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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Oncogenesis

A novel combinatorial treatment for Neurofibromatosis type 1 tumours revealed through cross-species genetic analysis

Megan Stevens, Sebastian Oltean, Benjamin E. Housden

Abstract Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder associated with a wide range of symptoms, including the formation of tumours along nerves. These tumours can affect nerve function, leading to pain and loss of sensory or motor capacity. Drug treatments are currently limited, and relatively few new targets have emerged for NF1 tumours despite intensive research. Therefore, new drugs to target NF1 -deficient tumour cells are urgently required. Here, we have used a cross-species screening strat …

21.08.2026journal-article

Journal of the International Child Neurology Association

Spinal muscular atrophy: history and current treatment landscape

Olcay Ünver, Jo Wilmshurst, Haluk Topaloğlu

In recent years, pediatric neurology has witnessed significant advances in the development of disease-modifying therapies, with spinal muscular atrophy (SMA) emerging as one of the most impactful conditions in this field. This article provides a comprehensive overview of the history of SMA, highlighting its evolving classification and the genetic basis underlying its clinical variability. Moreover, it outlines the development and clinical trial data of the three Food and Drug Administration- and European Medicines …

21.08.2026journal-article

International Journal of Innovative Technologies in Social Science

PREMENSTRUAL DYSPHORIC DISORDER (PMDD): CURRENT PHARMACOTHERAPY AND EMERGING TREATMENT APPROACHES

Julia Oziębło, Magdalena Kijowska, Karolina Klusek, Michał Batory, Jakub Jakubowski, Karol Kraska, Nadzieja Krasucka, Aleksandra Zynkowska, Aleksandra Magdalena Skrzyniarz, Maria Kiełbus

Premenstrual dysphoric disorder (PMDD) is a cyclic mood disorder affecting a subset of women in the late luteal phase, marked by severe affective and physical symptoms that resolve with menses. It is distinguished from milder premenstrual syndrome (PMS) by symptom severity and functional impairment. PMDD causes substantial distress: women with PMDD have functional impairments comparable to other depressive disorders and increased work absences, and PMDD is associated with higher rates of suicidal ideation and attem …

21.08.2026journal-article

ACS Applied Bio Materials

Low-Cost Nucleic-Acid-Based Radial Flow Assay for the Detection of GSTP1 Promoter DNA Methylation in Prostate Cancer

Debashree Kar, Prashant Mishra

Abstract DNA methylation of the glutathione S-transferase pi 1 (GSTP1) promoter is a widely studied epigenetic biomarker for prostate cancer; however, its direct detection in genomic DNA remains analytically challenging without complex chemical or amplification-based workflows. Here, we report a nucleic acid-based radial flow assay (NABRFA) that enables visual and pattern-based detection of gene-specific DNA methylation using gold nanoparticle (AuNP)-conjugated oligonucleotide probes. Thiol-modified single-stranded …

21.08.2026journal-article

Langmuir

Forsythia suspensa -Derived Carbon Dot Nanozyme for Periodontitis Treatment via Antioxidative and Macrophage-Polarizing Activities

Zifan Chen, Jingmin Wang, Yuqing Hu, Keming Chen, Min Zhang, Yongzhong Wang

Abstract Periodontitis is a chronic inflammatory disease driven by reactive oxygen species (ROS) overproduction and immune dysregulation. Carbon dots derived from traditional Chinese medicine (TCM) integrate the functional chemical features of herbal precursors with the favorable physicochemical properties of nanomaterials. As an exemplary case, we hydrothermally synthesized Forsythia suspensa-derived carbon dots (Fo-CDs), which exhibited a high superoxide dismutase (SOD)-like activity of 340 U/mg, along with catal …

21.08.2026journal-article

Suranaree Journal of Science and Technology

EXPLAINABLE MACHINE LEARNING FOR NON-INVASIVE PROSTATE CANCER DETECTION USING SIGNAL-DERIVED VOC FEATURES

Settawut Chalermwat, Chatiwat Piyarom, Watcharapong Anakkamatee, Anawin Pechbooranin, Sekdusit Aekgawong

The present study aimed to develop an explainable artificial intelligence (AI) model by using urinary volatile organic compound (VOC) profiles for non-invasive prostate cancer (PCa) detection. A total of 123 participants were included: 29 with PCa, 67 with benign prostatic hyperplasia (BPH), and 27 healthy controls. Urinary VOC signals were recorded by metal oxide semiconductor sensors across six thermal cycles, generating 120 features per subject. Mutual Information and Random Forest importance identified 15 key f …

21.08.2026journal-article

Cancer Prevention Research

Lung cancer screening uptake in patients with rheumatoid arthritis in community settings

