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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Clinical Medicine

Surgical Management of Hidradenitis Suppurativa Using Staged Carbon Dioxide Laser Marsupialization

Sydney R. Resnik, Alexander R. Gomez-Lara, Lauren Fernandez, Irena Pastar, Akhil Wadhera, Paul G. Hazen, Barry I. Resnik

Background: Hidradenitis suppurativa (HS) is a chronic disease marked by symptoms of pain, drainage, and odor. Persistent abscesses, nodules, and scarred tunnels can be resistant to pharmacologic management, with chronic lesions often requiring complex surgical intervention. Treatments include en bloc excision with primary closure, tissue flaps or skin grafts. Such procedures are associated with post-operative challenges, including pain, infection, contractures, and high recurrence rates. Methods: Herein we report …

28.08.2026journal-article

World Journal of Gastroenterology

P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis

Yu-Wei Liu, Yi-Ke Chen, Jin-Yang Yan, Hua Shen, Fang-Ming Mai, Zheng-Hui Kong, Hui-Long Chen, Li-Ping Li, Wei-Ping Liu, Yong Gao, Lun Zhang

P-element-induced wimpy testis (PIWI)-interacting RNAs are a class of small non-coding RNAs, typically 24–31 nucleotides in length. They function by binding to PIWI proteins and play important roles in gene regulation. Initially identified in germline cells, PIWI-interacting RNAs (PiRNAs) mediate transposon silencing and maintain genomic integrity. Accumulating evidence indicates that, beyond their roles in mammalian germ cells, PiRNAs are also aberrantly expressed in a variety of human cancers, where they particip …

28.08.2026journal-article

Gastroenterologie a hepatologie

Severe upadacitinib-induced anemia in a multi-refractory Crohn’s disease patient – a case report

Anna Gojdicova, Igor Sturdik, Juraj Toth, Stanislav Majna, Jana Skubakova, Michaela Granak-Pytliakova, Tibor Hlavaty

Úvod: Inhibítory Janusovej kinázy (JAK) predstavujú účinnú perorálnu liečebnú možnosť pri stredne ťažkej až ťažkej forme zápalového ochorenia čriev (IBD), ktoré nereaguje na konvenčné a biologické lieky. Boli hlásené hematologické nežiaduce účinky, avšak závažná myelosupresia je zriedkavá a jej klinické zvládnutie – najmä rozhodnutie o pokračovaní liečby u pacientov, ktorí z nej majú podstatný prínos – naďalej predstavuje výzvu. Popis prípadu: Predkladáme prípad 45-ročnej ženy s Crohnovou chorobou postihujúcou hrub …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Dermatoses as an iatrogenic complication of invasive device-based procedures

O.I. Letyaeva, T.V. Trapeznikova, V.O. Gubina

Background. In modern cosmetology, high-intensity energy-based technologies, which utilize the interaction of physical modalities with biological tissues, are effectively and widely used. These manipulations will disrupt the epithelial barrier, activating the tissue regeneration process. In some cases, adverse events or iatrogenic complications may develop, requiring additional medical intervention. Dermatitis after invasive device-based procedures can arise from clinician non-compliance with treatment protocols or …

28.08.2026journal-article

eLife

Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

Tess Cherlin, Stephanie Mohammed, Samantha Strydesky, Sasha Ottey, Katherine Sherif, Shefali Setia Verma

Background: Polycystic ovary syndrome (PCOS), recently renamed as polyendocrine metabolic ovarian syndrome (PMOS), is a prevalent endocrine disorder in women, often accompanied by various symptoms, including significant pain, such as dysmenorrhea, abdominal, and pelvic pain, which remains underexplored. Methods: This retrospective study examines electronic health records (EHR) data to assess the prevalence of pain in women with PMOS. Conducted in January 2026, using data from 120 Health Care Organizations within th …

