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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Düzce Tıp Fakültesi Dergisi

Evaluation of Hepatitis B Vaccination Coverage and Serological Response in People Living with HIV

Sengül Üçer, Pınar Gürkaynak, Uğur Emre Gümüş, Melek Sena Altun, Şerife Altun Demircan, Esra Kaya Kılıç, Cigdem Ataman Hatipoglu, Gunay Tuncer Ertem, Salih Cesur, Sami Kınıklı

Aim: People living with HIV (PLWH) face a heightened risk of acquiring hepatitis B virus (HBV) infection because these two viruses share common transmission pathways. HIV/HBV coinfection is associated with accelerated liver disease progression. Consequently, hepatitis B vaccination is a critical preventive measure for PLWH. This study was designed to assess the serological response to hepatitis B vaccination in PLWH.Material and Methods: PLWH followed at the Infectious Diseases and Clinical Microbiology Clinic who …

21.08.2026journal-article

Science Advances

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hiroshi Kobayashi, Shintaro Watanuki, Yusuke Shiozawa, Motohiko Oshima, Shuhei Koide, Naoya Takayama, Takayuki Morikawa, Miho Haraguchi, Shinpei Tamaki, Takayoshi Asakura, Toshio Miyata, Atsushi Iwama, Seishi Ogawa, Keiyo Takubo

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used single-cell RNA sequencing data to show that old HSCs contain two distinct transcriptional programs: one shared with megakaryocytes and the other reflecting the most primitive HSC state. Developmental time-series profiling further suggests that …

21.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

INFLUÊNCIA DO SEXO NA MORTALIDADE HOSPITALAR POR DOENÇA DE ALZHEIMER NO BRASIL

Juliene Amanda Salvador, Gustavo Almiron Lopes, Rafaela Meneguetti, Victor Hugo Lemos Miguel, Lisa Schultz, Amábile Vittoria Miliorini, Maria Luísa de Oliveira Santos, Maria Fernanda Americo de Oliveira, Andressa Beatriz Weyer Zanato, Amanda Moliterno, Laura Parpineli Ardenghi, Nayla Caroline de Moraes Pinelli, Ana Júlia Paglia

Introdução: A doença de Alzheimer é a principal causa de demência e representa um importante problema de saúde pública. Objetivo: Analisar a taxa de mortalidade hospitalar por doença de Alzheimer no Brasil, segundo o sexo, entre 2020 e 2025. Métodos: Estudo ecológico, retrospectivo e descritivo, realizado com dados secundários do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS), disponíveis no DATASUS. Foram analisadas as taxas de mortalidade hospitalar por sexo e ano de processamento. Result …

21.08.2026journal-article

Psychogeriatrics

From Overload to Understanding: How Caregivers Experience and Use Information in Dementia Counselling

Esther Yin Hui Chew, Wen An Matilda Heng, Ee‐Yuee Chan

ABSTRACT Background Caregiver education is fundamental to dementia care, yet novice caregivers often receive large amounts of information immediately following diagnosis, when emotional adjustment and learning readiness may influence engagement. Less is known about how caregivers engage with, understand and apply dementia‐related information in this period. This study explored caregivers' experiences of receiving and applying information during nurse‐led dementia counselling, using Cognitive Load Theory as one inte …

25.08.2026journal-article

Journal of Physics: Condensed Matter

Recent progress in the free energy landscape theory and its application to aging and slow Arrhenius process

Takashi Odagaki

Abstract The Helmholtz free energy landscape (FEL) picture is known to provide a theoretical framework which can explain various aspects of non-equilibrium systems. I first show that the landscape for various thermodynamic potentials including enthalpy and Gibbs free energy can be properly defined. In order to find physics behind two complex phenomena observed in non-equilibrium systems, protocol-dependent aging and the slow Arrhenius process (SAP), I introduce phenomenologically a delayed response of the FEL to a …

21.08.2026journal-article

Frontiers in Medicine

Number of natural teeth and intrinsic capacity among hospitalized older adults in China: a cross-sectional study on the role of social support

