Medizin: neue Gesundheitspublikationen – Seite 15

27.08.2026journal-article

Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

S. Martínez, M. J. Del Sole, L. Maté, S. Sánchez Bruni, A. Lifschitz, M. Ballent

ABSTRACT Canine demodicosis is an inflammatory skin disease caused by Demodex canis mites. While newer isoxazoline classes currently represent the standard of care where licensed and available, prolonged ivermectin treatment remains an effective and cost‐effective alternative under specific socioeconomic contexts or clinical challenges associated with specific presentations, such as refractory pododemodicosis. Prolonged ivermectin treatment remains the primary choice, especially in resource‐limited settings and cer …

27.08.2026journal-article

Clinical Orthopaedics & Related Research

Is Femoral Head Decentration Reversible After Periacetabular Osteotomy for the Treatment of Developmental Dysplasia of the Hip?

Florian Schmaranzer, Alexander F. Heimann, Michael B. Millis, Ata M. Kiapour, David Liu, Young-Jo Kim, Eduardo N. Novais

Background Femoral head decentration, seen on MRI as a fluid gap between the femoral head and acetabulum, has recently been introduced as a sign of hip instability. Although periacetabular osteotomy (PAO) effectively corrects bony morphology in developmental dysplasia of the hip (DDH), it is unknown whether femoral head decentration is reversible after acetabular reorientation or whether it persists because of factors such as femoral version or intraarticular degeneration. Questions/purposes (1) Does femoral head d …

27.08.2026journal-article

Mathematics

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Shiqi Zhao, Yaqiong Lv, Xiaohu Zhang, Jian Hao

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, variations in operating conditions often introduce domain-specific characteristics that interfere with fault-related representations, resulting in significant performance degradation across unseen domains. To address this issue, this paper form …

27.08.2026journal-article

Environments

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Vanesa Benito, Naroa Lopez-Herguedas, Maite Cabañas, Santos Paunero, Ane Rivas-Macho, Iker Alvarez-Mora, Manu Soto, Felipe Goñi-de-Cerio

Wastewater treatment plants (WWTPs) are key nodes in the environmental dissemination of antimicrobial resistance (AMR), although their net role as sources or barriers of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG) under full-scale conditions remains insufficiently understood. This study evaluated the occurrence and dynamics of ARB and ARG in a full-scale urban WWTP and its receiving river over a two-year monitoring campaign. Samples were collected from the WWTP influent and effluent, a …

27.08.2026journal-article

Journal of Clinical Medicine

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Lana Fluk, Yuval Nachalon, Amit Shiff, Haya Fogel-Grinvald, Nogah Nativ-Zeltzer

Objectives: Dysphagia in older adults is associated with malnutrition, aspiration, and reduced quality of life. This study aimed to estimate the prevalence of self-reported swallowing difficulties among community-dwelling older adults in Israel and to identify demographic, medical, and socioeconomic predictors. Method: In this cross-sectional study, 1064 community-dwelling adults aged ≥ 60 years (mean 75.1 ± 7.5 years; 68.1% female) completed an online questionnaire capturing demographics, medical diagnoses, physic …

27.08.2026journal-article

Light: Science & Applications

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Zhengyuan Pan, Naikun Song, Shanshan Cheng, Wen Pang, Hongen Liao, Yu Wang, Bobo Gu

Abstract Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature. A restoration method capable of distinguishing these signal voids from stochastic noise to render quantitative pathology is lacking. Here, we proposed a deep learning framework of AFN-DeSeg (Auto-Fluorescence Nuclei Denoising and S …

27.08.2026journal-article

European Journal of Therapeutics

Mapping Gaps and Improvement Targets in Large Language Model-Generated Melanoma Patient Education in a Non-English Setting

Niyazi Çetin, Ahmet Uğur Atılan

Objective: Large language models (LLMs) are increasingly being used to develop medical education materials; however, it remains unclear how reliable, readable, or guideline-compliant the content generated by these models is for non-English-speaking patient groups. We evaluated the quality of Turkish melanoma patient education texts generated by seven frontier LLMs. Methods: A standardized 22-item Turkish prompt, built from international melanoma guidelines, was put to seven models in zero-shot sessions: ChatGPT 4.0 …

27.08.2026journal-article

Frontiers in Plant Science

Genome-wide identification of the superoxide dismutase gene family in Lycium barbarum and their expression profiles under abiotic stress and phytohormone treatment

