Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 155

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
09.08.2026journal-article

Sensors

Spatial-Temporal Relation Enhancement for Speech Emotion Recognition from Acoustic Signals Using Fibonacci Encoding with Diverse Feature Fusion

Shicong Huang, Jinghao Zhang, Jingchao Xu, Qi Zhang, Zihan Li, Songyang Wang, Zirui Qiu, Zijia Xiong, Jintian Liang, Changzeng Fu

Speech emotion recognition (SER) infers affective states from speech signals, but positional encoding for acoustic tokens remains underexplored in Transformer-based SER. Existing models often reuse encodings designed for text and do not explicitly account for the different sequential and two-dimensional structures of acoustic representations. We propose Fibonacci Position Embedding (FPE) and Fibonacci Target Shutter (FTS). FTS constructs overlapping candidate-index sets over time–frequency token grids, and FPE samp …

09.08.2026journal-article

International Journal for Neurology and Neuroscience

Evaluating the Neuroprotective Effects of Personalized Ayurvedic Integrative Therapy on Cognitive Function, Brain Connectivity, and Neuroinflammatory Biomarkers in Early Neurodegenerative Disorders: A Prospective Clinical Study

Dr Ritesh Kumar, Dr. Astha Raj, Dr Tanuja Shiromani

Background: Early neurodegenerative disorders are characterized by progressive cognitive impairment, altered functional brain connectivity, oxidative stress, and chronic neuroinflammation. Conventional treatments provide limited disease-modifying benefits, creating interest in safe, personalized integrative approaches. Ayurveda combines individualized herbal therapy, dietary regulation, yoga, meditation, sleep optimization, and cognitive stimulation, which may influence multiple neurobiological pathways. Objective: …

09.08.2026journal-article

Journal of Nursing and Midwifery Sciences

Medical Knowledge and Clinical Skills as Mediators Between Evidence-Based Medicine and Clinical Competence in Postpartum Hemorrhage Management: A Cross-Sectional Study

Ign Teguh Budhi Bimantara, I Gusti Putu Asto Buditjahjanto, Lilik Anifah, Ratna Suhartini

Background: Postpartum hemorrhage (PPH) is the leading cause of maternal mortality, accounting for approximately 28% of maternal deaths in Indonesia. Although evidence-based medicine (EBM) is widely advocated as the foundation for clinical quality improvement, the specific pathways through which EBM enhances clinical competence in PPH management remain insufficiently characterized. Objectives: To assess Indonesian midwifery students’ knowledge and clinical skills as mediators of the relationship between evidence-ba …

09.08.2026journal-article

Biophysica

Body Distribution and Occupational Dispersion of Scandium-47 Chloride: Safety Considerations for Radiopharmaceutical Development

Haruna Yorifuji, Yoshifumi Shirakami, Tadashi Watabe, Masashi Murakami, Kazuhiro Ooe, Kentaro Hisada, Atsufumi Akai, Sifan Feng, Hidetoshi Kikunaga, Takuya Yokokita, Kazuki Kajiyama, Akina Mitsukai, Atsushi Toyoshima, Takashi Yoshimura, Jens Cardinale, Frederik L. Giesel, Kazuko Kaneda-Nakashima

This study investigated the distribution and dispersion of Sc-47 (47Sc), a β-emitting radionuclide that can be produced in large quantities using accelerators. As the stability of labeled compounds inside the body is essential for nuclear medicine therapy, we examined the biodistribution of free 47Sc to distinguish it from the distribution of compounds labeled with 47Sc. [47Sc]ScCl3 was administered to normal mice. Body distribution, excretion routes, and contamination of laboratory equipment were also measured. 47 …

09.08.2026journal-article

British Journal of Clinical Pharmacology

Managing HIV in the extreme: Viral load and drug monitoring in a patient with BMI > 60 on long‐acting cabotegravir/rilpivirine therapy

Leah D. Baker, Patricia Pecora Fulco

This case describes the use of long‐acting injectable (LA‐I) cabotegravir/rilpirivine (CAB/RPV) therapy in a morbidly obese person (body mass index [BMI] = 62 kg m −2 ) living with HIV without sustained viral load (VL) suppression after historic poor adherence to daily oral antiretroviral therapy. Increased BMI > 30 kg m −2 is a known risk factor for VL rebound with CAB/RPV failures; thus, RPV therapeutic drug monitoring (TDM) was followed with regularly scheduled VL assessments. Based on TDM concentrations, monthl …

09.08.2026journal-article

Analytical Chemistry

A Light-Controlled DNA Nanoclaw Machine: Integrated Multiplexed Recognition, Spatiotemporally Programmable Therapy, and Real-Time Electrochemical Signaling for Precision Receptor Regulation