Maria A. Lopez-Olivo, Zhigang Duan, Huifang Lu, Robert J. Volk, Edwin J. Ostrin, Ying Xu, Sharon Giordano, Hui Zhao

Abstract Individuals with rheumatoid arthritis (RA), particularly those with a history of smoking, are at increased risk for lung cancer. However, real-world data on the use of low dose computed tomography (LDCT) screening for lung cancer in this population are lacking. Therefore, we assessed the rates, trends, and predictors of LDCT screening among patients with a smoking history and RA. A retrospective cohort study using the IQVIA PharMetrics® Plus for Academics Closed Health Plan claims database was conducted. P …

21.08.2026journal-article

Frontiers in Public Health

Influencing factors of low-dose computed tomography screening behavior among first-degree relatives of lung cancer patients based on the theory of planned behavior: a qualitative study

Si Lin, Yaming He, Weixuan Ye, Xiaokun Wu, Lixue Liang, Yinsong Chen

Objective To explore the factors influencing the screening behavior of first-degree relatives of lung cancer patients toward low-dose computed tomography (LDCT) screening based on the Theory of Planned Behavior (TPB), gain deeper insights into their subjective experiences and core demands, and provide a theoretical basis and improvement measures for enhancing screening participation rates among this high-risk population. Methods Employing a descriptive phenomenological approach, semi-structured interviews were cond …

21.08.2026journal-article

Precision Radiation Oncology

Effects of proton therapy on the tumor immune system and clinical implications: A review

Rundong Liu, Mei Tao, Min Fu, Yingjia Hu, Zhen Tao, Guangyuan Hu

Abstract Proton therapy, an emerging radiation therapy technique, has gained significant attention owing to its unique physical properties and biological effects. This review aims to explore the impact of proton therapy on the tumor immune system and of its combination with other therapies. This review outlines the fundamental principles and oncological applications of proton therapy, followed by an analysis of its impact on the immune system—encompassing draining lymph nodes, peripheral blood immune cells, tumor c …

21.08.2026journal-article

International Journal of Health Management Review

TREATMENT AND CLINICAL MANAGEMENT PROTOCOLS FOR ACUTE VIRAL BRONCHIOLITIS IN INFANTS

Max Dias Lemos, Francisco Yago Assunção Serpa, Agatha Caroline Valanera Teixeira, Giovana Boufet Zanini, Bruna Righi Bisognin, Percílio dos Santos Fernandes Júnior, Taísa Yamaguchi, Layla Monteiro de Andrade, Dayane de Castro Lopes, Maria Eduarda Silva Silton, Valeria Silva da Costa, Aline Halfeld Fernandes Vale, Tallyta Danielly de Sousa Libo, Thiago Felipe de Araújo Figuerêdo, Luísa Mattar Avezum

Objective: To critically review recent scientific evidence regarding treatment protocols and clinical management of acute viral bronchiolitis in infants, emphasizing supportive interventions, pharmacological therapies, respiratory support, and strategies for preventing respiratory syncytial virus (RSV) infection. Methods: A narrative literature review was conducted using PubMed, employing keywords related to viral bronchiolitis and therapeutic interventions. Priority was given to recent studies addressing the clini …

21.08.2026journal-article

Bioengineering

Functional Vascularization in Tumor Organoid and Tumor-on-Chip Models: Evidence Requirements for Attributing Therapy-Resistance Mechanisms

Yafang Li, Yiyi Yang, Lina Zhao, Zihao Bian, Zongjiu Zhang

Vascularized tumor organoid and tumor-on-chip models are increasingly used to examine treatment response, yet a weak therapeutic effect does not by itself identify the failed transport or biological step. Reduced efficacy may result from inadequate delivery, altered endothelial transport or signaling, stromal protection, impaired immune access or function, tumor-intrinsic resistance, or several processes acting together. A structured literature search and narrative synthesis were combined with a focused qualitative …

21.08.2026journal-article

The Oncologist

IUC26665-90 Global inequalities in prostate cancer incidence and mortality: an ecological analysis

M Hosseini, Y Vaez-Gharamaleki, A Motamedi

Abstract Background To evaluate global inequalities in prostate cancer incidence and mortality across countries with different levels of human development. Methods A cross-sectional ecological study was conducted using country-level data from the World Health Organization Global Cancer Observatory (v1.1) in June 2026. Age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) per 100,000 population in 2022 were extracted for prostate cancer. Human Development Index (HDI) was obtained from …

