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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Molecules

Combinatorial Treatment with Chlorogenic Acid and Cinnamaldehyde Disrupts Intracellular pH and Metabolic Transport in Breast Cancer Cells

Yusuff Olayiwola, Vindya Edgunpati, Li Li, Lauren Gollahon

Breast cancer cells exhibit a reversed pH gradient and metabolic plasticity that promote proliferation, invasion, and resistance to therapy. Natural products such as chlorogenic acid (CGA) and cinnamaldehyde (CA) have shown emerging anticancer potential. However, their effects on intracellular pH and metabolic transport systems remain undefined. Therefore, the aim of this study was to characterize these parameters in breast cancer and non-tumorigenic breast cells. This study evaluated the physiochemical properties …

21.08.2026journal-article

Blood Journal

International Consensus Criteria for the Diagnosis, Treatment Initiation, and Response Assessment for T-LGL Leukemia

Jonathan E. Brammer, Natali Pflug, Renato Zambello, Julia Almeida, Dima El-Sharkawi, Lubomir Sokol, David Feith, Zachary Braunstein, Miguel Ruiz, Till Braun, Tony Marchand, Satu Mustjoki, Carlos Bravo-Perez, Monika Brüggemann, Pierluigi Porcu, Fumihiro Ishida, Jaroslaw P. Maciejewski, Marshall E. Kadin, Gianpietro Semenzato, Anton W. Langerak, Thierry Lamy, Thomas P Loughran, Marco Herling

Large granular lymphocytic leukemia (LGLL) is an uncommon and likely under-diagnosed leukemia that causes severe neutropenia and anemia and can have profound effects on the quality of life for afflicted patients. Frequently associated with various auto-immune phenomena, LGLL is a paradigm for a highly interdisciplinary disease. Recent advances in our pathobiological understanding of LGLL, along with the development of novel agents, have stimulated a growing number of clinical trials and innovative approaches target …

21.08.2026journal-article

Healthcare

Fear of Cancer Recurrence and Psychological Symptom Burden in Breast Cancer Survivors Without Evidence of Active Disease: A Cross-Sectional Real-World Study

Salih Karatlı, Safiye Kübra Çetindağ Karatlı, Selahattin Çelik, Tülay Eren, Doğan Yazılıtaş

Objective: This study assessed the prevalence of fear of cancer recurrence (FCR) and its clinical, treatment-related, and psychological correlates in breast cancer survivors without active disease. Materials and Methods: This cross-sectional study included 200 breast cancer survivors after curative treatment. FCR was assessed using the Fear of Cancer Recurrence Inventory–Short Form (FCRI-SF), with scores ≥ 13 indicating clinically significant FCR. Hospital Anxiety and Depression Scale-Anxiety (HADS-A) and Depressio …

21.08.2026journal-article

Anti-Cancer Agents in Medicinal Chemistry

Wogonoside Suppresses the Self-renewal Ability of Glioma Stem Cells via Down-regulating AKT/ZEB1 Signaling Pathway

Biyun Zhang, Hong Lu, Yijun Wang, Di Zhao, Zhengyu Wu, Yuandong Cao

Introduction: Glioma is the most prevalent primary central nervous system malignancy. Wogonoside, a flavonoid bioactive derived from Scutellaria baicalensis Georgi, has been reported to induce apoptosis in glioblastoma cells. However, the functional roles and molecular mechanisms in regulating glioma stem cell (GSC)-driven malignant progression remain poorly defined. The authors initially investigated the inhibitory effects of wogonoside on GSCs, as well as the intrinsic mechanisms responsible for these actions. Ma …

