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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Internal and Emergency Medicine

Clinically recognized sepsis in older adults admitted to medical wards: patient characteristics and hospital outcomes from the REPOSI register

Marta Chiara Sircana, Alfredo Caturano, Mauro Tettamanti, Sara Ratti, Chiara Ronchetti, Alessandro Nobili, Francesca Innocenti, Pier Mannuccio Mannucci, Roberto Manetti, REPOSI Investigators, Nicola Montano, Giorgio Sesti, Antonello Pietrangelo, Antonio De Vincentis, Alessandra Marengoni, Luca Pasina, Carlotta Franchi, Alessia Antonella Galbussera, Sara Mandelli, Ilaria Ardoino, Alessio Novella, Enrico Nicolis, Domenico Prisco, Elena Silvestri, Giacomo Emmi, Irene Mattioli, Matteo Mazzetti, Edoardo Biancalana, Gianni Biolo, Giacomo Bartelloni, Ilaria Martini, Matteo Pirro, Graziana Lupattelli, Vanessa Bianconi, Riccardo Alcidi, Alessia Giotta, Massimo R. Mannarino, Domenico Girelli, Fabiana Busti, Giacomo Marchi

Abstract Older adults admitted to internal medicine wards represent a growing population at high risk of sepsis, characterized by frailty, multimorbidity, functional impairment and reduced physiological reserve. While sepsis outcomes have been extensively studied in intensive care settings, less is known about prognostic determinants in non-ICU wards. Using data from the Italian REPOSI registry (2009–2023), we analyzed patients aged ≥65 years hospitalized in internal medicine and geriatric wards. Clinically recogni …

24.08.2026journal-article

Frontiers in Neurology

Group mindfulness-based cognitive therapy associated with reduced professional caregiver burden and improved quality of care in dementia: a multi-method study

Longyun Chen, Bencheng Wang, Ting Li, Nan Li, Xuanxuan Chen, Fei Liu, Tao Lv

Purpose To evaluate the association between an 8-week group Mindfulness-Based Cognitive Therapy (MBCT) program and changes in professional dementia caregiver burden, perceived stress, and patient neuropsychiatric symptoms. Methods This retrospective multi-method study included 94 professional dementia caregivers at a psychiatric hospital in China (intervention: n = 48; control: n = 46). The intervention group participated in an 8-week group MBCT program, while the control group received routine education. Caregiver …

24.08.2026journal-article

Laser & Photonics Reviews

Deuterated Molecular Vibration Locking in Self‐Assembled Monolayers Enables Positive Aging‐Free SnO 2 ‐Based QLEDs With Over 30% External Quantum Efficiency

Mengxin Liu, Desheng Li, Xinan Shi, Bingsuo Zou, Kai Chen, Daocheng Pan

ABSTRACT The development of efficient and stable hole injection layers (HILs) remains a critical challenge for high‐performance quantum‐dot light‐emitting diodes (QLEDs), as the conventional PEDOT:PSS suffers from inherent acidity and hygroscopicity. Herein, we demonstrate a novel strategy of molecular vibration engineering by employing deuterated self‐assembled monolayers (SAMs) as an efficient alternative. The designed deuterated molecular backbone (Ph‐4PACzd10), featuring extended conjugated structures, not only …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Evaluation of anti-aging effects of swimming exercise on inflammatory parameters in D-galactose-treated Wistar albino male rats

Sriram B. S., Ravichandra V., Pooja K. M., Jayanthi M. K.

Background: The present study was undertaken to investigate the anti-ageing effect of swimming exercise on inflammatory parameters in D-galactose-induced Wistar albino male rats. Methods: Wistar albino rats were divided into four groups, namely, normal control, D-galactose-treated group (positive control), normal control with swimming exercise, and D-galactose-treated rats with swimming exercise. The experiment was conducted for 42 days. D-galactose was administered as a compound to induce ageing-like changes, and …

24.08.2026journal-article

Sexes

Sexual Union Status and HIV Viral Load Suppression Among Older Adults in Rural South Africa: A Population-Based Study

Betty Sebati

The success of HIV treatment is primarily measured through viral load suppression. However, little is known regarding the association between sexual union status and viral suppression among older adults. This study aimed to assess the association between sexual union status and HIV viral load suppression among adults aged 40 years and older living with HIV in rural Mpumalanga, South Africa. An observational analytical study design was followed, utilising data from the HIV After 40 study in Mpumalanga. The study foc …