21.08.2026journal-article

International Journal of Molecular Sciences

17β-Estradiol Modulates Cancer Cell–Fibroblast Communication via Autophagy-Mediated Extracellular Vesicle Secretion and Promotes Poor Prognosis in Non-Small Cell Lung Cancer

Rosa Vona, Camilla Cittadini, Barbara Ascione, Lucrezia Gambardella, Katia Fecchi, Lucia Bertuccini, Annalisa Tocci, Lorenzo D’Ambrosio, Maria Cristina Gagliardi, Federica Felicetti, Elena Ortona, Paola Nisticò, Anna Maria Mileo, Paola Matarrese

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Smoking is the primary etiological factor, but growing evidence suggests the involvement of estrogen in its development and progression, although its role remains unclear. This study explores: (i) the effects induced by estrogen, namely, 17β-estradiol (E2), alone or in combination with a mixture of inflammatory cytokines (Mix), in two human NSCLC cell lines, A549 and Calu1, and (ii) whether and how tumor cells can modulate the a …

21.08.2026journal-article

Frontiers in Veterinary Science

Tumor necrosis factor alpha triggers mitochondrial dysfunction and ROS-driven cytokine amplification in bovine fibroblast-like synoviocytes

Natalia Andrea Godoy, Jan Gallastegui, Gabriela Velásquez, Stefanie Teuber, Sebastian Brauchi, John Quiroga, Pablo Alarcón, Gabriel Moran, María Angélica Hidalgo, Juan Hancke, Rafael Agustín Burgos

Lameness in dairy cattle, driven by joint inflammation, involves fibroblast-like synoviocytes (FLS) that produce inflammatory mediators and reactive oxygen species (ROS). Tumor necrosis factor alpha (TNF- α ) has been proposed as an early systemic inflammatory marker that precedes and accompanies the development of lameness in transition cows. TNF- α signaling promotes ROS production and amplifies the inflammatory response. However, the role of mitochondrial ROS (mtROS) in regulating pro-inflammatory gene expressio …

21.08.2026journal-article

Medicine

Exploration of the mechanism of gut microbiota-mediated immune modulation in the pathogenesis of pancreatic cancer

Mengwei Cai, Haonan Cheng, Yakang Jia, Tianjian Qiu, Zenghui Liu, Junyan Xu, Hui Li, Zhihao Zhang, Jin Wang

The pathogenesis of pancreatic cancer is complex. While immune dysregulation and gut microbiota disturbances are considered key factors, the causal pathway between them remains unclear. This study employs a 2-step Mendelian randomization (MR) approach to empirically investigate the “immune cells - gut microbiota - pancreatic cancer” mediation pathway from a genetic perspective. Relevant data on 731 immune cell phenotypes (N = 3757), 473 gut microbiota (N=8293), and pancreatic cancer (N = 3,87,888) were extracted fr …

21.08.2026journal-article

Annual Review of Nutrition

The Influence of Diet on Cancer Progression and Treatment

Anna M. Barbeau, John W.R. Kincaid, Alissandra L. Hillis, Edrees H. Rashan, Yichi Zhang, Gillian E. Oaks, Matthew G. Vander Heiden

Growing evidence suggests that dietary interventions can influence cancer progression and patient outcomes. Here, we discuss mechanistic links between diet and cancer biology including those related to systemic hormone signaling, modulation of nutrient availability within the tumor microenvironment, and interactions with the immune system and microbiome, while highlighting their interconnectedness. Further, we review preclinical and clinical data evaluating specific diets, including their use with cancer therapies. …

21.08.2026journal-article

Biology

Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State

Bibi Amina, Zainab Nasir, Rida Nasir Butt, Ashar Alban Chanan-Khan, Safee Ullah Chaudhary

Age-associated mitochondrial decline reduces NAD+ availability, impairs oxidative phosphorylation (OXPHOS), and leads to accumulation of reactive oxygen species (ROS) thereby reshaping cellular metabolism. However, the regulatory logic coupling mitochondrial aging to metabolic dysregulation resulting in tumorigenic cell-fate transitions has not been modeled systematically. In this work, we propose a Boolean biomolecular network model of mitochondrial aging and integrate it with metabolic, cell-cycle, and apoptotic …

21.08.2026journal-article

International Journal of Surgery Case Reports

Solid pseudopapillary neoplasm of the pancreas: a rare tumor case report

Ana C. Moreira, Daniela Lira, Maria Costa, Maria Reigota, Filipe Ribeiro, Joana Noronha

Introduction: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor, accounting for about 0.3–2.7% of pancreatic neoplasms. It mainly affects young women aged 20–40 years and usually presents as an asymptomatic abdominal mass. Although typically indolent, approximately 15% exhibit malignant potential. Complete surgical resection is curative in most cases. Presentation of the case: A 28-year-old woman was referred for a general surgery consultation due to a suspected adrenal gland mass that had been m …

