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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Advanced Science

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang

ABSTRACT Transfer RNA‐derived small RNAs (tsRNAs) are a novel class of small non‐coding RNAs abundant in the bloodstream of cancer patients and involved in various physiological and pathological processes. However, the regulatory mechanisms and clinical significance of tsRNAs in colorectal cancer (CRC) remain unclear. In this study, PANDORA‐seq was used as an exploratory screen of CRC tissues, paired adjacent tissues, and CRC plasma samples, followed by validation in larger independent cohorts. Quantitative real‐ti …

21.08.2026journal-article

Discover Oncology

Prognostic significance of DNA polymerase theta and its association with immune infiltration in hepatocellular carcinoma

Min Yang, Yi Zhang, Xulin Peng, Yang Lu, Jie Zhang, Yang Wang, Peng Sun

Abstract Background Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. DNA polymerase theta (POLQ) plays multiple roles in HCC, primarily in DNA damage repair, tumor progression, and resistance to chemoradiotherapy. However, the upstream and downstream signaling pathways regulated by POLQ, along with its association with immune cell infiltration, remain unclear. Methods We conducted comprehensive bioinformatics analyses to evaluate POLQ expression in HCC versus normal tissues using data fr …

21.08.2026journal-article

Systematic Reviews

Evaluation of telemedicine intervention implementation during cancer follow-up: a mixed methods systematic review protocol

Gwen Saalmink, Faatimah Patel, Sue Hartup, Lynn Calman, Lisa McCann, Gemma Madigan Johnson, Dan Stark, Kate Absolom

Abstract Background In recent years, telemedicine use in cancer care has grown rapidly to support long-term cancer survivorship care needs. While remote care offers many benefits such as reduced travel burden for patients and increased clinic capacity for those with complex needs, challenges with adoption remain. Existing systematic reviews on telemedicine focus on barriers and facilitators of implementation. This systematic review will use the RE-AIM framework to evaluate telemedicine in cancer follow-up, aiming t …

21.08.2026journal-article

International Journal of Innovations in Science and Technology

A Framework for Skin Cancer Classification using Ensemble Transfer Learning and Data Fusion

Shabib Aftab, Tuba Mubarik, Muhammad Anwaar Saeed

Skin cancer is a serious and growing health problem worldwide. Its cases keep rising every year. Early diagnosis plays a key role in improving survival. Manual diagnosis through visual checks and dermoscopy depends on the doctor's experience. It can also give inconsistent results. Biopsy is the most reliable method. But it is invasive and time-consuming. These limits have pushed researchers toward deep learning-based systems. Most past studies use only one model. This lowers accuracy when skin lesions vary in colou …

21.08.2026journal-article

Langmuir

Gas-Sensing Performance of Ru- or Rh-Modified ZrS2 Monolayers toward Typical Lung Cancer Biomarker Gases: A DFT Study

Xin Zhang, Xiaoqian Lin, Zhenhong Han, Jinxia Yang, Yuangen Yao

Abstract Early detection of lung cancer via exhaled breath analysis requires gas-sensing materials with high sensitivity and selectivity. In this work, the sensing performance of Ru- and Rh-modified ZrS2 monolayers toward representative biomarkers (benzene (C6H6), acetone (C3H6O), and isoprene (C5H8)) is systematically investigated using density functional theory (DFT). The results show that transition-metal modification significantly enhances gas adsorption, converting weak physisorption on pristine ZrS2 into stro …

21.08.2026journal-article

BMC Cancer

Anticancer activity of Artemisia biennis L. via induction of apoptosis and regulation of BAX, BCL-2, MMP1, and MMP9 in SW480 colorectal cancer cells

Farah Farahani, Batoul Khafaji, Fatemeh Bidgolian, Shahla Mohammad Ganji

Abstract Colorectal cancer is one of the most common malignancies worldwide and, despite recent advances in diagnosis and treatment, it remains associated with high mortality rates. Therefore, there is a growing need for novel therapeutic strategies. Medicinal plants, as natural sources of bioactive compounds, offer promising opportunities for anticancer drug development. The present study aimed to investigate the effects of Artemisia biennis L. on the SW480 colorectal cancer cell line and its impact on the express …

21.08.2026journal-article

Journal of Surgical Oncology

Disparities in Pancreatic Cancer Survival: The Overlooked Role of Demographic and Socioeconomic Factors