Xia Liu, Ying Zhao, Guoxi Xia, Minglei Zhang, Jiabo Wang, Yusi Bu, Xiaoyu Xie

Abstract Cell membrane receptors are pivotal targets in precise therapeutics, yet their ubiquitous expression across tissues remains a fundamental barrier to achieving cell-specific intervention. To overcome the limitations of conventional monotargeting approaches, we developed a light-gated DNA nanoclaw machine (L-DNM) that integrates high-specificity recognition, spatiotemporally controlled therapy, and real-time monitoring of molecular activation within a unified nanoplatform. The L-DNM employed a multivalent ta …

09.08.2026journal-article

Behavioral Sciences

Elite Athletes’ Experiences During Injury Rehabilitation from a Biopsychosocial Perspective: An Exploratory Qualitative Study

Moonjung Bae

Elite athletes experience diverse biological, psychological, and social challenges during injury rehabilitation, yet few qualitative studies have explored these experiences and their interactions from a biopsychosocial perspective. This exploratory qualitative study investigated the biopsychosocial experiences of elite athletes during injury rehabilitation and the interactions among these experiences through semi-structured interviews with five participants, using inductive content analysis. Athletes reported biolo …

09.08.2026journal-article

Healthcare

Adjunctive Antimicrobial Photodynamic Therapy in Non-Surgical Periodontal Treatment: Clinical and Microbiological Insights from a Randomized Split-Mouth Trial

Alessia Pardo, Gabriel Gallo, Annarita Signoriello, Elena Messina, Gloria Burlacchini, Caterina Signoretto, Giorgio Lombardo, Massimo Albanese

Background/Objectives: Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunct to non-surgical periodontal therapy, although its benefits remain debated. This study evaluated the clinical and microbiological effects of aPDT combined with ultrasonic scaling and root planing (US-SRP) compared with US-SRP alone in patients with periodontitis. Methods: In this randomized split-mouth clinical trial, 40 patients with stage II–III periodontitis were included. Two non-adjacent sites with probing pocket de …

09.08.2026journal-article

Human Gene Therapy

Physiologically Regulated Frataxin Gene Replacement Restores Neurological Function in a Mouse Model of Friedreich Ataxia

Federica Pilotto, Laure Dall’Agnol, Laurence Reutenauer, Marie Paschaki, Hélène Puccio

Friedreich ataxia (FA) is a progressive neurodegenerative disorder caused by reduced expression of frataxin (FXN), a mitochondrial protein essential for iron-sulfur (Fe-S) cluster biogenesis. Although gene therapy strategies aimed at restoring FXN have shown promise, excessive expression can lead to mitochondrial dysfunction, emphasizing the importance of maintaining FXN within a physiological range. Here, we evaluated a gene therapy approach based on a human mini-frataxin construct (miniFXN7) incorporating an endo …

09.08.2026journal-article

THEORIA. An International Journal for Theory, History and Foundations of Science

Self, inner speech, rationality and explanation

José Luis Bermúdez

This paper collects the responses by J.L. Bermúdez to articles discussing his work by Matheus Valente, Víctor Verdejo, Derek H. Brown, Shaun Gallagher, Carlota Serrahima, Daphne Bernués and Marta Jorba, Daniel Dohrn, Sarah A. Fisher and Marko Jurjako.

09.08.2026journal-article

Pakistan Journal of Positive Psychology

Efficacy of Online Dialectical Behavior Therapy Interventions on Emotional and Behavioral Outcomes: A Systematic Review and Meta-Analysis

Pulwasha Anwar, Mashat Zahra, Hajira Javed, Summia Naveed, Zeeshan Mehfooz Sindhu, Sabeen Sabir

Dialectical behavior therapy (DBT) is an evidence-based, skills-based intervention originally developed for chronic suicidality and borderline personality disorder and later adapted transdiagnostically for disorders involving emotional and behavioral dysregulation. Online and app-delivered DBT adaptations have proliferated, but their efficacy relative to in-person delivery has not been systematically quantified. This review systematically reviewed and meta-analyzed, where data permitted, randomized controlled trial …

09.08.2026journal-article

Pharmaceutics

Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theranostics

Yuhang Jiao, Huiling Zuo, Jiaxin Chen, Shihao Zheng, Sen Tong, Xiaoyi Feng, Wei Zhao