24.08.2026journal-article

European Journal of Clinical Pharmacology

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials

Tianyu Cheng, Lin Zhang, Yizhou Zhang, Huazheng Liang, Junyan Wang, Gengzhen Chen, Yujia Huo

Abstract Purpose Randomized evidence for pharmacological interventions in vascular dementia (VaD) is fragmented. We conducted a VaD-focused, scale-specific systematic review and meta-analysis. Methods We searched four databases for English-language parallel-group randomized controlled trials (1990–2025). Comparable placebo-controlled outcomes were pooled using random-effects meta-analysis; non-poolable outcomes were synthesized according to SWiM. Risk of bias and certainty were assessed with RoB 2 and GRADE. Result …

24.08.2026journal-article

BMC Medicine

Associations of CLivD score with dementia, cardiovascular disease, cancer, and mortality in the general population from the UK biobank

Guozhe Sun, Jie Chen, Hongmei Yang, Caiyu Zhang, Chenhua He, Ying Zhou, Lin Guan, Shiyu Zhou, Yao Yu, Jun Wang, Xiangyu Tan, Yangzhi Yin, Ziyi Xie, Wei Miao, Wenhang Li, Yifei Chen, Xiaoxuan Tian, Tianhao Li, Xiaobing Zhou, Mengling Lu, Guangxiao Li, Xiaofan Guo

Abstract Background The Chronic Liver Disease (CLivD) score is a non-invasive marker of advanced liver disease risk. We evaluated its associations with dementia, cardiovascular disease (CVD), cancer, and all-cause mortality. Methods This prospective cohort study included UK Biobank participants with calculable CLivD scores at baseline (2006–2010). Two previously validated versions of the score were calculated: a laboratory-based CLivD (CLivD lab ), incorporating age, sex, waist-hip ratio, alcohol consumption, diabe …

24.08.2026journal-article

American Journal of Speech-Language Pathology

“It's Hard Hard to Hard to Make It That Way. But You Gotta Make It All Different Levels”: Making Aphasia Groups Work From the Perspective of People With Severe Aphasia

Eleanor Gulick, Brent E. Archer

Purpose: Facilitators require further guidance on best practices to support people with severe aphasia (PWSA) who attend their aphasia groups. In this study, we position PWSA as experts who can inform future research and practice patterns. The aim of this study was to explore the ideas PWSA have regarding how aphasia groups should function with a specific focus on aspects that relate to meeting their needs, given the severity of their aphasia. Method: We analyzed data from interviews with five PWSA that were comple …

24.08.2026journal-article

Theoretical and Natural Science

Spatially Organized Immune Remodeling in Menopause: Single-Cell and Spatial Transcriptomic Evidence from Ovarian Aging and Atherosclerosis

Yinshu Zhang

As the proportion of people in their mid-to-late years increases around the world, so too does the prevalence of multiple long-term illnesses associated with menopause, many of which involve changes in the immune system. Bulk RNA sequencing averages expression in heterogeneous cell populations and thus cannot identify which cells are changing or where those changes occur. Collectively, single-cell RNA sequencing and spatial transcriptomics have provided two major examples of menopausal changes, ovarian aging and at …

24.08.2026journal-article

PLOS One

Effect of vision training on visual function in older adults: A pilot randomized trial

Daisuke Sudo, Daisuke Toyoda

Falls among older adults are a major public health concern; however, scientific evidence for interventions that specifically target visual function remains limited. Therefore, this exploratory pilot randomized trial evaluated changes in multiple visual-function outcomes associated with an oculomotor-focused vision training (VT) program in community-dwelling older adults. Thirty community-dwelling older adults (mean age, 73.7 ± 4.8 years) were randomly assigned to a lower-limb strength training group (SLR) or a grou …

24.08.2026journal-article

Journal of Interventional Epidemiology and Public Health

High mpox mortality in people living with HIV and immune suppression: Lessons from Sierra Leone for integrated outbreak preparedness and response

Rosamund Felicity Lewis, Chikwe Andreas Ihekweazu

The 2025 mpox outbreak in Sierra Leone provides compelling evidence that people living with advanced HIV infection remain at greatly increased risk of death from mpox. The national cohort study by Ikoona et al demonstrates the value of integrated health information systems, linking 90% of confirmed mpox cases with their HIV status, largely using a national unique health identifier. The study illustrates how health service data can be used during an outbreak to identify vulnerable populations and guide interventions …