28.08.2026journal-article

Clinical Pharmacology & Therapeutics

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju

Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to contribute substantially to preventable morbidity and mortality. Long‐acting therapeutics (LATs) may help address selected pediatric health priorities by sustaining the …

28.08.2026journal-article

Journal of Patient Safety and Risk Management

Patient safety in hospital dentistry: A model for dentists without operating room privileges

Amal Al-Khotani, Reem Turkiastani, Hiba Alahmadi

A lack of compliance with professional privileging and training requirements is the most common cause of dental malpractice. In hospital dentistry, some dental specialties are trained to treat patients in the operating room, whereas others, including restorative dentists, endodontists, prosthodontists, and periodontists, are occasionally required for dental management under general anesthesia, yet typically hold no operating room privileges. This creates a gap in standardized care and patient-safety compliance. To …

28.08.2026journal-article

Italian Journal of Medicine

Prospective observational studies in clinical research: pros and cons

Luca Bertolaccini, Matteo Nicoletto, Paola Piccolo, Fulvio Pomero

Prospective observational studies are essential in clinical research, mainly when randomized controlled trials (RCTs) are infeasible, unethical, or impractical. These studies involve the prospective collection of data from cohorts stratified by exposure status, allowing investigators to observe the natural progression of outcomes while preserving temporality. Their main strengths include measuring incidence, assessing multiple outcomes, and avoiding recall bias, thus offering valuable insights into real-world clini …

28.08.2026journal-article

World Journal of Gastroenterology

Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases

Tian-Shuai Zhang, Xiao-Ming Zhu, Rong-Bo Wen, Le-Qi Zhou, Hai-Feng Gong, En-Da Yu, Hao Wang, Gang Li, Wei-Ping Zhou, Li-Qiang Hao, Guan-Yu Yu, Wei Zhang

BACKGROUND Simultaneous resection of colorectal cancer liver metastases (CRLM) has been widely adopted; however, clinical efficacy still varies across different surgical approaches, and the best surgical strategy remains controversial. AIM To investigate the efficacy and safety of laparoscopic hybrid surgery (LHS) vs total open surgery (TOS) the in simultaneous resection of CRLM. METHODS This was an observational study conducted at a tertiary medical center, enrolling 266 patients who undergoing simultaneous resect …

28.08.2026journal-article

Journal of Perinatal Medicine

Ultrasound-based prediction of fetal hyperinsulinemia: development of a fetal metabolic score

Roberto Noya Galluzzo, Karine Souza Da Correggio, Aldo von Wangenheim, Heron Werner, Edward Araujo Júnior, Gustavo Yano Callado, Alexandre Sherlley Casimiro Onofre

Abstract Objectives Gestational diabetes mellitus (GDM) is associated with fetal hyperinsulinemia, excessive adiposity, and adverse perinatal outcomes; sonographic markers of fetal adiposity, liver enlargement, and septal thickening may allow direct assessment of fetal metabolic adaptation. This study aimed to develop an ultrasound-based fetal metabolic score (FMS) estimating the risk of fetal hyperinsulinemia. Methods The FMS was developed from a prospective cohort of 223 pregnant women (128 with GDM, 95 controls) …

28.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/ G3BP1 Axis

Ke Li, MeiXia Li, XueQiang Pan, JiaWen Xu, Rui Jiang

ABSTRACT Background and Objective Brucea javanica oil emulsion (BJOE), a traditional Chinese medicine extract, has been demonstrated to possess antitumor activity in multiple cancers. However, its molecular mechanisms in breast cancer, particularly those involving circRNAs, remain unclear. This study investigates whether BJOE exerts its anti‐breast cancer effects by inducing autophagy and apoptosis through regulating hsa_circ_0001589/G3BP1/PAX6 signalling axis. Methods After BJOE treatment of MCF‐7 cells, cell viab …

28.08.2026journal-article

European Journal of Plastic Surgery

A novel indication of Glyaderm®: its use as a nerve wrap in the treatment of compression neuropathies

