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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

BMC Public Health

Using the behaviour change wheel to co-design an intervention to interrupt prolonged bouts of sedentary behaviour in older homeworking employees

Lily Mott, Amelia Parchment, Annemarie Money, Sheena Johnson, Chris Todd, Danielle Harris

Abstract Background Sedentary desk-based workers are at risk of adverse health. With hybrid working on the rise, interventions suitable for homeworkers are needed. Given the ageing working population, it is imperative to ensure older employees (≥ 50) can remain economically active in the years before retirement, without being exposed to additional health risks. This study aimed to use co-design methods, guided by the Behaviour Change Wheel (BCW), to develop an intervention to help interrupt prolonged bouts of seden …

21.08.2026journal-article

Annual Review of Nutrition

Mechanisms of NAD+ Homeostasis in Aging and Disease

Melanie R. McReynolds

Aging is the greatest risk factor for many of society's most prevalent diseases, including diabetes, cancer, cardiovascular disease, and neurodegenerative disorders. A common thread underlying these conditions is the disruption of cellular and metabolic homeostasis. All hallmarks of aging converge on mechanisms that disrupt how cells communicate, interact, and coordinate their functions. Emerging studies have implicated diminished NAD + levels as a contributor to several hallmarks of aging, underscoring their regul …

21.08.2026journal-article

Medical Sciences

Orthopaedic Trauma in Patients with Documented Alcohol Use: Injury Mechanisms, Clinical Characteristics, and Geriatric Vulnerability

Irina Sirbu, Bianca-Ana Dmour, Stefan-Dragos Tîrnovanu, Bogdan Puha, Eliza-Geanina Cogian, Mariana Zubenschi, Alexandru Filip, Ioana-Dana Alexa, Mihaela-Camelia Tîrnovanu, Popescu Dragos-Cristian, Adrian-Claudiu Carp, Awad Dmour

Background: Alcohol-related conditions may influence both injury patterns and in-hospital management in orthopaedic trauma. This study evaluated the clinical characteristics, injury mechanisms, treatment patterns, and hospital outcomes of adults with acute orthopaedic trauma and documented alcohol use, with particular attention to geriatric vulnerability and alcohol withdrawal. Methods: This retrospective single-centre cohort included adults admitted between January 2018 and December 2025 with acute musculoskeletal …

21.08.2026journal-article

Journal of Intelligent Decision Making and Information Science

AI-Enabled IoT Wearable System for Real-Time Fall Detection and Emergency Alerting in Older Adults

Chandrani Mukherjee

Falls are a significant health issue for older people, and can result in injury, disability, hospitalisation and loss of independence. Continuous monitoring and quick caregiver notification can be enabled using an AI-powered wearable IoT system. Objective: The purpose of this study was to design and test an edge-based wearable IoT framework for real-time fall detection based on the accelerometer and gyroscope signals. Methodology: A synthetic dataset was created by using the features of SisFall and MobiAct, includi …

21.08.2026journal-article

Journal of Clinical Medicine

Explainable Multimodal Machine Learning Predicts 90-Day Treatment Failure in Older Patients with Fragility Fractures of the Pelvis

Kangwei Wang, Yulin Cao, Nan Gao, Cong Ma, Jianwen Wang, Zishen Xia, Aiwen Gui, Yong Liu, Yuxiong Weng

Background: Fragility fractures of the pelvis (FFP) are increasingly encountered in older adults, yet early deterioration is difficult to anticipate because fracture instability interacts with frailty and systemic vulnerability. We developed and validated an admission-based multimodal framework to predict 90-day treatment failure (TF90) before definitive management. Methods: This multicentre retrospective prediction study included 1684 consecutive patients aged ≥65 years with FFP treated at five tertiary hospitals. …

21.08.2026journal-article

Scientific Reports

Development and psychometric evaluation of a cognitive function health questionnaire for older adults with subjective cognitive decline or mild cognitive impairment

Junyu Zhao, Ye Le, Hong Li, Wanxin Wu, Yaming Zhang, Wanxin Lu, Wilson Wai San Tam, Rong Lin, Yuanjiao Yan

Abstract Disease perceptions and attitudes play an important role in cognitive health awareness among older adults with cognitive impairment or dementia risk. In particular, the specific health behavioural and psychological symptoms of cognitive dysfunction are different from other chronic diseases. However, there is no tool for evaluating the behavioural consciousness and cognitive health beliefs of older participants at risk of dementia during their early stage of cognitive impairment. This study aimed to develop …

21.08.2026journal-article

PLOS One

Effects of integrating self-efficacy strategies into multi-joint resistance exercise for overweight and obese older adults: A randomized controlled trial