24.08.2026journal-article

Health Economics Review

A scoping review on the economic burden of falls among older adults

Dhika Dharmansyah, Laili Rahayuwati, Iqbal Pramukti, Kuswandewi Mutyara

Abstract Background Falls are the second leading cause of unintentional injury death globally, and the World Health Organization estimates that approximately 82% of fall-related mortality occurs in low- and middle-income countries (LMICs). Despite this disproportionate burden, the economic impact of falls among older adults in resource-limited settings remains poorly documented. This scoping review aimed to map the existing evidence on the economic burden of falls among older adults, describe the extent and nature …

24.08.2026journal-article

AGING MEDICINE

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen

ABSTRACT Aortic dissection (AD) is a life‐threatening vascular disorder characterized by separation of the layers of the aortic wall, primarily triggered by an intimal tear or an intramural hemorrhage. Age is a well‐recognized and critical risk factor for AD. Epidemiological evidence consistently demonstrates a strong positive correlation between age and AD incidence, with peak occurrence in the 50–70‐year age group. Its pathogenesis involves vascular inflammation, extracellular matrix (ECM) degradation, vascular s …

24.08.2026journal-article

Frontiers in Psychology

Invisible harm and constrained response: a conceptual analysis of psychological domestic abuse against disabled people in China

Zehua Feng, Yilin Li, Wenzong Xia, Yu Hu

Psychological domestic abuse against disabled people is under-recognised at the intersection of violence prevention, public mental health, and disability policy. Here, invisible harm does not mean wholly unseen harm; it denotes cumulative abuse that remains difficult for victims, social networks, and institutions to identify or translate into action. Constrained response denotes the linked restrictions on recognition and disclosure, evidentiary translation, and safe exit. This conceptual analysis synthesises Chines …

24.08.2026journal-article

Frontiers in Aging Neuroscience

Epicenter mapping of cortical morphological dedifferentiation in type 2 diabetes mellitus using morphometric inverse divergence

Taipeng Zeng, Liyuan Fu, Zhifeng Huang, Minghui Mao, Fang Chen, Hao Huang, Xiaoping Cui, Xiaoyang Wang

Background Type 2 diabetes mellitus (T2DM) is associated with widespread cortical alterations and cognitive decline. However, the macroscopic organizational principles of T2DM-associated cortical degradation remain poorly understood. This study investigated whether T2DM-related cortical morphological dedifferentiation follows specific topological network principles. Methods We analyzed structural MRI data from 49 T2DM patients and 49 matched healthy controls (HCs), representing an aging-relevant middle-aged and old …

24.08.2026journal-article

Frontiers in Psychology

Perceived community environment and depressive symptoms among older adults in China: a cross-sectional analysis of physical activity as a moderator

Zhijia Du, Junyue Yue, Zirui Lin, Xiaoyu Han

Introduction Perceived community environment is an important contextual factor related to depressive symptoms in later life. However, few studies have examined whether physical activity (PA), a modifiable behavioral factor, moderates this association, particularly across specific aspects of perceived community environment and different types of PA. Methods This study used data from the 2023 China Longitudinal Aging Social Survey, including 9,410 older adults. Linear regression models were used to examine the associ …

24.08.2026journal-article

Quality in Ageing and Older Adults

Perceived social value of volunteering, social capital and volunteer participation in later life: evidence from Slovakia

Alžbeta Brozmanová Gregorová, Estera Frgelcová, Ivana Hačková

Purpose This study aims to examine how older adults structure their perceptions of the social value of volunteering, how these perceptions relate to cognitive and structural social capital and to what extent these factors, together with sociodemographic characteristics, predict volunteering participation in later life. The study is set in a post-socialist country. Design/methodology/approach The study uses a quantitative approach, drawing on data from a representative survey conducted in 2023. The research sample c …

24.08.2026journal-article

Cancers

Quality of Outcome Reporting for Older Subgroups in FDA Registration Gastroesophageal Cancer Trials (2010–2024): A Systematic Review

