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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Frontiers in Oncology

Case Report: Safety and efficacy of tarlatamab for SCLC in a liver transplant recipient

Jonas Leonhardt, Johann Pratschke, Jürgen Behr, Jeremias Götschke, Philipp Jurmeister, Diego Kauffmann-Guerrero, Frederick Klauschen, Laura Lambrecht, Paula Mras, Christian Schneider, Blerina Resuli, Amanda Tufman

Tarlatamab is a bispecific T-cell engager used for the treatment of small cell lung cancer (SCLC). Patients with a history of solid organ transplantation carry an elevated risk of malignancy yet are excluded from most clinical trials. We report the first case of Tarlatamab use in a liver transplant recipient with SCLC, resulting in marked tumor response and a favorable safety profile without evidence of graft rejection.

21.08.2026journal-article

Obstetric Anesthesia Digest

Treatment of Traumatic Birth Experience With Postpartum Early Eye Movement Desensitization and Reprocessing Therapy: A Randomized Clinical Trial

YMGA Hendrix, MG van Pampus, A Hofman, J Henrichs, HE van der Horst, A de Jongh

( Am J Obstet Gynecol 2025;233:654.e1–25. doi: 10.1016/j.ajog.2025.07.051) Studies show that around 10% to 20% of women view childbirth as a traumatic experience. This can happen in both medically complicated and uncomplicated deliveries and can have vast negative effects for both mother and infant. These potential effects include post-traumatic stress disorder (PTSD), troubles with mother-infant bonding, postpartum depression, childbirth fears, or lower quality of life.

21.08.2026journal-article

Frontiers in Urology

Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management

Jeremy Sheiber, Jordan Nguyen, Michelle Smith, Manish Bajaj, Abhishek Seth, Pamela Ellsworth, Peter Y. Cai

Paratesticular tumors are uncommon in the pediatric population and can represent a wide range of benign and malignant pathologies. We report the case of an otherwise healthy 2-year-old boy who presented with an asymptomatic right scrotal mass. Serial scrotal ultrasounds demonstrated a stable, well-circumscribed extratesticular lesion adjacent to the epididymal head with internal vascularity and normal bilateral testicular architecture. Serum tumor markers, including alpha-fetoprotein, beta-human chorionic gonadotro …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

Development and internal validation of a task-conditioned multimodal radiology–pathology model for breast cancer staging and biomarker profiling: a retrospective cohort study

Yang Liu, Yunfei Dong, Guiyun Zhang, Yue Wu, Shanshan Zhang, Yufo Chen, Ruirui Cao, Rui Wang, Chengliang Yin, Yumei Li

Objectives To retrospectively develop and evaluate a task-conditioned multimodal artificial intelligence framework, in which a learned task embedding and modality-availability mask generate endpoint-specific weights over predefined radiology-only, pathology-only, and fusion experts, for breast cancer staging and biomarker profiling. Methods We retrospectively assembled a cohort of 923 patients with paired radiology and pathology data. Nine tasks included TNM components [tumor extent (T), nodal involvement (N), and …

21.08.2026journal-article

Frontiers in Pharmacology

A multicenter, randomized, double-blind, double-simulated, positive drug parallel-controlled clinical trial to evaluate the efficacy and safety of Xiao’er Fengreqing oral liquid in the treatment of acute pharyngitis/tonsillitis in children

Lei Shi, Kai Liu, Yike Song, Chunsun Mu, Chunxiang Wang, Yongchao Jiang, Robb Russell, Yaqian Wen, Rihe Liu, Jianping Liu, Huilan Liu, Zhaolan Liu

Background Acute pharyngitis and tonsillitis are common in children. Xiao’er Fengreqing Oral Liquid (XFQOL) shows potential benefits in previous studies of pediatric acute upper respiratory tract infections and influenza, but high-quality clinical evidence for pediatric acute pharyngitis/tonsillitis remains limited. Methods This multicenter, block-randomized, double-blind, double-dummy, active-controlled trial enrolled 120 children from three tertiary hospitals. Participants were randomly assigned in a 1:1 ratio to …

21.08.2026journal-article

Endocrine-Related Cancer

Molecular clusters and precision medicine in pheochromocytomas and paragangliomas

Madson Q. Almeida, Patricia L. M. Dahia, Mercedes Robledo

Abstract Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and extra-adrenal paraganglia. Over the past two decades, the genomic characterization of PPGLs has profoundly transformed their diagnosis, classification, risk stratification, and therapeutic management. Up to 40% of PPGLs harbor germline pathogenic variants, the highest proportion among human neoplasms, and somatic driver events are identified in a substantial fraction of the r …