Oratai Kanlayawut, Raweewan Maphong, Waris Wongpipit, Thanomwong Kritpet

Obesity among older adults is increasing globally and contributes to functional decline, highlighting the need for interventions that address both physical and psychological barriers to exercise. However, it remains unclear whether embedding self-efficacy strategies within each session of progressive multi-joint resistance training provides added benefits beyond resistance training alone. This study examined the additional effects of integrated self-efficacy strategies on body composition (primary outcome) and seco …

21.08.2026journal-article

Aging Cell

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu

ABSTRACT Bone mechanosensitivity declines with age, resulting in a reduced anabolic response to mechanical stimulation. Although the mechanosensitive ion channel Piezo1 plays a critical role in bone mechanoresponsiveness, its mechanisms of mechanotransduction in aged bone remain incompletely understood. Here, we report that aged tibiae from 19‐month‐old male mice exhibit a blunted anabolic response to axial cyclic compressive loading or administration of the Piezo1 agonist Yoda1 alone. However, chemical activation …

21.08.2026journal-article

The Journal of School Nursing

Digital Mental Health Interventions for Emotional Resilience and Mental Well-Being in Children and Young People: A Narrative Review

Saffiatu Nantwi, Siobhan O’Connor

Children and young people's mental health remains an international public health concern. Digital mental health interventions have the potential to bridge existing gaps in care and increase health literacy in youths, as recommended in global health policies. This review explores the factors affecting the implementation and utilisation of self-directed and practitioner-facilitated (e.g. school nurse, counsellor or teacher-led) digital mental health interventions to promote emotional resilience and mental well-being …

21.08.2026journal-article

Frontiers in Nutrition

Effects of peanut consumption on task-related brain activation, cognition and neuroinflammation in older adults with memory complaints: a randomized controlled trial

Gabriela Chiriac, Samuel R. Barnes, Jonathan H. Venezia, Grace J. Lee, Joan Sabate, Sujatha Rajaram

Objective Peanuts are rich in unsaturated fats, antioxidants like polyphenols, and other bioactive compounds that may reduce neuroinflammation and support cognitive health. Although limited evidence suggests potential cognitive benefits of peanut intake, none have explored these effects in older adults at risk for cognitive decline or assessed brain activity using functional magnetic resonance imaging (fMRI). This study explored the effects of daily peanut consumption on task-related brain activation, cognition, an …

21.08.2026journal-article

Epilepsia Open

Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review

Katherine Wang, Sarah Loveday, Monica S. Cooper, Emma Macdonald‐Laurs

Abstract Regulatory restrictions and evolving clinical guidelines have aimed to reduce sodium valproate use in people of reproductive potential over the past decade due to its teratogenic risk. While clinical evidence and policy responses are well established, stakeholder perspectives remain less explored. This scoping review synthesizes the existing evidence on the attitudes of patients, caregivers and healthcare professionals regarding sodium valproate use, withdrawal and counseling in females of childbearing age …

21.08.2026journal-article

American Journal of Lifestyle Medicine

Sex and Age Differences in Physical Activity and Dietary Patterns Among Brazilian Middle-Aged and Older Adults: Evidence From ELSI-Brazil

Jemimah O. Bakare, Minakshi Raj, Rafael Tassitano, Emerson Sebastião

Healthy aging is influenced by behaviors such as physical activity (PA) and diet. This study examined sex- and age-related differences in PA and selected food consumption among Brazilian middle-aged and older adults. Data from 9,949 non-institutionalized adults aged ≥50 years participating in the Brazilian Longitudinal Study of Aging were analyzed. PA was assessed using the International Physical Activity Questionnaire and three frequency-based questions on activity intensity. Food consumption was assessed using st …

21.08.2026journal-article

Frontiers in Nutrition

Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis

Zhiqing Zhou, Lingling Zhao, Lei Chen, Xuanxiang Zhao, Xinwei Li, Xuying Luo, Bin Zhang, Jianyin Miao, Feitong Liu

Background Skin aging involves intrinsic chronological aging and extrinsic photoaging, characterized by impaired barrier function, extracellular matrix (ECM) degradation, and chronic inflammation. Methods This study evaluated anti-aging efficacy and mechanisms of ergothioneine (EGT), collagen peptides (CP) and sodium hyaluronate (NaHA) using an ex vivo human skin model and a clinical trial. Results Ex vivo results showed that the EGT+CP+NaHA triple combination (TC) attenuated UV-induced epithelial thinning and coll …

