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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

The Gerontologist

Adverse Childhood Experiences, Cognitive Outcomes, and Frailty in Older Adults: A Systematic Review and Meta-analysis

Fengxue Yang, Hongli Miao, Bing Cao, Li Zeng, Yin Zhou, Zhongqing Yuan, Yi Tian, Yuanting Li

Abstract Background and Objectives Adverse childhood experiences (ACEs) are important life-course determinants of health and may contribute to vulnerability in later life. Frailty and cognitive outcomes are important concerns in older adults, yet evidence linking ACEs to these outcomes has not been systematically synthesized. This review evaluated the associations between ACEs and frailty or cognitive outcomes in middle-aged and older adults. Research Design and Methods Following PRISMA guidelines, we searched seve …

22.08.2026journal-article

Research Involvement and Engagement

Patient and public involvement and engagement in co-designing guidance for mental health professionals supporting neurodivergent children and young people in child and adolescent mental health services

Naomi Williams, Helene Torr, Julie Taylor, Helena Tuomainen

Abstract Background Neurodivergent children and young people, including those with autism, attention-deficit/hyperactivity disorder and intellectual disability, experience higher rates of mental health difficulties than their neurotypical peers. Despite this increased need, many families encounter barriers when accessing child and adolescent mental health services (CAMHS). These barriers may occur across the service pathway, including referral, triage, assessment, treatment, and discharge. Patient and Public Involv …

22.08.2026journal-article

Diseases of the Esophagus

P1.236. Surgical Decision Model for Elderly Patients With Esophageal Cancer: Development and Validation of a Geriatric Stage (gStage) System

Yasue Kimura, Naomichi Koga, Rena Yokomizo, Munehide Terashi, Ayako Iwanaga, Masahiko Sugiyama, Masaru Morita

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The increasing age of patients with esophageal cancer poses significant challenges in surgical decision-making. Elderly individuals frequently present with multimorbidity, impaired physiological reserve, and nutritional vulnerability, all of which increase postoperative risk. Chronological age and performance status alone are insufficient to determine surgical eligibility. A structured approach incorporating mu …

22.08.2026journal-article

Community Mental Health Journal

Exploring the Role of Lived Experience Advocacy in Enhancing Civic Participation among Young People with Mental Ill-Health

Christopher Wainwright, Neil Harris, Rob O’Leary, Tom Riley, Ernesta Sofija

Abstract Civic disengagement among young adults is a significant societal challenge, exacerbated in those experiencing mental ill-health where stigma and social isolation can create a debilitating cycle of withdrawal. This exploratory study investigated how advocacy training for young people with mental ill-health cultivates self-determination through efficacy and increases civic participation. We conducted semi-structured interviews with 18 lived experience advocates (LEAs) participating in advocacy opportunities …

22.08.2026journal-article

Nature Communications

Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables

Jinjoo Shim, Jukka-Pekka Onnela

Abstract Disrupted rest-activity rhythms have been associated with aging and chronic disease, yet longitudinal evidence from free-living populations has been lacking. Here we integrate multi-year Fitbit activity data from the All of Us Research Program with clinical biomarker-derived PhenoAge from 2,222 participants (8,447 person-years). Through high-dimensional digital phenotyping, we show that circadian rest-activity rhythm intensity, timing, and stability are associated with biological aging trajectories. Higher …

22.08.2026journal-article

Healthcare

Preliminary Psychometric Evaluation of the Economic Living Standards Index Short Form (ELSI-SF) Among Spanish Older Adults

Celia Álvarez-Bueno, María Eugenia Visier-Alfonso, Mar de Miguel-Brox, Blanca Zuheros-Lara, María Frontelo-García, Beatriz Rodríguez-Martín

Objective: To examine the reliability, construct validity, and discriminative capacity of the Spanish version of the Economic Living Standards Index Short Form (ELSISF) in a sample of older adults in Spain. Methods: This analysis was conducted using baseline data from 133 participants (mean age = 66.2 years, SD = 5.6; 53.8% women) recruited from community health and social centers in the provinces of Cuenca, Albacete, and Toledo within the PEPE cohort. Participants completed the ELSISF (25 items), sociodemographic …