21.08.2026journal-article

Journal of Eating Disorders

Help-seeking and accessing treatment for eating disorders: a systematic review of qualitative studies with a focus on ethnic differences

Melissa Chang, Manvir Dobb, Helena Tuomainen

Abstract Background Eating disorders (ED) are serious mental health conditions characterised by disordered eating behaviour and associated emotional distress. EDs are associated with high rates of mortality and morbidity, yet rates of help-seeking remain low. There is a misconception that EDs only affect “skinny, white, affluent girls” (SWAG) although anyone can be affected. Likewise, despite similar rates in minoritised ethnic communities, studies suggest that help-seeking from these populations remain low. The ai …

21.08.2026journal-article

Egyptian Journal of Medical Human Genetics

Association between out-seed miRNA variants targeting WNT/NOTCH signaling and breast cancer risk in Vietnamese women

Thanh Thi Ngoc Nguyen, Thuy Thi Chung Duong, Nga Thi Nguyen, Luan Huu Huynh, Hue Thi Nguyen

Abstract Background Breast cancer susceptibility is shaped by regulatory variation that may act in a subtype-dependent manner, yet miRNA polymorphisms, particularly those in the out-seed region that can modulate non-canonical target pairing, remain underexplored in Vietnamese populations. Methods A pathway-informed case–control study was conducted with 50 breast cancer patients and 50 non-cancer controls to evaluate 23 single-nucleotide polymorphisms located in miRNA out-seed regions. These SNPs were predicted in-s …

21.08.2026journal-article

Supportive Care in Cancer

From optimistic to overwhelmed: exploring health beliefs and barriers to oral anticancer medication adherence among cancer survivors

Meng-Jung Wen, Maite A. Zapata, Olayinka O. Shiyanbola

Abstract Purpose This study explored cancer survivors’ health beliefs about oral anticancer medications (OAMs) and examined how these beliefs influence adherence-related decision-making, while identifying barriers and strategies to support cancer management. Methods Twelve patients with cancer using OAMs, previously categorized into three health belief profiles, were interviewed virtually. Thematic analysis and theme mapping were used to examine the complexity of how survivors formed beliefs about cancer and OAM us …

21.08.2026journal-article

Current Oncology Reports

Cardiac Monitoring for Patients Undergoing Treatment With MEK Inhibitor Monotherapy

Jondavid Menteer, Devorah Segal, Stefania Maraka, Laura J. Klesse, Prakash Ambady, Michael G. Fradley

Abstract Purpose of Review Aberrant activation of the RAS-RAF-MEK-ERK signaling pathway contributes to numerous malignancies, congenital syndromes, and cardiovascular disorders, establishing MEK inhibitors (MEKi) as crucial therapeutic agents. MEKi demonstrate substantial clinical benefit as monotherapy (e.g., NF1-associated tumors) or combination therapy (e.g., melanoma, glioma, congenital RASopathies). Cardiovascular adverse events, primarily asymptomatic reductions in left ventricular ejection fraction (LVEF), h …

21.08.2026journal-article

JMIR Cancer

Digital Health Interventions and Psychosocial Outcomes in Women With Breast Cancer: Systematic Review

Rocío Zúñiga-Tapia, Mercè Boixadós, Eulàlia Hernández Encuentra

Abstract Background Breast cancer and its treatment can negatively affect women’s quality of life (QoL), including physical, psychological, and social well-being. Digital health interventions have been increasingly used to provide supportive care, but their effectiveness on QoL and related psychosocial outcomes remains unclear. Objective This review aimed to evaluate the effectiveness of digital health interventions on QoL in women with breast cancer and to assess their effects on anxiety, depression, and self-effi …

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21.08.2026journal-article

Kufa Journal for Veterinary Medical Sciences

Differential Cytotoxic and Morphological Effects of Curcumin and Etoposide on MCF-7 Breast Cancer Cells

Ali D. Hadi, Bushra H Faris, Murtadha A AL-Mudhafar

Curcumin, a turmeric-derived polyphenol, modulates apoptotic signaling and cell-cycle control, whereas etoposide, a topoisomerase II inhibitor, exerts cytotoxicity by inducing DNA strand breaks. To delineate their relative actions on tumor cell viability, the objective was to directly compare the dose-dependent cytotoxic and anti-proliferative effects of curcumin and etoposide in ER-positive MCF-7 breast cancer cells, quantifying changes in viability and survival across graded concentrations and characterizing atte …