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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Targeting EGFR in lung cancer: lessons in signal transduction and treatment-induced mutagenesis

Arturo Simoni-Nieves, Marieke Van Daele, Harrison B. Konsker, Yosef Yarden

Abstract The epidermal growth factor receptor (EGFR) plays pivotal role in cancer promotion and progression, particularly in non-small cell lung cancer (NSCLC), where activating EGFR mutations drive tumour growth. Targeted therapies, such as tyrosine kinase inhibitors (TKIs), have improved patient survival rates, but resistance inevitably develops through mechanisms ranging from secondary mutations to bypass signalling pathways and histological transformation. A key factor in resistance development is the emergence …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Transjugular intrahepatic portosystemic shunt via the caudate lobe portal vein due to anatomic variation: Two case reports

Tao Xu, Xiao-Huan Lai, Qiao-Xia Ye, Li-Guan Liu, Zheng-Ju Xu

BACKGROUND The target sites for transjugular intrahepatic portosystemic shunt (TIPS) treatment of esophageal and gastric varices are typically the left and right branches of the portal vein and its confluence. In clinical practice, the puncture needle may inadvertently puncture secondary branches or other smaller branches of the portal vein. It was observed that when the caudate lobe portal vein (CLPV) was successfully targeted, a covered stent can be effectively placed. CASE SUMMARY This study reports two patients …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Incidence and risk factors of poor wound healing following emergency surgery for intestinal tuberculosis

Qian He, Juan-Min Xue, Jian-Feng Weng, Xia-Nan Li, Cai-Xia Zhang

BACKGROUND Intestinal tuberculosis accounts for 11%-16% of extrapulmonary tuberculosis cases and frequently mimics Crohn’s disease or intestinal neoplasms due to nonspecific clinical presentations. When complicated by obstruction, perforation, or hemorrhage, emergency surgery becomes necessary. These patients often present with malnutrition, anemia, and immune dysfunction, substantially increasing the risk of poor postoperative wound healing a complication that prolongs hospitalization and predisposes patients to i …

27.08.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Recent advances in arterial spin labeling MRI for imaging brain tumors

Gabriel Hoffmann, Matthias J. P. van Osch

Abstract Perfusion MRI plays an important role in brain tumor assessment, especially for tumor grading and differentiation of tumor progression from pseudoprogression. Arterial spin labeling (ASL) MRI is a non-invasive method for measuring cerebral blood flow (CBF) using blood water as an endogenous tracer, which has great clinical potential for brain tumor imaging and might help to lower the use of gadolinium-based contrast agents. In this review, we discuss recent advances of the ASL method with a special focus o …

27.08.2026journal-article

Journal of Applied Clinical Medical Physics

Fast fourier transform based spectral features for machine learning prediction of gamma passing rates in virtual VMAT PSQA: A feasibility study

Bing Yan, Hu Peng, Xudong Xue, Chichao Zheng, Aidong Wu

Abstract Purpose This study aimed to evaluate the feasibility of fast Fourier transform (FFT) based spectral features for predicting volumetric modulated arc therapy (VMAT) gamma passing rates (GPRs) in virtual patient‐specific quality assurance (PSQA). Methods A total of 481 VMAT treatment plans were retrospectively collected. Multileaf collimator (MLC) trajectories and monitor units (MU) were extracted from control points (CPs) and interpolated onto a uniform gantry‐angle grid. FFT‐based power spectra were then c …

27.08.2026journal-article

Medical Sciences

Clinical Remission Trajectories Beyond 12 Months in Severe Asthma Patients Continuing a Single Biologic: A Real-World Single SANI Center Cohort

Simone Negrini, Stefania Nicola, Francesco Sardanapoli, Rocco Francesco Rinaldo, Marco Russo, Iuliana Badiu, Anna Quinternetto, Luca Lo Sardo, Francesco Blasi, Pierluigi Paggiaro, Enrico Heffler, Giovanni Rolla, Caterina Bucca, Giorgio Walter Canonica, Fulvia Ribolla, Paolo Solidoro, Luisa Brussino

