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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Medicine

Intranodal palisaded myofibroblastoma of the supraclavicular region in an adolescent with an HDAC2 variant: a case report

Yiyang Yu, Yiming Zhao, Lili Cao

Intranodal palisaded myofibroblastoma (IPM) is a rare benign mesenchymal tumor of lymph nodes that most often arises in the inguinal region. We report an 18-year-old woman with an incidentally detected left supraclavicular mass. Imaging showed a well-circumscribed hypervascular lesion, and core biopsy demonstrated a spindle-cell neoplasm for which low-grade malignancy could not be excluded. Complete excision revealed an intranodal spindle-cell proliferation with nuclear palisading, hemorrhage, compressed peripheral …

27.08.2026journal-article

Metabolites

A Hybrid and Comparative Machine Learning Framework for Predicting Gestational Diabetes Mellitus via a Prospective Case-Control Design: A Pilot Study Integrating Periodontal Health and Hematological Inflammatory Markers

İsa Temur, Mehmet Özsan, Katibe Tuğçe Temur, Andaç Batur Çolak

Background/Objectives: This pilot study aimed to develop and compare advanced machine learning models, specifically a Bayesian-regularized artificial neural network (ANN) and a transformer-enhanced physics-informed neural network (PINN), by integrating periodontal health indices and hematological inflammatory markers for the prediction of GDM. Methods: Utilizing a prospective case–control study design, a clinical dataset comprising 80 pregnant women (40 with GDM and 40 healthy controls) was evaluated to develop and …

27.08.2026journal-article

Health Affairs Scholar

FDA Drug Quality Assurance Inspections: Frequency, Outcomes, and Time to Reinspection, 2008–2025

Yunxiang Sun, Jeromie Ballreich, Joy Acha, Riya Modi, Mohammad Ali Alamdar Yazdi, Maqbool Dada, Tinglong Dai, Gerard Anderson, Mariana P Socal

Abstract Background FDA inspections are central to oversight of the pharmaceutical manufacturing base, but long-term inspection and reinspection patterns remain incompletely characterized. Methods We analyzed 25,629 FDA Drug Quality Assurance inspections conducted from October 2008 through December 2025. We described annual, regional, and outcome patterns. Linking inspections to facilities, we examined time to reinspection according to the outcome of preceding inspections. Results Annual Drug Quality Assurance insp …

27.08.2026journal-article

Designs

A Health Belief Model- and TRIZ-Based Design Method for Transfer Assistive Equipment for Individuals with Lower-Limb Mobility Impairment

Haiqiang Wang, Jiali Deng, Xuan Huang, Yexin Chen

Individuals with lower-limb mobility impairment often experience fear of falling and difficulty coordinating with caregivers during transfer tasks. Therefore, safe, stable, and easy-to-operate collaborative transfer assistive equipment is urgently needed. This study proposes a Health Belief Model-driven design method for transfer assistive equipment, aiming to translate users’ risk perceptions and behavioral needs into implementable structural design strategies. First, transfer-related behavioral characteristics we …

27.08.2026journal-article

Frontiers in Global Women's Health

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin

Claire L. Townsend, Lynne Mofenson, Sami Gottlieb, Remco P. H. Peters, Oriol Mitjà, Clara Pérez-Mañá, Elaine J. Abrams, Sinead Delany-Moretlwe, Shahin Lockman, Catriona Waitt, Kathryn Miele, Melanie M. Taylor, Françoise Renaud

Syphilis infection during pregnancy leads to around 390,000 adverse birth outcomes each year and is an important cause of preventable stillbirth. Although benzathine penicillin G is safe and effective during pregnancy for treating maternal and fetal infection, there are frequent global shortages and limited options for people with penicillin allergy. We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceft …

27.08.2026journal-article

Frontiers in Pediatrics

Gestational age–dependent risk patterns in small for gestational age preterm infants: a large multivariable cohort study

Josep Figueras-Aloy, Xavier Carbonell-Estrany, Francesc Botet-Mussons, Óscar García-Algar, Martí Iriondo-Sanz, Giorgia Sebastiani

Background Small for gestational age (SGA) preterm infants remain at high risk for morbidity and mortality, yet the influence of gestational age (GA) on these outcomes is not fully understood. Methods The influence of gestational age on morbidity and mortality in SGA preterm infants (23–34 weeks) was analyzed in a cohort of 11,208 preterm infants. Infants were divided into three groups according to gestational age (23–27 weeks, 28–31 weeks, and 32–34 weeks). Results Compared with non-SGA infants of the same gestati …