Milly van de Warenburg, Claire van Houdt, Stefan Hummelink, Till Wagner

Abstract Background Fibrotic changes following surgical decompression of nerve entrapment can restrict nerve regeneration, and exert pressure on the nerve, leading to symptoms of recurring entrapment. This case series reports on the outcomes of using Glyaderm® (ETB-BISLIFE Multi Tissue Center, The Netherlands) as a low-cost, customizable, and biocompatible nerve wrap in patients with recurrent or post-traumatic compression neuropathies, highlighting its potential benefits as a neuroprotective shield. Methods We rev …

28.08.2026journal-article

Journal of Innovations in Materials and Manufacturing Engineering

Influence of Heat Treatment and Thermal Aging on the Fatigue Performance of LPBF Fabricated AlSi10Mg Alloy

Edel Arrieta, Luis A. Marquez, Lawrence E. Murr, Diego A. Ariza, Mark Benedict, Jason Thomas, James Carney, Francisco Medina

This investigation explores fatigue performance of laser powder bed fusion (LPBF)-fabricated AlSi10Mg alloy subjected to various post-processing treatments: stress relief (SR), Hot Isostatic Pressing (HIP), and HIP + T6, all followed by prolonged thermal aging at 177 °C for up to 1000 h. Microstructural evolution, hardness, density, and uniaxial fatigue performance, including SEM fractography, were examined to recommend practical service life thresholds. Microstructural analysis confirmed that HIP and HIP + T6 trea …

28.08.2026journal-article

Education in Medicine Journal

Fostering Excellence in English Academic Writing Among Health Profession Students and Lecturers: An Action Research

Izzudeen Ayub, Megat Mustaqim Megat Iskandar, Siti Yusrina Nadihah Jamaludin, Yasrul Izad Abu Bakar, Mohd Salami Ibrahim

Academic writing is a critical skill for researchers and educators. However, many, especially in nonnative English-speaking contexts, face challenges in mastering it. This study employed action research (AR) involving 27 participants to address these challenges through the design and implementation of an academic writing workshop for postgraduate students and lecturers from the Facultiesof Medicine, Health Sciences, and Pharmacy. The AR workshop integrated hands-on learning, structured guidance, and innovative tool …

28.08.2026journal-article

Journal of Clinical Medicine

The Three Faces of IgA Nephropathy: Clinicopathological Heterogeneity and Urinary Albumin-to-Protein Ratio in a Case Series

Anna Masajtis-Zagajewska, Blazej Kieszek, Michał Nowicki

Background/Objectives: IgA nephropathy (IgAN) is a highly heterogeneous glomerular disease with variable clinical presentation and response to therapy. Standard histopathology provides a static assessment and may not fully reflect dynamic podocyte injury. The objective of this case series was to characterize distinct clinical phenotypes of IgAN and explore the relationship between urinary protein composition assessed by the urine albumin-to-protein ratio (uAPR) and ultrastructural glomerular injury. Methods: We ret …

28.08.2026journal-article

Tropical Medicine and Infectious Disease

Application of Genomics to Prevent and Combat Emerging Infectious Disease Threats in Latin America: Perspectives from an Overseas U.S. Navy Research Command

Hugo O. Valdivia, Maria Silva, Cristopher D. Cruz, Paul Rios, Marisa E. Lozano, Julia S. Ampuero, Yeny Tinoco, Jeffrey Spiro, Yuliya S. Johnson, Alden S. Estep, Steev Loyola, Carmen Flores-Mendoza, Gissella M. Vasquez, Jose A. Garcia-Rivera, Henju Marjuki

Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of these diseases. High-throughput sequencing technologies have become a critical resource for the field of infectious disease monitoring, specifically for tracking pathogen evolution, antimicrobial resistance, and transmission. This review prov …

28.08.2026journal-article

Hippocrates Medical Journal

When Artificial Intelligence Speaks For The Obstetrician: Multilingual Accuracy On Real Patient Questions

