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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Healthcare

Association of Physical Activity with Psychological Distress and Poor Mental Health Days Among Informal Caregivers of Older Adults: Findings from the 2023 BRFSS Caregiver Module

Damián Pereira-Payo, Raquel Pastor-Cisneros, María Mendoza-Muñoz, Amparo Rodríguez-Gutiérrez

Background/Objectives: Informal caregivers of older adults are a high-burden population for psychological problems, yet evidence on the relationship between physical activity (PA) and mental health in this population is still limited. The aim of this work is to examine the association between PA status and self-reported mental health indicators (psychological distress and the number of poor mental health days) among caregivers of older adults. Methods: This cross-sectional study used data from the 2023 Behavioral R …

27.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Lifestyle activities and risk of incident dementia from linked insurance claims in the Baltimore Experience Corps Study

Kyle D Moored, Vishaldeep K Sekhon, Qian-Li Xue, Jeanine M Parisi, Halima Amjad, George W Rebok, Dana A Eldreth, Michelle C Carlson

Abstract Objectives Lifestyle activity engagement in later life may protect against dementia, but studies have often been limited to short follow-up periods and predominantly White samples. We examined activity variety and frequency as predictors of incident dementia, leveraging 15 years of linked longitudinal insurance claims data in the Baltimore Experience Corps Study (BECS). Methods Participants were 482 individuals from BECS (2006-2013) with linked insurance claims (mean age=68.2, 84% women, 95% Black/African …

27.08.2026journal-article

Archiv Euromedica

QUALITY MANAGEMENT IN RESISTANCE TRAINING PROGRAMS FOR OLDER ADULTS: A NARRATIVE REVIEW

Maciej Łabuś, Aleksandra Skawińska, Tomasz Wołoszczuk, Zofia Graca, Jakub Kołodziej, Aleksandra Skowronek, Julia Jeziorna, Elżbieta Siudmak, Agnieszka Sawina, Adam Iwanicki

Background Aging is associated with declines in muscle strength, muscle mass, and physical function, which increase the risks of falls, disability, and loss of independence. The effectiveness and safety of resistance training depend on both exercise prescription and program implementation. Aim This narrative review aimed to systematize the principal components of quality management in resistance training programs for older adults, summarize their effects on functional and health outcomes, and examine how program qu …

27.08.2026journal-article

Journal of International Relations and Development

Geopolitical imaginations and construction of ‘the people’: Turkey’s populist spatial logic in its engagement with Africa

Hamid Talebian, Mira Demirdirek

Abstract Research on foreign policy at the intersection of International Relations, critical geopolitics and the study of populism remains limited, particularly regarding emerging powers. While political geographers have shown that foreign policy is shaped by geopolitical imaginations, little attention has been paid to how populist logics inform the spatial articulation of such imaginaries. The article addresses this gap by introducing ‘Populist Spatial Logic’ (PSL) as a conceptual lens for analysing how space and …

27.08.2026journal-article

Blood Pressure Monitoring

Effects of home-based isometric handgrip or aerobic training on blood pressure variability and vascular health in older adults with elevated blood pressure and hypertension: secondary results from The HoldAge Trial

Diogo Pinto, Nuno Dias Rato, Catarina Garcia, Manuel Teixeira, Maria J. Marques, Teresa Amaral, Leonor Amaral, Ricardo Abreu, Cristiana Carneiro, Ana P. Oliveira, Daniela Figueiredo, Jorge Polónia, José Mesquita-Bastos, João L. Viana, Linda S. Pescatello, Fernando Ribeiro, Alberto J. Alves

Background Hypertension is a multifactorial condition that is likely to affect older adults. We evaluated the effects of home-based isometric handgrip training (IHT) or aerobic exercise training (AET) on vascular health of older adults with elevated blood pressure (BP) and hypertension. Methods The HoldAge trial (NCT04275032) was a two-center prospective randomized controlled trial. Eighty-four participants (46 women, 71.1 ± 3.6 years, BP: 137.1 ± 13.8/80.8 ± 8.3 mmHg) were randomized into IHT, AET, or usual medica …

27.08.2026journal-article

Spinal Cord

Leisure-time physical activity for middle-aged and older people with spinal cord injuries: beyond physical gains and individual responsibility

Laura Stendell, Camila Quel De Oliveira, Antony Jones, Peter W. Stubbs, Simon Darcy, Rachael Presdee, Robert Wynn, Anne Currie, Nathalia Costa