22.08.2026journal-article

Diseases of the Esophagus

OA10.5. Laparoscopic Repair of Paraesophageal Hernia in Patients Older Than Seventyyears: A High-Volume Center Experience

Arianna Vittori, Andrés R Latorre-Rodriguez, Sai Padithala, Hideyuki Takeuchi, Sumeet K Mittal

Abstract Topic Benign Disease: Esophageal Surgery Background With increasing life expectancy, more elderly patients are diagnosed with large paraesophageal hernias (PEHs). However, the optimal management of PEHs in patients aged ≥70 years remains debated because of concerns regarding operative risk, frailty, and postoperative recovery. While elective minimally invasive repair is commonly performed in younger populations, evidence describing perioperative safety, short-term outcomes, and patient-reported satisfactio …

22.08.2026journal-article

Diseases of the Esophagus

P1.183. Salvage Surgery and Conversion Surgery for Esophageal Cancer in Patients Aged 80 Years or Older

Hiroshi Sato, Yutaka Miyawaki, Yusuke Suzuki, Yutaka Kishimoto, Shinichi Sakuramoto

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background With the rapid aging of the population, esophageal cancer in individuals aged 80 and older continues to increase. Conversely, with recent advances in multidisciplinary treatment, including novel chemotherapies and immune checkpoint inhibitors, “salvage surgery” and “conversion surgery” are increasingly being performed. These procedures often involve more invasive techniques than standard approaches, and their applicability in the e …

22.08.2026journal-article

Forests

Serving More People or Reaching Farther? Landscape Feature Synergies and Trade-Offs in Urban Park Recreational Services

Jingnan Zhu, Xiaoma Li, Li Hu, Peng’ao Liu, Luying Wang, Dexin Gan, Di Shu

Understanding how urban park landscape features are associated with service population and service radius can inform park planning and management. In Changsha, China, this study measured both indicators for 29 parks on one weekday and one weekend day in spring 2025 using mobile signaling data, quantified landscape features from multisource data, and examined their associations. Service population and service radius were not highly correlated. The adjusted R2 values for the two indicators were 71.8% and 84.5%, respe …

22.08.2026journal-article

American Journal of Aging Science and Research

Social isolation and loneliness in older adults: A growing public health challenge with evidence from Nepal

Hom Nath Chalise

Social isolation and loneliness are increasingly recognized as major public health concerns in ageing populations, yet they remain under-addressed in low- and middle-income countries. This article examines the definitions, epidemiology, health consequences, and evidence-based responses related to social isolation and loneliness among older adults, with focused attention to Nepal. Nepal faces a dual challenge: a rapidly growing older adult population—exceeding 10% of the national total in 2021 —and large-scale youth …

22.08.2026journal-article

International Journal For Multidisciplinary Research

Formulation And Evaluation Of Anti-Aging Facial Serum Containing Resveratrol-Rich Red Grape Skin Extract

Aishwarya Pandit, Ashwini Pansare -, Arti Ingole -, Dr. Hitanshi Darji -, Sakshi Kohakade -, Pravinkumar Sable -

The growing demand for natural and plant-based cosmetic products has increased interest in the development of herbal formulations with anti-aging properties. Resveratrol, a polyphenolic compound abundantly present in red grape (Vitis vinifera) skin, possesses potent antioxidant, anti-inflammatory, and photoprotective activities that may help prevent premature skin aging. The present study aimed to formulate and evaluate an anti-aging facial serum containing resveratrol-rich red grape skin extract. Red grape skins w …

22.08.2026journal-article

Journal of Travel Research

When Visuals Meet People with Disabilities: How Destination Image Featuring Disability Drives Travel Intention?

Mengfan Li, Lingxue Zhan, Litang Wen, Ji Chen, Mingming Cheng

This research investigates how featuring people with disabilities in tourism destination images on social media shapes viewers’ travel intention. Guided by warm glow theory, a mixed-methods approach was employed, comprising a field study, semi-structured interviews, and five online experiments. The findings demonstrate that including people with disabilities in tourism destination images has a significant positive effect on travel intention. Moreover, the results show that cognitive mechanisms involving self-projec …

22.08.2026journal-article

Journal of Health Psychology

Post-traumatic growth in people with cancer: A meta-synthesis of qualitative studies

