Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 22

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Neuro-Oncology

12 Anatomy as prognosis: are frontal lobe glioblastomas associated with worse outcomes? A single-centre retrospective population-based review

Nia Mihaylova, Leon Gerard D’Cruz, Eleni Simpson

Abstract Introduction Glioblastoma multiforme (GBM) is an aggressive brain malignancy with universally poor outcomes, and multiple covariant prognostic factors. While clinicians have long suspected that GBM’s lobe-location influences surgical and functional outcomes, its independent effect on survival has not been previously established. We aimed to determine whether frontal lobe involvement is associated with reduced overall survival in patients with GBM. Methods A retrospective cohort review of 58 patients diagno …

27.08.2026journal-article

Neuro-Oncology

48 Enabling paediatric optic pathway glioma segmentation via adult tumour transfer learning

Xinyu Tian, Enrico De Vita, Kshitij Mankad, Emily R Drabek-Maunder, James K Ruffle, Chris A Clark

Abstract Introduction Accurate quantitative tumour assessment is central to longitudinal monitoring of paediatric optic pathway gliomas (OPGs), informing treatment decisions. However, MRI protocols in routine clinical practice are frequently incomplete due to patient tolerance or institutional variability. Moreover, since annotated paediatric datasets remain scarce, developing reliable automated tools has hitherto been infeasible. Here, we develop and evaluate a solution that addresses these challenges by leveragin …

27.08.2026journal-article

Neuro-Oncology

90 Developing Patient-Focused Outcomes for Routine Clinical Care in Glioma: A Synthesis of Qualitative Evidence from the COMBaT Study

Noreen Hopewell-Kelly, Vimeeka Raj Devarajan, Silvia Goss, Helen Bulbeck, Rhian Burke, Anthony Byrne, Andrew Carson-Stevens, Gwawr Evans, Cerys Harris, Cressida Lorimer, James Powell, Sarah Puntoni, Alasdair G Rooney, Kathy Seddon, Colin Watts, Andrew Wright, Stephanie Sivell, Ameeta Retzer

Abstract Introduction There is a critical need to identify and routinely measure the outcomes that matter most to people living with glioma. Care needs in this population are complex and variable, yet current clinical practice lacks consistent, systematic approaches to assessing them. This may limit timely symptom management, personalised treatment and improvements in quality-of-life. We present findings from the first stage of the COMBaT study, to develop a person-focused core outcome set for routine glioma care. …

27.08.2026journal-article

Minerals

Enhanced Slag–Metal Separation for Preparation of Al-Si Alloys from Crystalline Silicon Cutting Waste by a CaO-Al2O3-CaF2 Slag Treatment

Donghui Wei, Kai Li, Tianding Li, Shan Ren, Haiyu Li, Hongbin Du, Xiangdong Xing

Crystalline silicon cutting waste (SCW) is a promising secondary silicon resource for Al-Si alloy production, but high-melting Al2O3 generated during aluminothermic reduction hinders alloy droplet coalescence and slag–metal separation. In this study, a CaO-Al2O3-CaF2 slag treatment strategy was developed to regulate in situ formed Al2O3 and improve Al-Si alloy recovery from SCW. The effects of slag composition, smelting temperature, and holding time on separation behavior, massive alloy yield, and Si recovery were …

27.08.2026journal-article

JAMA Network Open

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Trang Thuy Do, Jordan Maccora, Rebecca Wallace, Veronica Aedo-Lopez, Marliese Alexander, Sonia Ancoli-Israel, Bei Bei, Robert Blum, Frances Boyle, Daphne Day, Justine Diggens, Prudence A. Francis, Maria Ftanou, Sheila N. Garland, Alysia Kepert, Duncan Mortimer, Andrew J. K. Phillips, Sharad Sharma, Lesley Stafford, Michelle White, Joshua F. Wiley

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone and in combination, and few have evaluated the use of either during chemotherapy. Objective To determine the main effects of CBT-I and BLT on insomnia and fatigue symptoms in women undergoing chemotherapy for breast cancer. Design, Setting, …

27.08.2026journal-article

PLOS One

Efficacy and safety of 15 mA transcranial alternating current stimulation (tACS) in the therapy of treatment-resistant depression with increased inflammatory activity: Study protocol for a randomized, double-blind, sham-controlled trial

Xuguang An, Jin Zhang, Xiaofei Hou, Chenghao Yang

Background and Objectives Treatment-resistant depression (TRD) poses a significant clinical challenge, with traditional antidepressant therapies often ineffective. Elevated peripheral inflammation has emerged as a potential biological subtype of TRD, highlighting the need for novel treatments. Transcranial alternating current stimulation (tACS) has garnered attention for its potential antidepressant effects, particularly through its impact on glial cells, which are involved in neuroinflammation and neuronal interac …