21.08.2026journal-article

Pharmacoepidemiology and Drug Safety

A Catalogue of Dispensation Lengths for Building Treatment Episodes—Application of the Waiting Time Distribution to All Commonly Prescribed Drugs in Denmark

Mette Reilev, Lotte Rasmussen, Jonas Kanstrup Olsen, Martin Thomsen Ernst, Saad Hanif Abbasi, Rikke Wesselhoeft, Mette Bliddal, Jesper Hallas, Henrik Støvring

ABSTRACT Background In pharmacoepidemiologic research, correct assignment of the length of single dispensation is critical to build treatment episodes. The parametric reverse waiting time distribution (rWTD) is a particularly attractive data‐driven method to estimate dispensation lengths. Aim To provide an easily accessible resource of estimated dispensation lengths covering all commonly used drugs for use in treatment episode building in applied pharmacoepidemiologic research. Methods We used a random 20% sample o …

21.08.2026journal-article

Journal of Computational Biophysics and Chemistry

Integrated In Silico Profiling of Altissimacoumarin H in Prostate Cancer-Related Molecular Networks

Saleh M. Bufarwa, Mustapha Belaidi

Prostate cancer involves interconnected androgenic, inflammatory, hypoxia-related, receptor tyrosine kinase, and survival pathways, motivating hypothesis-generating multi-target analyses. This study investigated Altissimacoumarin H (ATSC), a naturally occurring terpenylated coumarin, using an integrated in silico workflow combining target prediction, network pharmacology, transcriptomic assessment, molecular docking, molecular dynamics (MD), ADME/toxicity prediction, and density functional theory (DFT). Target pred …

21.08.2026journal-article

Frontiers in Oncology

Prognostic significance of the C-reactive protein-to-lymphocyte ratio in patients with cancers

Xiaohui Liu, Shaobo Zhang, Yi Liu

Background The C-reactive protein-to-lymphocyte ratio (CLR), a novel inflammation-based biomarker, has been reported to be associated with prognosis in various cancers. However, the prognostic significance of CLR remains controversial. Therefore, we performed a meta-analysis to comprehensively evaluate the prognostic value of CLR in patients with cancers. Methods Relevant studies were systematically searched in PubMed, Embase, and Web of Science up to March 21, 2026. Pooled hazard ratios (HRs) with corresponding 95 …

21.08.2026journal-article

Frontiers in Oncology

Analysis of latent profiles of stressors and their influencing factors in patients with breast cancer undergoing postoperative chemotherapy: a mixed-methods study

Jingjing Chen, Tiantian Yang, Xiaoling Yan

Objective To explore the heterogeneity of stress experiences, identify latent stressor profiles, and analyze their influencing factors in patients with breast cancer undergoing postoperative chemotherapy, in order to provide evidence for implementing precise psychosocial interventions. Methods An explanatory sequential mixed-methods design was employed. A total of 232 patients with breast cancer undergoing postoperative chemotherapy at Nantong University Affiliated Hospital were conveniently sampled and participate …

21.08.2026journal-article

Frontiers in Psychiatry

The lived experience of resilience in families of children with cancer: a meta-aggregative synthesis of qualitative studies

Chunyan Li, Chuanying Zhang, Sijing Peng, Yixin Wang, Qianqian Hu

Background Childhood cancer imposes substantial psychological, social, and practical challenges on families, often disrupting emotional stability, caregiving roles, financial security, and family functioning. Family resilience has increasingly been recognized as a dynamic process that supports adaptation under prolonged adversity. However, qualitative evidence regarding how families develop and sustain resilience in the context of childhood cancer remains fragmented. Objective This qualitative systematic review aim …

21.08.2026journal-article

Frontiers in Psychiatry

Associations of body mass index and chemotherapy emetogenic risk with sleep disturbance in patients with cancer: a retrospective study

Chunlin Feng, Jun Dai, Jingju Liu, Ling Zhu, Zhang Zhang, Qiming Sun

Objective To examine the associations of body mass index (BMI) and chemotherapy emetogenic risk with sleep disturbance in patients with cancer and to explore their multiplicative interaction and joint associations. Methods This retrospective cross-sectional study analyzed the medical records of 300 patients with cancer who received chemotherapy at Wuhu Second People’s Hospital between January 2023 and February 2025. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Multivariable binary log …

21.08.2026journal-article

Journal of Clinical Medicine

Structural and Functional Treatment of Persistent Spinal Pain Syndrome Type 2: A Fibrosis-Stratified Network Meta-Analysis of Epidural Adhesiolysis and Neuromodulation