Jason Pieri, Courtney Day, Aaron Spaulding, Mary Tice, Cornelius A. Thiels, Zhi Ven Fong, John A. Stauffer, Katherine E. Poruk

ABSTRACT Background and Objectives Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, but the contribution of nonbiological factors to long‐term survival is unclear. We evaluated demographic, socioeconomic, clinical, treatment, and care‐delivery factors associated with 3‐year survival and whether these associations persisted at 5 years. Methods National Cancer Database patients with stage I–III PDAC diagnosed from 2012 to 2022 were analyzed using multivariable logistic regression adjusted for treatment …

21.08.2026journal-article

Polymers

Green Synthesis and Functional Design of Polypyrrole-Based Nanomedicines for Cancer Theranostics: A Critical Review and Sustainability-Guided Perspective

Jiaqiao Zhong, Yuanzhe Li

Nanomedicine has advanced cancer theranostics via targeted delivery and phototherapy, yet many high-performance systems rely on inorganic or metal-intensive materials synthesized through energy-demanding routes, raising concerns about biocompatibility, environmental accumulation, and sustainability. This review re-evaluates polypyrrole (PPy)-based nanomedicines from a green chemistry perspective, shifting focus from performance-centric optimization to sustainability-guided design. PPy, an organic conductive polymer …

21.08.2026journal-article

Journal of Alzheimer’s Disease

The role of microglia glucose metabolism reprogramming in Alzheimer's disease treatment

Qingyu Cao, Mengmeng Shen, Yan Liu, Caicai Li, Lu Liu, Jidong Zhou, Rujing Yue, Dejun Niu, Yayun Ren, Lihong Pan, Jingchun Yao, Guimin Zhang

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment, and there remains a lack of effective treatments capable of reversing or significantly slowing disease progression. Accumulating evidence indicates that the immune function of microglia, the resident immune cells of the central nervous system, is a critical factor in regulating AD pathogenesis. Emerging research in immunometabolism further reveals that glucose metabolic reprogramming serves as a central drive …

21.08.2026journal-article

Bioconjugate Chemistry

Development of a Homogeneous Trastuzumab-Triptolide Conjugate for Targeted Therapy of HER2-Overexpressing Ovarian Cancer

Idowu E. Fadayomi, Maria Jangan, Dilna Varghese, Elisabete Pires, James McCullagh, Alan Richardson, Adrian Murray Brunt, Wen-Wu Li

Abstract Ovarian cancer remains a lethal malignancy due to chemoresistance and toxicity, which limits the dose of chemotherapy that can be used, necessitating the development of more targeted therapies such as antibody-drug conjugates (ADCs). However, conventional ADCs suffer from heterogeneity. This study aimed to develop a stable, homogeneous ADC by utilizing a bifunctional dibromomaleimide (DBM) linker to cross-link antibody cysteine residues via disulfide-bridging. A DBM linker was synthesized from 3,4-dibromof …

21.08.2026journal-article

Biology

Bioinformatic Identification and Experimental Validation of a Prognostic Transcriptional Signature Derived from Asparagine Metabolism-Related Genes in Breast Cancer

Tianyang Liu, Guijuan Zhang, Jialin Li, Xianxin Yan, Min Ma

Breast cancer (BRCA) possesses prominent molecular heterogeneity, where aberrant expression of genes annotated to asparagine metabolism networks drives malignant progression and therapeutic resistance. However, systematic construction of prognostic signatures from a holistic asparagine metabolic pathway perspective remains scarce, limiting the clinical translation of metabolic insights into prognostic tools. We integrated TCGA and GEO BRCA transcriptomic datasets to screen asparagine metabolism-related differential …

21.08.2026journal-article

World Journal of Gastroenterology

H3K18 La-METTL5-CCT2 signaling axis promotes colorectal cancer progression by inhibiting pyroptosis

Xiao-Peng Wang, Chang Liu, Hao-Wen Zhang, Jing-Ming Zhai, Jia-Xin Zhu, Guan-Duo Sun, Ya-Hang An, Hai-Jun Yang, Dong-Shuai Jing, De-Chun Liu

BACKGROUND Histone lactylation, a novel epigenetic mark, has been revealed to be involved in tumorigenesis. However, its role in colorectal cancer (CRC) remains unclear. In this study, the functional roles and mechanisms of histone lactylation in CRC progression were explored. AIM To investigate the functional roles and molecular mechanisms of histone H3K18 lactylation (H3K18 La) in CRC progression, focusing on its regulation of pyroptosis and the downstream METTL5/CCT2 axis. METHODS Using 80 paired CRC/normal tiss …

