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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Frontiers in Immunology

Impact of time-of-day and timing interval of neoadjuvant immunotherapy and chemotherapy infusions among patients with operable NSCLC using the inverse probability of treatment weighting method: a dual-center, retrospective study

Xiang-yang Yu, Wen-yu Zhai, Zheng-zheng Xia, Kai Ma, Bai-hua Zhang, Xin Yu, Sheng-cheng Lin, Xiao-tong Guo, Ze-rui Zhao, Zhen-tao Yu

Background Although multiple studies have confirmed that adjusting the time-of-day (ToDA) of immunotherapy and timing interval (TI) of chemoimmunotherapy can improve long-term outcomes in patients with advanced non-small cell lung cancer (NSCLC), whether this model similarly improves survival among patients with operable NSCLC has not been reported. Patients and methods This dual-center, retrospective study included adult patients who received neoadjuvant chemoimmunotherapy (neoCIT) for clinical stage T1-4N0-3M0 NS …

28.08.2026journal-article

Journal of Clinical Medicine

Surgical Management of Hidradenitis Suppurativa Using Staged Carbon Dioxide Laser Marsupialization

Sydney R. Resnik, Alexander R. Gomez-Lara, Lauren Fernandez, Irena Pastar, Akhil Wadhera, Paul G. Hazen, Barry I. Resnik

Background: Hidradenitis suppurativa (HS) is a chronic disease marked by symptoms of pain, drainage, and odor. Persistent abscesses, nodules, and scarred tunnels can be resistant to pharmacologic management, with chronic lesions often requiring complex surgical intervention. Treatments include en bloc excision with primary closure, tissue flaps or skin grafts. Such procedures are associated with post-operative challenges, including pain, infection, contractures, and high recurrence rates. Methods: Herein we report …

28.08.2026journal-article

Journal of Clinical Medicine

Visual and Semiquantitative Assessment of 123I-Ioflupane SPECT in Probable Dementia with Lewy Bodies and Its Association with Autonomic Dysfunction: A Retrospective Study

Tahmina Arslan, Recep Bekiş, Mehmet Selman Ontan, Ahmet Turan Isik

Background/Objectives: Dementia with Lewy bodies (DLB) is a clinically heterogeneous neurodegenerative disorder characterized by cognitive, neuropsychiatric, motor, and autonomic manifestations. Reduced striatal dopamine transporter availability on 123I-ioflupane single-photon emission computed tomography (SPECT) is an established indicative biomarker of DLB. However, the associations among expert visual interpretation, regional semiquantitative dopamine transporter measurements, autonomic manifestations, and demen …

28.08.2026journal-article

Scientific Reports

Genome-wide analysis of the Ehretia macrophylla AUX/IAA family under drought and SiO₂ nanoparticle treatment

Zhe Wang, Shuaizheng Qi, Jianmin Fan, Lihua Xie, Shiping Cheng

Abstract Auxin/indole-3-acetic acid (AUX/IAA) proteins are central transcriptional repressors in auxin signaling and are increasingly implicated in plant responses to water deficit. However, AUX/IAA family organization and drought-responsive expression remain poorly characterized in woody plants, and the transcriptional response to silicon dioxide nanoparticles (SiO₂ NPs) is still largely unexplored. In this study, we identified 42 EmAUX/IAA genes in Ehretia macrophylla Wall. and analyzed their chromosomal distribu …

28.08.2026journal-article

AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment)

A Study of Removal Efficiency and Kinetics of Cadmium Using Activated Carbon Derived from Sulfurized Wastewater Treatment Plant Sludge

Rintang Wanda Septiyana, Restu Hikmah Ayu Murti

Cadmium (Cd) pollution in water bodies requires effective treatment methods that utilize sustainable alternative materials. This study aims to analyse the efficiency of Cd removal using sulfur-modified activated carbon derived from wastewater treatment plant (WWTP) sludge at varying contact times and to analyse its adsorption kinetics. We converted wastewater treatment plant (WWTP) sludge into activated carbon via KOH activation and Na?S sulfurization. We conducted batch adsorption experiments at different contact …

28.08.2026journal-article

The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine

Choosing Death So That Others May Live: The Permissibility of Living Vital Organ Donation

DIDDE BOISEN ANDERSEN, Andreas Albertsen

Abstract The conventional admiration for supererogatory acts, where individuals sacrifice themselves to aid others, contrasts sharply with the hesitance observed when considering the living donation of vital organs. This article challenges this inconsistency, contending that no relevant moral difference exists between other celebrated supererogatory acts and the act of living vital organ donation. I go beyond the proposed concept of organ donation euthanasia, advocating for the moral permissibility of living vital …

