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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Chronic Diseases and Translational Medicine

Efficacy and Safety of Durvalumab and Tremelimumab in Metastatic Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Ikhwan Rinaldi, Eric Ricardo Yonatan, Tasia Esterita

ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low or negative PD‐L1 expression, and in the overall population. Methods A systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted following PRISMA 2020 guidelines. Pooled efficacy an …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Epidermal growth factor receptor dysregulation and climate change: insights into pollution-promoted lung cancer

Taysia Nikaido-Landry, Yujia Zhang, Emilia L. Lim

Abstract The global increase of fine particulate matter pollution, intensified by anthropogenic activity, has been increasingly implicated in lung cancer risk, particularly among never-smokers. We discuss how air pollution contributes to respiratory diseases through interactions with the epidermal growth factor receptor (EGFR) signalling pathway. In particular, recent evidence has shown that fine particulate matter promotes lung cancer in cells harbouring a pre-existing EGFR mutation. As such, we also outline how o …

1 Zitationen
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Mechanisms and treatment of metabolic dysfunction-associated fatty liver disease after liver transplantation

Jun-Rong Liu, Liu Zhao, Qing-Hui Niu, Jin-Zhen Cai, Han-Yun Liu

Metabolism dysfunction-associated fatty liver disease (MAFLD) has emerged as a frequent complication for liver transplant (LT) recipients. In view of the high incidence of MAFLD after LT, research on MAFLD is of considerable clinical significance. Key research areas include the mechanisms responsible for the development of MAFLD following LT, therapeutic strategies, and the optimization of immunosuppressive regimens to achieve a balance between graft protection and metabolic protection. Most existing studies relati …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Pelvic floor rehabilitation improves anorectal function after sphincter-preserving surgery for low rectal cancer

Xiao-Jun Liu, Ming-Li Wei, Li-Li Liu, Jing-Jing Qin

BACKGROUND Sphincter-preserving surgery with prophylactic colostomy is the benchmark treatment for low rectal cancer, although postoperative anorectal dysfunction significantly reduces quality of life. Although pelvic floor muscle training seems effective in functional recovery, there is currently little systematic evidence regarding the efficacy of this therapy in this specific population. AIM To investigate whether structured pelvic floor muscle rehabilitation training provides better anorectal functioning than s …

27.08.2026journal-article

Neuro-Oncology

73 Modification of Tryptanthrin Enhances Drug Activity in Glioblastoma Cells

Aoife Hurrell, Sofie Edwards, Sally Prior, Christopher Gabbutt, Anke Brüning-Richardson

Abstract Introduction Glioblastoma (GBM) is the most aggressive adult brain tumour, with a poor prognosis and limited therapeutic approaches. We recently showed ARHGAP12 regulates cell morphology and contributes to tumour recurrence, with co-expression of ARHGAP29 linked to reduced survival after treatment. As Glycogen Synthase Kinase 3 (GSK-3) signalling regulates this, we hypothesised that targeting ARHGAP12 in combination with migrastatic drugs could enhance GBM cell migration inhibition. Previous investigations …

27.08.2026journal-article

Electronics

TSF U-Net: A Texture-Span and Frequency-Gated U-Net for Brain Tumor MRI Segmentation

Xia Wang, Longde Mao, Jianing Tang, Zhongbin Dai

Accurate brain tumor magnetic resonance imaging (MRI) segmentation is essential for objective lesion assessment and treatment planning, yet it remains challenging because tumors exhibit large-scale variations, irregular morphologies, heterogeneous internal textures, and indistinct boundaries. Conventional U-Net variants commonly improve either spatial feature extraction or skip connection fusion, but they do not jointly address the adaptive representation of pathological texture changes and the semantic filtering o …

27.08.2026journal-article

CVIR Endovascular

Identifying research areas in peripheral artery disease treatment—a Delphi consensus approach

Stefan Müller-Hülsbeck, Franziska Reiter, Andreas H. Mahnken, Nathalie Kaufmann, Robert A. Morgan

Abstract Background The multitude of existing techniques for the endovascular treatment of peripheral artery disease (PAD), as well as newly emerging technologies combined with the diversity of patient profiles highlight the need for further research in this area. We conducted a Delphi consensus study, an established method utilising an iterative approach to reach consensus within a group of experts over several rounds, to identify gaps and new areas of research in the field of PAD. Results Using a four-round Delph …

