Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 23

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Pediatric Blood & Cancer

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

Elizabeth A. Mullen, Lindsay A. Renfro, Peter F. Ehrlich, Geetika Khanna, Amy L. Treece, Eric J. Gratias, Nicholas G. Cost, Paul E. Grundy, Conrad V. Fernandez, Jeffrey S. Dome, James I. Geller, for the AREN03B2 Study Committee

ABSTRACT Background The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real‐time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review process on timely therapeutic protocol assignment. Procedure COG Renal Tumor Committee members performed real‐time central radiology review to assess lung metastasis and bilateral renal lesions, pathology review for histologic diagn …

27.08.2026journal-article

JAMA Oncology

Systemic Therapy Considerations in Older Adults With Early-Stage Breast Cancer

Claire E. Smith, Sarah L. Sammons, Christina A. Minami, Mina S. Sedrak, Allison Magnuson, Tracey O’Connor, Tammy T. Hshieh, Sydney Smith, Karen Ruderman, Kate Bak, Nancy U. Lin, Rachel A. Freedman

Importance The treatment of older adults with chemotherapy for early-stage breast cancer involves a complex decision-making process that weighs the competing risks of disease recurrence against the potential harms of treatment. While older adults continue to be underrepresented in therapeutic clinical trials, there is a growing body of evidence to support optimal management of each subtype of early-stage breast cancer, including novel strategies like adjuvant cyclin-dependent kinase 4/6 inhibitors in hormone recept …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer

Yao Xing, Min Gu

BACKGROUND Postoperative radiotherapy reduces local recurrence in locally advanced colorectal cancer, but its efficacy depends on accurate target volume delineation. This study assessed the impact of delineation accuracy on treatment outcomes. AIM To investigate the impact of target volume delineation accuracy on treatment outcomes of postoperative radiotherapy for colorectal cancer. METHODS Clinical data of 218 colorectal cancer patients who underwent radical surgery followed by adjuvant radiotherapy at our hospit …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Correction to: “Liuzijue” Qigong training enhances early pulmonary function recovery after esophageal cancer surgery

Yu Bai, Yi-Bin Wu

Correction to: Bai Y, Zhang ZL, Qiao L, Shi LL, Wang J, Nian H, Du QC, Tian ZH, Yao ZL, Wu YB. "Liuzijue" Qigong training enhances early pulmonary function recovery after esophageal cancer surgery. World J Gastrointest Surg 2025; 17(12): 113408 [PMID: 41479713 DOI: 10.4240/wjgs.v17.i12.113408]. In this article, we have identified an error in Tables 3 and 4: The columns labeled “Control group” and “Experimental group” were inadvertently transposed during a post-publication review.

27.08.2026journal-article

Clinical Cancer Research

A Phase 2 Basket Trial of Ado-Trastuzumab Emtansine for Patients with HER2 Amplified Cancers: A Non-Randomized Clinical Trial

Jessica S. Ross, Winston Wong, Lauren Schoech, Alex Makhnin, Dazhi Liu, Ranieri Yllanes, Jonathan Loi, Ala'A Damrah, Amanda Johnson, Michelle S. Ginsberg, Vetri Sudar Jayaprakasam, Mark Dunphy, Ronglai Shen, Nora Katabi, Kanika Arora, Michael F. Berger, David B. Solit, Mark Y. Jeng, Charles Hsu, Alexander Drilon, Vicky Makker, Gopakumar Iyer, Rona Yaeger, Gregory J. Riely, Mark G. Kris, Bob Li, Alan Ho, Jamie E. Chaft

Abstract Purpose: To evaluate the efficacy of ado-trastuzumab emtansine (T-DM1) among patients with advanced/metastatic HER2-amplified solid tumors. Patients and Methods: This was a single-center, non-randomized phase 2 basket trial conducted at Memorial Sloan Kettering Cancer Center. All 95 patients had HER2-amplified metastatic/advanced disease and were enrolled in 1 of 5 cohorts. HER2 amplification was diagnosed either with next-generation sequencing or in-situ hybridization. All patients received intravenous T- …

27.08.2026journal-article

The Canadian Journal of Psychiatry

Targeting Addiction Treatment Engagement: A Canadian Randomized Effectiveness Trial of Remotely Administered Contingency Management for Treatment Attendance: Cibler l’engagement en matière de traitement des dépendances : essai d’efficacité à répartition aléatoire mené au Canada portant sur la gestion des contingences mise en œuvre à distance pour la participation au traitement

David C. Hodgins, Jane Yi, Angela Wallace, Laurence Macrae Lynch, Ashley Ethier, Luija Long, Megan E. Cowie

Introduction Contingency management (CM) is an evidence-based treatment used as a stand-alone treatment or an adjunct to usual care for individuals with substance use disorders (SUDs). However, its use in clinical practice is limited, particularly in Canada. This study implemented and evaluated the effectiveness of CM for SUDs in 2 outpatient addiction clinics in Alberta. Methods A 3-month, 2-armed, parallel-group, unblinded intervention comparing attendance-based CM ( n = 43) with a treatment-as-usual (TAU) contro …

27.08.2026journal-article

Frontiers in Oncology

Case Report: How to tailor adjuvant radiotherapy after open partial laryngeal surgery in the setting of a secure R0-resection?