21.08.2026journal-article

Cancer Gene Therapy

Investigating the role of costimulatory domains in enhancing CAR-T cell persistence in TNBC

Hany E. Marei, Giacomo Pozzoli, Carlo Cenciarelli

Abstract This work summarizes how costimulatory domains can mediate the persistence, function, and therapeutic potential of CAR-T cells in triple-negative breast cancer (TNBC), a highly aggressive malignancy with limited treatment options and an immunosuppressive tumor microenvironment. Although CAR-T cell therapy has produced remarkable results in hematologic malignancies, its translation to TNBC remains limited by poor T cell persistence, metabolic dysfunction, and rapid exhaustion. Current evidence identifies ca …

21.08.2026journal-article

European Journal of Nutrition

Fruit and vegetable consumption, dietary and plasma carotenoids and risks of recurrence and progression in patients with non-muscle-invasive bladder cancer

Alina Vrieling, Joann Kiebach, Michiel Balvers, Katja K. Aben, Antoine G. van der Heijden, Ellen Kampman, Lambertus A. Kiemeney

Abstract Purpose Fruit and vegetable consumption may decrease bladder cancer risk, but research on its relation to outcomes of non-muscle-invasive bladder cancer (NMIBC) is scarce. We investigated the association of (changes in) pre- and postdiagnosis fruit and vegetable consumption, as well as postdiagnosis dietary and plasma carotenoids, with risks of recurrence and progression in patients with NMIBC. Methods Data from patients with newly diagnosed NMIBC between 2014 and 2021 from the prospective multi-centre coh …

21.08.2026journal-article

ChemEngineering

Bioelectrochemical Treatment of Ibuprofen-Contaminated Wastewater Using Hypersaline Sediment Microbiomes: Emergence of Chromohalobacter as a Key Degrader

Ghada Sellami, Nesrine Saidi, Syrine Berhouma, Ons Kasraoui, Oumaima Achour, Khouloud Hammami, Ameur Cherif, Federico Aulenta, Habib Chouchane

Ibuprofen (IBU), a widely used anti-inflammatory drug, is increasingly found in aquatic environments, particularly in pharmaceutical wastewater, raising concerns about its persistence and ecological risks. This study investigates IBU removal using a bioelectrochemical system (BES) under laboratory conditions with synthetic pharmaceutical wastewater (SPWW) and halophilic microbiomes from two hypersaline sediments of Chott El-Djerid (CJ–S1 and CJ–S2). Three bioanode reactors were operated at +0.1 V/SCE for 15 days wi …

21.08.2026journal-article

Journal of Health Science and Medical Research

Cervical Cancer Overlying a Cervical Leiomyoma: A Rare Diagnostic and Therapeutic Challenge

Siboonluk Lukkhan, Chayut Pongpanit

A 44-year-old woman presented with heavy menstrual bleeding for two months. A gynecological examination revealed an 8-cm bulky cervical mass. Magnetic resonance imaging demonstrated cervical mass measuring 7.0 cm. without organ invasion. Biopsy confirmed moderately differentiated squamous cell carcinoma, and the patient was diagnosed with early- stage cervical cancer coexiting with cervical leiomyoma.She underwent radical hysterectomy with bilateral salpingectomy and pelvic lymphadenectomy. Histopathological examin …

21.08.2026journal-article

Experimental Oncology

PHENOTYPIC SHIFT OF ADENOCARCINOMA TO SQUAMOUS CELL CARCINOMA OF RECTUM AFTER NEOADJUVANT CHEMORADIOTHERAPY WITH DETECTION OF HPV16: A CLINICAL CASE

O. Kovalyov, S. Zavhorodniy, O. Tolok, A. Anenko, M. Kubrak, M. Danilyuk, K. Kovalyov

Adenosquamous carcinoma and pure squamous cell carcinoma (SCC) of the rectum are extremely rare malignancies, accounting for approximately 0.15% of all colorectal cancers. Increasing attention has been paid to tumor phenotypic plasticity in the context of intensive anticancer therapy. We report the case of a 45-year-old patient with locally advanced rectal adenocarcinoma (cT4bN2M0) who underwent total neoadjuvant therapy consisting of XELOX chemotherapy combined with pelvic radiotherapy. Baseline biopsy samples fro …