27.08.2026journal-article

Sports Health: A Multidisciplinary Approach

The Effect of Stud Flexibility on Lower Limb Biomechanical Demands in Football-Specific Movements

Gabriele Azzolini, Silvia Fantozzi, Andrea Ferretti, Ezio Preatoni

Background: Stud design is critical in modulating impact forces between football boot and turf, yet most systems prioritize traction using rigid materials, largely neglecting the role of material flexibility in load attenuation. This study assessed the biomechanical effects of 2 novel flexible stud designs compared with a traditional rigid stud during football-specific cutting and landing tasks. Hypothesis: Replacing traditional rigid studs with more flexible alternatives would reduce the magnitude and increase the …

27.08.2026journal-article

Frontiers in Pediatrics

CFTR mutations and genotypic patterns among cystic fibrosis patients with allergic bronchopulmonary aspergillosis: analysis from a tertiary care center in Saudi Arabia

Maryam Fuad Ali, Hessa AlOtaibi, Talal AlZahrani, Bushra Hafez, Ayesha Khokhar, Maad Jalal, Amal Albalawi, Raghad AlHuthil, Hanaa Banjar

Introduction Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Allergic bronchopulmonary aspergillosis (ABPA) is a recognized complication in CF, with genetic variability potentially influencing susceptibility. This study aims to assess the distribution of CFTR genotype classes in CF patients with ABPA and explore their association with disease severity and baseline pulmonary function. Methods A retrospective cross-sectional stu …

27.08.2026journal-article

Frontiers in Digital Health

From free association to free parameters: machine-learning empowers artificial intelligence models to rate the affective-relational aspects of narratives like an expert psychologist

Caleb J. Siefert, Barry Dauphin, Jenelle Slavin-Mulford, Sai Dileep Kumar Mukkamala, Venkat Akhila Reddy Tatipally, Areen Alsaid, Abdallah Chehade

Background Narrative assessment offers unique insight into psychological functioning but is resource-intensive, requiring extensive expert training and time. Recent work suggests Artificial Intelligence (AI), including moderately sized, adaptable large language models (LLMs), can master narrative assessment's complex, multi-step scoring rules. This study examined whether fine-tuning could enable AI raters to accurately assess narratives. Method We fine-tuned five diverse LLMs (3–7 billion parameters) on two dataset …

27.08.2026journal-article

Neuro-Oncology

150 The Value of Early Biological Information in Glioblastoma Drug Development: A Health Economic Evaluation of Window-of-Opportunity Trials

Melyda Melyda, Sue Jowett, Peter Auguste, Victoria Wykes, Collin Watts, Gary Middleton, Vinton Cheng

Abstract Introduction Window-of-opportunity (WoO) trials are increasingly proposed in glioblastoma drug development to test early biological activity (tumour penetration and target engagement), before progression to large, costly late-phase trials. While WoO designs may improve early decision-making, they introduce additional operational complexity and upfront costs. Their economic value remains uncertain. Methods An early decision-analytic model was developed to assess the cost-effectiveness of incorporating a WoO …

27.08.2026journal-article

Frontiers in Public Health

What limits a bystander’s action to perform cardiopulmonary resuscitation in China? Insights from a cross-sectional study conducted in Shaanxi Province

Dongdong Li, Kun Wang, Qiang Fu, Yan Li, Wangang Guo, Xiaolan Guo, Xin Zhang, Yuchan Hu, Liping Liao, Zhuoni Ma, Xin Chen, Miaomiao Cheng

Background Rate of bystander-initiated cardiopulmonary resuscitation (CPR) remains critically low in China. Identifying the underlying reasons may help reduce mortality from out-of-hospital cardiac arrest (OHCA). Methods A cross-sectional study was conducted among 572 participants in Shaanxi, China. A researcher-developed questionnaire was used to assess four domains: ability to recognize the need for CPR, willingness to perform CPR, internal concerns about initiating CPR, and actual CPR competence. Subgroup analys …

27.08.2026journal-article

Frontiers in Public Health

Population-level association of layperson cardiopulmonary resuscitation training with survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis

Pan Pan, Zhou YaXiong, Jiang YaoWen, Xia YiQin, Chen Yao

Background Out-of-hospital cardiac arrest (OHCA) is a significant worldwide cause of death and is highly dependent upon bystander intervention. Layperson cardiopulmonary resuscitation (CPR) training has been widely promoted, but its population-level association with survival after out-of-hospital cardiac arrest remains incompletely characterized. Methods This systematic review and meta-analysis was conducted according to PRISMA guidelines and registered in PROSPERO. PubMed, Embase, Web of science and Cochrane Libra …

27.08.2026journal-article

Med Phoenix

Prescription Pattern in Neonatal Intensive Care Unit of Tertiary Care Teaching Hospitals of Birgunj, Nepal.