Background: Clinical remission is an emerging therapeutic goal in severe asthma treated with biologics. However, remission may evolve beyond the conventional 12-month assessment, and limited real-world data are available on patients who continue the same biologic after incomplete remission at 12 months. We evaluated longitudinal remission trajectories in patients with severe T2-high asthma continuing the same biologic therapy. Methods: This retrospective real-world single-center SANI cohort included adults with sev …

27.08.2026journal-article

Archiv Euromedica

SOCIAL MEDIA AND MENTAL HEALTH SELF-DIAGNOSIS: RISKS, BENEFITS, AND CLINICAL IMPLICATIONS FOR ADOLESCENTS AND YOUNG PEOPLE

Bogna Błachowska, Wojciech Frączyk, Agata Świątek, Kamil Andruszkiewicz, Bartosz Machnio, Natalia Jasińska, Mateusz Krysiak, Natalia Turzyńska, Katarzyna Mania, Julia Bąk, Agnieszka Stankowska

Background Adolescents increasingly use social media platforms, including TikTok, Instagram, and Reddit, to obtain information about mental health and psychiatric disorders. Such content may facilitate mental health literacy, validation, and help seeking, but may also expose users to misinformation, oversimplified diagnostic narratives, and algorithmically reinforced content. Aim To examine the potential benefits and risks of mental health self-diagnosis through social media among adolescents and young people, with …

27.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Plant‐Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection

Jindong Dai, Xue Xia, Xincheng Hu, Thangamani Kanagaraj, Kanagaraj Rajalakshmi, Mangirish Deshpande, Natarajan Kiruthiga, Dongwei Zhu, Yisun Fan

ABSTRACT Rheumatoid arthritis (RA) represents a persistent autoimmune disease that causes continuous joint inflammation and results in synovial tissue overgrowth and worsening cartilage breakdown together with degeneration of bones. The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant‐derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide …

27.08.2026journal-article

Frontiers in Medicine

Treatment and clinical outcomes among stage II–IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA

Ci-ming Sun, Zhen Xu, Cheng-hao Li, Jun-xiang Chen, Xin-yi Su, Jing-xia Song, Shuang-hong Song, Qing-qing Xu, Yan-Ling Wu

Background This study analyzed the efficacy of multiple combined chemotherapy modalities on the long-term survival outcomes in stage II–IVA nasopharyngeal carcinoma (NPC) patients with undetectable pretreatment Epstein-Barr viral DNA (pre-DNA). Patients and methods We retrospectively analyzed 2,440 patients with stage II–IVA NPC with undetectable pre-DNA. Patients received any of the following treatment modalities: intensity-modulated radiotherapy (IMRT) alone; concurrent chemoradiotherapy (CCRT); induction chemoth …

27.08.2026journal-article

Journal of Medical Internet Research

Stigmatizing Language in Gender-Expansive Patient Records: Corpus Development, Disparity Analysis, and Natural Language Processing–Based Detection Study

Liyang Xue, Mary Chayko, Vivek Kumar Singh

Background Stigmatizing language (SL) in electronic health records (EHRs) can influence clinical decision-making, propagate bias across care encounters, and undermine patient trust. Gender-expansive patients (GEPs) may be particularly vulnerable to documentation-based stigma; however, large-scale quantitative evidence and fairness-aware evaluation of automated SL detection methods remain limited. Objective This study aims to construct a gender-expansive-inclusive EHR corpus, quantify demographic disparities in SL u …

27.08.2026journal-article

International Journal of Sports Medicine

Post-Exercise Circulatory Occlusion Differently Affects Soleus Spinal/Supraspinal Excitability

André D. Gonçalves, Andréia Terra, Rodrigo Marques, Pedro Pezarat-Correia, Carolina Vila-Chã, Goncalo V Mendonca

Abstract Post-exercise circulatory occlusion allows the investigation of the effects of group III/IV muscle afferent feedback on central nervous system responsiveness. This study explored the effects of post-exercise circulatory occlusion on soleus H- and V-wave excitability. Following a randomized-crossover design, in 1 day, 16 healthy men (24.6±3.5 y) completed a 3-minute sustained plantar-flexion contraction at 40% of maximal voluntary isometric contraction. Then, for testing, a cuff was inflated around the ipsi …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Mediating Role of Rumination in the Relationship Between University Students' Attachment Dimensions and Future Anxiety