27.08.2026journal-article

Clinical and Investigative Medicine

Expression and clinical significance of CA9 and SEC61G in non–small cell lung cancer

Yu Luo, Dehe Chen, Yunxi Wu, Yi Cai, Gaoxiong Xiao, Dinghai He, Yanjun Bai, Li Jiang

Abstract Background: Lung cancer is the malignancy with the highest mortality rate globally. This study aimed to investigate the expression of carbonic anhydrase IX ( CA9 ) and SEC61G in non-small cell lung cancer (NSCLC) tissues and adjacent lung tissues and to analyze the relationships of these genes with clinicopathological features to identify potential biomarkers and therapeutic targets. Methods: Bioinformatic analysis was performed using the TIMER, TCGA, and GTEx databases to evaluate the differential express …

27.08.2026journal-article

Transplantation

Cancer Risk in Kidney Transplant Recipients on Belatacept Versus Calcineurin Inhibitors: A Systematic Review and Meta-Analysis

Zein Alabdin Hannouneh, Muhsen Issa, Hiroki Mizuno, Naoka Murakami

Background. Belatacept has been increasingly used as a maintenance immunosuppression in kidney transplant recipients since its approval in 2011, due to favorable renal and cardiovascular profiles compared with calcineurin inhibitors (CNIs). However, the long-term risk of cancers associated with beletacept, particularly skin cancer, remains incompletely characterized. Methods. We conducted a systematic review and meta-analysis of clinical studies comparing cancer risk in kidney transplant recipients receiving belata …

27.08.2026journal-article

Cell Death Discovery

Glutamine synthesis pathway promotes the survival and recurrence of dormant tumor cells in prostate cancer

Bing Zhao, Qingwei Meng, Jun Zhou, Kun He, Hekang Ding, Jing Wang, Hailiang Hu, Lingfan Xu

Abstract Cancer cell dormancy presents a major obstacle to curative therapy, particularly in metastatic prostate cancer. Although the initial efficacy of hormonal therapy is satisfying, tumors will inevitably develop resistance. Dormant tumor cells may act as the initial source for the tumor recurrence, but the underlying mechanism remains largely unknown. Here we report that the glutamine synthesis pathway is required for cellular dormancy under androgen-deprived conditions. The key enzyme, glutamine synthetase (e …

27.08.2026journal-article

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Terminal lucidity in women with advanced gynecologic cancer: a case series and focused review of the literature

Sarita Kumari, Abhinav Tiwari, Rudrika Chandra

Terminal lucidity (TL) is characterized by an unexpected, transient restoration of mental clarity, coherent communication, or purposeful behaviour shortly before death. Although reported in patients with neurodegenerative disorders, psychiatric illness, and pediatric oncology, TL has not previously been described in women with advanced gynaecological malignancies. We retrospectively reviewed 20 consecutive deaths among women with advanced gynaecological cancers at a tertiary gynaecologic oncology centre during 2025 …

27.08.2026journal-article

Alimentary Pharmacology & Therapeutics

Treatment Patterns in Patients With Eosinophilic Oesophagitis Referred for Expert Consultation

Sydney F. Pomenti, Elina Stoffel, Alexa Choy, Emma Fanuele, Nirmala Gonsalves, Evan S. Dellon, David A. Katzka

ABSTRACT Background & Aims Eosinophilic esophagitis (EoE) patients deemed treatment‐refractory are frequently referred to tertiary centres. We aimed to characterize expert perspectives on patients referred for refractory EoE, including its causes, prevalence, and evaluation. Methods We conducted an anonymous and blinded cross‐sectional survey of international EoE experts ( n = 52) assessing provider characteristics, referral patterns, perceived causes of treatment failure, diagnostic approaches, and prior therapies …

27.08.2026journal-article

Med Research

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong

ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability. Currently, the clinical management of TBI relies primarily on palliative care, whereas complex secondary injury cascades limit the ability of traditional single‐target drugs to achieve consistent clinical benefits. Exosomes, as natural nanoscale extracellular vesicles, offer a highly promising innovative strategy for neuroprotection and repair in TBI due to their inherent abi …

27.08.2026journal-article

Biopsychosocial Science and Medicine

Prospective Links between Intraindividual Measures of Negative Affect and Physical Well-being among Couples Coping with Cancer

Shelby L. Langer, Michael Todd, Laura S. Porter, Rachel Koffer

Objective: Research examining associations between intraindividual variability in affective experiences and health stems largely from non-clinical samples and individuals versus within a dyadic context. We sought to examine this linkage in couples coping with cancer. Methods: 233 patients with cancer and their spouses/partners (mean age = 52.5) completed twice-daily ecological momentary assessments for 14 days. Nine negative affect items were used to compute intraindividual negative affect means, standard deviation …