Smita Singh, Dhivya Chakravathy, Md. Ashfaque Ansari, Prabin Kumar Singh

Introduction: Neonates admitted to neonatal intensive care units are subjected to wide range of medications so drug utilization studies provide a glimpse of ongoing treatment trend, identifying and avoiding side effects and promoting rationale use of medications. This study was conducted with an objective to assess the drug utilization pattern among neonates admitted at tertiary health care centres in Birgunj. Materials and Methods: A cross sectional observational study was conducted at two tertiary hospitals of Bi …

27.08.2026journal-article

Frontiers in Pediatrics

Chronic respiratory morbidity and wheeze after preterm birth: a narrative review

A. Jenkinson, S. Ahmed, A. Gupta, A. Greenough

Preterm birth, defined as birth before 37 weeks of gestation, affects approximately 10% of pregnancies worldwide. Premature birth disrupts normal lung development with those born at earlier gestations most affected. Individuals born preterm are at increased risk of lifelong respiratory morbidity, including recurrent wheeze. As a consequence, affected individuals are often given an incorrect diagnosis of asthma. Asthma is considered a clinical description and is defined as a clinical syndrome characterised by wheeze …

27.08.2026journal-article

European Health Psychologist

The opportunities, benefits, and challenges of applying health psychology in non-academic settings: summary of a roundtable discussion

Alice Le Bonniec, Lisa Hynes, Koula Asimakopoulou, Ana-Maria Schweitzer, Alexandra Dima

This article summarizes a roundtable discussion about the application of health psychology in non-academic settings that was presented at the EHPS conference 2024. Five contributors shared their experiences applying health psychology in non-academic settings. Contributors’ non-academic roles reflect a variety of applications for health psychology: cancer screening; cardiovascular disease prevention, medication adherence, pharmacy, and management of chronic conditions. They discussed the benefits of their roles such …

27.08.2026journal-article

BMC Women's Health

Long-term risk of second primary malignancies and symptomatic heart failure after pegylated liposomal doxorubicin versus conventional anthracycline-based chemotherapy in early-stage breast cancer survivors: a single-center experience

Yu-Ting Lee, Hsin-Yi Yang, Chi-Wen Tu, Yu-Chen Hsu, Min-Chieh Shieh, Cheng-Yen Lee, Chih-Chia Chang, Yuk-Wah Tsang, Yu-Wen Wang, Wei-Yu Wang, Chin-Ho Kuo, Ming-Yang Lee, Yin-Che Lu, Po-Yen Hsu, Michael W. Y. Chan

Abstract Background Anthracycline-based chemotherapy is a crucial treatment for early-stage breast cancer but be associated with second primary malignancy (SPM) and heart failure (HF). Pegylated liposomal doxorubicin (PLD) has been used as an alternative to conventional non-pegylated anthracyclines; however, long-term data regarding SPM and symptomatic HF after PLD-based treatment remain limited. This study evaluated the long-term risks of SPM and symptomatic HF and compared survival outcomes between PLD-based and …

27.08.2026journal-article

Frontiers in Endocrinology

Case Report: Pasireotide treatment in neonatal congenital hyperinsulinism due to a homozygous ABCC8 mutation

Calvin Kurz, Marcia Roeper, Lisa Friesl, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer, Henrike Hoermann, Alena Welters

Mutations in ABCC8 and KCNJ11 are associated with the most severe and diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are commonly used off-label as second-line treatment. While octreotide and lanreotide are the most established options, pasireotide—a second-generation somatostatin analogue with higher affinity for somatostatin receptor subtype 5—has been hypothesized to offer improved suppression of insulin secretion. We report the off-label use of subcutaneous pasireotide in …

27.08.2026journal-article

The Milbank Quarterly

Stigma as a Social Determinant of Health: A Policy Classification Framework and Call to Action

