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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Pigment International

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Dalitso Namutowe, Yun Xu, Jin Gong

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the transition from aggressive mono-therapies to a multi-layered, synergistic approach. To locate, select, and extract relevant data, a comprehensive search of recent clinical protocols and emerging technological studies was conducted. This literat …

27.08.2026journal-article

European Journal of Therapeutics

Associations of the February 2023 Earthquakes with Semen and Serum Parameters in Men Undergoing Infertility Evaluation, Stratified by Psychiatric Diagnosis: a Retrospective Cross-Sectional Study

Emrah Zayman, Feyza İnceoğlu, Muhammet Serdar Buğday, Kübra Orman

Objective: To compare semen and serum parameters between the pre- and post-earthquake periods among men undergoing infertility evaluation and to examine whether the observed patterns differed according to recorded psychiatric diagnosis. Methods: This retrospective comparative cross-sectional study used hospital records from before (January 1, 2021-February 5, 2023) and after (February 6, 2023-December 31, 2024) the February 6, 2023 earthquakes, which affected 11 provinces in Türkiye. Participants were selected by s …

27.08.2026journal-article

Head & Neck

Symptom‐to‐Diagnosis Interval, Treating‐Center Context, and Survival in Nasopharyngeal Carcinoma in Nonendemic Northern China: A Multicenter Real‐World Cohort Study

Qi An, Qingxin Wang, Yubing Qian, Minghan Qiu, Shenglin Zhang, Xinyu Zhao, Xiaoyan Chen, Rui Jian, Zhongjie Chen, Wei Wang, Peiguo Wang, Zhongqiu Wang

ABSTRACT Background In nonendemic northern China, symptom recognition prompts diagnostic evaluation for nasopharyngeal carcinoma. Methods We analyzed 1022 patients with nonmetastatic nasopharyngeal carcinoma treated with definitive‐intent intensity‐modulated radiotherapy. The symptom‐to‐diagnosis interval extended from first symptom onset to pathological diagnosis. Logistic and Cox models assessed stage and survival; treating‐center analyses used a 2016–2022 common‐window cohort. Results Stages III–IVA disease occu …

27.08.2026journal-article

Research in Veterinary Science and Medicine

Effects of Room Temperature Storage Duration on the Quality of Cauda Epididymal Spermatozoa Recovered from Red Sokoto Bucks

Linda Ijeoma Okoro, Philip Makama Dawuda, Gbemi Olatunde Fanaiye, Hope Mhohe Agama, Mlumun Love Ayila

Objectives: The conservation of valuable genetic resources in livestock is essential for sustainable breeding programs, particularly when superior breeding males die unexpectedly before semen collection. This study evaluated the quality of cauda epididymal spermatozoa recovered from Red Sokoto Bucks immediately after slaughter and following storage of testes-epididymides at room temperature. Material and Methods: Forty pairs of testes-epididymides were collected from apparently healthy mature Red Sokoto Bucks and r …

27.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

The spiral evolution of techniques for the laboratory diagnosis of microbial infections

Yi-Wei Tang, Nahed Ismail, Rodolfo García-Contreras

The laboratory diagnosis of microbial infections has undergone a profound transformation over the past century, evolving from classical phenotypic methods to molecular genetic approaches and now toward ultra-sensitive molecular phenotyping. While this progression is often described as linear, a closer examination reveals a cyclical pattern: an initial reliance on observable biological function, followed by a shift toward genetic abstraction, and, more recently, a return to phenotypic measurement at unprecedented mo …

27.08.2026journal-article

Frontiers in Medicine

Focusing on persistent hypoxemia during VV-ECMO secondary to traumatic tricuspid valve injury: a case report

Yunpeng Zhao, Jing Liu, Kun Chen

Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving salvage therapy for treating severe respiratory failure. We present a case of trauma-related hypoxemia with severe tricuspid chordae tendinae rupture managed with VV-ECMO. Case presentation We report the successful use of VV-ECMO in a 29-year-old patient with severe acute respiratory distress syndrome (ARDS). Refractory hypoxemia persisted despite maximal conventional therapy during the course of treatment at the outside hospital. …