28.08.2026journal-article

World Journal of Gastroenterology

P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis

Yu-Wei Liu, Yi-Ke Chen, Jin-Yang Yan, Hua Shen, Fang-Ming Mai, Zheng-Hui Kong, Hui-Long Chen, Li-Ping Li, Wei-Ping Liu, Yong Gao, Lun Zhang

P-element-induced wimpy testis (PIWI)-interacting RNAs are a class of small non-coding RNAs, typically 24–31 nucleotides in length. They function by binding to PIWI proteins and play important roles in gene regulation. Initially identified in germline cells, PIWI-interacting RNAs (PiRNAs) mediate transposon silencing and maintain genomic integrity. Accumulating evidence indicates that, beyond their roles in mammalian germ cells, PiRNAs are also aberrantly expressed in a variety of human cancers, where they particip …

28.08.2026journal-article

Gastroenterologie a hepatologie

Severe upadacitinib-induced anemia in a multi-refractory Crohn’s disease patient – a case report

Anna Gojdicova, Igor Sturdik, Juraj Toth, Stanislav Majna, Jana Skubakova, Michaela Granak-Pytliakova, Tibor Hlavaty

Úvod: Inhibítory Janusovej kinázy (JAK) predstavujú účinnú perorálnu liečebnú možnosť pri stredne ťažkej až ťažkej forme zápalového ochorenia čriev (IBD), ktoré nereaguje na konvenčné a biologické lieky. Boli hlásené hematologické nežiaduce účinky, avšak závažná myelosupresia je zriedkavá a jej klinické zvládnutie – najmä rozhodnutie o pokračovaní liečby u pacientov, ktorí z nej majú podstatný prínos – naďalej predstavuje výzvu. Popis prípadu: Predkladáme prípad 45-ročnej ženy s Crohnovou chorobou postihujúcou hrub …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Dermatoses as an iatrogenic complication of invasive device-based procedures

O.I. Letyaeva, T.V. Trapeznikova, V.O. Gubina

Background. In modern cosmetology, high-intensity energy-based technologies, which utilize the interaction of physical modalities with biological tissues, are effectively and widely used. These manipulations will disrupt the epithelial barrier, activating the tissue regeneration process. In some cases, adverse events or iatrogenic complications may develop, requiring additional medical intervention. Dermatitis after invasive device-based procedures can arise from clinician non-compliance with treatment protocols or …

28.08.2026journal-article

eLife

Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

Tess Cherlin, Stephanie Mohammed, Samantha Strydesky, Sasha Ottey, Katherine Sherif, Shefali Setia Verma

Background: Polycystic ovary syndrome (PCOS), recently renamed as polyendocrine metabolic ovarian syndrome (PMOS), is a prevalent endocrine disorder in women, often accompanied by various symptoms, including significant pain, such as dysmenorrhea, abdominal, and pelvic pain, which remains underexplored. Methods: This retrospective study examines electronic health records (EHR) data to assess the prevalence of pain in women with PMOS. Conducted in January 2026, using data from 120 Health Care Organizations within th …

28.08.2026journal-article

Clinical Pharmacology & Therapeutics

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju

Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to contribute substantially to preventable morbidity and mortality. Long‐acting therapeutics (LATs) may help address selected pediatric health priorities by sustaining the …

28.08.2026journal-article

Journal of Patient Safety and Risk Management

Patient safety in hospital dentistry: A model for dentists without operating room privileges

Amal Al-Khotani, Reem Turkiastani, Hiba Alahmadi

A lack of compliance with professional privileging and training requirements is the most common cause of dental malpractice. In hospital dentistry, some dental specialties are trained to treat patients in the operating room, whereas others, including restorative dentists, endodontists, prosthodontists, and periodontists, are occasionally required for dental management under general anesthesia, yet typically hold no operating room privileges. This creates a gap in standardized care and patient-safety compliance. To …

28.08.2026journal-article

Italian Journal of Medicine

Prospective observational studies in clinical research: pros and cons

Luca Bertolaccini, Matteo Nicoletto, Paola Piccolo, Fulvio Pomero

Prospective observational studies are essential in clinical research, mainly when randomized controlled trials (RCTs) are infeasible, unethical, or impractical. These studies involve the prospective collection of data from cohorts stratified by exposure status, allowing investigators to observe the natural progression of outcomes while preserving temporality. Their main strengths include measuring incidence, assessing multiple outcomes, and avoiding recall bias, thus offering valuable insights into real-world clini …