Abstract Study design We conducted a descriptive qualitative study. Objective To identify strategies to enhance access to and engagement in leisure-time physical activity (LTPA) for Australians aged ≥45 years of age with spinal cord injury, with the view to address the high rate of inactivity and associated health risks in this group. Setting Community-dwelling middle-aged and older adults living in Australia. Methods Qualitative data were gathered through focus groups and collaboratively analysed with individuals …

27.08.2026journal-article

PLOS One

Co-producing access to care with young people living in Zambia through digital and vending machine-enabled innovation in sexual and reproductive health: A place-based, human-centred design research approach

Mary Darking, Helen Ayles, Steve Belemu, Paloma Chausa, Francisco J. Gárate, Enrique J. Gómez, Melleh Gondwe, David Lane, Deborah Kaluba-Milimo, Monde Mwamba, Musonda Simwinga, Jennifer Whetham, Jaime H. Vera

Digital health innovation can fail to move beyond prototype or pilot stages or achieve intended outcomes due to a lack of involvement and attunement to local context. This article shares the potential of place-based co-production to support the development, acceptability and usability of context-attuned, digital health service innovation for young people. To illustrate the approach, we report on a collaborative, interdisciplinary project involving a Zambian public health research partner based in Lusaka, Zambia, th …

27.08.2026journal-article

npj Aging

Sleep bout length and nighttime activity predict longevity in medflies

Poorbita Kundu, Su I Iao, Han Chen, Vasilis G. Rodovitis, Nikos T. Papadopoulos, James R. Carey, Hans-Georg Müller

Abstract Sleep, a fundamental biological process, plays a crucial role in health and longevity across species. This study investigates the intricate relationship between sleep characteristics and lifespan in Mediterranean fruit flies (medflies), transcending the traditional focus on sleep duration. We identify specific sleep characteristics that are associated with remaining lifespan and also characterize how sleep patterns change with aging. Longer, uninterrupted sleep bouts are linked to extended lifespans, while …

27.08.2026journal-article

Frontiers in Aging Neuroscience

Query-based multimodal interaction and adaptive gated fusion for Alzheimer's disease detection

Yongqi Shao, Cong Tan, Hong Huo, Tao Fang

Early detection of Alzheimer's disease is crucial for delaying disease progression and improving patient outcomes. Speech has emerged as a promising biomarker for Alzheimer's disease detection because it is convenient, non-invasive, and low-cost. However, existing studies often rely on a single modality or fail to fully exploit complementary information across modalities. To address these limitations, we propose a query-based multimodal interaction and adaptive gated fusion framework for Alzheimer's disease detecti …

27.08.2026journal-article

Asian Journal of Research in Infectious Diseases

Seroprevalence of Hepatitis B Virus and Hepatitis C Virus Coinfection in People Living with HIV at the Al Nadjma Multipurpose Center in N'Djamena, Chad

Mahamat Ali Bolti, Tekila Mahamat Seid, Yusra Aboulbachar Ali, Mahamat Nour Aguid, Hamit Mahamat Alio, Ali Mahamat Moussa

Introduction: Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) are all bloodborne viruses that share similar routes of transmission. People with HIV who become infected with HBV or HCV are at increased risk of liver-related morbidity and mortality, which are common in our region. Chad is part of sub-Saharan Africa, which is a highly endemic region. Objective: The objective of this study was to assess the seroprevalence of HIV-HBV and HIV-HCV coinfection in patients at the Al …

27.08.2026journal-article

BMC Public Health

Association between visits to blue spaces within walking distance and mental health among older adults in Japan: a cross-sectional study from the Japan Gerontological Evaluation Study

Kazuki Matsumoto, Yu-Ru Chen, Yoko Matsuoka, Hiroaki Yoshida, Atsushi Nakagomi, Katsunori Kondo, Masamichi Hanazato

Abstract Background Exposure to blue spaces has been associated with better mental health, but most studies have focused on environmental proximity rather than actual use (frequency of visits and activity types) and have been conducted in Western countries. Evidence among older adults in Asian settings remains limited. This study examined the associations between frequency of visits to blue spaces within walking distance, activity types performed there, and mental health among older adults using data from 69 munici …

27.08.2026journal-article

Frontiers in Public Health

Prevalence and factors of frailty among community-dwelling older adults: a multimorbidity perspective