21.08.2026journal-article

Experimental Oncology

EXPRESSION PATTERNS AND CLINICAL SIGNIFICANCE OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR, AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2/neu IN GALLBLADDER CANCER

Deepti Mishra, Akhilesh Krishna, Priyanka Sameer, Shreshtha Ghosh, Durgesh Kumar, Ankur Verma

Background. Gallbladder carcinoma (GBC) is a rare cancer. However, it is the most common malignancy of the biliary tract system and ranks as the sixth most common malignancy of the digestive tract. It occurs primarily in females, and previous reports indicate that the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2/neu (HER2/neu) play significant roles in GBC. However, reported findings remain inconsistent. This study aimed to determine the expression status of ERα, …

21.08.2026journal-article

Journal of Intelligent Decision Making and Information Science

MSTF-Net: A Multi-Scale Transformer-Guided Feature Fusion Framework for Accurate Lung Cancer Detection from CT Images

Sharath N C

Lung cancer is one of the most common causes of cancer death worldwide, and early and accurate diagnosis is crucial to upsurge patient survival. Deep learning-based computer-aided diagnosis systems have demonstrated promising results, however they are difficult to recognise fine-grained local lesion traits and long-range contextual connections from CT scans. To overcome these limitations, to propose a Multi-Scale Transformer-Guided Feature Fusion Network for lung cancer diagnosis using the LIDC-IDRI dataset, named …

21.08.2026journal-article

Anti-Cancer Agents in Medicinal Chemistry

Research Progress on the Antitumor Effects of Isorhamnetin (ISO) and Its Molecular Mechanisms

Yanan Hua, Xinxu Shen, Shuqi Niu, Jinlin Guo

Introduction: Cancer remains a leading contributor to global mortality, and current therapeutic interventions continue to grapple with significant limitations. The multi-target characteristics and low toxicity of natural products position them as promising sources of novel anti-tumor agents. Isorhamnetin (ISO), a naturally occurring O-methylated flavonol, exemplifies this potential, demonstrating diverse bioactivities such as cardiovascular protection, inflammation modulation, and cancer suppression. Method: This r …

21.08.2026journal-article

Farmaciâ Kazahstana

THE ROLE OF IVABRADINE IN THE EFFECTIVE TREATMENT OF POSTURAL ORTHOSTATIC TACHYCARDIA ARTER «COVID-19»

Arailym Seydanova, Khamida Abdikadirova, Aikerym Ikromova, Sevinch Abdinabieva, Sevinch Rezhametova, Akniet Adil

Introduction: COVID-19 is a novel type of coronavirus that has had a profound impact on global human health and economic systems. Since its emergence in 2019, it has escalated into a worldwide pandemic, resulting in significant mortality across populations. The COVID-19 pandemic not only led to a spike in acute-phase illnesses and deaths, but also, over time, contributed to the development of so-called “long COVID” or chronic post-COVID symptoms in many patients over time. One manifestation of post-COVID syndrome i …

21.08.2026journal-article

Bioengineering

Computational Oncology of Chemotaxis-Driven Tumour–Immune Spatial Patterning and Stability

Zonghao Liu, Jiguang Yu, Louis Shuo Wang, Lei Su, Ye Liang, Yang Du, Jingfeng Liu

We develop a reaction–diffusion–chemotaxis model for spatial tumour–immune–chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent immune recruitment, chemotactic migration, and signal production. For the non-dimensional system, we establish local classical solvability, nonnegativity, a uniform tumour-density bound, and global mass estimates for the immune and chemokine components. The tumour-free equilibrium is stable precisely when the baseline immune-control index sat …

2 Zitationen
21.08.2026journal-article

International Journal of Colorectal Disease

Endopelvic fascia in rectal cancer surgery: cadaveric anatomy and histological continuity between the obturator fascia and the rectum

Satoru Muro, Yuichiro Tsukada, Masaaki Ito, Akimoto Nimura, Keiichi Akita

Abstract Purpose In rectal cancer surgery, dissection on either side of the endopelvic fascia (EPF) determines whether this layer remains on the pelvic wall or is included with the specimen. However, its continuity with adjacent pelvic wall and rectal supporting tissues, and the anatomical meaning of these local dissection planes, remain unclear. This cadaveric study aimed to clarify the macroscopic and histological characteristics of the EPF in relation to the obturator fascia, rectal wall, and hiatal ligament. Me …