21.08.2026journal-article

Experimental Oncology

SURVIVAL PREDICTORS IN CANCER PATIENTS WITH BONE METASTASIS: RETROSPECTIVE COHORT SINGLE-CENTER STUDY

M. Vorobchuk, A. Burlaka, A. Diedkov

Background. Bone metastasis, a frequent complication in cancer patients, is associated with a significant decline in quality of life and reduced survival. Overall survival prognosis is critical for selecting the optimal treatment strategy, particularly for planning orthopedic surgery in patients with bone metastasis. The aim of the study was to delineate prognostic factors for overall survival in patients with bone metastasis following orthopedic surgery. Materials and Methods. 136 patients with bone metastasis tre …

21.08.2026journal-article

Medicine

Development and preliminary evaluation of a Neuman Systems Model–based protocol for postoperative delirium prevention in patients undergoing pancreatic cancer surgery

Shujia Wang, Li Yu, Wenli Xu

This study aimed to develop and evaluate a Neuman Systems Model–based protocol for the prevention and management of postoperative delirium in patients undergoing surgery for pancreatic cancer. The protocol was developed through literature review and a modified Delphi process, and its clinical effectiveness was assessed in a single-center study using a historical control design. A total of 120 patients who underwent radical resection for pancreatic cancer between January 2024 and December 2025 were included, with 60 …

21.08.2026journal-article

Frontiers in Oncology

Profibrogenic Gremlin-1 expression in prostate cancer and the clinicopathologic association

Danqing Ren, Yu-Hsuan Chien, Reina Xu, Kai-Yuan Tsung, Gustavo E. Ayala, Tien C. Ko, Yanna Cao, Run Wang, Tung Shu

Background Gremlin-1 (GREM1) is a profibrogenic molecule involved in TGF-β signaling. Recent studies have implicated GREM1 in androgen receptor (AR)-independent signaling and castration resistance in advanced prostate cancer. However, its compartment expression patterns and clinicopathologic significance in primary prostate cancer remain unclear. Methods GREM1 mRNA expression and clinicopathologic associations were analyzed in the Cancer Genome Atlas (TCGA) prostate adenocarcinoma (TCGA-PRAD), the Memorial Sloan Ke …

21.08.2026journal-article

Frontiers in Malaria

Holding the line against artemisinin partial resistance in Africa: the case for preemptive treatment policy

Shyamkumar Sriram

Two decades of progress against falciparum malaria have been bought with a single class of medicines, and that class is now being undermined on the continent that can least absorb the loss. Partial resistance to artemisinin, encoded by mutations in the Plasmodium falciparum kelch13 gene, has emerged independently across East Africa and the Horn of Africa, and the World Health Organization now records confirmed or suspected resistance in at least eight African countries. Southeast Asia has already shown where this r …

21.08.2026journal-article

Open Forum Infectious Diseases

Immune checkpoint inhibitors in cancer patients with concurrent active tuberculosis: A real-world study in a high tuberculosis burden region

Xunqi Liu, Yuan Cai, Ling Shao, Hu Liu, Jianghong An

Abstract Objective This study aimed to assess the incidence and clinical characteristics of active tuberculosis in cancer patients treated with immune-checkpoint inhibitors (ICIs) to inform optimal ICI utilization strategies in TB-endemic areas. Methods We conducted a retrospective analysis of 889 consecutive cancer patients who received at least one cycle of ICIs at Shenzhen Third People’s Hospital between 01/01/2018 and 31/12/2024. Patients who developed active tuberculosis following ICIs initiation were identifi …

21.08.2026journal-article

Journal of Clinical Medicine

Integrated Cranio-Cervical Organization in Adults: Association Between Morphocranial Pattern and Segmental Cervical Alignment After Orthodontic Treatment

Marta Serra Alierta, Meritxell Sánchez-Molins, Aroa Casado Rodriguez, Maria Cristina Manzanares Cespedes, Juan Gonzalo Olivieri

Objective: This study aimed to examine the association between the study-specific Cl-Na/Cl-Ba cranial-base angle and segmental cervical organization in adults, considering both inclination and sagittal spatial position, and to explore whether longitudinal changes in cervical inclination differed among morphocranial groups over the observed orthodontic treatment interval. Materials and Methods: Pre-treatment and post-treatment lateral cephalograms from 297 adult orthodontic patients obtained in natural head position …