27.08.2026journal-article

Current Oncology

Management of Advanced Solid Tumors Recurring After Adjuvant Immune Checkpoint Inhibitors: A Structured Narrative Review

Fausto Petrelli, Lorenzo Dottorini, Antonio Ghidini, Alberto Zambelli

Adjuvant and perioperative immune checkpoint inhibitors (ICIs) have created a growing population of patients who relapse after prior programmed death-1 or programmed death-ligand 1 blockade, yet these patients were underrepresented in many trials that established metastatic standards. We performed a structured narrative review of PubMed/MEDLINE, ClinicalTrials.gov, reference lists, and international oncology guideline repositories through 15 August 2026. Eligible reports addressed recurrence patterns or treatment a …

27.08.2026journal-article

PLOS One

First cell-patterning of primary, patient-derived mesenchymal glioblastoma brain cancer cells on parylene-C/SiO2 substrates

Nicholas G. Mellor, Sylvia A. Chung, Pierrette Michaux, Josiah Firth, Scott E. Graham, Bryan W. Day, Charles P. Unsworth

The mesenchymal subtype of the WHO grade IV Glioblastoma (GBM) is the most common and lethal form of adult brain cancer, characterised by its rapid growth, invasiveness and colonisation. Current standard of care includes surgical resection, chemotherapy and radiotherapy. Despite this, mortality remains dismal with median patient survival of less than 15 months after treatment. For these reasons, the World Health Organisation (WHO) classifies GBM as an incurable disease. To address this challenge, the GBM scientific …

27.08.2026journal-article

JMIR Research Protocols

Clinical and Patient-Reported Outcomes Following Multidisciplinary Management of Cancer-Related Pain: Protocol for a Prospective Observational Pre-Post Study

Juan Jose Amate Pena, Laura García Reza, Patricia Concheiro-Moscoso, Betania Groba, Sara Sierra Cardalda, Clara García Lorenzo, Miguel Angel Pereira Loureiro

Background Cancer-related pain remains highly prevalent and frequently undertreated despite advances in oncological therapies and analgesic strategies. Multidisciplinary approaches are recommended to optimize complex cancer pain management and integrate supportive care; however, robust real-world evidence evaluating their measurable clinical and patient-reported impact remains limited. Structured multidisciplinary cancer pain committees may be associated with changes in pain outcomes, quality of life, and patient e …

27.08.2026journal-article

Neuro-Oncology

88 Slip Interface Imaging in Glioblastoma: A Pilot Study of Tumour-Brain Adhesion and Surgical Resectability

Lucy Hiscox, Jennifer Golten, Robert Davis, Louisa Wood, Muhammad Usman Akbar, Tara Davies, Sarah Jones, Marco Palombo, James Powell

Abstract Background Achieving a macroscopic complete resection (CR) is a primary prognostic goal in glioblastoma multiforme (GBM) surgery, yet it is often limited by aggressive tumour infiltration at the tumour–brain interface (TBI). The mechanical quality of this interface dictates the ease of surgical dissection, but it cannot currently be assessed preoperatively. Here, we investigated Slip Interface Imaging (SII), derived from in vivo Magnetic Resonance Elastography (MRE), as a non-invasive tool to quantify TBI …

27.08.2026journal-article

Neuro-Oncology

148 Using real-world data from GlioCova to assess the feasibility and revise the design of the ARISTOCRAT trial in recurrent glioblastoma

Joshua Savage, Divya Bhaskaran, Amanda Kirkham, Rhys Mant, Kerlann Le Calvez, Fiona Collinson, Matthew Williams, Lucinda Billingham, Susan Short

Abstract Introduction ARISTOCRAT is a blinded trial of cannabinoids with standard-of-care temozolomide in recurrent glioblastoma, which initially aimed to recruit 234 patients over 18 months. Recruitment started on 03-Feb-2023, and it soon became apparent, from screening and recruitment data, that our initial site feasibility data was not reflected in actual recruitment. Estimating the eligible population size for studies is a recognised challenge. National cancer data is difficult to access and does not include th …

27.08.2026journal-article

Neuro-Oncology

8 MonoGerm: Phase II trial of carboplatin or vinblastine monotherapy prior to radiotherapy for intracranial germinoma, using novel proof-of-principle Bayesian design

Laura Kirton, John Apps, Anna Lawson, Theodoros Arvanitis, Dipayan Mitra, Richard Gagen, Hiten Patel, Andrew Peet, Lorna Fern, Emma Williams, Nicholas Coleman, Thankamma Ajithkumar, Brigitte Bison, Gareth Veal, Daniel Stark, Shivani Bailey, Cinzia Scarpini, Giovanni Morana, James Nicholson, Lucinda Billingham, Matthew Murray