27.08.2026journal-article

Frontiers in Neuroinformatics

Interpretable AI for neural signal decoding in dementia: an EEG ensemble approach to differential diagnosis

Fawad Muhammad, Irfan Ahmed Usmani, Muhammad Aamir, Mai Alduailij, Mehrez Marzougui, Rab Nawaz

Introduction The differential diagnosis between Alzheimer’s disease (AD) and frontotemporal dementia (FTD) presents a significant clinical challenge due to overlapping early-stage symptom profiles. Conventional resting-state EEG provides limited sensitivity to the impaired neural plasticity and lateralized cortical degeneration frequently observed in FTD. Methods We developed a domain-informed heterogeneous ensemble framework incorporating dynamic neural reactivity and hemispheric asymmetry metrics from 19-channel …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Plastic & Reconstructive Surgery

“A Split-Muscle Support Technique for Direct-To-Implant Breast Reconstruction”

Michelle Park, Brittany M. Lala, Alexandra N. Townsend, Melissa Rony, Pedro S. Piccinini

Many patients who undergo direct-to-implant breast reconstruction with subpectoral implant placement experience animation deformity, where implants move up toward the axilla with contraction of the pectoralis muscle. The deformity affects quality of life and prompts patients to seek revisionary surgery. 1 Prepectoral implant placement has gained popularity over the past decade as an alternative. However, prepectoral placement may increase implant visibility and rippling, and provide inadequate coverage. Additionall …

27.08.2026journal-article

JAMA Ophthalmology

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Jing Zhong, Yu Liu, Tianli Peng, Jing Ma, Ziting Huang, Xiao Yang, Shi-Ming Li, Jin Yuan

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progression. Design, Setting, and Participants This randomized clinical trial was conducted among children aged 6 to 12 years with myopia enrolled in July 2024, with follow-up completed in September 2025. The trial was conducted at a single center …

27.08.2026journal-article

Frontiers in Surgery

3D accurate osteotomy for pediatric cubitus varus deformity using a custom-matched surgical osteotomy template combined with a reduction template via a limited lateral incision: a case report and literature review

Jiang-Long Guo, Xiao Zeng, Jian-Hao Guan, Hai-Yun Chen, Kui Zhao, Mei-Ren Zhang

Background Cubitus varus deformity is a common complication following supracondylar fractures of the humeri in children. Due to the limited capacity of the distal humeral epiphysis to spontaneously correct existing varus deformity, the deformity typically persists into adulthood without improvement. Accurate correction of this deformity is essential to prevent late complications and significantly improve cosmetic appearance. However, achieving precise correction through a limited incision remains technically emandi …

27.08.2026journal-article

Journal of Clinical Medicine

Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea: Clinical Applications, Classification Systems, and Anesthetic Considerations

Patryk Oskar Manycz, Monika Morawska-Kochman, Jakub Zieliński

Background/Objectives: Drug-induced sleep endoscopy (DISE) enables dynamic, real-time visualization of the level, severity, and configuration of upper airway collapse during pharmacologically induced sleep, providing anatomical information that polysomnography cannot. It is increasingly used to guide individualized surgical planning in obstructive sleep apnea (OSA), particularly in children with persistent OSA after adenotonsillectomy or at elevated risk of surgical failure. However, the absence of a universally ac …

27.08.2026journal-article

Bioengineering

Preliminary Clinical Outcomes of an Alternating-Current-Assisted Implant Surface Decontamination Protocol: A Prospective Case Series with 12-Month Follow-Up

Dorian Kostandini, Antonella Mattei, Giovanni Falisi, Arianna Viarchi, Davide Gerardi, Angelo Bruni, Edra Qorri, Lia A. Hoz-Rodriguez, Eduardo Basañes Rivera, Sofia Rastelli, Roberto Gatto, Marco Severino, Gianluca Botticelli

Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clinical trial, in which short-term clinical outcomes following use of a multimodal protocol to decontaminate the titanium implant surface were obtained; consequently, the independent contribution of the Ximplant® device to the observed outcomes …