21.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Healthcare Provider Perspectives on Barriers to Fertility Preservation in Oncology Care in Iraq: A Qualitative Study

Abdulrahman Mohammed Agha, Mohammed Ibrahim Aladul

ABSTRACT Aim To investigate the understanding, approach, and experience of fertility preservation counseling among oncology healthcare providers in Iraq in treating reproductive age cancer patients. Methods We have performed a qualitative study with semi‐structured face‐to‐face interviews with 27 healthcare providers who had been engaged in cancer care, such as oncologists and clinical pharmacists. Interviews were conducted to examine the level of awareness on fertility preservation, the existing counseling practic …

21.08.2026journal-article

The Oncologist

IUC26679-95 A pilot study of the implementation of the G8 frailty assessment in oncology clinics for patients with newly diagnosed metastatic hormone-sensitive prostate cancer

A Hague, S Appleyard, A Balagopal, N Samkaoui

Abstract Background Treatment intensification for patients with metastatic hormone-sensitive prostate cancer (mHSPC) is now recommended as standard of care with either doublet or triplet therapy. The 2025 National Prostate Cancer Audit showed 47% men with mHSPC received treatment intensification in England. We audited our own practice over 1 year and found that 70% of patients with mHSPC were offered treatment intensification. A 2024 systematic review found that younger patients with fewer comorbidities were more l …

21.08.2026journal-article

Advanced Science

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang

ABSTRACT Transfer RNA‐derived small RNAs (tsRNAs) are a novel class of small non‐coding RNAs abundant in the bloodstream of cancer patients and involved in various physiological and pathological processes. However, the regulatory mechanisms and clinical significance of tsRNAs in colorectal cancer (CRC) remain unclear. In this study, PANDORA‐seq was used as an exploratory screen of CRC tissues, paired adjacent tissues, and CRC plasma samples, followed by validation in larger independent cohorts. Quantitative real‐ti …

21.08.2026journal-article

Discover Oncology

Prognostic significance of DNA polymerase theta and its association with immune infiltration in hepatocellular carcinoma

Min Yang, Yi Zhang, Xulin Peng, Yang Lu, Jie Zhang, Yang Wang, Peng Sun

Abstract Background Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. DNA polymerase theta (POLQ) plays multiple roles in HCC, primarily in DNA damage repair, tumor progression, and resistance to chemoradiotherapy. However, the upstream and downstream signaling pathways regulated by POLQ, along with its association with immune cell infiltration, remain unclear. Methods We conducted comprehensive bioinformatics analyses to evaluate POLQ expression in HCC versus normal tissues using data fr …

21.08.2026journal-article

Systematic Reviews

Evaluation of telemedicine intervention implementation during cancer follow-up: a mixed methods systematic review protocol

Gwen Saalmink, Faatimah Patel, Sue Hartup, Lynn Calman, Lisa McCann, Gemma Madigan Johnson, Dan Stark, Kate Absolom

Abstract Background In recent years, telemedicine use in cancer care has grown rapidly to support long-term cancer survivorship care needs. While remote care offers many benefits such as reduced travel burden for patients and increased clinic capacity for those with complex needs, challenges with adoption remain. Existing systematic reviews on telemedicine focus on barriers and facilitators of implementation. This systematic review will use the RE-AIM framework to evaluate telemedicine in cancer follow-up, aiming t …

21.08.2026journal-article

International Journal of Innovations in Science and Technology

A Framework for Skin Cancer Classification using Ensemble Transfer Learning and Data Fusion

Shabib Aftab, Tuba Mubarik, Muhammad Anwaar Saeed

Skin cancer is a serious and growing health problem worldwide. Its cases keep rising every year. Early diagnosis plays a key role in improving survival. Manual diagnosis through visual checks and dermoscopy depends on the doctor's experience. It can also give inconsistent results. Biopsy is the most reliable method. But it is invasive and time-consuming. These limits have pushed researchers toward deep learning-based systems. Most past studies use only one model. This lowers accuracy when skin lesions vary in colou …