Wolfgang Auffermann, Mohammed Al Jumaily, Alina Auffermann

Background/Objectives: Persistent spinal pain syndrome type 2 (PSPS-T2) is treated with two mechanistically distinct interventional families: epidural adhesiolysis (EA), directed at structural epidural pathology, and neuromodulation (NM), directed at modulation of nociceptive signaling. Epidural fibrosis is a biologically plausible candidate for treatment stratification, but whether it independently modifies treatment response remains unproven. This study reviewed the available evidence to determine both the compar …

21.08.2026journal-article

Supportive Care in Cancer

Exploring facilitators and barriers to the implementation of prehabilitation for individuals with pancreatic cancer: a survey of healthcare professionals

Elizabeth Wrench, Elizabeth McGladrigan, Robert M. Lauder, Declan Dunne, Cliff Shelton, Joel Lambert, Laura L. Machin, Daren A. Subar, Theodoros M. Bampouras, Christopher J. Gaffney

Abstract People with pancreatic cancer experience poor survival, low quality of life and limited treatment options compared to those with other cancers; interventions that can improve outcomes and quality of life are urgently required. Pancreatic Cancer UK recently released ‘optimal care guidelines’ for pancreatic cancer, which recommends that all patients, no matter the treatment route, should be offered prehabilitation (typically exercise, nutrition and psychosocial intervention) at the point of diagnosis. We inv …

21.08.2026journal-article

European Heart Journal – Cardio-Oncology

Cardiovascular Risk of First and Second Generation Bruton’s Tyrosine Kinase Inhibitors: A Systematic Review and Network Meta-Analysis

Hardil Anup Bhatt, Ibrahim Alqassas, Farid Foroutan, Rachel Lu, Mackenzie Dryburgh, Nikhila Butani, Joshua G Lee, Ani Orchanian-Cheff, Darryl P Leong, Anca Prica, Daniel Addison, Lee Mozessohn, Michael Fradley, Abi Vijenthira, Praloy Chakraborty, Kumaraswamy Nanthakumar, Paaladinesh Thavendiranathan, Husam Abdel-Qadir

Abstract Aims Ibrutinib increases cardiovascular adverse events, but the comparative cardiovascular safety of second-generation Bruton’s tyrosine kinase inhibitors (BTKi) remains uncertain. We compared cardiovascular adverse events among ibrutinib, acalabrutinib, zanubrutinib, and non-BTKi therapies. Methods and Results We conducted a systematic review and frequentist network meta-analysis of Phase II/III randomised trials of BTKi in adults with haematological malignancies. Outcomes included atrial fibrillation (AF …

21.08.2026journal-article

The Oncologist

IUC26667-92 Assessment of QRISK®3 and Major Cardiovascular Events in Patients with Metastatic Hormone-Sensitive Prostate Cancer Treated with ADT ± ARPI ± Docetaxel: A Retrospective Cohort Study

T Alom, A Kutty, G Neola, L Pedapati, A Sandulache, W The-Zar, C Chau, A Maniam, B Smalley, G L Banna

Abstract Background Cardiovascular disease is a major source of morbidity in patients with metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy (ADT)-based treatment. Although cardiovascular risk assessment is increasingly recommended before treatment initiation, its integration into routine therapeutic decision-making remains limited. We evaluated baseline cardiovascular risk using QRISK®3 and its association with major adverse cardiovascular events (MACE) in patients receivi …

21.08.2026journal-article

Journal of Translational Medicine

FSTL1 promotes M2 polarization of macrophages via the DIP2A–Smad2/3 Axis in gastric cancer

Ming Yang, Rongfei Wang, Xiao Wang, Zheng Chen, Yonghui Su

Abstract Background Follistatin-like protein 1 (FSTL1) is aberrantly overexpressed in gastric cancer (GC) and modulates immune cell infiltration in the tumor microenvironment. However, the molecular mechanism underlying its regulation of macrophage polarization remains incompletely defined. Methods In this study, we analyzed the expression of FSTL1 and its correlations with clinical prognosis and M2 macrophage infiltration using data from The Cancer Genome Atlas (TCGA) database and clinical GC tissue microarrays. I …

21.08.2026journal-article

Experimental Oncology

DYNAMIC ANDROGEN RESPONSE INDEX AND ITS ASSOCIATION WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY FOLLOWING NEOADJUVANT ANDROGEN DEPRIVATION THERAPY

Ye. Afanasiev, S. Vozianov, R. Danylets, V. Grygorenko, O. Shulyak, M. Sosnin, I. Kholokharenko

Background. Neoadjuvant androgen deprivation therapy (NADT) before radical prostatectomy (RP) remains controversial in the management of localized and locally advanced prostate cancer. A major limitation of this strategy is the lack of biomarkers capable of identifying tumors biologically sensitive to androgen deprivation. This study aimed to evaluate the prognostic value of a dynamic androgen response index (IAR) and develop a predictive model for biochemical recurrence (BCR) after RP. Materials and Methods. The r …