27.08.2026journal-article

Current Oncology

Return to Intended Oncologic Therapy After Brain Metastasis Surgery: Mapping the Early Postoperative Pathway

Alexis Hadjiathanasiou, Martin Liebisch, Johanna Dahn, Johannes Lemcke, Patrick Schuss

Surgery for brain metastases (BM) is embedded in a multidisciplinary oncologic pathway. This study evaluated oncologic readiness and return to intended oncologic therapy (RIOT) after surgery for BM. Patients undergoing surgery for histologically confirmed BM were retrospectively identified. Oncologic readiness was defined as sufficient postoperative clinical and neurological recovery to allow the next indicated oncologic treatment. RIOT was defined as postoperative radiotherapy and/or systemic treatment within 30 d …

27.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Timing of mental disorders in relation to cancer-specific mortality in cancer patients

Mingyi Li, Zhengyi Deng, Minji Jung, Kevin L'Espérance, Michael Baiocchi, David Spiegel, Benjamin I Chung, Marvin E Langston, Melissa L Bondy

Abstract Background To evaluate whether mental disorders identified before cancer diagnosis, within one year, or 2-5 years after cancer diagnosis are associated with cancer-specific mortality, and whether having both pre- and post-diagnosis disorders displays the highest mortality. Methods We conducted a cohort study of 22,281 UK Biobank participants linked to cancer and death registries. Mental disorders were ascertained from inpatient and outpatient diagnoses and psychiatric prescriptions, then categorized by per …

27.08.2026journal-article

Angewandte Chemie International Edition

Harnessing the E3 Ligase KLHL12 for Tumor‐Selective Protein Degradation

Shicheng Xu, Xian Zhang, Shunbo Hu, Xinyi Wang, Yuxin Ge, Ziquan Zhao, Tianbao Zhu, Nan Wang, Limin Du, Qidong You, Xiaoke Guo, Zhengyu Jiang

ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are currently constrained by a reliance on ubiquitously expressed E3 ligases, which compromises tumor selectivity and raises toxicity risks. Here, we identified KLHL12 as a potentially tumor‐selective E3 ligase and reported the development of the first‐in‐class KLHL12‐recruiting PROTACs. Guided by a structure‐based macrocyclization strategy, we obtained a high‑affinity cyclic peptide, cp4 , as a KLHL12‑binding ligand and constructed novel PROTACs against oncogenic B …

27.08.2026journal-article

Frontiers in Surgery

Robotic right hemicolectomy for transverse colon cancer in a patient with stringer type IIa intestinal malrotation: a case report with intraoperative video

Go Ito, Dai Shida, Jun Imaizumi, Junko Mukohyama, Satoko Monma, Naoki Sakuyama

Background Intestinal malrotation results from disrupted midgut rotation and fixation during embryogenesis. Pure duodenal non-rotation (Stringer Type IIa), featuring isolated duodenal malrotation with a normally positioned colon, is extremely rare. Its unique anatomical distortions—specifically the absence of standard duodenal landmarks—present significant challenges for colorectal surgery. Case description An asymptomatic 61-year-old male was diagnosed with transverse colon cancer during routine screening. Preoper …

27.08.2026journal-article

Discover Oncology

Integrative transcriptomic analysis identifies shared coding and non-coding biomarkers in tongue squamous cell carcinoma across diverse populations

Ronit Roy, Monika Rajput, Manoj Pandey

Abstract Background Tongue cancer, a prevalent subtype of oral malignancy, remains a significant global health burden with high morbidity and mortality, particularly in developing countries. Understanding its molecular landscape is crucial for developing targeted diagnostics and therapeutics. Objective This systematic review aimed to identify common differentially expressed protein-coding genes (DEGs) in tongue cancer across multiple populations and explore their functional significance through integrative bioinfor …

27.08.2026journal-article

Frontiers in Oncology

Radiomics-based MRI model for differentiating ovarian cystadenoma and cystadenocarcinoma

Mohamed Muntasir Ramjaun, Palpasa Shrestha, Beebee Kaneeze Hasanayn Bhoodoo, Lisong Dai, Bulat Abdrakhimov, Zhen Huang, Xuechun Wang, Prajal Shrestha, Jun Chen