Alihan Tığlı, Yakup Baykuş, Rulin Deniz, Sefer Üstebay, Muammer Hayri Bektaş, Çağdaş Çöllüoğlu

BackgroundThe use of generative large language models (LLMs) in healthcare is rapidly increasing, offering easier access to medical information. However, comprehensive data on their multilingual accuracy and the reliability of cited scientific references remain limited. This study aimed to compare the response accuracy and reference quality of three free LLMs (ChatGPT, Google Gemini, DeepSeek) in Turkish and English using common pregnancy-related questions.MethodsIn this comparative observational study, 14 frequent …

28.08.2026journal-article

Gynecology Obstetrics & Reproductive Medicine

Longitudinal Assessment of Fetal Ductus Arteriosus Morphometry: Establishing Gestational Age-Specific Reference Values

Murat Cagan, Umutcan Kayikci, Erdem Fadiloglu, Ayse Cigdem Bayrak, Edip Alptug Kir, Hayrettin Hakan Aykan, Ozgur Deren

OBJECTIVES: To longitudinally evaluate fetal ductus arteriosus (DA) morphometric changes and establish normative reference values between 18 and 36 weeks of gestation. STUDY DESIGN: This prospective cohort study included 29 pregnant women with structurally normal singleton fetuses and confirmed gestational ages. Each participant underwent serial standardized ultrasound examinations to evaluate DA length and proximal, mid, and distal diameters. We defined weekly growth trends using regression analyses and assessed c …

27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Systematic evaluation of foundation models for organ-level classification on CT scans

Jan Tagscherer, Sarah de Boer, Fennie van der Graaf, Lena Philipp, Colin Jacobs, Ewoud J. Smit, Alessa Hering

Abstract Purpose Foundation models are increasingly used as frozen feature extractors for CT classification tasks, yet the determinants of their downstream performance remain unclear. We assess how foundation model choice, feature aggregation strategy, and abnormality type are associated with performance in organ-level abnormality classification. We further evaluate whether more expressive aggregation strategies outperform simple pooling, and whether performance varies by abnormality type. Methods We evaluate five …

27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (<4 weeks duration) underwent clinical, psychometric, and functional mag …

27.08.2026journal-article

International Journal of Molecular Sciences

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Andressa Oliveira Peixoto, Larissa Ferreira Selicani, Camila Bento Safi, Daniela Souza Paiva Borgli, Adyléia Aparecida Dalbo Contrera Toro, Nathália Mariana Santos Sansone, Andrea de Melo Alexandre Fraga, Fernando Augusto Lima Marson, José Dirceu Ribeiro

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This retrospective study aimed to clinically characterize individuals with cystic fibrosis who developed HHMA, characterize their CFTR genetic profile and compare it with that of other individuals with cystic fibrosis followed at a Brazilian te …

27.08.2026journal-article

Cancers

Trends in Treatment and Survival Among Patients with Glioblastoma in the United States from 2000 to 2020

Jianan Chen, Catherine M. Boldig, Qiong Wu, Hannah M. Cardenas, Kaitlyn N. Bernard, Kwadwo Darko, Patrick T. Grogan, Yu Sun, Robert J. Macaulay, Ekokobe Fonkem, Arnold B. Etame

Background: Population-level patterns in the real-world use of initial treatment combinations for glioblastoma (GBM) remain poorly characterized. Materials and Methods: We assessed temporal trends in treatment and survival among patients with GBM in the SEER registry. Guideline-concordant multimodal therapy was defined as cancer-directed surgery combined with radiotherapy and chemotherapy. Outcomes were further stratified by extent of resection, including gross total resection (GTR) versus subtotal resection. Resul …

27.08.2026journal-article

Pigment International

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Dalitso Namutowe, Yun Xu, Jin Gong

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the transition from aggressive mono-therapies to a multi-layered, synergistic approach. To locate, select, and extract relevant data, a comprehensive search of recent clinical protocols and emerging technological studies was conducted. This literat …