Pierluigi Bonomo, Maja Guberina, Jon Cacicedo

In this report, we discuss this clinical case, when the laryngeal remnant, or “neo-larynx”, is not part of the clinical target volume, it should be delineated as a bona-fide organ at risk or avoidance structure: recognizing the post-surgical anatomy could help maximize the preservation of the functional outcome. In addition, raising awareness on this rare yet very challenging disease presentation could foster a more homogeneous practice among radiation oncologists treating laryngeal cancer analogue to thoracic canc …

27.08.2026journal-article

The Anatolian Journal of Cardiology

Comparison of Direct Oral Anticoagulants and Low-Molecular-Weight Heparins in Cancer Patients with Nonvalvular Atrial Fibrillation: Insights from a Single-Center Experience

İmran Ceren, Yusuf Ziya Şener, Kemal Göçer, Hatice Gülgün Fırat, Kardelen Ohtaroğlu Tokdil, Fatih Yıldız, Fadime Bozduman Habip, Eser Açıkgöz, Öztürk Ateş, Demet Menekşe Gerede Uludağ, Elif Eroğlu Büyüköner

Background: Atrial fibrillation (AF) is frequently encountered in patients with cancer and poses challenges for anticoagulant management. The present study was conducted to compare clinical outcomes associated with direct oral anticoagulants (DOACs) and low-molecular-weight heparin (LMWH) in individuals with active malignancy and nonvalvular AF (NVAF). Methods: Data from patients with active cancer who received LMWH or DOACs for NVAF were retrospectively screened. Efficacy, safety, and survival outcomes were analyz …

27.08.2026journal-article

Cytopathology

Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm

Miyu Okuda, Keishi Mizuguchi, Tatsuya Mori, Urara Okawa, Hiroko Ikeda

ABSTRACT Pancreatic neuroendocrine tumors (PanNETs) are rare epithelial neoplasms with endocrine differentiation. Although most PanNETs exhibit typical cytological features, uncommon morphological variants occasionally occur. We report the first case of a rhabdoid‐type PanNET diagnosed solely by cytology. A 48‐year‐old woman was incidentally found to have a pancreatic head mass. Endoscopic ultrasound‐guided fine‐needle aspiration cytology revealed tumor cells with eccentric nuclei, granular chromatin, and prominent …

27.08.2026journal-article

Colorectal Disease

Threshold association analysis between residual tumour size and distant metastasis risk after neoadjuvant therapy for rectal cancer: A multicentre retrospective study

Hao Zeng, Xueyi Xue, Dongbo Chen, Xiaojie Wang, Kun Lan, Zhilong Yuan, Wenchang Gan, Baodong Liao, Bozhang Wu, Dongbo Xu, Bing Zeng, Pan Chi, Shuangming Lin, Ying Huang

Abstract Purpose This study aimed to perform a threshold analysis of residual tumour size (RTS) to identify the critical threshold influencing distant metastasis (DM), thereby enabling more precise risk stratification. Methods This multicentre retrospective cohort study included patients with locally advanced rectal cancer who underwent radical surgery following neoadjuvant chemoradiotherapy (nCRT). Kaplan–Meier survival curves were plotted and compared using the log‐rank test. Multivariable Cox proportional hazard …

27.08.2026journal-article

Cancers

Treatment Sequencing of CDK4/6 Inhibitors in Bone-Only Hormone Receptor-Positive Metastatic Breast Cancer: Multi-Center Real-World Data Revealing a Numerical Trend Favoring Later-Line Use

Serkan Yıldırım, Büşra Bülbül, Bekir Ucun, İrem Turgut Yeğen, Cengiz Yılmaz, Atike Pınar Erdoğan, Ece Şahin Hafızoğlu, Erhan Gökmen, Murat Araz, Ahmet Oruç, Orhan Önder Eren

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the gold standard in the first-line treatment of hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC). However, the optimal timing of CDK4/6i initiation in patients with bone-only disease (BoD) remains a matter of clinical discussion. This multicenter retrospective study evaluated the impact of CDK4/6i treatment line (first-line vs. second-or-later-line) on progression-free survival (PFS) a …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Prognostic Value of the Hemoglobin–Albumin–Lymphocyte–Platelet Score, Red Cell Distribution Width, and Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer

İsmail Kırlı, Ozgur Tanriverdi, Ali Alkan

Red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and the hemoglobin–albumin–lymphocyte–platelet (HALP) score are easily accessible inflammatory and nutritional biomarkers associated with prognosis in various malignancies; however, their role in metastatic castration-resistant prostate cancer (mCRPC) remains unclear. This study evaluated the prognostic significance of RDW, NLR, and the HALP score in patients with mCRPC treated with androgen receptor pathway inhibitors. In this retrospective s …

27.08.2026journal-article

Neuro-Oncology

60 Persistent minimal contrast enhancement following autologous stem cell transplantation in primary CNS lymphoma

Ellie-May Bond, Nitin Menon, Paul Morgan, Alberto Schena, Christopher Fox, Stefanie Thust

Abstract Introduction Primary CNS lymphoma (PCNSL) is a rare, aggressive form of extranodal non-Hodgkin’s lymphoma. High-dose methotrexate-based chemotherapy regimens have substantially improved PCNSL outcomes, but long-term survival remains unpredictable. The IPCG criteria guide semiquantitative response assessments by contrast-enhancing lesion measurement. This study investigated the association of persistent minimal contrast enhancement in PCNSL lesions with survival. Method Ethics permission was obtained for a …

27.08.2026journal-article

Neuro-Oncology

26 Investigating boron neutron capture therapy for the treatment of glioblastoma

Bethany Mackinnon

Abstract Introduction With an average survival of 12-18 months, glioblastoma is the most commonly diagnosed malignant brain tumour in adults. Despite treatment advances, survival outcomes have shown minimal improvements over the past decades. Persistent treatment resistance, and disease recurrence, highlight the need for alternative, more effective, therapies to be explored. Driven by advances in accelerator-based neutron sources and next-generation boron compounds, boron neutron capture therapy (BNCT) has re-emerg …

27.08.2026journal-article

World Journal of Surgery

A Population‐Based Study of Incidence, Presentation, Treatment and Short‐Term Outcomes of Acute Thromboembolic Ischemia in the Lower Limbs

Jørgen B. Vennesland, Kjetil Søreide, Jan Terje Kvaløy, Andreas Reite, Morten Vetrhus

ABSTRACT Objectives To investigate the current epidemiology and short‐term outcomes in patients with acute lower limb ischemia (ALI) in a well‐defined Norwegian population. Methods A retrospective, single‐center, observational cohort study in a defined population catchment area. All patients with ALI from the catchment area were included in the period from January 2000 to December 2019. Age‐ and sex‐adjusted incidence rates were calculated using population demographics from Statistics Norway. Results A total of 359 …

27.08.2026journal-article

The Egyptian Journal of Otolaryngology

Clinical presentation, management and outcomes of differentiated thyroid cancer: a tertiary center experience

Samer Ahmed Ibrahim, Ahmed Adly Mohammed, Mohammed Naguib Mohamed, Reham Mohamed Faheim, Rehab Saeed Hussein, Ahmed Abdelmoneim Teaima

Abstract Introduction Thyroid cancer is considered the most common endocrine tumor worldwide and its incidence is increasing. Objective We conducted this study to analyses demographic, clinicopathological, imaging data, treatment, outcomes, recurrence rate, overall survival and prognosis of differentiated thyroid cancer (DTC) cases. Patients & methods This is a retrospective study done in our tertiary hospital including patients diagnosed with DTC from 2015 to 2020. One hundred seventy-six patients’ data were revie …

27.08.2026journal-article

Addiction Science Reviews

Positive Psychotherapy in the Treatment of Alcohol Use Disorder: A Systematic Review

Atakan Taşkıran, Reşat Güven, Deniz Ergün

This study is a systematic review examining the effects of positive psychotherapy-based treatment of alcohol dependence on craving and relapse within the framework of psychiatry, clinical psychology, and addiction literature. Alcohol use disorder is a chronic and relapsing mental health problem characterized by impaired control over alcohol use, tolerance development, and continued use despite negative consequences. Positive psychotherapy, developed by Nossrat Peseschkian as a humanistic, psychodynamic, resource-or …

27.08.2026journal-article

Journal of Bone and Joint Surgery

Principles of Level Selection for Instrumentation in Adult Cervical Spinal Deformity Surgery

Zeeshan M. Sardar, Josephine R. Coury, Anson G. Bautista, Katherine Dong, K. Daniel Riew, Justin L. Reyes

➢ For isolated cervical deformities in patients with good bone health, the upper instrumented vertebra can be C3 or C4. ➢ For patients with global cervical deformity, poor bone health, planned 3-column osteotomies, or long fusion constructs, C2 may be an appropriate upper instrumented vertebra. ➢ For patients with focal kyphosis, optimal sagittal alignment, and preserved bone stock, a lower instrumented vertebra cranial to the cervicothoracic junction is appropriate. ➢ For patients with poor cervical sagittal align …