Shubing Feng, Pengpeng Wang, Hongxia Huang, Zhenhong Lin, Yuanhang Liu

Background Frailty is a geriatric syndrome that reduces quality of life and increases social burden. Existing frailty research predominantly focuses on hospitalized or nursing home-residing older adults, while surveys targeting community-dwelling older adults with multimorbidity remain scarce. Objective To investigate the prevalence and influencing factors of frailty among community-dwelling older adults with multimorbidity. Methods A cross-sectional survey was conducted from May to November 2025. Convenience sampl …

27.08.2026journal-article

Neuro-Oncology

39 Barriers to participation in research: the experience of people with brain tumours

Clair Thorstensen-Woll, Marcus Cahill-Evans

Abstract Introduction Brain tumours remain the biggest cancer killer of people under 40, with minimal survival improvements over recent decades. Despite the critical role of research in advancing understanding, improving treatments and ultimately, patient outcomes, many people diagnosed with brain tumours experience significant barriers to participating in research activities such as clinical trials or tissue donation. This report explores the systemic and patient-centred barriers that hinder research participation …

27.08.2026journal-article

Neuro-Oncology

122 Surgical Outcomes for High Grade Glioma in Patients Aged 70 Years and Older: A 10 Year Single Centre Cohort Study

Hazem Eid, Attika Chaudhary, Mohammad Ashraf, Meghan Minnis, Muitu Asha, Ahmed Elbelkasy, Athanasios Grivas, Edward Jerome St George

Abstract Background High‑grade gliomas are increasingly diagnosed in older adults, but surgical risks and benefits beyond age 70 remain uncertain. This study reports a 10‑year single‑centre experience of surgical management and outcomes in patients aged ≥70 years with high‑grade glioma. Methods A retrospective cohort analysis was conducted for patients aged ≥70 years who underwent surgery for WHO grade 3–4 glioma between 2015–2025. Data included demographics, performance status, tumour features, surgical strategy ( …

27.08.2026journal-article

European Journal of Investigation in Health, Psychology and Education

Selective Similarity Preference: People with a “Darker Core” Desire More Partner Similarity in Dark Traits but Not in Big Five

Hao Wu, Shanhong Luo, Whitney Wall, Karryll Winborne-Phillips

Research on assortative mating has shown that couples share strong similarities in demographic and attitudinal variables, while the similarity in personality is generally weak. However, a recent meta-analysis indicated that couple similarity in dark traits is considerably greater than that in the Big Five. If these differential similarities are primarily due to active preference, we expect that (1) the desire for similarity in dark traits should be higher than that for the Big Five and (2) the strongest desire for …

27.08.2026journal-article

Alzheimer Disease & Associated Disorders

Hypertension and 10-Year Dementia Risk Among Older Asian American and Non-Latino White Adults in Northern California

L. Paloma Rojas-Saunero, Natalie Gradwohl, Joseph O. Fong, Yixuan Zhou, Yingyan Wu, Taylor M. Mobley, Eleanor Hayes-Larson, Roch A. Nianogo, Gilbert C. Gee, Ron Brookmeyer, Rachel A. Whitmer, Paola Gilsanz, Elizabeth Rose Mayeda

Introduction: Hypertension is a modifiable risk factor for dementia, but its contribution among Asian American ethnic groups remains understudied despite heterogeneity in cardiovascular risk factors. Methods: Participants were Kaiser Permanente Northern California members aged 60 to 90 years without prevalent dementia at baseline, surveyed between 2002 and 2009 [Chinese (n=4,848), Filipino (n=4,130), Japanese (n=2,786), South Asian (n=823), non-Latino White (n=123,593)]. We used ICD-codes to identify hypertension ( …

27.08.2026journal-article

Cells

Mitochondria–Lysosome Quality Flux in Aging Mesenchymal Stem/Stromal Cells: Quality-Control Bottlenecks and Therapeutic Opportunities for Regenerative Decline

Lingling Cheng, Gaojie Song

Aging mesenchymal stem/stromal cells (MSCs) lose regenerative capacity as redox imbalance, mitochondrial damage, defective organelle quality control and chronic inflammation converge. Yet these processes are commonly considered in isolation, obscuring whether damaged mitochondrial cargo reaches lysosomes and is ultimately degraded. Here, we define mitochondria–lysosome quality flux (MLQF) as an author-proposed, evidence-graded framework that tracks mitochondrial damage from recognition and sorting through lysosomal …

27.08.2026journal-article

Frontiers in Aging

Age-related hearing loss persisted in mice that had demonstrated improved healthspan, reduced inflammaging and extended lifespan following expression of the naked mole-rat transgene for hyaluronan synthase 2