Xiaoming Zhang, Xinjuan Wu

Background Tooth loss is common in older adults and has been associated with adverse health outcomes, but its relationship with intrinsic capacity (IC), a multidimensional indicator of healthy aging, remains insufficiently understood. Whether social support is involved in this association is also unclear. Methods This cross-sectional study included 421 hospitalized adults aged 60 years or older who were recruited from Peking Union Medical College Hospital, Beijing, between February and May 2022. The number of natur …

21.08.2026journal-article

Nursing Ethics

From autonomy to well-being: Reimagining ethics consultation in dementia

Optimus Hurtig

Respect for patient autonomy is a cornerstone of modern bioethics, yet the gap between ethical ideals and clinical practice remains pronounced. To bridge this divide, Björk and Hirsch have proposed the introduction of a new professional role: autonomy consultants. This essay critically examines the applicability of such a role within dementia care, a context characterized by progressive cognitive decline and irreversible alterations of personal identity. Using a philosophical and theoretical analysis, illustrated t …

21.08.2026journal-article

Postgraduate Medical Journal

Association between ischemic stroke and herpes zoster in older people: a propensity-matched cohort study

Shih-Wei Lai, Kuan-Fu Liao

Abstract Objective Ischemic stroke is known to cause immune dysregulation, yet its potential impact on subsequent herpes zoster risk remains unclear. This study aimed to evaluate whether ischemic stroke was associated with incident herpes zoster among patients aged 65–84 years. Methods This retrospective cohort study utilized electronic medical records from 2006 to 2024, obtained through the TriNetX Collaborative Network. Two study groups were identified: patients aged 65–84 years with a diagnosis of ischemic strok …

21.08.2026journal-article

Frontiers in Psychiatry

Exploratory prescribing risk profiles and drug drug interaction burden in older adults with depressive episodes

Florina-Diana Goldiş, Sebastian-Mihai Ardelean, Lucreţia Udrescu

Introduction Older adults with depressive episodes are frequently treated in the context of psychiatric multimorbidity, somatic co-treatment, and polypharmacy, increasing their vulnerability to drug-drug interactions (DDIs) and cumulative medication-related risk. This study characterized DDI burden and exploratory prescribing risk profiles among psychogeriatric outpatients, focusing on patients with depressive episodes. Methods We conducted a retrospective observational study of psychiatric outpatient visits in 202 …

21.08.2026journal-article

Journal of Transcultural Nursing

Culturally Relevant Heart Health Program for Older African American Women of Rural Areas

Mudasir Andrabi, Betty Key, Kelvin Ovabor, Chen Lin, Mercy Mumba, Avani Shah, Karlene Ball

Introduction: Cardiovascular disease (CVD) remains a major public health issue, with the highest rates in the United States found among African Americans (AA) in rural areas like Alabama’s Black Belt. In this pilot study, we evaluated the feasibility and preliminary efficacy of a culturally relevant heart health program for older AA women in rural Alabama. Methods: We recruited 30 AA women aged 65 years and older from Alabama’s rural Black Belt with CVD or multiple risk factors. Feasibility was assessed via recruit …

21.08.2026journal-article

PLOS One

Normative emotional responses to environmental sounds in middle-aged to older adults with normal hearing: Stimuli from the Marcell database

Dina Lelic, Frederic Marmel

Purpose This study aimed to provide normative affective ratings for middle-aged to older adults with normal hearing using the Marcell database. The database includes 120 diverse environmental sounds representing various real-world acoustic events, such as those produced by animals, humans, musical instruments, tools, signals, and liquids. Secondary aims were to examine the relationship between valence and arousal, and whether factors such as age, gender, hearing-related lifestyle, hearing demands, and self-reported …

21.08.2026journal-article

Geriatrics

Feasibility and Process Evaluation of a Screening Intervention for Early Detection of Malnutrition Risk Among Community-Dwelling Older Adults Receiving Home Care Services

Tine Louise Launholt, Palle Larsen, Jemma Hawkins, Hanne Kaae Kristensen

Background: Malnutrition is prevalent among older adults (OAs), ≥65 years, receiving home care services. Despite recommendations for early detection and multifactorial interventions, a gap remains between routine practice and evidence. We therefore developed a complex intervention for early detection of malnutrition risk in a Danish home care setting, comprising an implementation strategy with staff learning activities and a screening procedure with a start-up conversation and follow-up screenings. This article out …