27.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ARTIFICIAL INTELLIGENCE IN MODERN MEDICINE: A COMPREHENSIVE REVIEW OF CURRENT APPLICATIONS, CHALLENGES, AND FUTURE PERSPECTIVES

Aleksandra Stańczyk, Kinga Haduch, Zuzanna Michalska, Anna Łęczycka, Nicole Aleksandra Ordyczyńska-Mardyła, Izabela Zuzanna Stranz, Olga Chorąży, Joanna Strzelczyk, Iga Suchta, Amelia Kędziora

Introduction: The digital transformation of healthcare is accelerating, driven by unprecedented advancements in Artificial Intelligence (AI). From large language models (LLMs) to biomolecular structure prediction, AI is redefining modern diagnostic and therapeutic standards. Aim: This review evaluates the current state of AI applications in medicine, focusing on clinical knowledge encoding, molecular drug discovery, and administrative workflow optimization, while critically addressing the technical, ethical, and sy …

27.08.2026journal-article

Seminars in Respiratory and Critical Care Medicine

Use of Oxygen in the Emergency Department

Riccardo Guglielmi, Antonio Campanella, Jesús Villar, Carlos Ferrando

ABSTRACT Oxygen is one of the most frequently used treatments in the emergency department (ED), but it should be prescribed and reassessed as an active therapy rather than left as a harmless default. Acute hypoxemia may reflect ventilation-perfusion mismatch, shunt, hypoventilation, impaired oxygen transport, circulatory failure, or a combination of these mechanisms. For this reason, the response to oxygen, the choice of device, and the need for escalation depend less on the SpO2 value alone than on the physiology …

27.08.2026journal-article

International Journal of Clinical and Experimental Medical Sciences

Biofilm Formation and Detection of the icaA Gene in Staphylococcus Aureus Isolates from Ocular Infections

Karar Abdulkhuder, Mahmood Awad

Background: Staphylococcus aureus is a major opportunistic pathogen implicated in various infections, including ocular infections. One of its key virulence factors is the ability to form biofilms, which are structured bacterial communities embedded in a self-produced extracellular matrix. Biofilm formation enhances bacterial survival under adverse conditions, including antibiotic exposure and host immune defenses, thereby contributing to chronic and recurrent infections. Aim: This study aimed to evaluate the biofil …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Prevalence of Parosmia Among Coronavirus Disease 2019 Patients in a Tertiary Center: A Retrospective Cross Sectional Study

Amani Algouhi, Maha A. Aljrayed, Sara F. Alhuwairini, Ghadi A. Almohaisen, Shmokh M. Alsalamah, Riyadh Alhedaithy

Abstract Background: After the COVID pandemic, many people experience a long-term symptom of olfactory dysfunction. Most of the affected cases recovered within weeks to a few months, while minority had persistent parosmia. This study aims to investigate the prevalence and factors associated with parosmia in patients who were diagnosed with COVID-19. Methods: A retrospective cross-sectional study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. Adult COVID-19 patients diagnosed between January 2 …

27.08.2026journal-article

Scientific and Technical Journal of Information Technologies, Mechanics and Optics

Combined feature selection in machine learning for disease diagnosis in medicine

K. S. Dyomin, I. V. Germashev

Often, the initial data sets for machine learning contain an excessive number of features, among which there may be highly informative and insignificant, correlating or even noise variables. Solving the feature selection problem not only optimizes machine learning processes, but also opens up new opportunities for implementing machine learning in practice-oriented areas that require high accuracy and trust in algorithms. This phenomenon leads to a number of critical problems: distorted training of the model based o …

27.08.2026journal-article

Journal of NeuroInterventional Surgery

Millipede Aspiration for Revascularization in Stroke (MARRS): prospective trial of a novel 0.088 inch corrugated catheter