Xiaoyu Cao, Xiaorong Bai, Yingwu Li, Xuedong Hui, Jinfeng Niu, Xiaojie Liang, Yue Yin, Wei An

Background Superoxide dismutases (SODs) are crucial metalloenzymes that constitute the first line of defense against reactive oxygen species in plants under abiotic stress. Wolfberry ( Lycium barbarum ) is an economically important medicinal plant with notable stress tolerance, however, a comprehensive genome-wide analysis of its SOD gene family has not yet been performed. Results We identified ten wolfberry SOD genes ( LbaSODs ) and classified them into three subfamilies: iron-SODs (Fe-SODs), manganese-SODs (Mn-SO …

27.08.2026journal-article

Clinical Case Reports

Digital Implant Rehabilitation in Multiple Idiopathic Root Resorption: A Case Report

Shoresh Afnan, Thomas Alexander Cursiter Hunter, Kåre Jan Attramadal, Jashan Singh Kamboj

ABSTRACT Multiple idiopathic root resorptions (MIRs) represent a rare condition with uncertain etiology and limited treatment options, and they may compromise the prognosis of affected teeth. A digitally guided interdisciplinary approach combining cone‐beam computed tomography (CBCT) diagnostics, virtual implant planning, and immediate implant‐supported restoration can provide predictable, functional, and esthetic outcomes in complex cases.

27.08.2026journal-article

Movement Disorders Clinical Practice

Interrater and Intrarater Reliability of the TWSTRS ‐Delphi Motor Severity Scale for Cervical Dystonia

Glenn T. Stebbins, Charles H. Adler, Alberto Albanese, Richard L. Barbano, Anna Rita Bentivoglio, Carlo Colosimo, Maria Fiorella Contarino, Dirk Dressler, Stewart A. Factor, Susan H. Fox, Victor S.C. Fung, Christopher G. Goetz, Joseph Jankovic, Hyder A. Jinnah, Wolfgang H. Jost, Marina A.J. Tijssen, Elena Moro, Joel S. Perlmutter, Stephen G. Reich, Ramon L. Rodriguez, Lawrence Severt, Natividad P. Stover, Marie Vidailhet, Julianne Lee, Cynthia L. Comella, David A. Peterson

Abstract Background Cervical dystonia (CD) motor severity is typically quantified with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). An expanded version of the Motor Severity section of the TWSTRS (“TWSTRS‐Delphi”) has been previously evaluated for its clinimetric properties but not for inter‐ and intrarater reliability. Objective In this study we quantified inter‐ and intrarater reliability of the Motor Severity section of the TWSTRS‐Delphi for CD. Methods Ten raters familiar with the TWSTRS‐Del …

27.08.2026journal-article

Clinical Implant Dentistry and Related Research

Peri‐Implant Soft Tissue Phenotype Remodeling Following Peri‐Implantitis Surgery: A Prospective Profilometric Analysis

Hee‐Sun Choi, Seung‐Hyun Park, Seulbin Im, Da‐Mi Kim, Eun‐Kyoung Pang, Ignacio Sanz‐Martin, Jae‐Kook Cha

ABSTRACT Aim To characterize longitudinal changes in peri‐implant soft tissue phenotype following surgical therapy of peri‐implantitis. Materials and Methods Twenty‐one patients with superimposable intraoral scan datasets at four timepoints—pre‐operative (T0), intra‐operative (T1), 3‐month (T2), and 12‐month (T3) follow‐up—were included. Soft tissue parameters including mean mucosal thickness (mMT), supracrestal tissue height (STH), keratinized mucosal area, and volumetric shrinkage were assessed. Clinical paramete …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Combined inflammation/nutrition-based prognostic score for overall survival in gastric adenocarcinoma: A retrospective cohort study

Mehmet Hanifi Çanakcı, Ilgaz Kayılıoğlu, Ahmet Şimşek, Tolga Dinç

BACKGROUND Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer-related death. The tumor-node-metastasis (TNM) staging system, while fundamental, does not account for systemic inflammation and nutritional status, which impact survival. AIM To assess the prognostic value of a novel inflammation/nutrition-based combined score (INCS) for predicting overall survival in patients undergoing curative gastrectomy for gastric adenocarcinoma. METHODS This retrospective cohort study includ …