İlayda Üçer, Manolya Çalışır

The purpose of this study is to examine the mediating role of ruminative thought processes in the relationship between attachment dimensions and future anxiety among college students. To this end, 420 participants were included in the study. Participants completed the Sociodemographic Information Form, the Experiences in Close Relationships Inventory II, the Rumination Response Scale, and the Future Anxiety Scale for College Students online. According to the study results, there are positive correlations between th …

27.08.2026journal-article

Veterinary Medicine and Science

Clinical Case and Follow‐Up of Babesia banethi Infection in a Red Fox

Mariaelisa Carbonara, Michela Prioletti, Antonio Camarda, Stefano Castellana, Giuseppe Menga, Giovanna Girardi, Gad Baneth, Domenico Otranto

ABSTRACT Background Red foxes play an important role in the circulation of ticks and tick‐borne pathogens, including Babesia spp. While for Babesia vulpes many studies are available on its epidemiology in fox populations as well as pathogenicity in dogs, no data are reported for the recently described Babesia banethi infecting red foxes. Objective Here we describe the clinical and parasitological follow‐up of a naturally occurring B. banethi infection in a red fox from southern Italy. Case presentation An adult mal …

27.08.2026journal-article

Journal of Clinical Medicine

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Haoruo Zhang, Yanfeng Tian, Songqing Yang, Rui Cao, Haoran Jing, Chunlin Gong, Jiaoyue Zhong, Yuran Chen, Siting Hong, Zhaojun Wang

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibility and short-term outcomes of percutaneous endocardial septal pulsed field ablation in patients with symptomatic hypertrophic obstructive cardiomyopathy. Methods: Five patients with symptomatic hypertrophic obstructive cardiomyopathy and …

27.08.2026journal-article

Visualization in Medicine

Галерея истории лучевой диагностики

Татьяна Николаевна Трофимова, Наталия Александровна Карлова, Марина Геннадьевна Бойцова, Ярослав Петрович Зорин, Ирина Григорьевна Камышанская

Первая в мире виртуальная Галерея истории лучевой диагностики открылась в октябре 2025 г. в Санкт-Петербургском государственном университете (СПбГУ). Мультимедийный ресурс посвящен развитию рентгенологии в России и охватывает все направления лучевой визуализации от момента открытия рентгеновского излучения до наших дней. В основу виртуальной Галереи истории лучевой диагностики была положена концепция сохранения исторических материалов, фотографий, воспоминаний врачей, ученых, персонала отделений лучевой диагностики …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Role of Anima-Animus Balance in Relationships and Its Psychopathological Reflections: A Review within the Framework of Analytical and Clinical Psychology

Gamze Küçükaslan, Reşat Güven, Buse Odabaşı, Deniz Ergün

This study is a systematic review examining the role of anima and animus archetypes in the spiritual integration processes of individuals, their effects on interpersonal relationships, and their psychopathological manifestations within the framework of Carl Gustav Jung’s analytical psychology theory. Anima and animus are defined as opposite-sex archetypes located in the unconscious of the individual and play a decisive role in the individuation process. In this context, the effects of anima and animus on the indivi …

27.08.2026journal-article

International Journal of Translational Medicine

Efficacy of Doxycycline as Monotherapy or in Combination with Levofloxacin in Treating Late-Stage Systemic Anthrax in Non-Human Primates

Amir Ben-Shmuel, Assa Sittner, Itai Glinert, Elad Bar-David, Josef Schlomovitz, Haim Levy, Shay Weiss

Background: Bacillus anthracis spores pose a major biosecurity threat, in light of their use in several documented bioterror attacks and the fact that it was weaponized. The absence of specific and accurate treatment instructions in the 2001 anthrax letter attacks and the poor prognosis of patients receiving ineffective treatment emphasized the need for reliable guidelines for treating exposed (prophylaxis) or symptomatic populations. The recent 2023 CDC guidelines for treating systemic anthrax recommend a combined …

27.08.2026journal-article

Frontiers in Oral Health

Comparative effectiveness of therapeutic ultrasound and pharmacotherapy in the management of muscular temporomandibular disorders: a randomized clinical trial