21.08.2026journal-article

Journal of Psycholinguistic Research

Enhancing Pragmatic Communication in Healthy Aging: A Preliminary Investigation of the Long-Term Effects of the Advanced Cognitive Pragmatic Treatment

Ilaria Gabbatore, Giorgia Vegna, Dize Hilviu, Ariele Merlini, Francesca M. Bosco

Abstract The aging process is associated with changes in cognitive and communicative skills, including pragmatic one, the ability to appropriately use language and other expressive means in social contexts. Despite its importance for quality of life and autonomy, the decline of pragmatic ability has received little attention in aging research and intervention. This preliminary study aims to investigate the efficacy and specificity of the Advanced Cognitive Pragmatic Treatment (Advanced-CPT), a novel training progra …

1 Zitationen
21.08.2026journal-article

COVID

Relation Between Digital Literacy and Internet Use Changes in People with Physical Disabilities During COVID-19

Eun-Young Park

Since COVID-19, reliance on digital technology has surged, and digital literacy has gained attention as a key factor in explaining changes in how people use the Internet. However, most existing studies have focused on the general public, and there has been insufficient research on how digital literacy relates to changes in Internet usage among people with disabilities. This study examined the effect of digital literacy among people with physical disabilities on changes in Internet use on personal computers (PC) and …

21.08.2026journal-article

Annual Review of Nutrition

Ultraprocessed Foods and the Aging Brain: State of the Science

Owen T. Carmichael, Puja Agarwal, Benedict C. Albensi, Vyshnavy Balendra, Nathan M. D'Cunha, Diandra N. Denier-Fields, Naomi Vidal Ferreira, Natalia Gomes Gonçalves, Rashi Kumar, Corinne Labyak, Susanna Lopez, Mychael V. Lourenco, Ilianna Lourida, Rishav Nag, Zuzana Nedelska, Juliet Nnenda Olayinka, Jung Hyun Park, Kayalvizhi Rajendran, Ashley Shaw, Hom Lal Shrestha, Aaron N. Smith, Natalia Soldevila-Domenech, Débora G. Souza, Claudia Kimie Suemoto, Jodi R. Titiner, Rafael de la Torre, Debora Melo van Lent

Ultraprocessed foods (UPFs), which feature reductions in naturally occurring food components (fiber, phytochemicals) as well as the addition of fat, sugar, salt, and artificial food components (colorings, preservatives) are consumed in large quantities globally. Although a growing body of research has suggested that higher levels of UPF consumption are associated with poorer cardiometabolic outcomes, literature synthesizing the evidence that UPF consumption has negative effects on the aging brain has been scarce. T …

1 Zitationen
21.08.2026journal-article

Odontology

Extended hydrothermal aging and glass infiltration on minimally processed recycled 3Y-TZP: microstructural and optical properties

Henrico B. Strazzi-Sahyon, Bruna M. Silva, Tiago M. B. Campos, Claudinei dos Santos, Mariana M. T. Piza, Edmara T. P. Bergamo, Sergio M. Tebcherani, Lukasz Witek, Paulo G. Coelho, Satoshi Yamaguchi, Estevam A. Bonfante

Abstract This study evaluated the effects of glass infiltration and hydrothermal aging on the microstructural and optical properties of minimally processed recycled 3Y-TZP. Unprocessed 3Y-TZP remnants were milled into powder, compacted into discs, and sintered. Specimens were divided into six groups according to glass infiltration and hydrothermal aging (immediate, 50 h, and 100 h at 134 °C/2.2 bar). Particle size was measured by laser diffraction. Density and optical properties (contrast ratio and translucency) we …

21.08.2026journal-article

Frontiers in Aging

PolyPIMuse significantly increases fall risk: comparison of three medication evaluation tools

András Érszegi, Réka Viola, Bettina Vargáné Szabó, Zsófia Engi, Mária Matuz, Ria Benkő, Zoltán Pető, Dezső Csupor

Introduction Falls are a leading cause of injury and hospitalization in older adults, with pharmacotherapy identified as a modifiable risk factor. Tools for identifying potentially inappropriate medications (PIMs), such as the EU(7)PIM, PRISCUS, and FORTA lists, differ in methodology. However, their comparative performance in predicting fall risk has not been systematically evaluated. The aim of our work was to investigate the association between PIM use and fall risk among older adults and to analyze the correlati …

21.08.2026journal-article

Frontiers in Pharmacology

Effects of premedication with atropine, penehyclidine, and glycopyrrolate on postoperative delirium in older patients undergoing endoscopic gastric or esophageal submucosal dissection: a randomized, double-blind, multicenter, controlled clinical trial