Background Accurate differentiation between benign and malignant ovarian tumors is crucial to ensure timely intervention for high-risk patients and minimizing overtreatment in others. Thus, the objective was to develop a radiomics-based machine learning model to differentiate between non-cancerous and cancerous lesions in ovaries. Methods This retrospective study included 271 patients with ovarian cystadenocarcinoma and 266 patients with ovarian cystadenoma who underwent T2-weighted magnetic resonance imaging (MRI) …

27.08.2026journal-article

Neuro-Oncology

49 Clinical Outcomes and Survival Analysis of IDH1-Mutant Grade 4 Astrocytoma: A Retrospective Review in NHS Tayside (2018-2025)

Mustafa Shah, Hannah Lord

Abstract Introduction IDH1-mutant Grade 4 astrocytoma’s are associated with younger age and superior prognosis compared to IDH wildtype glioblastoma. However long-term outcomes remain variable. We evaluate outcomes, treatment tolerance, and survival within NHS Tayside. Methods Retrospective review of IDH1-mutant grade 4 astrocytoma between 2018 and 2025. Data extracted from NHS database, including demographics, surgery (biopsy vs debulking), MGMT methylation status, adjuvant treatment (Radiotherapy (XRT) and Temozo …

27.08.2026journal-article

Cancer Research

Cross-talk between Schwann Cells and CD4+ T Cells Promotes Perineural Invasion in Colorectal Cancer

Huayuan Liu, Yiqiao Deng, Yi Yang, Junshuai Xue, Nuersimanguli Maimaitiming, Bingzhi Wang, Yujing Xin, Jinxue Zhou, Xiaomeng Liu, Chengyao Guo, Lang Yang, Zhen Huang, Haitao Zhou, Jianqiang Cai, Hong Zhao

Abstract Perineural invasion (PNI) is a common pathologic feature associated with poor prognosis in colorectal cancer. A better understanding of the mechanisms underlying PNI formation could help identify potential strategies to inhibit tumor progression. In this study, we revealed an integral role of CD4+ T cells in the development and progression of PNI in colorectal cancer. Single-cell RNA sequencing, spatial transcriptomics, and multiplex IHC profiling uncovered a distinct HSPA6+ CD4+ T-cell subset expressing T …

27.08.2026journal-article

Pigment International

Optimizing Lip Vitiligo Treatment: The Role of Microneedling with 5-Fluorouracil

Aruna Chintaginjala, Mani Deepika Atmuri, Mohana Rao Telu Sathyananda, Ramya Vetapalem, Kolisetty Venkata Sridevi, Lakshmi Kamcharala

Background: Vitiligo is an autoimmune disease characterized by depigmented macules and patches over the skin or mucosa and is of great aesthetic concern. It affects 2% of the world’s population with an average age of 20 years. Lip vitiligo is a distinct focal subtype of vitiligo accounting for 16% of total cases and has a significant impact on life, including lowered self-esteem. Though there are many topical and systemic agents available, it is often resistant to medical treatment, and there is an unmet medical ne …

27.08.2026journal-article

Informatics

Feature-Centric AI for Breast Cancer Metastasis Analytics: A Systematic Review and Evidence-Based Framework for Feature Engineering and Multimodal Integration

Wellington Kanyongo, Bester Chimbo

The importance of understanding how feature engineering contributes to breast cancer metastasis analytics is growing as artificial intelligence (AI) technologies rapidly transform the field of precision oncology. This systematic review collated, thematically synthesised, and analysed the evidence related to feature engineering processes, multimodal integration techniques and explainability mechanisms used in AI-driven breast cancer metastasis analytics. Following PRISMA 2020, studies from 2020 to 2026 were retrieve …

27.08.2026journal-article

Blood

Ibrutinib for early-stage CLL: genetic risk factors and treatment outcome in the GCLLSG CLL12 trial

Armin Riecke, Sandra Robrecht, Deyan Y. Yosifov, Christof Schneider, Adam Giza, Lothar Müller, Ursula Vehling-Kaiser, Michael Eckart, Werner Freier, Björn Schöttker, Tobias Gaska, Marcel Reiser, Anna-Maria Fink, Kirsten Fischer, Barbara Eichhorst, Michael Hallek, Petra Langerbeins, Stephan Stilgenbauer, Eugen Tausch