21.08.2026journal-article

Palliative Medicine

The economic costs of unpaid cancer caregiving: A qualitative study

Cara Madeleine Platts, Anna Collins, Chris Schilling, Brian Le, Sue-Anne McLachlan, Louise Dillon, Samantha Chandler, Terry Maher, Clare Gardiner, Jennifer Philip

Background: Unpaid caregivers play a crucial role in providing care for people with life-limiting illnesses such as cancer, yet their economic contributions are rarely recognised in economic evaluations, leaving caregivers to shoulder significant direct and indirect costs. Aim: To explore the direct and indirect costs experienced by unpaid caregivers of people with cancer receiving palliative care. Design: A qualitative study underpinned by a social constructivist framework, reported in line with COREQ and RTARG gu …

21.08.2026journal-article

Journal of Intelligent Decision Making and Information Science

Attention-Guided Mask R-CNN for Liver Tumor Segmentation and Classification from CT Scans: A Tailored Approach

Babeetta Bbhagat

Computed tomography (CT) images have poor tissue contrasts, irregular appearance of lesions, and unclear tumor borders which limit reliable diagnosis of liver malignancy. This paper introduces an attention-controlled automated liver tumor segmentation and classification based on a customized Mask Region Convolutional Neural Network (tm-RCNN) with an addition of Multi-Scale Attention Gate (MSAG). To increase the local contrast and reduce artifacts caused by acquisition, adaptive histogram equalization is used. The s …

21.08.2026journal-article

Indian Journal of Palliative Care

Medical Costs of Palliative and Hospice Care versus Usual Care in Terminal Cancer: A Systematic Review and Meta-Analysis

Nurlelasari Harahap, Vebby Amelia Edwin, Halimatun Syakdiyah Harahap

To evaluate medical costs associated with palliative care (PC) and hospice care (HC) compared with usual care among patients with terminal cancer, while accounting for variations in cost definitions and models of care. A systematic review and meta-analysis of observational studies were conducted. Literature searches were performed in PubMed, Scopus, and ProQuest (January 2010–July 2025). Eligible studies compared the medical costs of palliative or hospice care with usual care in adult terminal cancer patients. Care …

21.08.2026journal-article

World Journal of Gastroenterology

Letter to the Editor: Mechanistic insights into tumor necrosis factor-α-mediated islet β-cell apoptosis in acute pancreatitis-associated abnormal glucose metabolism

Peng Zhang, Shang-Ming Liu

The study by Chen et al , published in the recent issue of the World Journal of Gastroenterology , which systematically elucidate the role of tumor necrosis factor-α (TNF-α) in abnormal glucose metabolism following acute pancreatitis, demonstrating that TNF-α induces islet β-cell apoptosis through activation of the Bax / Bcl-2 /caspase-3 pathway. While these findings provide mechanistic insights, the study’s scope remains limited by insufficient investigation into upstream/ downstream TNF-α signaling, including the …

21.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Steven‐Johnson Syndrome and Toxic Epidermal Necrolysis in a Patient Treated With Cabozantinib: A Case Report of a Fatal Adverse Reaction

Alberto Zambudio‐Munuera, Miguel Herráez‐Marcos, Miguel Angel Arrabal‐Polo, Francisco Gutiérrez‐Tejero, Miguel Arrabal‐Martín

ABSTRACT Cabozantinib is a multikinase inhibitor with high efficacy in patients with metastatic renal cell carcinoma. We present the case of a 53‐year‐old patient undergoing second‐line treatment for metastatic renal cell carcinoma who presented with extensive skin lesions consistent with Stevens–Johnson syndrome, confirmed by biopsy. He presented a torpid course, progressing to toxic epidermal necrolysis and subsequent death despite supportive measures and immunoglobulin treatment. Although cabozantinib can cause …

21.08.2026journal-article

International Journal of Surgery Case Reports

3D-printed navicular replacement for giant cell tumor: a case report on a feasible indication and surgical outcome

Tran Quang Sang Nguyen, Nhat Anh Luong, Duc Huy Le, Sy Quyen Nang Vo, Trung Hieu Pham, Trung Dung Tran

Introduction and importance: Giant cell tumor of the navicular is extremely rare and difficult to manage due to the complex biomechanics of the midfoot. Conventional curettage carries a high recurrence risk. This report presents a feasible approach using total navicular replacement for a giant cell tumor, offering a solution for achieving both oncologic control and functional reconstruction. Case presentation: A 32-year-old man presented with progressive midfoot pain and a Campanacci grade II giant cell tumor confi …