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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

ACS Nano

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy

Lili Xia, Xiangxuan Chao, Zitong Zhao, Xiaozhen Zhou, Chenyao Wu, Xinran Song, Wenli Zhou, Yuyao Li, Wei Feng, Yu Chen

Abstract Bioorthogonal chemistry provides a compelling strategy for in situ cytotoxin generation. However, the clinical translation of conventional bioorthogonal catalysts is impeded by poor tumor accumulation, insufficient targeting specificity, limited in vivo catalytic efficiency, and inadequate spatiotemporal control. Meanwhile, excessive lactate accumulation in the tumor microenvironment (TME) drives metabolic reprogramming, malignant progression, and therapeutic resistance. Here, we develop a living bacterial …

21.08.2026journal-article

International Journal of Health Management Review

DIAGNOSTIC CHALLENGES AND TREATMENT OPTIONS FOR ATHEROSCLEROSIS IN DOGS

Letícia de Oliveira Del Tedesco, Maria Eduarda Andrade de Carvalho, Isadora Pinto Sobreira, Larissa Marques Luque, Lucas Eduardo Silva Favaro, Camile Carvalho de Castro, Leticia Lais Zambiasi, Júlia Maso Rissardi, Cleidiane Maria Aguiar da Silva, Tassili Queiroz de Oliveira Costa, Mirella Rangel Teixeira, Mykaela Kessya da Silva Ferreira, Karoline Wencionek Nunes

Atherosclerosis in dogs is a chronic inflammatory vascular disease that occurs infrequently but is clinically significant due to its association with ischemic events and severe systemic complications. This narrative review analyzed the pathophysiology, metabolism, diagnostic methods, and therapeutic management of the disease. Results indicate that lipid metabolism disorders, endocrinopathies (such as hypothyroidism and hyperadrenocorticism), endothelial dysfunction, and pro-thrombotic states are the primary factors …

21.08.2026journal-article

Cancers

SMAD7-Associated Glycolytic Regulation Promotes Lactate-Dependent Macrophage Phenotype Modulation in Colorectal Cancer

Marco Colella, Andrea Iannucci, Rachele Frascatani, Claudia Maresca, Viviana Casagrande, Vincenzo Formica, Edoardo Troncone, Andrea Divizia, Massimo Federici, Giovanni Monteleone

Colorectal cancer (CRC) progression is shaped by dynamic interactions between tumor-intrinsic metabolic adaptations and immune remodeling within the tumor microenvironment. In CRC, the expression of SMAD7, a classical inhibitor of TGF-β1 signaling, is increased and has been associated with tumor-associated inflammatory responses and malignant progression. In this study, we investigated the potential role of SMAD7 in regulating glycolytic metabolism and macrophage phenotype in CRC. Knockdown of SMAD7 in CRC cell lin …

21.08.2026journal-article

Advanced Science

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang

ABSTRACT The efficacy of chemotherapy in colorectal cancer (CRC) is closely linked to its ability to remodel the tumor immune microenvironment (TIME), though the underlying molecular determinants remain incompletely defined. Here, we identified tumor‐cell intrinsic autophagy as a pivotal orchestrator of an immunologically active TIME, essential for chemotherapy response. We demonstrated that 5‐FU/Oxaliplatin treatment triggers autophagy‐dependent TIMP‐2 production, which restrains MMP‐2/9 activity and promotes intr …

21.08.2026journal-article

Frontiers in Pharmacology

RPN1 at the crossroads of glycosylation, tumor immunity, and disulfidptosis

Xiaoxi Chang, Linjun Weng, Weiquan Yu, Yan Shen

Ribophorin I (RPN1), a core component of the oligosaccharyltransferase complex, is traditionally known for its role in endoplasmic reticulum-associated N-glycosylation. Recent studies have identified RPN1 as an emerging regulator of tumor progression and immunity. Aberrant RPN1 overexpression has been reported in multiple malignancies, including glioma, hepatocellular carcinoma, sarcoma, and triple-negative breast cancer, where it is frequently associated with aggressive clinicopathological features and poor progno …

21.08.2026journal-article

Frontiers in Molecular Neuroscience

Engineering exosomes in the treatment of sensorineural hearing loss: from basic research to clinical applications

Siqi Wang, Juanjuan Li, Bingxing Yang, Mengdi Li, Man Yu, Peng Zhang, Suwen Bai, Xianhai Zeng

Engineered exosomes demonstrate good biocompatibility, barrier-crossing ability, and programmable drug-loading capacity. Recently, they have steadily emerged as a promising area of study for precision intervention in sensorineural hearing loss. This review focuses on numerous main topics, including the selection of exosome sources and donor-cell pretreatment techniques, surface targeting strategies, therapeutic cargo loading methods, the mechanisms by which exosomes cross the blood-labyrinth barrier, and recent adv …