M. Subhikshaa, Prathima Shetty, K. M. Veena, Prashanth Shenoy, Rachana Prabhu, Laxmikanth Chatra

Introduction Temporomandibular disorders (TMDs) of muscular origin are a common cause of chronic orofacial pain and functional limitation. Conservative management includes pharmacotherapy and physiotherapeutic modalities such as therapeutic ultrasound. However, evidence directly comparing their effectiveness remains limited. This randomized clinical trial compared therapeutic ultrasound and pharmacotherapy in reducing pain intensity and improving mandibular function in patients with muscular TMDs. Materials and met …

27.08.2026journal-article

Frontiers in Neurology

“Internal carotid artery-type cervical spondylosis” is not supported as an independent subtype: a perspective on diagnostic classification and clinical differentiation

Tianjun Zhai, Yeping Chen, Wei Feng, Hui Zhang

Cervical spondylosis is a common degenerative disorder, yet its diagnostic boundaries may be inappropriately expanded when nonspecific symptoms such as dizziness coexist with age-related cervical imaging changes. This Perspective evaluates the hypothetical concept of “internal carotid artery-type cervical spondylosis” and whether it qualifies as an independent clinical subtype. Using an adapted validity–utility framework, the proposed entity was assessed according to five criteria: a specific anatomical relationshi …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Refined endoscopic technique combined with cold forceps polypectomy for diminutive colorectal polyps

Xue-Man Wang, Qin-Wei Xu, Yu-Zhen Bi, Quan Luo, Bo Lian, Jian Dong, Xin-Tong Jiang, Jun Zhang

BACKGROUND The most appropriate endoscopic management for small (≤ 5 mm) colorectal adenomas has not yet been well established. Although cold snare polypectomy (CSP) is recommended by the guidelines, cold forceps polypectomy (CFP) remains a popular technique because it is easy to perform. However, previous data have suggested that a modified CFP technique using jumbo biopsy forceps, post-resection narrow-band imaging (NBI), and submucosal injection can yield high en bloc resection rates. AIM To assess the performan …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Endoscopic management of common bile duct stump fistula after choledochojejunostomy: A case report

Wen-Fei Wang, Zhen-Yu Qiao, Zhuang Li, Ke-Zhong Zheng, Deng-Qun Sun, Ming-Hui Sheng

BACKGROUND Common bile duct (CBD) stump fistula after choledochojejunostomy is an exceedingly rare phenomenon. We report a unique case suffering from pancreaticobiliary reflux. CASE SUMMARY A 73-year-old man underwent Roux-en-Y end-to-side choledochojejunostomy for recurrent CBD stones. Fourteen days after surgery, the patient presented with high-amylase bile drainage (3192 U/L). Imaging revealed a CBD stump fistula. Endoscopic retrograde cholangiopancreatography showed pancreaticobiliary maljunction and sphincter …

27.08.2026journal-article

Journal of Clinical Medicine

Bad Ragaz Ring Method Versus Halliwick Method in Verbally Cooperative Children with Spastic Cerebral Palsy (GMFCS Levels I–II): A Pilot Comparison Study

Na-Yeon Ye, Eun-Ju Lee

Background/Objectives: Aquatic therapy is widely used for children with cerebral palsy (CP), but existing approaches such as the Halliwick method focus primarily on postural control and mobility with limited active resistance exercise. The Bad Ragaz Ring Method (BRRM) integrates proprioceptive neuromuscular facilitation (PNF) diagonal patterns with closed kinetic chain (CKC) exercise in the aquatic environment, yet its direct application to children with spastic CP has rarely been examined. This pilot study compare …

27.08.2026journal-article

Revista ft

Capacitação da equipe de clínica médica quanto às atualizações do manejo agudo hospitalar de fibrilação atrial de alta resposta ventricular

Victor Souza Nobre, Marilia Mendes de Saboya, Felipe de Araújo Lucena, Camila Amora Santos Albuquerque D’Alva, Natália Marinho Porto Lima, Luiza Targino Studart, José de Ribamar Barroso Jucá Neto

Atrial fibrillation with rapid ventricular response is a common condition in the hospital setting and requires prompt recognition, assessment of hemodynamic stability, and evidence-based therapeutic decision-making. Given the variability in clinical management and the need for professional updating, this study aims to train the Internal Medicine medical team on current recommendations for the acute hospital management of atrial fibrillation with rapid ventricular response, with the goal of standardizing clinical pr …