Lingling Pan, Jiayue Wu, Qianyun Jiang, Linyan Wang, Yumei Li

This qualitative meta-synthesis systematically reviewed studies on post-traumatic growth (PTG) in people with cancer. A comprehensive search of nine databases was conducted up to February 2025. Following PRISMA guidelines, the methodological quality of included studies was assessed using the JBI checklist, and data were analyzed via thematic synthesis. Fifteen studies, all rated as Level B (moderate quality), were included, generating three core themes: the psychological journey of PTG, its facilitators and barrier …

22.08.2026journal-article

International Journal of Applied Chemistry

Aging of Palm Wine Source: Its Implication on the Physicochemical Properties and Vitamin Content of Palm Wine

Nwachoko Ndidi, Akuru Udiomine Brantley, Chukwudi Omeni Egbunefu, Clement-Aken Victor Obarijima, Goodluck Samuel

Palm wine, a traditional alcoholic beverage widely consumed in sub-Saharan Africa, is derived from the sap of various palm trees. This study investigated the effects of aging of the palm wine source on the physicochemical properties and vitamin content of palm wine for 30 days. Standard laboratory procedures were employed to analyze these parameters. The results revealed significant (P<0.05) changes in most physicochemical properties and vitamin levels during aging. The pH decreased from (4.95±0.07) on Day 1 to (3. …

22.08.2026journal-article

Diabetology & Metabolic Syndrome

The association between a novel visceral lipoprotein risk index and new-onset diabetes in middle-aged and older Chinese adults

Jin Dong, Fan Yang, Lei Luo, Jianhua Liu, Jian Chen, Xiangyang Shao

Abstract Background The global health burden of diabetes continues to grow. While the Chinese Visceral Adiposity Index (CVAI) and low-density lipoprotein cholesterol (LDL-C) are well-established risk factors for diabetes, the potential compounding effect of these factors is not well characterized. This study aimed to explore the relationship between a novel integrative index, the Visceral Lipoprotein Risk (VLR) index, and incident diabetes. Methods This prospective cohort study included 7,559 participants aged ≥ 45 …

22.08.2026journal-article

BMC Psychiatry

Cognitive status and depressive symptoms among older adults: a SEM analysis study

Farnaz Fathollahzadeh, Azadeh Borna, Parvin Dibajnia, Behrooz Mahmoodi-Bakhtiari, Elizabeth D. Leigh, Mahdi Azizi, Alireza Akbarzade Baghban, Seyede Zohre Mousavi

Abstract Background The increase of age is related with high concerns of cognitive decline and depression which frequently influence each other in both directions. The objective of the current study is the assessment of the cognitive status and the symptoms indicating depression the older adults, in order to evaluate a structural model that subjective cognitive complaints mediate the relationship between objective cognitive performance and depression. Methods The current study, cross-sectional in nature, was carrie …

22.08.2026journal-article

International Journal of Molecular Sciences

Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy

Marta Grycan, Rafał Zyśk, Gabriela Grycan, Grzegorz Jakiel, Alicja Dudek, Grażyna Gromadzka

Aging is the strongest risk factor for chronic diseases such as cardiovascular diseases, cancer, diabetes, and neurodegenerative disorders. Advances in geroscience indicate that pharmacological modulation of conserved molecular pathways may extend healthspan and delay multimorbidity. A structured narrative review of the PubMed, Scopus, and Web of Science literature published between January 2010 and May 2026 was conducted, with seminal earlier studies retained where relevant. The review focused on molecular pathway …

22.08.2026journal-article

Innovation in Aging

Comparing sensor-based activity features of frailty across Fried Frailty Phenotype and deficit-accumulation frailty index

Andrew Song, Kailin Xu, Kuan-Yuan Wang, Lingsong Kong, Stephanie Denise M Sison, Sandra M Shi, Amanda Paluch, Dae Hyun Kim

Abstract Background and Objectives Wearable sensors offer a low-burden approach to assessing frailty in free-living settings, but how sensor-derived features relate to different frailty definitions is unclear. This study compared thigh-worn sensor-derived activity features associated with pre-frail/frail status under the Fried Frailty Phenotype (FFP) and the Comprehensive Geriatric Assessment–Based Frailty Index (CGA-FI). Research Design and Methods We enrolled 44 older adults (mean age 82.3 years, 84% women) from …