21.08.2026journal-article

Stroke: Vascular and Interventional Neurology

Early Reperfusion in Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment

Dylan N. Wolman, Rahul R. Karamchandani, Kwadwo Darko, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al-Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan-Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Clemens M. Schirmer, Raul G. Nogueira, Bradley N. Bohnstedt, Alexandra R. Paul, Philipp Hendrix

BACKGROUND: Timely reperfusion is a critical determinant of favorable outcomes in basilar artery occlusion (BAO) stroke. We aimed to examine whether the choice of thrombolytic agent predicts early reperfusion (ER) in BAO stroke managed with tenecteplase versus alteplase before endovascular treatment. METHODS: This was a retrospective, multicenter US cohort of consecutive patients with BAO from 14 stroke centers treated with tenecteplase or alteplase within 4.5 hours of last known well before endovascular treatment. …

21.08.2026journal-article

Journal of Cardiovascular Development and Disease

Evolution of Sac Filling Techniques and Concepts in Endovascular Treatment of Abdominal Aortic Aneurysm: A Narrative Review

Linyao Zhu, Yuhang Zhou, Jichun Zhao, Ding Yuan, Tiehao Wang, Jiarong Wang, Chengxin Weng

Endovascular aortic aneurysm repair (EVAR) has become the first-line treatment for abdominal aortic aneurysms (AAA); however, its long-term durability is affected by Type II endoleak. This narrative review describes the evolution of sac filling techniques and concepts developed to address this complication. In selected cases of diagnosed Type II endoleaks, early therapeutic sac filling, while clinically indicated, is frequently constrained by difficult access, variable success rates, and recurrence. Consequently, p …

21.08.2026journal-article

Experimental Oncology

STUDY OF PREDICTIVE VALUE OF RAD51 EXPRESSION FOR THE EFFECTIVENESS OF PLATINUM-BASED THERAPY OF HIGH-GRADE SEROUS OVARIAN CARCINOMA

P. Gordiichuk, M. Doronina, O. Ponomarova, M. Gordiichuk, D. Shapochka, D. Melnyk, A. Tereshchenko

Background. The search for novel markers of predictive significance is an important issue in the management of ovarian cancer (OC) patients. Recently, the expression of the RAD51 protein, involved in homologous DNA repair has been shown to be predictive of platinum chemotherapy response in OC patients. Aim. To establish the relationship between the level of RAD51 protein expression in patients with high-grade serous ovarian carcinoma (SOC) after neoadjuvant platinum chemotherapy and the frequency of recurrence, dis …

21.08.2026journal-article

Journal of Thermoplastic Composite Materials

Multiresponse optimization of Ar/O 2 cold plasma treatment for fully biobased PLA/luffa fiber biocomposites

Nadia Teherani, Hasan Mashroteh, Mohsen Hadizadeh, Milad Sadeghi

The intrinsic incompatibility between hydrophilic natural fibers and hydrophobic biopolymer matrices remains a critical challenge in the development of high-performance fully biobased composites. This study presents a novel multiresponse optimization framework for Ar/O 2 cold-plasma surface modification of Luffa fibers to enhance the mechanical performance of polylactic acid (PLA)/Luffa biocomposites. A Box–Behnken experimental design combined with response surface methodology was employed to model and optimize the …

21.08.2026journal-article

Frontiers in Psychology

Confianza, culture, and care: barriers to and facilitators of mental health treatment engagement among Latinos with serious mental illness

Oscar F. Rojas Perez, Monique T. Cano, Andrea Mendiola, Luis M. Añez Nava, Marilyn Perez Avilés, Estela Meléndez, Manuel Paris, Michelle A. Silva

Introduction Among the 3.2 million Latinos in the United States with serious mental illness (SMI) in 2024, less than 15.5% received any treatment or medication. Research on mental health treatment engagement among Latinos has largely conceptualized engagement broadly, overlooking nuances in the engagement process, disorder severity, and community heterogeneity. Most studies on treatment engagement among Latinos with SMI have explored macro-level factors without a guiding framework or theory. Thus, the aim of the cu …

21.08.2026journal-article

Frontiers in Psychology

What plays beneath: mental health burden, personal resources, and treatment utilization among professional musicians and music students

Isabel Fernholz, Jens Plag, Ann Sophie Brehm, Stefanie Gestrich, Moritz Bruno Petzold, Alexander Schmidt, Antonia Bendau

Introduction Professional musicians may be exposed to distinctive occupational, psychosocial, and artistic demands, yet integrated evidence on their mental health, psychological resources, and treatment utilization remains scarce. Therefore, this study examined mental health indicators, including symptom burden and self-reported diagnosed mental disorders, personal psychological resources (resilience, self-efficacy, and self-esteem), occupational characteristics, and treatment use in a nationwide sample of professi …