27.08.2026journal-article

Current Issues in Molecular Biology

URMylation Signaling Pathway in Cancer: Molecular Mechanisms and Therapeutic Opportunities

Jingchao Wang, Peiqiang Yan, Weiwei Jiang, Li Chen, Daoyuan Huang, Tao Hou, Hiroyuki Inuzuka, Wenyi Wei

Ubiquitin-related modifier 1 (URM1) defines a distinctive ubiquitin-like system in which URM1 functions both as a covalent protein modifier and a sulfur carrier required for wobble uridine (U34) thiolation of cytosolic tRNAs. This dual role places URM1 signaling at the intersection of protein post-translational modification and codon-sensitive translational control. Although URM1 remains less well characterized than ubiquitin and other ubiquitin-like modifiers, accumulating evidence links URM1-associated processes …

27.08.2026journal-article

British Journal of Haematology

LTB ‐ TREAT : A validated international prognostic model for time to treatment in low tumour burden follicular lymphoma

Luani Barge, Lachlan Webb, Anita Pelecanos, Niamh Waters, Ross Salvaris, Sam Lai, Tessa Potezny, Helen Cashman, Caitlyn Nguyen‐Ngo, Denise Lee, Costas K. Yannakou, Nada Hamad, Adrien Chauchet, Sylvain Choquet, Cédric Rossi, Adélie Herbin, Lukshe Kanagaratnam, Cyrielle Rodier, Constantine S. Tam, Abir Bhattacharyya, Chan Y. Cheah, Eliza A. Hawkes, Kirk Morris, Eric Durot, Joshua Tobin, Greg Hapgood

Summary Watchful waiting (WW) in low tumour burden follicular lymphoma (LTB FL) defers treatment. There is a need to develop a model to predict time to treatment (TTT). We aimed to develop and externally validate a model for TTT in LTB FL. We conducted a retrospective analysis across eight centres within the Australasian Lymphoma Alliance. Two hundred and twenty‐nine patients were included between 2004 and 2022 with a median follow‐up of 5.0 years (range 0.5–17.8 years) and a median age was 64 years. All patients w …

27.08.2026journal-article

Scientific Reports

W-AGRU-Net: a dual-stream attention framework for robust brain tumor segmentation in clinical MRI imaging

Marwa Abbas, Hussein Mogahed, Aziza Hussein, Ashraf Khalaf, Mohamed Mourad

Abstract Segmenting brain tumors from MRI scans is a challenging aspect of medical image analysis because of anatomical complexity, ambiguous tumor boundaries, and variability of shape. In this paper, we propose W-AGRU-Net, a new dual-stream U-Net framework that combines W-Attention mechanisms with residual connections for strong and accurate glioma segmentation. Our framework uses two asymmetric streams that have pyramid-shaped dilated convolution schemes (PDCS) for hierarchical multi-scale context capturing. The …

27.08.2026journal-article

Neuro-Oncology

54 Access to Prehabilitation in UK Neuro-Oncology: Insights from a UK-wide review of adult brain tumour services (2024-2026)

Sara Melhuish, Nicola Peat, Andrew Wright, Camille Goetz, Nicky Huskens

Abstract Background Prehabilitation aims to optimise physical, psychological and functional health prior to and during cancer treatment. While an increasing focus in neuro-oncology, little is known about its availability or structure across the United Kingdom (UK). Methods As part of the Tessa Jowell Centre of Excellence programme, workforce and service data were collected from 25 UK adult neuro-oncology centres (2024–2026), covering 90+% of the UK population. Responses were extracted from application forms and the …

27.08.2026journal-article

Neuro-Oncology

33 Endoscopic Transsphenoidal Surgery for Pituitary Tumors: Experience and Outcome Analysis from a Tertiary Care Center Nepal

Dipendra Kumar Shrestha

Abstract Introduction Pituitary tumors account for 10–15% of brain tumors and frequently cause morbidity through mass effect or hormonal dysfunction. Endoscopic transsphenoidal surgery (ETS) has become the global standard due to superior visualization and reduced risk compared to microscopic techniques. In Nepal, delayed patient presentation and constrained resources limit the widespread adoption of endoscopic surgery. With limited local outcome data, our study provides benchmark evidence to guide practice in resou …

27.08.2026journal-article

Journal of Pancreatology

Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer

Yi Liu, Yina Liao, Zhiwen Xiao, Yiying Li, Nuoyan Zhang, Yang Shi, Yilin Song, Xinyue Wang, Quanxing Ni, Timothy M. Pawlik, Xianjun Yu, Guopei Luo

Abstract Background: Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Methods: Data from patients who underwent curative-intent resection for pancreatic cancer and have diabetic status records were retrieved from a prospectively maintained database from November 2010 to May 2017. Postoperative FBG was measured at 2–4 months after …