27.08.2026journal-article

European Journal of Heart Failure

Treatment effects of dapagliflozin in patients with aortic stenosis undergoing transcatheter aortic valve implantation across left ventricular ejection fraction

Sergio Raposeiras Roubín, Rafael Gonzalez-Manzanares, Ignacio Amat-Santos, María Melendo Viu, David Dobarro, Diego López Otero, Luis Nombela Franco, Livia Gheorge, Jorge Sanz-Sánchez, Baladrón Zorita Carlos, Soledad Ojeda, Andrés Iñiguez Romo, Antonio Jesús Muñoz García, Victoria Vilalta, Gabriela Veiga Fernández, Juan Gabriel Córdoba Soriano, Ander Regueiro, Miriam Sandín Rollán, Xacobe Flores Ríos, Aitor Uribarri, Roberto Martín Reyes, Rafael Romaguera, Pablo Avanzas, Sergio García Blas, Juan A Franco-Peláez, Javier Martín Moreiras, José Ramón Gonzalez Juanatey, Gabriela Tirado, German Calle, José Luis Díez, Sandra Santos-Martínez, Rocío González Ferreiro, Erika Muñoz García, Xavier Carrillo Suarez, Xoan Sanmartín, Nieves Gonzalo, Alejandro Gutierrez Barri, Lluis Asmarats, Felipe Díaz Del Hoyo, Santiago Camacho Freire

Abstract Aims Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in heart failure (HF) across the left ventricular ejection fraction (LVEF) spectrum, but patients with severe valvular heart disease have been excluded from pivotal trials. We investigated the efficacy and safety of dapagliflozin across the full range of baseline LVEF in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Methods and results DapaTAVI was a pragmatic, multicentre, randomized, open-label trial wit …

27.08.2026journal-article

Journal of Craniofacial Surgery

Upper Eyelid Blepharoplasty Reduces Perceived Age: An Artificial Intelligence-Based Analysis

Zeynep Erdoğan Çetin, Begüm Yılmaz, Ahmet Can Çiftçi

Upper eyelid blepharoplasty is a commonly performed procedure for periorbital rejuvenation; however, objective evaluation of its aesthetic outcomes remains limited. This study aimed to assess changes in perceived age following upper blepharoplasty using an artificial intelligence (AI)-based age estimation model. In this retrospective cohort study, patients who underwent isolated upper blepharoplasty between January 2022 and January 2025 were included. Standardized preoperative and postoperative (3–6 mo) facial phot …

27.08.2026journal-article

Reports

Verification Index for the Repositioning of a Single Implant Analog in the Correct Place: A Clinical Technical Case Report

Socratis Thomaidis

Background and Clinical Significance: Implant impressions can present inaccuracies, affected by many factors, such as impression technique, impression material, and parallelism or lack thereof among the implants. The use of a verification index can assess the accuracy of the mastercast and can be used in order to adjust the inaccuracy of the mastercast. This article presents a technical variation in established verification-index procedures, followed by implant analog repositioning, which can be used in case of an …

27.08.2026journal-article

Journal of the American Geriatrics Society

Impact of ACE Units and Geriatrics Consults on Adherence to the 4Ms and Patient Outcomes

Sandra Zeng, Julia Adler‐Milstein, Robert Thombley, James D. Harrison, Melody Luo, W. John Boscardin, Sarah Ngo, Stephanie Rogers

ABSTRACT Background The Age‐Friendly Health Systems (AFHS) movement, guided by the 4Ms framework has been widely adopted to improve care for older adults. While specialized inpatient models such as Acute Care for Elders (ACE) units and Geriatrics Consults aim to improve outcomes, gaps remain in understanding how these models align with 4Ms adherence and their relationship to patient outcomes. Methods We conducted a retrospective observational study of 28,833 hospital encounters for patients aged ≥ 65 at an academic …

27.08.2026journal-article

Frontiers in Medicine

An easy-to-use model for screening type 2 myocardial infarction in geriatric patients with acute coronary syndrome: a retrospective cohort study

Yun-yue Luo, Hui Wang, Xiao-ya Ma, Yue Li, Wu-lin Li, Yue Liu, Yu-xin Wang, Wen-hui Kang, Jian-jun Xia, Fei Wang

Objective In this study, we aimed to develop and validate an easy-to-use model for screening type 2 myocardial infarction (T2MI) in geriatric patients with acute coronary syndrome (ACS). Method From January 2017 to December 2022, 891 geriatric patients who were clinically diagnosed with ACS and who underwent coronary angiography visited the Chest Pain Center of the Emergency Department at Jiading District Central Hospital affiliated Shanghai University of Medicine & Health Sciences were included. Univariate and …