Abstract Watch-and-wait is standard of care in asymptomatic early-stage chronic lymphocytic leukemia (CLL). The CLL12 trial investigated ibrutinib vs placebo for patients with early-stage CLL with intermediate to very high risk of progression, improving event-free survival (EFS) but not overall survival (OS). Building on these findings, our analysis examined whether a benefit could be identified within distinct genetic subgroups. After a median follow-up of 69.3 months, there were 166 EFS and 32 OS events in 515 tr …

1 Zitationen
27.08.2026journal-article

Angewandte Chemie International Edition

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Neuro-Oncology

27 Development of Precision Virotherapies for Diffuse Midline Gliomas

Mariana Varela Pereira, Emily A Bates, Florian Siebzehnrubl, Chris Jones, William Gray, Alan L Parker

Abstract Introduction Diffuse Midline Gliomas (DMGs) are highly aggressive paediatric brainstem tumours with a median survival of 9-11 months - a figure unchanged for over four decades. This indicates a critical need for targeted therapies. The VITAL lab has developed Ad5NULL-RGD, an engineered adenovirus modified to ablate binding to native adenovirus receptors minimising off-target effects. The vector was redirected to αvβ3/5 integrins highly expressed in several brain tumours, via an RGD motif, enhancing tumour- …

27.08.2026journal-article

Neuro-Oncology

11 Single-nucleus and spatially resolved multi-omics uncover intracranial germinomas’ microenvironment and associated molecular features

Ho-keung Ng

Abstract Introduction Germinoma is the most common intracranial germ cell tumor and has a high incidence in East Asia. It is unique in having an intense immune-cell infiltration. Method We studied the tumor microenvironment (TME) of 51 cases by snRNA-seq, spatial transcriptomics (STs) and imaging mass cytometry (IMC). Results Specific TME types were related to the interferon gene module which was inversely correlated with M2-macrophages. Macrophage migration inhibitory factor (MIF) was the main signaling pathway fr …

27.08.2026journal-article

Current Oncology

Real-World Toxicities and Outcomes of Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Emmanuel Joran Boujeke, Aaron Catalan, Laurice Arayan, Alfred Patrick Mina, Christian Edward James-McDonald, Rasna Gupta, Swati Kulkarni, Abdullah Nasser, Deepro Chowdhury, Muriel Brackstone, John Mathews, Caroline Hamm

Purpose: Pembrolizumab combined with chemotherapy is the standard of care for early-stage triple-negative breast cancer (TNBC) following KEYNOTE-522. However, real-world data on immune-related adverse events (irAEs) remain limited. We evaluated the incidence, severity, and clinical consequences of irAEs in a real-world cohort and compared outcomes with KEYNOTE-522. Methods: We conducted a retrospective cohort study of patients with stage II–III TNBC treated according to the KEYNOTE-522 regimen at two Ontario cancer …

27.08.2026journal-article

BMC Medicine

miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities

Theresa Kordaß, Ann-Katrin Schlosser, Marijan Czygan, Luisa Vieira Codeco Marques, Melisa Wartusch, Eric Nerenz, Vincencia Stefanie Muliawan, Stephan Kersting, Wolfram Osen, Stefan B. Eichmüller

Abstract Background T cell-based immunotherapies have improved cancer treatment, however their efficacy is frequently limited by tumor-intrinsic resistance mechanisms and by the immune suppressive tumor microenvironment, counteracting tumor specific immune responses through impaired antigen presentation and the accumulation of M2-like tumor-associated macrophages. MicroRNAs have emerged as regulators of tumor cell – immune cell interactions, yet the miRNAs’ capacity to coordinate anti-tumor effects across different …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Integrated Traditional Chinese and Western Medicine Treatment of Oral Squamous Cell Carcinoma

Hualin He

The most prevalent of all oral cancers is the oral squamous cell carcinoma (OSCC), and it constitutes over 90 percent of this group. Its occurrence has only been on the rise in recent years, mostly because of the high use of betel nut, tobacco, and alcohol. The traditional treatment procedures mostly consist of approaches relying on Western medicine, as surgery is the dominant form of treatment, and this is complemented by chemotherapy and/or radiotherapy. Though these methods have short-term ability to treat tumor …