Breast cancer treatment still faces challenges including local recurrence, systemic toxicity, tumor heterogeneity, drug resistance, and immunosuppression. Conventional systemic administration provides limited exposure at the tumor site and exhibits significant toxicity. Injectable hydrogels, combining the properties of minimally invasive administration, in situ gelation, local retention, and sustained release, have become a key platform for local precision drug delivery. Compared with nanomedicines or free drugs, h …

09.08.2026journal-article

ACS Applied Materials & Interfaces

Multifunctional Magnetothermo-Responsive Smart Hydrogel for On-Demand Controlled Drug Release in Cancer Therapy

Zahra Moazzami Goudarzi, Sohrab Asgaran, Magdalena Osial, Njemuwa Nwaji, Dorota Kołbuk, Arkadiusz Gradys, Bartlomiej Kalaska, Olga Urbanek, Paweł Sajkiewicz

Abstract Targeted and on-demand drug delivery technologies have attracted considerable interest for personalized cancer therapies. In this study, we developed a UV-crosslinkable and thermo-responsive gelatin methacrylate (GelMa)—poly(N-isopropylacrylamide) (PNIPAM) (G/P) hybrid hydrogel, integrated with folic acid-functionalized superparamagnetic iron oxide nanoparticles (SPIONs). Differential scanning calorimetry (DSC) and alternating magnetic field (AMF) evaluations confirmed that introducing GelMa modulated the …

09.08.2026journal-article

Healthway

MRI-GUIDED LASER INTERSTITIAL THERMAL THERAPY IN MODERN NEUROSURGERY: THERMAL DOSIMETRY, PATIENT SELECTION, NEURO- ONCOLOGICAL APPLICATIONS, AND PRECISION ABLATION FOR DRUG- RESISTANT EPILEPSY

Aliev M.A.

Background. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has evolved from an experimental stereotactic technique into a clinically relevant minimally invasive neurosurgical platform. Its principal advantage is the combination of stereotactic targeting, controlled thermal ablation, and real-time magnetic resonance thermometry. Contemporary indications include deep or surgically difficult gliomas, recurrent glioblastoma, progressive brain metastases after stereotactic radiosurgery, radiation …

09.08.2026journal-article

Cancers

Association Between Mutations in DNA Damage Response Genes and Efficacy of Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Huixia Li, Wing San Yiu, Guo-Min Li, Feng-Ming (Spring) Kong

Background: Immunotherapy has improved outcomes in non-small cell lung cancer (NSCLC), but reliable predictive biomarkers remain limited. DNA damage response (DDR) gene mutations may enhance tumor immunogenicity and response to immune checkpoint inhibitors (ICIs), yet clinical findings remain inconsistent. We aimed to systematically evaluate the association between DDR gene mutations and ICI outcomes in NSCLC. Methods: PubMed and Embase were searched for eligible studies. Data on objective response rate (ORR), prog …

08.08.2026journal-article

International Archives of Medical Sciences and Public Health

FACTORS ASSOCIATED WITH PATIENT UNDERSTANDING OF PHYSIOTHERAPY SERVICE FLOW: A CROSS-SECTIONAL STUDY BASED ON PERMENKES NO. 65 OF 2015

Balqis Wasliati, Nadia Wasliati, Laily Wasliati

Patient understanding of physiotherapy service flow is essential for adherence and outcomes. This study analyzes factors associated with patients' understanding based on Minister of Health Regulation No. 65/2015 at BLU Timikan Hospital. A cross-sectional study was conducted among 158 outpatients selected by consecutive sampling at BLU Timikan Hospital from January to March 2025. Data were collected using observation sheets, a validated questionnaire (Cronbach's alpha = 0.87), and medical records. Bivariate analysis …

08.08.2026journal-article

Microorganisms

Exploration of the Interaction Between Bismuth-Containing Quadruple Anti-H. pylori Therapy and the Gut Microbiota

Xue Yang, Yan Pan, Cai-Ping Gao, Ying-Hui Zhang, Shan Du, Lu Chao, Chun-Li Huang, Shi-Yu Xiao, Zhou Zhou

Helicobacter pylori (H. pylori) eradication with bismuth-containing quadruple therapy (BQT) is effective but often accompanied by adverse gastrointestinal reactions and gut microbiota disturbances, while the impact of probiotic supplementation and the predictive value of the gut microbiota remain incompletely understood. In this single-center prospective randomized controlled trial, 109 H. pylori-positive patients were assigned to receive a 14-day BQT alone treatment or BQT combined with compound Lactobacillus acid …

08.08.2026journal-article

Iranian Journal of Psychiatry and Clinical Psychology

Developing and Validating a Sensory-Motor Play Therapy Program Based on Deleuze and Guattari's Philosophy for Autistic Children: A Qualitative Study