Ilse Trip, Martha Kormi, Elizabeth Smyth, Russell D. Petty, Mark A. Baxter

Background: Gastroesophageal adenocarcinoma is predominantly a disease of older adults. However, older adults are underrepresented in randomised controlled trials (RCTs), and outcomes specific to this subgroup are underreported. Clinicians therefore extrapolate data from younger, fitter trial populations, which can lead to over- and undertreatment of older cancer patients. This study examines the inclusion and completeness of outcome reporting for older patients in practice-changing trials in gastroesophageal cance …

24.08.2026journal-article

Critical Sociology

Beyond anomie: The social and political consciousness of marginalized people

Christopher Wimmer

The political capacity of marginalized people to act has long been a recurring topic in political and public discourse. While a substantial body of scholarship has documented everyday forms of resistance, informal solidarity, and collective organization among marginalized groups, public debates and parts of the academic literature continue to portray them as politically disengaged, or incapable of collective action. This article contributes to that debate by examining how marginalized people themselves understand t …

24.08.2026journal-article

Research on Aging

Multidimensional Social Isolation and All-Cause Mortality Among Middle-Aged and Older Adults in China: Gender and Rural-Urban Differences

Jianfeng He, Zhiyong Lin

This study examines whether multidimensional social isolation is associated with all-cause mortality and explores whether these associations vary by gender and rural–urban residence in China. Using nationally representative longitudinal data from 12,686 adults aged 45 and older in the China Health and Retirement Longitudinal Study (2011–2020), we estimated Cox proportional hazards models examining social isolation as structural disconnectedness across five domains: partnership status, contact with parents, contact …

24.08.2026journal-article

The Journal of Cardiovascular Aging

Epicardial adipose tissue and cardiovascular disease: biology, imaging biomarkers, and therapeutic opportunities

Jing Zhang, Ziyu An, Hanzhong Luo, Libo Liu, Huan Zhang, Yunqi Zhang, Xin Zhao, Xueyao Yang, Lijun Zhang, Jinfan Tian, Xiantao Song

Cardiovascular diseases (CVDs) are characterized by high morbidity and mortality rates. Recent studies highlight the significance of epicardial adipose tissue (EAT) in the pathophysiology of coronary artery disease (CAD), arrhythmias, and heart failure (HF), primarily through its direct effects on cardiac structure and function mediated by inflammatory, metabolic, and biomechanical pathways. This review provides a comprehensive overview of the biology and regional variability of EAT, summarizes the molecular mechan …

24.08.2026journal-article

Middle Black Sea Journal of Health Science

Prehabilitation before Total Knee and Hip Arthroplasty in Older Adults: A Narrative Review

Yasemin Salkın, Dilek Hande Esen

Background: This review aims to investigate the components of prehabilitation for older surgical patients based on current evidence, while evaluating its impact on clinical outcomes, functional independence and postoperative quality of life within this vulnerable group. Review Text: A systematic search of PubMed was conducted for studies published between 2020 and 2026 using the keywords “prehabilitation”, “total knee arthroplasty”, “total hip arthroplasty”, “older adults”, “preoperative exercise”, and “postoperati …

24.08.2026journal-article

Blood Journal

Ferroptotic stress promotes hematopoietic stem cell aging through S1P-dependent epigenetic and lipid remodeling

Yijun Zhao, Yishan Li, Xiaobin Tian, Jingjing Guan, Yixin Ma, Xiaoqi Wang, Hongjian Zhang, Kaitao Wang, Kaizheng Jiang, Yalan Yang, Yuan Pan, Weiwei Liu, Xianzhe Hu, Jiafan Cao, Weiming Liu, Mengyun Xie, Kexin Sun, Jiayin Zheng, Ying Wang, Yucan Zheng, Yanjun Ling, Keyue Yang, Xuying Pei, Xiang-yu Zhao, Xi Zhang, Pengxu Qian, Changzheng Li, Tian Lan, Linjia Jiang, Meng Zhao

Aging of hematopoietic stem cells (HSCs) impairs hematopoietic regeneration and differentiation, contributing to immune aging, systemic inflammation, and reduced lifespan. Strategies to rejuvenate aged HSCs and restore immune homeostasis remain limited. Here, we identify ferroptotic stress as a key contributor to HSC aging. Mechanistically, increased sphingosine metabolism elevates sphingosine-1-phosphate (S1P), which suppresses HDAC activity and enhances H3K9 acetylation to upregulate lysophosphatidylcholine acylt …