21.08.2026journal-article

Diagnostics

Non-Invasive Skin Cancer Diagnosis by Electrical Impedance Spectroscopy: Biophysics, Devices, Clinical Evidence, and Future Directions

Jing Yang, Ling Wu, Huan Xue, Jingxiu Chai, Yuchong Chen, Cheng Zhong

Skin cancer represents a growing global health burden. Current diagnostic pathways combine clinical examination and dermoscopy with histopathological confirmation; however, overlap between benign and malignant lesions can create diagnostic uncertainty and lead to potentially avoidable biopsies. Electrical impedance spectroscopy (EIS) has emerged as a non-invasive technique with potential for portable and cost-efficient implementation that quantifies the dielectric contrast between malignant and healthy tissue, prov …

21.08.2026journal-article

Journal of Intelligent & Fuzzy Systems: Applications in Engineering and Technology

Automatic lung cancer classification using histopathological images: A hybrid DenseNet121-slantlet transform framework

Biswaranjan Debata, Rojalina Priyadarshini, Sudhir Kumar Mohapatra

Accurate classification of histopathological images is essential in the early diagnosis and treatment of lung cancer. Conventional deep learning approaches often face the challenges of simulating fine-grained texture features of low-level features as well as high-level semantic features that can be observed in complex tissue structures. To address this issue, the current paper introduces a novel hybrid deep learning architecture that combines SLT and DenseNet121 for accurate lung cancer classification. Publicly ava …

21.08.2026journal-article

Anti-Cancer Agents in Medicinal Chemistry

Wogonoside Suppresses the Self-renewal Ability of Glioma Stem Cells via Down-regulating AKT/ZEB1 Signaling Pathway

Biyun Zhang, Hong Lu, Yijun Wang, Di Zhao, Zhengyu Wu, Yuandong Cao

Introduction: Glioma is the most prevalent primary central nervous system malignancy. Wogonoside, a flavonoid bioactive derived from Scutellaria baicalensis Georgi, has been reported to induce apoptosis in glioblastoma cells. However, the functional roles and molecular mechanisms in regulating glioma stem cell (GSC)-driven malignant progression remain poorly defined. The authors initially investigated the inhibitory effects of wogonoside on GSCs, as well as the intrinsic mechanisms responsible for these actions. Ma …

21.08.2026journal-article

Scholars Journal of Medical Case Reports

Primary Intramuscular Hydatid Cyst of the Thigh Mimicking a Soft Tissue Tumor: A Case Report

Omar MOURAFIQ, Hicham SALAHI, Omar MERGAD

Background: Primary intramuscular hydatid cyst of the thigh is an exceptionally rare manifestation of echinococcosis and may mimic a soft-tissue tumor, making diagnosis challenging. Case Presentation: A 66-year-old man presented with an eight-month history of a slowly enlarging, slightly painful mass of the left thigh. MRI revealed a well-defined multiloculated intramuscular cystic lesion containing multiple daughter cysts, suggestive of a hydatid cyst. No hepatic or pulmonary involvement was identified, and hydati …

21.08.2026journal-article

International Journal of Molecular Sciences

Iron Oxide Nanozyme for Magnetothermal Activation of ER-TRPV1 Enables Efficient Intravesical Therapy of Bladder Cancer

Galong Li, Dongyan Li, Bin Lan, Yuanyuan Cheng, Hongxia Liang, Wenli Zhang, Xiaopan Xu, Hongbing Lu

Drug-mediated intravesical therapy is a widely used treatment approach for bladder cancer (BCa), which is limited by poor tumor accumulation and the toxicity of drugs. Herein, a facile approach utilizing magnetic hyperthermia therapy (MHT) for BCa treatment is reported through intravesical instillation of tumor-targeting iron oxide nanoparticles (IONPs), which are coated with anti-FGFR3 antibodies for specific binding to FGFR3 overexpressed on BCa cells. The antibody coating significantly enhanced targeting ability …

21.08.2026journal-article

The Oncologist

IUC26692-90 Benchmarking Artificial Intelligence-Based Clinical Prediction Models for Immune Checkpoint Inhibitor Response and Overall Survival in Bladder Cancer

R Das, B Gonsalves, V Ravindran, Y Agarwala, D Khanna, A Tiwari, A Ghose, G Luigi Banna, R Dylan Frazer, S Adeleke, A Maniam

Abstract Background Bladder cancer (BLCA) is a common urological malignancy with high recurrence and heterogeneous treatment response. Immune checkpoint inhibitors (ICIs) have transformed advanced BLCA treatment, yet response prediction remains challenging. AI-based models have been developed to predict ICI response and OS prognosis in BLCA. To benchmark AI models predicting ICI response and overall survival (OS) in BLCA, evaluating both predictive performance and reporting quality. Methods A search of OVID MEDLINE …

