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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

American Journal of Hematology

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Samuel Urrutia, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine McMahon, Rory M. Shallis, Joshua F. Zeidner, Michael R. Savona, Shougat Barua, Namrata Sonia Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L. Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Parisa Abedi, Shai Shimony, R. Coleman Lindsley, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach

ABSTRACT Baseline IPSS‐M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo‐HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS‐M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to evaluate the impact of International Working Group (IWG) 2023 bes …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Multistakeholder Consultations on Programmatic Progress, Challenges, and Policy Priorities for Lymphatic Filariasis Elimination in India

Muhammed Jabir, Raja Jeyapal Dinesh, Adinarayanan Srividya, Anju Viswan, Manikandan Kishanthini, Richa Sharma, Manju Rahi

ABSTRACT. This report presents the key proceedings and outcomes of three regional consultative workshops convened to review progress, identify challenges, and propose strategic actions for lymphatic filariasis elimination in India. The workshops were organized by the Indian Council of Medical Research-Vector Control Research Centre, Puducherry in collaboration with the Women’s Collective Forum, New Delhi from June 2025 to August 2025. Consultations were held in three endemic states representing different regions of …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Malaria Vaccine Rollout in Nigeria: Current Status and Challenges

Samuel Adeniyi Oyegbade, Samson Olusola Adeboye, Gbotemi Jerry Oni, Abosede Peace Oyegbade, James Joy Oziohu, Zawu Yoowa Duyann, Oluwatoyin Comfort Owoyemi

ABSTRACT. Malaria remains a leading cause of morbidity and mortality in Nigeria, particularly among children under 5 years of age, despite ongoing control efforts. The introduction of RTS,S/AS01, and R21/Matrix-M vaccines provides a promising complementary prevention strategy. This systematic review assessed malaria vaccine rollout in Nigeria, focusing on implementation, awareness, acceptance, willingness to pay, and health system readiness. A comprehensive search of PubMed, ScienceDirect, Google Scholar, African I …

27.08.2026journal-article

Revista ft

Segurança do paciente: estratégias de enfermagem para prevenção de erros na administração de medicamentos

Marcos Leal Rodrigues Pereira, Gerson Luiz Pereira Emerim da Silva, João Lucas Vaz Macedo, Leandro Ghilardi

This study aimed to analyze the nursing strategies used to prevent medication administration errors and promote patient safety. This is an integrative literature review conducted in the SciELO, LILACS, MEDLINE/PubMed, BDENF, and DOAJ databases, considering publications from January 2020 to July 2026 in Portuguese, English, and Spanish. The initial search identified 18 studies, of which 8 comprised the final sample after application of the inclusion and exclusion criteria. The main strategies identified included con …

27.08.2026journal-article

Evolution, Medicine, and Public Health

Running wild: Forest running enhances performance, enjoyment, mood and future exercise intentions

Matthew J Putland, Stephen J Bailey, Bryna C R Chrismas, Stacy Clemes, Morgan Ewers, Yu-Ling Ho, Eloise Jones, Adelina Lintuluoto, Kirsten McEwan, Riddhi Naik, Hanna Lal Rahimi, Hongbin Xiang, Erik P Willems, Colin N Shaw, Daniel P Longman

ABSTRACT Background and objectives Physical inactivity remains widespread despite the well-established physical and mental health benefits of regular physical activity (PA). There is an urgent need for strategies that increase both uptake and long-term adherence. The Environmental Mismatch Hypothesis proposes that natural environments may increase both engagement and performance of PA. Methodology Forty-seven healthy adults (16 females) completed a randomised, counterbalanced crossover trial. Participants undertook …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Prognostic factors of sepsis following laparoscopic hiatal hernia repair

Hong Yu, Jun-Ying Xu, Ya-Ru Zhang, Xiao-Bing Zhou, Han-Rong Zuo, Zhi Li

BACKGROUND Laparoscopic hiatal hernia repair (LHHR) is the surgical intervention of choice for symptomatic hiatal hernias; however, a major complication such as postoperative sepsis presents a serious challenge, particularly in elderly and comorbid patients. Acute kidney injury (AKI) occurring in patients with sepsis is termed sepsis-associated AKI. This complication has been reported to affect 40%–50% of intensive care unit patients with sepsis and is an independent risk factor for increased mortality and prolonge …

27.08.2026journal-article

Frontiers in Neurology

Clinical features associated with cerebrospinal fluid Epstein–Barr virus positivity in autoimmune GFAP astrocytopathy: a multicenter retrospective cohort study

Xing Mao, Qianqian Qu, Chao Quan, Haidong Lyu, Jingzi Zhangbao, Xuan Wang, Hongmei Tan, Xiang Li

Background Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an inflammatory disorder of the central nervous system. The clinical implications of Epstein–Barr virus (EBV) sequences detected in cerebrospinal fluid (CSF) by metagenomic next-generation sequencing (mNGS) remain uncertain. Methods This multicenter retrospective cohort study enrolled 60 patients with GFAP-A screened from electronic medical records of two hospitals (Jan 2019–Dec 2025). Patients were stratified into CSF EBV-positive ( n …

27.08.2026journal-article

Frontiers in Medicine

The proteomic architecture of clonal hematopoiesis: a systematic review of niche remodeling and multi-compartment predictors of malignant transformation