22.08.2026journal-article

Nutrients

Effects of a Commercial Fruit, Vegetable and Berry Juice Powder Concentrate on Metabolic Safety and Cardiovascular Health in Older Adults: 6-Month Results of a Randomized Controlled Trial

Tobias Ziegler, Azra Darko, Gerhard Ledinski, Gerd Kager, Gerd Hörl, Andreas Seemann, Gerhard Cvirn, Manfred Lamprecht

Background/Objectives: Fruit, vegetable and berry (FVB) juice powder concentrates are increasingly used to support cardiovascular health. Since they are usually consumed over long periods, this study assessed the metabolic safety of a commercial FVB supplement and its impact on selected biomarkers of systemic oxidative stress and cardiovascular health. Methods: In this open-label, randomized controlled trial, generally healthy older adults were allocated to a control group (n = 16) or an FVB group (n = 18), ingesti …

22.08.2026journal-article

npj Aging

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Reza Gheitasi, Mahnaz Rezaei, Parvaneh Nafisi Fard, Daniela Roel, Sabine Baumgart, Diana Dudziak, Norman Rose, Simon M. Petzinna, Thomas Kamradt, Carsten Watzl, Mathias W. Pletz, Valentin S. Schäfer

Abstract Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio earlier and more severely than females. We argue that age-by-sex stratification should guide vaccination and geroprotective strategies in an aging population.

22.08.2026journal-article

Healthcare

Factors Associated with Treatment Burden in Older Adults with Multimorbidity and Implications for Potential Reduction Strategies: A Scoping Review

Leandro Amato, Gianluca Ciccaglione, Noemi Giannetta, Emanuele Di Simone, Nicolò Panattoni, Sara Dionisi, Alessandra Improta, Sofia Taborri, Marco Di Muzio

Background: Treatment Burden (TB) refers to the workload imposed on patients by healthcare-related tasks involved in the management of chronic conditions. Despite increasing evidence on this phenomenon, strategies for its reduction in older adults with multimorbidity remain poorly explored. Aim: To map the factors associated with treatment burden reported for older patients with multimorbidity and to derive implications for potential reduction strategies, regardless of the care setting. Methods: A scoping review wa …

22.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Anal cancer burden among people with HIV across US states, DC, and major metro areas

Ashish A Deshmukh, Haluk Damgacioglu, Kalyani Sonawane, Cameron Haas, Qianlai Luo, Anna Satcher Johnson, Eric A Engels, Meredith S Shiels

Abstract Background Anal cancer screening is recommended for people with HIV in the United States (US). Because HIV prevalence varies geographically, the distribution of anal cancer diagnoses occurring among people with HIV may also differ by geography. Characterizing geographic variation can help identify areas needing enhanced screening infrastructure and outreach. Methods Using data from the HIV/AIDS Cancer Match Study, US cancer registries, and CDC’s National HIV Surveillance System, we estimated the proportion …

22.08.2026journal-article

Journal of Intellectual Disability Research

Well‐Being in First Person: A Relational Construction of Psychological Well‐Being Among Young People With Intellectual Disabilities

Javier Piñeiro‐Cossio, Paz Cancino, Ignacia Celis, Saray Santana

ABSTRACT Background Psychological well‐being (PWB) has become a central construct in contemporary psychology; however, young people with intellectual disabilities (ID) remain largely underrepresented in well‐being research. Much of the available evidence relies on proxy reports from caregivers or professionals, limiting understanding of how young people with ID themselves conceptualize and experience well‐being. This qualitative study explores the meaning of psychological well‐being from a first‐person perspective …

22.08.2026journal-article

BMC Geriatrics

Assessing concerns about falling: a comparison of telephone-based and face-to-face FES-I interviews in older adults

Anja Müller, Robert Kob, Ellen Freiberger, Nicolas Rohleder, Sabine Britting

Abstract Background Concerns about falling (CaF) are commonly assessed using the Falls Efficacy Scale-International (FES-I), but telephone versus face-to-face interviews may influence responses. The objective of this secondary paired method-comparison analysis was to assess agreement between telephone and face-to-face FES-I total scores in older adults and to explore whether the two administration modes differed at the total-score and item levels. Methods Data were drawn from the FEARFALL study, a longitudinal rand …