21.08.2026journal-article

Langmuir

Gas-Sensing Performance of Ru- or Rh-Modified ZrS2 Monolayers toward Typical Lung Cancer Biomarker Gases: A DFT Study

Xin Zhang, Xiaoqian Lin, Zhenhong Han, Jinxia Yang, Yuangen Yao

Abstract Early detection of lung cancer via exhaled breath analysis requires gas-sensing materials with high sensitivity and selectivity. In this work, the sensing performance of Ru- and Rh-modified ZrS2 monolayers toward representative biomarkers (benzene (C6H6), acetone (C3H6O), and isoprene (C5H8)) is systematically investigated using density functional theory (DFT). The results show that transition-metal modification significantly enhances gas adsorption, converting weak physisorption on pristine ZrS2 into stro …

21.08.2026journal-article

BMC Cancer

Anticancer activity of Artemisia biennis L. via induction of apoptosis and regulation of BAX, BCL-2, MMP1, and MMP9 in SW480 colorectal cancer cells

Farah Farahani, Batoul Khafaji, Fatemeh Bidgolian, Shahla Mohammad Ganji

Abstract Colorectal cancer is one of the most common malignancies worldwide and, despite recent advances in diagnosis and treatment, it remains associated with high mortality rates. Therefore, there is a growing need for novel therapeutic strategies. Medicinal plants, as natural sources of bioactive compounds, offer promising opportunities for anticancer drug development. The present study aimed to investigate the effects of Artemisia biennis L. on the SW480 colorectal cancer cell line and its impact on the express …

21.08.2026journal-article

Journal of Surgical Oncology

Disparities in Pancreatic Cancer Survival: The Overlooked Role of Demographic and Socioeconomic Factors

Jason Pieri, Courtney Day, Aaron Spaulding, Mary Tice, Cornelius A. Thiels, Zhi Ven Fong, John A. Stauffer, Katherine E. Poruk

ABSTRACT Background and Objectives Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, but the contribution of nonbiological factors to long‐term survival is unclear. We evaluated demographic, socioeconomic, clinical, treatment, and care‐delivery factors associated with 3‐year survival and whether these associations persisted at 5 years. Methods National Cancer Database patients with stage I–III PDAC diagnosed from 2012 to 2022 were analyzed using multivariable logistic regression adjusted for treatment …

21.08.2026journal-article

Polymers

Green Synthesis and Functional Design of Polypyrrole-Based Nanomedicines for Cancer Theranostics: A Critical Review and Sustainability-Guided Perspective

Jiaqiao Zhong, Yuanzhe Li

Nanomedicine has advanced cancer theranostics via targeted delivery and phototherapy, yet many high-performance systems rely on inorganic or metal-intensive materials synthesized through energy-demanding routes, raising concerns about biocompatibility, environmental accumulation, and sustainability. This review re-evaluates polypyrrole (PPy)-based nanomedicines from a green chemistry perspective, shifting focus from performance-centric optimization to sustainability-guided design. PPy, an organic conductive polymer …

21.08.2026journal-article

Journal of Alzheimer’s Disease

The role of microglia glucose metabolism reprogramming in Alzheimer's disease treatment

Qingyu Cao, Mengmeng Shen, Yan Liu, Caicai Li, Lu Liu, Jidong Zhou, Rujing Yue, Dejun Niu, Yayun Ren, Lihong Pan, Jingchun Yao, Guimin Zhang

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment, and there remains a lack of effective treatments capable of reversing or significantly slowing disease progression. Accumulating evidence indicates that the immune function of microglia, the resident immune cells of the central nervous system, is a critical factor in regulating AD pathogenesis. Emerging research in immunometabolism further reveals that glucose metabolic reprogramming serves as a central drive …