Nasrin Behnamnejad, Saead Rezaei, Noorali Farrokhi, Ahmad Salahshoori

Objectives For exceptional children, a diverse range of interventions is needed to effectively address their needs. This study aimed to develop and validate a sensory-motor play therapy program grounded in Deleuze and Guattari’s philosophy for children with autism spectrum disorder (ASD). Methods This is a qualitative study using the inductive content analysis approach. A search in online databases for articles and books related to Deleuze and Guattari’s philosophy published from 1953 to 2023 was first conducted to …

08.08.2026journal-article

Orphanet Journal of Rare Diseases

Fixed-cycle oral pomalidomide/lenalidomide-based therapy is associated with durable treatment-free remission in idiopathic multicentric castleman disease with TAFRO syndrome: a single-center retrospective study

Tang Bo, Xie Shuanglian, Yu Xiaojuan, Wang Wei, Shen Ye, Di Mingyi, Sun Yuhua, Liu Wei, Dong Yujun

Abstract Background Idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD-TAFRO) is a rare and severe subtype of iMCD characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Current treatments often require prolonged or indefinite administration and frequent hospital visits, imposing substantial burdens on patients. We evaluated the clinical outcomes and safety of a fixed-cycle oral immunomodulatory drug (IMiD)-based regimen in patients with iMCD-TAFRO. Methods In thi …

08.08.2026journal-article

International Journal of Innovative Science and Research Technology

Rehabilitation Through Physiotherapy in a Patient with Chronic Kidney Disease Receiving Maintenance Hemodialysis: A Case Report

Karthika Ramalingam, Geethapriya Vadamalai, Krishnan Saravanan, Manisha Jaisankar, P. Archana, Ragavi S., Mohammed Bilal Iliyas

Background: Chronic kidney disease (CKD) is a progressive condition associated with reduced kidney function, fatigue, decreased exercise tolerance, impaired quality of life, and multiple comorbidities. Patients undergoing maintenance hemodialysis frequently experience physical deconditioning and functional limitations. Exercise-based physiotherapy interventions have been increasingly recommended as an adjunctive treatment to improve overall health outcomes in this population.  Case Presentation: A 56-year-old male …

08.08.2026journal-article

General Engineering & Applied Science Journal

Analysis of Operational Current Consumption of the Control Block and Voltage Regulation in a Cascaded DC-DC Boost Converter as a Power Supply for Medical Therapy

Ivana Tawaru, Devi Yuliani Seran, Agung Nugraha Rahman, Eko Arianto

This study aims to analyze the voltage regulation and control current consumption characteristics of a two-stage Cascaded DC-DC Boost Converter (5 V to 12 V, and 12 V to 97 V) utilized as a power supply for medical therapy electrostimulators. The experimental method was conducted by integrating the power supply block with an active load configuration consisting of a Voltage Controlled Current Source (VCCS) circuit. Testing was performed by varying the therapy current from 2 mA to 10 mA at a frequency of 100 Hz acro …

08.08.2026journal-article

International Journal of Molecular Sciences

Natural Products as Modulators of the DNA Damage Response and Oncogenic Signaling in Breast Cancer Therapy

Maria Cuomo, Francesco Errichiello, Carolina Di Meo, Martino Forino, Luigi Frusciante, Michelino De Laurentiis, Antonio Giordano, Luigi Alfano

Breast cancer (BC) is the most frequently diagnosed malignancy and generally the leading cause of cancer-related mortality among women worldwide. Molecular targeted therapies, including endocrine treatment for hormone-responsive tumors, anti-HER2 agents for HER2-positive tumors and PARP inhibitors (PARPis) for homologous recombination-deficient (HRD) tumors, have significantly improved patient outcomes, but several clinical challenges are still open. The development of acquired resistance strongly limits the long-t …

08.08.2026journal-article

Indonesian Journal of Nursing and Health Care

The Application of Drawing Therapy in Reducing Auditory Hallucination Symptoms in Patients with Schizophrenia in the Working Area of UPTD Puskesmas Wabula: A Case Study

Sri Resky Mustafa, Putri Wulandari, Fitri Wijayati

Background: Auditory hallucinations are among the most common positive symptoms of schizophrenia and can significantly disrupt patients’ daily functioning. Drawing therapy has been suggested as a complementary non-pharmacological intervention to facilitate emotional expression and reduce hallucination symptoms.Objective: This study aimed to evaluate the potential benefit of drawing therapy in reducing auditory hallucination symptoms in a patient with schizophrenia.Methods: A descriptive case study was conducted inv …