Abstract Background Current European standard-of-care for localised intracranial germinoma is multi-agent chemotherapy (carboPEI: carboplatin/etoposide/ifosfamide) followed by definitive radiotherapy, with excellent survival. MonoGerm is a de-escalation, non-inferiority trial aiming to reduce toxicity. Twelve-week carboplatin AUC10 or vinblastine induction will be compared with carboPEI from SIOP-CNS-GCT-II. A novel trial design is required to answer this question pragmatically/safely. Methods Clinical trials in ra …

27.08.2026journal-article

Neuro-Oncology

22 Quality of life and services use in patients diagnosed with brain tumours: data from a national cancer survivorship study

Kerlann Le Calvez, Jonathan J Gregory, Jacqui Gath, Pete Wheatstone, Laura Ashley, Owen Chinembiri, Anthony Cunliffe, Garry Davenport, Kendall Jamieson Gilmore, Katri Langel, Clara Miglio, Lillie Pakzad-Shahabi, Danush Padmasri, Danny Ruta, Helen Williams, Matthew Williams

Abstract Introduction About 13,000 new patients are diagnosed annually with a primary brain tumour in the UK and less than 20% of patients survive 10 years post-diagnosis. Patient-Reported Outcomes and Experiences (PROMs & PREMs) are largely used in clinical trials that recruit fitter and younger patients than patients routinely treated. Indigo is a randomised controlled digital clinical trial aimed at capturing adult cancer patients’ PROMs and PREMs. Methods We have implemented an online, patient-completed, random …

27.08.2026journal-article

Neuro-Oncology

165 Astrocyte–Glioblastoma Metabolic Interactions at the Invasive Margin Reveal Therapeutic Vulnerabilities

Une Kontrimaite, Phoebe McCrorie, Carver Wong, Sandra Martinez Jarquin, Harry Porter, Stuart Smith, Dong-Hyun Kim, Ruman Rahman

Abstract Introduction Glioblastoma is an aggressive brain tumour that, despite multimodal treatment, almost always recurs. Infiltrative tumour cells within the brain microenvironment are thought to drive recurrence and are supported by surrounding non-cancerous brain cells. Among these, astrocytes, the most abundant glial cells in the brain, play key roles in regulating metabolic homeostasis. The metabolic dependencies underpinning astrocyte–glioblastoma interactions remain poorly defined. Identifying targetable me …

27.08.2026journal-article

Frontiers in Oncology

Case Report: Targeting EGFR exon 20 insertion and MTAP loss in refractory metastatic upper tract urothelial carcinoma

Karen Hoi Lam Li, Roland Ching Yu Leung, Thomas Yau, Joshua Jing Xi Li, Josephine Wing Yan Tsang, Jenny Wai Yan Lo, Gerry Gin Wai Kwok, Jeffrey Sum Lung Wong, Alvin Hoi Wai Chan, Bryan Cho Wing Li

This case report illustrates the use of amivantamab in combination with pemetrexed-based chemotherapy for the treatment of a 60-year-old man with refractory metastatic upper tract urothelial carcinoma (UTUC) with epidermal growth factor receptor (EGFR) exon 20 insertion (D770_N771insGF) and methylthioadenosine phosphorylase (MTAP) loss identified in both the primary left nephroureterectomy tissue and lung metastasis biopsy. The patient, who had progressed on five prior lines of therapy including platinum-based chem …

27.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Systemic inflammation and risk stratification in pheochromocytoma: Insights from PASS components, TNM stage, and the tumor immune microenvironment

Ümit Çavdar, Tuğçe Tekinaslan, Özlem Eren, Emine Özlem Gür, Serkan Karaıslı, Mehmet Haciyanli, Selda Gücek Haciyanli, Aslı Kahraman, Mehmet Sercan Ertürk, Barış Önder Pamuk, Serkan Yener

Introduction: The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Tumor–Node–Metastasis (TNM) staging capture histopathological and anatomical risk features in adrenal pheochromocytoma, but do not incorporate systemic inflammation. Objectives: To investigate the associations of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with individual PASS components and American Joint Committee on Cancer TNM stage in adrenal pheochromocytoma. Methods: We retr …

27.08.2026journal-article

Pediatric Blood & Cancer

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

Elizabeth A. Mullen, Lindsay A. Renfro, Peter F. Ehrlich, Geetika Khanna, Amy L. Treece, Eric J. Gratias, Nicholas G. Cost, Paul E. Grundy, Conrad V. Fernandez, Jeffrey S. Dome, James I. Geller, for the AREN03B2 Study Committee

ABSTRACT Background The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real‐time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review process on timely therapeutic protocol assignment. Procedure COG Renal Tumor Committee members performed real‐time central radiology review to assess lung metastasis and bilateral renal lesions, pathology review for histologic diagn …