Connor E. Owens, Aiden J. Borruso, Kevin A. Place, Andrei Seluanov, Vera Gorbunova, Patricia M. White, Ned J. Place

Background Approximately one in three adults aged 65–74 years reports hearing difficulty, including age-related hearing loss (AHL, presbycusis). The C57BL/6 mouse is widely used in preclinical AHL research because it develops AHL relatively early. Calorie restriction (CR) attenuates AHL and improves healthspan and longevity in this strain. A recently developed transgenic C57BL/6 mouse expressing naked mole-rat hyaluronan synthase 2 ( nmrHas2 ), which produces very high molecular mass hyaluronan (vHMM-HA), also exhi …

27.08.2026journal-article

Bipolar Disorders

A Shift in Trust: An Analysis of the Use of AI Chatbots Among People Living With Bipolar Disorder

Katherine Bassil, Dido Prins, Hine van Os, Georg Starke, Eline de Groot, Annemieke Dols, Edwin van Dellen

ABSTRACT Objectives To identify preliminary insights into the perceived utility and risks of commercially available AI chatbots such as ChatGPT used by individuals with severe mental illness (SMI), namely bipolar disorder, for self‐reflection and mental health support. Methods Data were collected via semi‐structured interviews from two individuals diagnosed with bipolar disorder who independently used ChatGPT for self‐reflection and to explore diagnosis, symptom management, and treatment. Both individuals presented …

27.08.2026journal-article

PLOS Digital Health

Digital mental health apps for young people in Europe: A systematic cross-country analysis

Alba Madrid Cagigal, Canan Citil Akyol, Nesime Can Angın, João Ferreira, Karolina Gabor-Siatkowska, Niko Männikkö, Anna Meyniel, Neslihan Önder Özdemir, Miloš Stojadinović, Vanesa Varga, Ine Beyens, Claudette Pretorius

Mental health smartphone applications have become widely available for self-management and support, offering young people new pathways for help-seeking. Despite their increasing popularity, little is known about how app accessibility, content, and features vary across countries, languages, and cultural contexts. This study aimed to systematically examine these differences by drawing on data from the available app stores. Both the Apple App Store and Google Play Store were searched across seven European countries (C …

27.08.2026journal-article

Alzheimer Disease & Associated Disorders

Factors for Avoiding Counseling Despite Experiencing Cognitive Impairment in South Korea

In Cheol Hwang, Hong Yup Ahn

This study examined factors associated with not seeking counseling among 46,156 Korean adults who experienced cognitive impairment in the past year, using data from the 2024 Korea Community Health Survey. Only 8.1% sought counseling. Age-stratified logistic regression showed that counseling-seeking increased with greater disruption of daily activities. Alcohol consumption consistently predicted not seeking counseling across all age groups, while depression was associated with greater counseling seeking. Lower econo …

27.08.2026journal-article

Natural and Life Sciences Communications

Motorcycle Riding-Related Functional Abilities among Older Adults and Recommendations for Mitigating Risk-Related Problems on Rural Community Roads in Ubon Ratchathani Province, Thailand

Laksanee Boonkhao, Pongsak Rattanachaikunsopon, Papatsorn Tuphila, Orathai Chanthason, Chiraporn Labcom, Nittaya Chakhamrun, Jittar Tancharoen, Somjate Thongdamrongtham, Wannee Kaewsuk, Ueamporn Hernmek

This study aims to assess motorcycle riding-related functional abilities among older adults and identify high-risk road locations in rural communities of Ubon Ratchathani Province, Thailand, to prevent accidents involving older motorcycle riders. The study administered a driving competency test to 202 older adults, modeled after the Thai driving license test, and required participants to complete a questionnaire. Fifty network partners participated in a focus group to identify potential risks and develop solutions. …

27.08.2026journal-article

Journal of Applied Gerontology

Outcomes Associated With Namaste Care for People With Dementia in Institutional Settings: A Systematic Review

Xueyi Sun, Yu Ding, Dijuan Meng, Meng Jin, Qinan Shen, Wen Zhou, Yiheng Zhang

Background Namaste Care is a person-centered, non-pharmacological approach supporting comfort and engagement in institutional dementia care. Objective To synthesize quantitative evidence on clinical outcomes associated with Namaste Care among people with dementia living in institutional settings. Methods A systematic search was conducted across eight databases during February 2026. Quantitative studies evaluating Namaste Care or explicit adaptations were included. Methodological quality was assessed using the revis …