LISA CARTER‐BAWA

Policy Points Stigma functions as a social determinant of health (SDOH), producing population health inequities through resource deprivation, social exclusion, constrained health care, physiological stress, and diminished agency—yet it lacks formal SDOH classification. Because stigma operates as a fundamental cause of health inequalities, policy responses must extend beyond health care systems to encompass housing, employment, education, and social participation. Discrimination is already classified as an SDOH; for …

27.08.2026journal-article

American Journal of Health-System Pharmacy

Improving patient safety with triple-scan technology for insulin pen administration

Courtney K Wulffson, Melissa M Babin, Merissa T Andersen Pinotti

Abstract Purpose High-alert medications such as insulin pose serious risks to patients when used in error. In response to vulnerabilities identified in existing insulin administration workflows, we implemented a comprehensive approach to mitigate the risk of errors in the hospital setting. Summary A new electronic health record capability, referred to as the “triple-scan system,” was introduced to enhance insulin pen administration safety. This system requires nurses to scan the patient’s wristband barcode, the ins …

27.08.2026journal-article

Annual Review of Developmental Psychology

Behaving Strategically: Adolescent Development of Efficient, Complex, and Socially Focused Behavior

Camille V. Phaneuf-Hadd, Leah H. Somerville

Strategic decision-making—the coordination of choices and actions in service of goals—refines into adulthood as the goals that guide behavior shift during adolescence to support the transition to independent life. This review highlights two trajectories of development that shape behavioral strategy use across adolescence. On the one hand, efficiency-oriented and complex information processing increases during adolescence and facilitates strategic behavior. On the other hand, a highly salient adolescent drive to lea …

27.08.2026journal-article

Frontiers in Public Health

Dating psychological violence among adolescents in a metropolitan region of southeastern Brazil: a school-based study

Isaura Barros Alves Pinto, Franciele Marabotti Costa Leite

Objective To analyze the prevalence of dating psychological violence among adolescents in the Metropolitan Region of the State of Espírito Santo (ES), Brazil, and its association with socioeconomic and behavioral characteristics and violence experiences. Methods A cross-sectional and analytical study was conducted with 1,238 adolescents aged 14–19, enrolled in public and private schools in the Greater Vitória Metropolitan Region (ES), Brazil, who were in a romantic relationship at the time of the research. Sampling …

27.08.2026journal-article

Frontiers in Health Services

The CLEAR model: a structured communication protocol for breast radiologists

Teresa Abbattista, Aram Hasan

Background Communication in diagnostic breast imaging remains a critical yet frequently neglected aspect of radiological training. Traditionally centered on technical image interpretation, radiological education often leaves practitioners unprepared to navigate the severe emotional and psychological burden of a suspected breast cancer diagnosis. Objectives This paper advocates for the communicative autonomy of the breast radiologist, arguing that direct, empathetic communication is not a secondary skill, but a core …

27.08.2026journal-article

International Journal of Environmental Research and Public Health

Micro- and Nanoplastic Exposure in Hospital Environments: A Scoping Review of Occupational Risks Among Healthcare Workers, with Particular Implications for Nursing

Otniel Alencar Bandeira, Lucas Barros de Araújo, Aline Franco da Rocha, Estefanía Coello Gonçalves Canedo, Vivian Vílchez Barboza, Weber da Silva Robazza, Gabriela Frutuozo Müller, Gilberto Costa Teodozio, Maria Lúcia do Carmo Cruz Robazzi

The extensive use of plastic-based materials in healthcare services has raised concerns about micro- and nanoplastic contamination in hospital environments, with potential implications for occupational health, environmental health, and public health nursing. This scoping review aimed to map the available evidence on occupational exposure to micro- and nanoplastics in healthcare settings, identifying exposure sources, pathways, potential health implications, and knowledge gaps, with particular attention to healthcar …

27.08.2026journal-article

Athens Journal of Sports

Advancing Women's Soccer: Interconnected Challenges in Athlete Health and Equity

Colin G. Pennington, Maxwell Premph, Carly Ellman

Women’s soccer has experienced unprecedented global growth, yet this expansion is shadowed by a high prevalence of anterior cruciate ligament (ACL) injuries and persistent systemic inequities. This exploratory narrative synthesis (2004–2026) aims to bridge the gap between biomechanical risk and social justice by examining the interconnected challenges of injury prevention and equity. The review identifies that female athletes face significant biomechanical vulnerabilities, including increased knee valgus and altere …