21.08.2026journal-article

EJNMMI Physics

Dosimetry and immunohistochemistry study to establish radiolabelled prostate-specific membrane antigen (PSMA) as a potential theranostic target in high-grade glioma treatment

Matthew Benger, Georgios Krokos, Karan Daga, Alan Wright, Istvan Bodi, Francesco Marchi, Sami Jeljeli, Lefteris Livieratos, James Rosekilly, Jose Lavrador, Shawna Kinsella, Tobias Wood, Paul Marsden, Cheryl Gillett, Philip Blower, Samantha Terry, Nicola Mulholland, Lucy Brazil, Keyoumars Ashkan, Gary Cook, Alexander Hammers, Thomas Calvert Booth

Abstract Prostate-specific membrane antigen (PSMA) is upregulated in high-grade glioma (HGG). This study aimed, firstly, to establish dosimetry for the radionuclide [ 68 Ga]-PSMA-11 – one of a number of PSMA-targeted tracers which do not cross an intact blood–brain barrier – in HGG patients; secondly, to determine theoretical tumour doses for [ 177 Lu]-PSMA, a potential therapeutic radionuclide; thirdly, to assess PSMA immunohistochemistry in targeted intra-operative HGG biopsies. Three HGG patients underwent PET-M …

21.08.2026journal-article

Oncologie

Lipid metabolism reprogramming in endometrial cancer: biologic underpinnings, prognostic implications, and therapeutic opportunities

Xinkun Li, Namei Wang, Lai Wei, Xiao Li

Abstract Endometrial cancer is strongly associated with obesity and other metabolic disorders, but host-level associations do not necessarily imply that tumor cells depend on a specific lipid pathway. This review therefore considers two related questions: how obesity, insulin resistance, and dyslipidemia influence endometrial cancer risk and outcome, and what evidence supports tumor-intrinsic changes in lipid uptake, fatty acid synthesis and desaturation, fatty acid oxidation, and cholesterol or oxysterol signaling …

21.08.2026journal-article

Blood Journal

International Consensus Criteria for the Diagnosis, Treatment Initiation, and Response Assessment for T-LGL Leukemia

Jonathan E. Brammer, Natali Pflug, Renato Zambello, Julia Almeida, Dima El-Sharkawi, Lubomir Sokol, David Feith, Zachary Braunstein, Miguel Ruiz, Till Braun, Tony Marchand, Satu Mustjoki, Carlos Bravo-Perez, Monika Brüggemann, Pierluigi Porcu, Fumihiro Ishida, Jaroslaw P. Maciejewski, Marshall E. Kadin, Gianpietro Semenzato, Anton W. Langerak, Thierry Lamy, Thomas P Loughran, Marco Herling

Large granular lymphocytic leukemia (LGLL) is an uncommon and likely under-diagnosed leukemia that causes severe neutropenia and anemia and can have profound effects on the quality of life for afflicted patients. Frequently associated with various auto-immune phenomena, LGLL is a paradigm for a highly interdisciplinary disease. Recent advances in our pathobiological understanding of LGLL, along with the development of novel agents, have stimulated a growing number of clinical trials and innovative approaches target …

21.08.2026journal-article

Molecules

Combinatorial Treatment with Chlorogenic Acid and Cinnamaldehyde Disrupts Intracellular pH and Metabolic Transport in Breast Cancer Cells

Yusuff Olayiwola, Vindya Edgunpati, Li Li, Lauren Gollahon

Breast cancer cells exhibit a reversed pH gradient and metabolic plasticity that promote proliferation, invasion, and resistance to therapy. Natural products such as chlorogenic acid (CGA) and cinnamaldehyde (CA) have shown emerging anticancer potential. However, their effects on intracellular pH and metabolic transport systems remain undefined. Therefore, the aim of this study was to characterize these parameters in breast cancer and non-tumorigenic breast cells. This study evaluated the physiochemical properties …

21.08.2026journal-article

Healthcare

Fear of Cancer Recurrence and Psychological Symptom Burden in Breast Cancer Survivors Without Evidence of Active Disease: A Cross-Sectional Real-World Study

Salih Karatlı, Safiye Kübra Çetindağ Karatlı, Selahattin Çelik, Tülay Eren, Doğan Yazılıtaş

Objective: This study assessed the prevalence of fear of cancer recurrence (FCR) and its clinical, treatment-related, and psychological correlates in breast cancer survivors without active disease. Materials and Methods: This cross-sectional study included 200 breast cancer survivors after curative treatment. FCR was assessed using the Fear of Cancer Recurrence Inventory–Short Form (FCRI-SF), with scores ≥ 13 indicating clinically significant FCR. Hospital Anxiety and Depression Scale-Anxiety (HADS-A) and Depressio …