28.08.2026journal-article

Nurse Educator

The Detective Nurse Practitioner: A Clinical Reasoning Pathway to Enhance Advanced Health Assessment Skills

Rashmi P. Momin

Background: Clinical reasoning is frequently underdeveloped in graduate nurse practitioner (NP) education. The National Organization of Nurse Practitioner Faculties Role Competencies define what NP students must achieve, and the Professional-Reporter-Interpreter-Manager-Educator-Nurse Practitioner (PRIME-NP) Model describes the sequence in which they develop. Problem: Advanced Health Assessment students can perform a thorough physical examination but struggle to determine relevant findings, prioritize working diffe …

28.08.2026journal-article

Journal of Shelter Medicine and Community Animal Health

Association Between Rabbit Café Visitor Experiences and Motivations to Feed Feral Rabbits in Vancouver, British Columbia

Lexis H. Ly, Silvija Grava, Oceania C. Kreutzer, Alexandra Protopopova

In Vancouver, British Columbia, feeding feral rabbits is prohibited due to risks to animal welfare and public health, yet feeding remains an ongoing issue in areas where populations of abandoned pet rabbits persist. One potential alternative to feeding animals in the wild is engaging in human–animal interaction opportunities in controlled settings such as rabbit cafés. This short report examined factors associated with visitors’ reported likelihood of feeding feral rabbits after visiting a rabbit café. Non-parametr …

28.08.2026journal-article

Interdisciplinary CardioVascular and Thoracic Surgery

Tumor-to-tumor metastasis: a rare case of clear cell renal cell carcinoma metastasizing into lung adenocarcinoma

Valerio Sebastianelli, Silvia De Maria, Paolo Graziano, Marco Anile

Abstract Tumor-to-tumor metastasis (TTM) is a very rare condition in which a malignant tumor (donor) metastasizes into another primary neoplasm, either benign or malignant (recipient). We report the case of a 74-year-old man previously surgically treated for a clear cell renal cell carcinoma(ccRCC) who developped a new subsolid nodule in the right upper pulmonary lobe discovered at a four-year follow-up CT scan. The patient underwent a right uniportal thoracoscopic S1 segmentectomy and mediastinal lymph node dissec …

28.08.2026journal-article

World Journal of Gastroenterology

Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases

Tian-Shuai Zhang, Xiao-Ming Zhu, Rong-Bo Wen, Le-Qi Zhou, Hai-Feng Gong, En-Da Yu, Hao Wang, Gang Li, Wei-Ping Zhou, Li-Qiang Hao, Guan-Yu Yu, Wei Zhang

BACKGROUND Simultaneous resection of colorectal cancer liver metastases (CRLM) has been widely adopted; however, clinical efficacy still varies across different surgical approaches, and the best surgical strategy remains controversial. AIM To investigate the efficacy and safety of laparoscopic hybrid surgery (LHS) vs total open surgery (TOS) the in simultaneous resection of CRLM. METHODS This was an observational study conducted at a tertiary medical center, enrolling 266 patients who undergoing simultaneous resect …

28.08.2026journal-article

Journal of Perinatal Medicine

Ultrasound-based prediction of fetal hyperinsulinemia: development of a fetal metabolic score

Roberto Noya Galluzzo, Karine Souza Da Correggio, Aldo von Wangenheim, Heron Werner, Edward Araujo Júnior, Gustavo Yano Callado, Alexandre Sherlley Casimiro Onofre

Abstract Objectives Gestational diabetes mellitus (GDM) is associated with fetal hyperinsulinemia, excessive adiposity, and adverse perinatal outcomes; sonographic markers of fetal adiposity, liver enlargement, and septal thickening may allow direct assessment of fetal metabolic adaptation. This study aimed to develop an ultrasound-based fetal metabolic score (FMS) estimating the risk of fetal hyperinsulinemia. Methods The FMS was developed from a prospective cohort of 223 pregnant women (128 with GDM, 95 controls) …

28.08.2026journal-article

European Journal of Plastic Surgery

A novel indication of Glyaderm®: its use as a nerve wrap in the treatment of compression neuropathies