Raul G Nogueira, Manuel Requena, Jaydevsinh Dolia, Syed Zaidi, Pedro Navia, Gaultier Marnat, Tarun Bhalla, Alhamza R Al-Bayati, Michael Nahhas, Osama O Zaidat, Ryan Priest, Romain Bourcier, Waldo R Guerrero, Reza Dashti, Gregory Gascou, Raoul Pop, Tareq Kass-Hout, Nitin Goyal, Amin Aghaebrahim, Adnan I Qureshi, Sameer A Ansari, Guilherme Dabus, Jose I Suarez, Levansri D Makalanda, Alberto Alvarez-Muelas, Xavier Barreau, Matthew T Bender, Mouhammad Jumaa, Eugene Lin, Guillaume Bellanger, Francesco Diana, Ryan Hebert, Sunil A Sheth, Richard Burgess, Diogo C Haussen, Charles Matouk, Christophe Cognard, Ameer E Hassan, Ricardo A Hanel, Benjamin Gory

Background The Millipede AspiRation for Revascularization in Stroke (MARRS) pivotal study was a prospective, multicenter, single arm trial evaluating the safety and efficacy of the corrugated Millipede catheter system in patients with acute ischemic stroke due to large vessel occlusion. Methods Patients aged 18–85 years with internal carotid artery, M1, M2, or basilar artery occlusions treatable within 8 hours were eligible. Catheter selection was based on target vessel diameter (Millipede88 >2.7 mm; Millipede70 >2 …

27.08.2026journal-article

Clinical and Translational Medicine

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

Danyi Yang, Yinyin Chen, Hao Li, Guoyong Liu, Yang Gao, Liyu He

Abstract Background NOP2/Sun RNA methyltransferase family member 4 (NSUN4)‐mediated 5‐methylcytosine (m5C) modification has been implicated in diabetes‐related diseases. However, its role and molecular mechanism in diabetic nephropathy (DN) remain unclear. Methods DN mouse model was constructed by injecting with streptozotocin (STZ). High glucose (HG)‐induced HK‐2 cells were used to establish a cellular model of DN. The levels of NSUN4, SMAD ubiquitination regulatory factor 1 (SMURF1), calcium/calmodulin‐dependent …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Value of serum procalcitonin levels and intraabdominal pressure in prognosis of severe acute pancreatitis course

Efstathios T Pavlidis, Christina Mouratidou, Alexandra G Marneri, Kalliopi E Stavrati, Theodoros E Pavlidis

Severe acute pancreatitis is associated with significant morbidity and mortality, primarily due to infected pancreatic necrosis, systemic inflammatory response syndrome, and multiple organ dysfunction, which can result in poor clinical outcomes. The identification of early prognostic biomarkers is essential for facilitating prompt and effective multidisciplinary intervention. Serum procalcitonin, which is recognized as a biomarker indicative of bacterial infection and systemic inflammation, and intra-abdominal pres …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Cutting seton as salvage strategy for complex or recurrent anal fistula: Single-tertiary center 10-year experience with 207 patients

Mohammed A Widinly, Mahmood H Aljohani, Abdullah Alrebdi, Mohammed Basem Beyari, Saleh Husam Aldeligan, Aisha M Abdulrahman, Abdullah Alkassim, Hadi Almohsen, Rasha Eidah Althebaity, Eman Almotairi, Reem A Alharbi, Asim M Almughamsi, Nasser Alsanea

BACKGROUND An ideal treatment for complex anal fistula that achieves a high success rate, low recurrence, and minimal risk of fecal incontinence has yet to be established. The cutting seton technique remains one surgical option for managing complex anal fistula. However, concerns persist regarding postoperative pain, recurrence, and sphincter-related complications. AIM To evaluate cure rate and clinical outcomes of cutting seton in the treatment of complex or recurrent anal fistula. METHODS A retrospective chart re …

27.08.2026journal-article

Clinical Kidney Journal

Managing hyponatremia: fast or slow? why, when, how, and controversies

Kamel S Kamel, Ziv Harel, Martin Schreiber

Abstract Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Its management is challenging because treatment must balance the risk of cerebral edema in acute hyponatremia against the risk of osmotic demyelination syndrome (ODS) from overly rapid correction of chronic hyponatremia. Recent observational studies have questioned current correction limits, prompting renewed debate regarding optimal management. This narrative review presents a physiology-based approach to the evaluation …