21.08.2026journal-article

Brain Sciences

Stimulus Incongruency Effects on Visual Short-Term Memory Binding in Young and Older Adults with and Without Cognitive Impairment

Monika McAtarsney-Kovacs, Raju Sapkota, Ian van der Linde, Shahina Pardhan

Background: Literature suggests that both the Stroop task and visual short-term memory (VSTM) binding tasks can differentiate individuals with Mild Cognitive Impairment (MCI) from cognitively normal older adults. These cognitive processes have rarely been examined together. This study investigated how Stroop-like color-word incongruency and directional incongruency between arrow orientation and motion affect memory accuracy and reaction time (RT) measures during a VSTM binding task in cognitively normal adults and …

21.08.2026journal-article

Frontiers in Endocrinology

Kinesiophobia phenotypes and fall history in older adults with osteoporosis: a cross-sectional study using latent profile analysis

MengPing Tian, Ling Li, WanQiu Lv, Gang Deng, Yang Ni, Jian Xiong

Objective Falls are a leading cause of morbidity among older adults with osteoporosis. While traditional risk assessment focuses on biological factors such as bone mineral density (BMD), psychological factors—particularly kinesiophobia—have received increasing attention. However, most studies conceptualize kinesiophobia as a continuous construct, potentially overlooking clinically meaningful heterogeneity. This study aimed to identify kinesiophobia phenotypes and examine their association with fall history in older …

21.08.2026journal-article

Psychology and Psychotherapy: Theory, Research and Practice

‘I just want an explanation’: A qualitative investigation of how people with psychosis make sense of their visual hallucinations

Charlotte Aynsworth, Rob Dudley, Samuel Sargeant, Clara Humpston, Felicity Waite

Abstract Objectives Visual hallucinations (visions) in people with psychosis are common and often distressing. Cognitive theory emphasises a central role of appraisals in determining distress. We explored how people made sense of their visions to inform the development of targeted cognitive treatments for visions. Design Semi‐structured interviews were conducted with 12 participants with psychosis recently reporting visions. Methods Reflexive thematic analysis was utilised. Results There was an overarching theme th …

21.08.2026journal-article

Frontiers in Human Neuroscience

Multi-system aging vulnerability associated with prolonged violence exposure: evidence from a Colombian sample

Eduar Herrera, Alvaro Barrera-Ocampo, Willian Orlando Castillo Ordoñez

Exposure to violence is a major social determinant that can influence aging trajectories and brain health. In Colombia, a country affected by decades of armed conflict, comprehensive assessment models are needed to capture the multiple factors that shape health and may accelerate aging. This study examined whether long-term exposure to violence is associated with greater multisystem aging vulnerability across cognitive, mental health, social, and neuroendocrine domains in a Colombian cohort. Fifty participants were …

21.08.2026journal-article

Aging Cell

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle‐Activating Capacity

Yating Chen, Wei Liu, Ying Tian, Xinyu Wang, Haonan Fan, Mingyu Yang, Feiyang Diao, Jing Li

ABSTRACT Cellular senescence is a fundamental hallmark of aging and represents a major barrier to the scalable and reproducible application of mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs). Senescent human umbilical cord mesenchymal stromal cells (hUCMSCs) exhibit impaired proliferative capacity, disrupted mitochondrial homeostasis, and altered secretory phenotypes, which may compromise the biological activity and therapeutic reliability of sEVs. Here, we investigated whether overexpres …

21.08.2026journal-article

Nature Medicine

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Raghav Sehgal, Daniel Borrus, Jenel F. Armstrong, John Gonzalez, Jessica Kasamoto, Yaroslav Markov, Ahana Priyanka, Ryan Smith, Natàlia Carreras-Gallo, Jessica Lasky-Su, Varun B. Dwaraka, Michael J. Corley, Albert Higgins-Chen

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested. Here we curate TranslAGE, a harmonized database of 51 public and private longitudinal interventional studies, and calculate a consistent set of 16 prominent epigenetic clocks for each study, a …

21.08.2026journal-article

Journal of Functional Morphology and Kinesiology

Long-Term Flywheel Resistance Training Enhances Cognitive Flexibility in Older Women: A 36-Week Randomized Controlled Trial