Milly van de Warenburg, Claire van Houdt, Stefan Hummelink, Till Wagner

Abstract Background Fibrotic changes following surgical decompression of nerve entrapment can restrict nerve regeneration, and exert pressure on the nerve, leading to symptoms of recurring entrapment. This case series reports on the outcomes of using Glyaderm® (ETB-BISLIFE Multi Tissue Center, The Netherlands) as a low-cost, customizable, and biocompatible nerve wrap in patients with recurrent or post-traumatic compression neuropathies, highlighting its potential benefits as a neuroprotective shield. Methods We rev …

28.08.2026journal-article

Journal of Innovations in Materials and Manufacturing Engineering

Influence of Heat Treatment and Thermal Aging on the Fatigue Performance of LPBF Fabricated AlSi10Mg Alloy

Edel Arrieta, Luis A. Marquez, Lawrence E. Murr, Diego A. Ariza, Mark Benedict, Jason Thomas, James Carney, Francisco Medina

This investigation explores fatigue performance of laser powder bed fusion (LPBF)-fabricated AlSi10Mg alloy subjected to various post-processing treatments: stress relief (SR), Hot Isostatic Pressing (HIP), and HIP + T6, all followed by prolonged thermal aging at 177 °C for up to 1000 h. Microstructural evolution, hardness, density, and uniaxial fatigue performance, including SEM fractography, were examined to recommend practical service life thresholds. Microstructural analysis confirmed that HIP and HIP + T6 trea …

28.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/ G3BP1 Axis

Ke Li, MeiXia Li, XueQiang Pan, JiaWen Xu, Rui Jiang

ABSTRACT Background and Objective Brucea javanica oil emulsion (BJOE), a traditional Chinese medicine extract, has been demonstrated to possess antitumor activity in multiple cancers. However, its molecular mechanisms in breast cancer, particularly those involving circRNAs, remain unclear. This study investigates whether BJOE exerts its anti‐breast cancer effects by inducing autophagy and apoptosis through regulating hsa_circ_0001589/G3BP1/PAX6 signalling axis. Methods After BJOE treatment of MCF‐7 cells, cell viab …

28.08.2026journal-article

Hippocrates Medical Journal

When Artificial Intelligence Speaks For The Obstetrician: Multilingual Accuracy On Real Patient Questions

Alihan Tığlı, Yakup Baykuş, Rulin Deniz, Sefer Üstebay, Muammer Hayri Bektaş, Çağdaş Çöllüoğlu

BackgroundThe use of generative large language models (LLMs) in healthcare is rapidly increasing, offering easier access to medical information. However, comprehensive data on their multilingual accuracy and the reliability of cited scientific references remain limited. This study aimed to compare the response accuracy and reference quality of three free LLMs (ChatGPT, Google Gemini, DeepSeek) in Turkish and English using common pregnancy-related questions.MethodsIn this comparative observational study, 14 frequent …

28.08.2026journal-article

Gynecology Obstetrics & Reproductive Medicine

Longitudinal Assessment of Fetal Ductus Arteriosus Morphometry: Establishing Gestational Age-Specific Reference Values

Murat Cagan, Umutcan Kayikci, Erdem Fadiloglu, Ayse Cigdem Bayrak, Edip Alptug Kir, Hayrettin Hakan Aykan, Ozgur Deren

OBJECTIVES: To longitudinally evaluate fetal ductus arteriosus (DA) morphometric changes and establish normative reference values between 18 and 36 weeks of gestation. STUDY DESIGN: This prospective cohort study included 29 pregnant women with structurally normal singleton fetuses and confirmed gestational ages. Each participant underwent serial standardized ultrasound examinations to evaluate DA length and proximal, mid, and distal diameters. We defined weekly growth trends using regression analyses and assessed c …

28.08.2026journal-article

Tropical Medicine and Infectious Disease

Application of Genomics to Prevent and Combat Emerging Infectious Disease Threats in Latin America: Perspectives from an Overseas U.S. Navy Research Command

Hugo O. Valdivia, Maria Silva, Cristopher D. Cruz, Paul Rios, Marisa E. Lozano, Julia S. Ampuero, Yeny Tinoco, Jeffrey Spiro, Yuliya S. Johnson, Alden S. Estep, Steev Loyola, Carmen Flores-Mendoza, Gissella M. Vasquez, Jose A. Garcia-Rivera, Henju Marjuki

Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of these diseases. High-throughput sequencing technologies have become a critical resource for the field of infectious disease monitoring, specifically for tracking pathogen evolution, antimicrobial resistance, and transmission. This review prov …