27.08.2026journal-article

Infection

Postoperative CT-derived spleen volumetry for recurrence risk stratification after curative-intent surgery for hepatic alveolar echinococcosis

Lukas Endrös, Jochen Schneider, Marc Martignoni, Christian Brückner, Markus Mergen, Daniel Spitzl, Felianty Teresa, Manuel Nickel, Mara Goetz, Daniel Martinez Heinemann, Christian Maegerlein, Jan S. Kirschke, Rickmer Braren, Lisa Steinhelfer

Abstract Purpose To evaluate automated CT-derived spleen volumetry as an opportunistic imaging biomarker for postoperative risk stratification in patients with surgically treated hepatic alveolar echinococcosis (AE) and to compare its prognostic performance with clinical and laboratory parameters. Methods This retrospective single-center cohort study included consecutive patients undergoing curative-intent R0 resection for hepatic AE. Baseline was defined as the immediate postoperative CT. Automated spleen segmenta …

27.08.2026journal-article

Supportive Care in Cancer

Coordination of care in the context of primary brain tumors: Australian healthcare professionals’ exploration of the unspoken impact and clinical implications

Megan S. Jeon, Hannah Isaac, Joanne Shaw, Dianne M. Legge, Sharon He, Thomas Carlick, Eng-Siew Koh, Georgia K. B. Halkett, Brian Kelly, Mark B. Pinkham, Raymond J. Chan, Tamara Ownsworth, Haryana M. Dhillon, for the BRAINS Investigator Group, Meera Agar, Thea Blackler, Helen Haydon, Robyn Leonard, Anna Nowak, Kerryn Pike, Nicole Rankin, Ursula Sansom-Daly, Joel Rhee, Annie Miller, Kristi Milley, Mona Faris, Rachel Campbell, Katarzyna Lion, Jill Chen, Tiffany Fazon, Melinda Lyne, Sian Virtue-Griffiths, Jessica Buster, Emma McDougall

Abstract Aim People with primary brain tumor (PBT) and their families experience high distress and face challenges navigating their disease and treatment, healthcare systems, and/or survivorship. Quality brain tumor care coordination (BTCC) enables continuous, timely care according to the individual care needs of patients. We aimed to explore healthcare professionals’ (HCPs) practices and perceptions of BTCC. Methods We conducted semi-structured interviews with 12 HCPs (92% female) working with people with PBT from …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Side branch ballooning in provisional stenting of coronary bifurcation lesions: the case for a selective, imaging- and physiology-guided approach

Zhangli Yuan, Yong Zhang, Dagang Huang, Xuewen Hou, Jianling Wang, Dechao Lai, Jian Xu, Yuping Xu, Gang Chen, Juan Wang

Coronary bifurcation lesions account for approximately 15%–20% of all percutaneous coronary interventions (PCI) and remain among the most technically demanding scenarios in interventional cardiology. Provisional stenting—stenting the main vessel and intervening on the side branch (SB) only when necessary—is the default strategy, yet SB ballooning's role remains contested and is frequently applied reflexively. This review advances a single, evidence-based argument: SB ballooning should be deployed selectively, gover …

27.08.2026journal-article

Journal of Eating Disorders

Improvements in sleep, weight, and eating-disorder symptoms following off-label leptin treatment in an adolescent with chronic anorexia nervosa and insomnia: a case report

Alexander Dück, Hang Zhu, Judith Melinat, Monika Kruzer, Christoph Berger, Michael Kölch, Martin Reinhardt, Hannes Brehme, Annelie Zimmermann, Linda Frintrop, Olaf Reis

Abstract We report off-label administration of human recombinant leptin (metreleptin) over a 12-day period in a 17-year-old female adolescent with chronic anorexia nervosa (AN) and clinically significant insomnia. Two observation windows are distinguished throughout: a short-term window between day 1 (pre) and day 12 (post) of dosing, and a longer-term window between day 12 and the two-month follow-up (d + 60), capturing both changes temporally associated with leptin administration and the course of continued weigh …