Wen Lin Xian, Jing Peng, Qinxian Wei, Na Wang, Xiao Pei Gao, Sisi Zeng, Qin Ye, Wu Chang Fu, Fang Jun Wang

Background Anticholinergic drugs are commonly used as premedication in clinical practice. The effects of premedication of atropine, penehyclidine, and glycopyrrolate on postoperative delirium in older patients remain unclear. Objective The aim of this study was to observe the effects of premedication with atropine, penehyclidine, and glycopyrrolate on postoperative delirium (POD) in older patients undergoing endoscopic gastric or esophageal submucosal dissection. Methods Older patients undergoing endoscopic gastric …

21.08.2026journal-article

Journal of Nonformal Education

Effectiveness of Interventions to Improve Socioeconomic Participation, Access to Services, Quality of Life, and Social Inclusion Among People with Disabilities: A Systematic Review and Meta-analysis

Abdul Malik, Sunardi Sunardi, Suminah Suminah, Haryani Haryani, Ghanis Putra Widhanarto

Background – The persistent exclusion of people with disabilities from social, economic, and health systems remains a critical global issue, driven by structural barriers, stigma, and unequal access to resources. Despite a growing number of intervention studies, evidence on their comparative effectiveness across contexts remains fragmented. Research Urgency – Existing disability interventions vary widely in design, implementation, and contextual adaptability, while systematic evidence on which models are most effec …

21.08.2026journal-article

Transplantation Direct

Favorable Adherence and Tolerability of Letermovir Versus Valganciclovir for Cytomegalovirus Prophylaxis in Kidney Transplant Recipients Aged 65 y or Older: Findings From a Randomized, Phase 3 Trial

Suphamai Bunnapradist, Flavio Vincenti, Oliver Witzke, Stefan Schneeberger, M. Hong Nguyen, Natalya Broyde, Christopher L. Gilbert, Barbara Haber

Background. Older patients undergoing kidney transplantation are at risk of perioperative complications, underscoring the need for optimized care. The number of kidney transplants in older adults has increased in the past decade, with greater reliance on transplants from deceased donors. Methods. The phase 3, randomized, double-blind, active-controlled P002 study evaluated 200 d of letermovir versus valganciclovir prophylaxis in cytomegalovirus-seronegative kidney transplant recipients who received kidneys from cyt …

21.08.2026journal-article

Public Health Nursing

Association Between the Dietary Inflammatory Index and Cognitive Frailty in Older Adults: A Cross Sectional Analysis of NHANES Data

Zihan Yi, Na Zhou, Zikejimu Sun, Xiaochu Liu, Chengchuan Chen

ABSTRACT Background Cognitive frailty (CF) is a prevalent geriatric syndrome associated with increased risks of falls, hospitalization, disability, and all‐cause mortality among older adults. Emerging evidence suggests that chronic inflammation may contribute to the pathophysiology of CF, while dietary patterns can modulate inflammatory responses. The Dietary Inflammatory Index (DII) is a validated tool for quantifying the inflammatory potential of diet. Although higher DII scores have been associated with physical …

21.08.2026journal-article

Biopsychosocial Science and Medicine

Social Network Density and Healthcare Access and Utilization Among Racially and Ethnically Diverse Older Adults

Melissa Flores, Savannah M. Boyd, Riley M. O’Neill, Amelia Ibarra-Mevans, Hatty Lara, Kelly N. B. Palmer

Objective: Previous literature emphasizes the benefits of social integration for accessing and utilizing healthcare. However, many studies overlook the role of social network infrastructure, specifically the degree to which a network is interconnected (social network density). Social network density has been associated physiological benefits for ethnic minority older adults; however, little is known about whether a densely connected social network facilitates healthcare access and utilization. The current study exa …

21.08.2026journal-article

Medical Sciences

Five-Year Cardiorenal Outcomes and Longitudinal Chronic Kidney Disease Screening in People with Type 2 Diabetes Managed by Endocrinologists: A Nationwide Retrospective Cohort Study

José Ignacio Martínez-Montoro, José Juan Aparicio-Sánchez, Belén Pimentel, Mónica Juárez-Campo, Maria Luisa Alamillo, Yesika Díaz, José Carlos Fernández-García

Background/Objectives: Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease and chronic kidney disease (CKD), yet the extent of longitudinal CKD screening in routine clinical practice remains unclear. This study aimed to assess long-term cardiorenal outcomes and CKD screening practices in patients with T2D managed across primary care and endocrinology settings, evaluating the feasibility of risk stratification in real-world practice. Methods: We conducted a retrospective cohort study using anonym …