 61-year-old woman initially diagnosed with stage I TNBC developed chest wall recu …