27.08.2026journal-article

Nutrients

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Ranuccio Nuti, Luigi Gennari, Bruno Frediani, Stefano Gonnelli, Daniela Merlotti, Carla Caffarelli, Giovanni Minisola, Antonino Catalano, Nazzarena Malavolta, Monica Pinto, Giulia Letizia Mauro, Vito Mascolo, Cristiano Maria Francucci, Vincenzo Vinicola, Anna Capozzi, Maria Punzo, Orazio Falla, Luca Dalle Carbonare, Serena Guiducci, Rosario Coltraro, Agostino Gaudio, Domenico Maria Carlucci, Alessandra Randazzo, Eleonora Mastria, Colin Gerard Egan, Mariangela Morelli, Giovanni Tripepi

Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at risk and optimize laboratory use. We aimed to develop and validate a clinical risk score for predicting hypovitaminosis-D based on easily assessable risk factors. Methods: This cross-sectional study included 1408 adults aged ≥50 years (1286 …

27.08.2026journal-article

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Moh. Khairul Hassan

Drug-sensitive tuberculosis (TB) treatment success in low- and middle-income countries (LMICs) has historically fallen short of the WHO's 85% benchmark. Predictors of treatment success are well described, but newer adherence-focused interventions, including digital tools introduced since 2018, have not been synthesized alongside contemporary evidence on predictors. Methods. A systematic review and meta-analysis followed PRISMA guidelines and covered the period from January 2018 to April 2023 across PubMed, ScienceD …

27.08.2026journal-article

Neuro-Oncology

101 Independent replication and validation of nanopore-based long read sequencing and methylome classification for rapid brain tumour diagnosis

Vassili Crispi, Luke Ames, Joanne Stockton, Sana Manan, Nicola Chadderton, Lisa James, Sahar Sanai, Tracy Bright, Rajwinder Rai, Santosh Nagaraju, Ute Pohl, Philipe Taniere, Andrew Beggs, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological-molecular analysis is essential to diagnose and guide precision therapies in brain tumours. Whilst standard of care (SoC) diagnostics takes weeks, long read sequencing (LRS) on Oxford Nanopore Technology (ONT) platform and bioinformatics research tools provide rapid diagnosis within hours/days. We independently replicated ONT-LRS diagnostic assay within the NHS. Methods Patients undergoing brain tumour surgery were prospectively consented for surplus tissue samplin …

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Aktuelle Forschung nach Fachgebiet

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

Is Femoral Head Decentration Reversible After Periacetabular Osteotomy for the Treatment of Developmental Dysplasia of the Hip?

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Mapping Gaps and Improvement Targets in Large Language Model-Generated Melanoma Patient Education in a Non-English Setting

Genome-wide identification of the superoxide dismutase gene family in Lycium barbarum and their expression profiles under abiotic stress and phytohormone treatment

Digital Implant Rehabilitation in Multiple Idiopathic Root Resorption: A Case Report

Interrater and Intrarater Reliability of the TWSTRS ‐Delphi Motor Severity Scale for Cervical Dystonia

Peri‐Implant Soft Tissue Phenotype Remodeling Following Peri‐Implantitis Surgery: A Prospective Profilometric Analysis

Combined inflammation/nutrition-based prognostic score for overall survival in gastric adenocarcinoma: A retrospective cohort study

Treatment effects of dapagliflozin in patients with aortic stenosis undergoing transcatheter aortic valve implantation across left ventricular ejection fraction

Upper Eyelid Blepharoplasty Reduces Perceived Age: An Artificial Intelligence-Based Analysis

Verification Index for the Repositioning of a Single Implant Analog in the Correct Place: A Clinical Technical Case Report

Impact of ACE Units and Geriatrics Consults on Adherence to the 4Ms and Patient Outcomes

An easy-to-use model for screening type 2 myocardial infarction in geriatric patients with acute coronary syndrome: a retrospective cohort study

Postoperative CT-derived spleen volumetry for recurrence risk stratification after curative-intent surgery for hepatic alveolar echinococcosis

Coordination of care in the context of primary brain tumors: Australian healthcare professionals’ exploration of the unspoken impact and clinical implications

Side branch ballooning in provisional stenting of coronary bifurcation lesions: the case for a selective, imaging- and physiology-guided approach

Improvements in sleep, weight, and eating-disorder symptoms following off-label leptin treatment in an adolescent with chronic anorexia nervosa and insomnia: a case report

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

101 Independent replication and validation of nanopore-based long read sequencing and methylome classification for rapid brain tumour diagnosis