Maria Luiza da Cruz Santos, Pablo Augusto Garcia Agostinho, Wanderson Matheus Lopes Machado, Thalia Miranda Rufino, Leonardo Silveira Goulart Silva, Isabella Evangelista Leite, Cláudia Eliza Patrocínio de Oliveira, Édison Andrés Pérez-Bedoya, Osvaldo Costa Moreira

Background: Executive functions (EFs) decline with aging, impacting functional independence. While resistance training (RT) is a promising non-pharmacological intervention, the optimal modality and duration for cognitive benefits remain unclear. Flywheel RT (FRT) imposes greater motor control and attentional demands than traditional RT (TRT), potentially enhancing EFs. Objective: To compare the effects of a 36-week FRT versus TRT program on executive function and serum insulin-like growth factor 1 (IGF-1) levels in …

21.08.2026journal-article

Frontiers in Public Health

Multidimensional sleep health is associated with mild cognitive impairment in older adults: a cross-sectional study

Yang Li, Xinxiu Dong, Hui Hu, Xiaotong Wang

Background Mild cognitive impairment (MCI) is a transitional stage preceding dementia and may be amenable to early intervention. Although sleep problems are common among older adults and related to cognitive function, most studies have focused on single sleep characteristics rather than multidimensional sleep health. Methods This cross-sectional study included 416 adults aged ≥ 60 years from three nursing homes and two communities in Wuhan, China. Sleep health was assessed using the Pittsburgh Sleep Quality Index ( …

21.08.2026journal-article

Frontiers in Public Health

Factors influencing self-care among older patients with heart failure and spouses in China: a mixed methods study

Xiaoyan Wu, Yiyu Zhuang, Manjun Wang, Jinhua Jin, Yuting Ke

Objective This study aimed to investigate the factors influencing self-care among older patients with heart failure (HF) and their spouses from a dyadic perspective. Methods An explanatory sequential mixed-methods design was employed. In the quantitative phase, 145 dyads of older HF patients and their spouses were recruited from a tertiary hospital in Zhejiang, China. Validated instruments were used to measure patient self-care, spouse contribution to self-care, disease-specific health literacy, mutuality, and soci …

21.08.2026journal-article

The Oncologist

IUC26682-89 Efficacy and tolerability of immune checkpoint inhibitors in older versus younger patients with metastatic renal cell carcinoma: a real-world Asian cohort

R Kanesvaran, H S Tan, J W K Chan, W C Tan, D J M Ang, J J X Tan, H X Tan, A Roy Chowdhury

Abstract Background Older adults are underrepresented in pivotal immune checkpoint inhibitor (ICI) trials for metastatic renal cell carcinoma (mRCC), resulting in uncertainty regarding treatment effectiveness and tolerability in routine clinical practice. We compared clinical outcomes and treatment-related toxicities between younger and older patients with mRCC receiving ICIs in a real-world Asian cohort. Methods We conducted a retrospective study of 171 patients with mRCC treated with ICIs at the National Cancer C …

21.08.2026journal-article

Healthcare

Perceived Barriers to Home-Based Telemedicine and Facilitators of Public Health Center-Based Telemedicine Among Digitally Capable Community-Dwelling Older Adults: A Cross-Sectional Scenario-Based Survey

Seung-Kwon Ji, Wonseuk Jang

Background/Objectives: Home-based telemedicine requires patients to perform technical tasks independently, whereas assisted public health center (PHC)-based telemedicine transfers some of these tasks to on-site personnel. This study describes model-specific perceptions and estimates the difference in intention to use between the two scenarios among relatively digitally capable, community-dwelling older adults. Methods: A cross-sectional, fixed-order, scenario-based online survey was completed by 300 adults aged 65 …

21.08.2026journal-article

Aging Cell

RICTOR Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating FoxO1 Nuclear Export

Yifeng Lin, Jiwei Sun, Yue Ying, Dan Li, Yuewen Ying, Xilin Shen, Xiao Sun, Dan Zhang, Yiqing Wu, Runju Zhang

ABSTRACT Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase. As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders; however, its role in regulating age‐related decidualization disorders remains unreported. In this study, we identified pronounced decidualization defects in AMA foster mice, accompanied by a …