Jana H. Husein, Rasha M. Khayata, Aisha Jahangir, Ghaith K. Mansour, Ahmed W. Hajjar, Muhammad Raihan Sajid

Background Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor to myeloid malignancies, yet the functional proteomic landscape that governs clonal fitness and microenvironmental remodeling remains poorly understood. This systematic review consolidates high-resolution proteomic evidence to map the transition from stable CHIP to overt malignancy. Methods Following PRISMA 2020 guidelines, we analyzed 15 high-quality studies (selected from 83 initial records) published between 2015 and 2025. The revie …

27.08.2026journal-article

Frontiers in Medicine

Severe recurrent hypernatremia and probable lithium-associated nephrogenic diabetes insipidus following pancreatectomy in a patient with schizophrenia: a case report

Yanfei He, Liuyin Jin, Xiaolei Xu, Qing Xia

Background Nephrogenic diabetes insipidus (NDI) is characterized by impaired renal responsiveness to arginine vasopressin, causing defective urinary concentration and large volumes of dilute urine. Long-term lithium exposure is an important acquired cause. Perioperative fasting, restricted free-water intake, and ongoing fluid losses may unmask compensated lithium-associated urinary concentrating dysfunction and precipitate severe hypernatremia. Case presentation A 61-year-old man underwent laparoscopic resection of …

27.08.2026journal-article

Pregnancy

Society for Maternal‐Fetal Medicine Special Statement: Quality metrics to assess prenatal detection of congenital heart defects—Updated 2026

Society for Maternal‐Fetal Medicine (SMFM), Adina Kern‐Goldberger, C. Andrew Combs, Afshan B. Hameed, Iffath Abbasi Hoskins, SMFM Patient Safety and Quality Committee

Abstract Congenital heart defects (CHDs) are a leading cause of neonatal morbidity and mortality. Accurate prenatal diagnosis of CHDs can reduce morbidity and mortality by improving prenatal care, facilitating predelivery pediatric cardiology consultation, and directing delivery to facilities with resources to manage the complex medical and surgical needs of newborns with CHD. Unfortunately, fewer than half of CHD cases are detected prenatally, resulting in lost opportunities for counseling, shared decision‐making, …

27.08.2026journal-article

Frontiers in Medicine

Skin phenotype diversity across populations: from skin morphology to molecular phenotype

Xiaoqian Yu, Meiting Yi, Jiayuan Shi, Yan Jia, Liya Song, Huaming He

The considerable range of phenotypic variation observed in human populations may partly reflect distinct processes of natural selection and adaptation to variable environmental conditions. Differences in physiological indices, structure, molecular phenotypes and metabolic mechanisms of the skin across populations with varying skin phototypes are also a reflection of this unique process. These differences are reflected in skin color, pH, moisture content, water loss, sebum secretion, and skin elasticity. The differe …

27.08.2026journal-article

BMC Medical Education

Impact of clinical case discussions in anatomy on national exam performance: a 10-year longitudinal cohort study

Fang Fang, Lan Yu, Yetao Ou, Si Zhou, Jun Ma, Yuntao Peng, Fang Liu, Junfeng Wang, Chunbo Xia, Houzhong Li, Weishan Zhang, Tan Cheng, Yu Chen, Yi Huang, Xin Li, Heng Guan

Abstract Background Traditional anatomy instruction often prioritizes structural memorization over clinical application. Although case-based learning is widely endorsed to bridge this theory-practice gap, longitudinal evidence regarding its sustained impact in foundational sciences remains limited, particularly concerning its performance over a decade amid massive enrollment expansion. Methods This 10-year longitudinal retrospective cohort study tracked seven clinical medicine cohorts (2015-2021). To maintain teach …

27.08.2026journal-article

Plant Health Progress

Current Status of Ceratobasidium theobromae Affecting Cacao and Cassava: Diagnosis and Management

Cansu Oksel, Fulya Baysal-Gurel

Ceratobasidium theobromae, the causal agent of vascular streak dieback in cacao, has recently been associated with cassava witches’ broom disease, expanding its known host range and increasing its importance in crop production systems. This review summarizes disease development, diagnosis, and management of C. theobromae in cacao and cassava. Diagnosis remains challenging due to difficulties in pathogen isolation and confirmation of pathogenicity, although molecular tools have improved detection and identification. …

27.08.2026journal-article

Journal of Clinical Medicine

Late-Course Lactate/Albumin Ratio and In-Hospital Mortality in CRRT-Treated Critically Ill Patients: A Retrospective Severity-Adjusted Analysis

Hasan Şenay, Mehmet Kürşad Orhan, Mahmut Sami Tutar, Munise Yıldız, Ece Ünüvar Şenay, Muhammed Halit Satıcı, Ahmet Erarkadaş, Betul Kozanhan

Background/Objectives: The lactate/albumin ratio (LAR) integrates tissue hypoperfusion and nutritional reserve into a single dimensionless index. As a late-course measurement (last available value before the primary outcome), it may reflect terminal metabolic deterioration rather than early prognostic signal. We examined the association of the final LAR with in-hospital mortality after adjustment for validated severity scores (APACHE II, SOFA) in critically ill patients receiving CRRT, and evaluated its incremental …

27.08.2026journal-article

International Journal of Molecular Sciences

Beyond Swelling: Clinical Insights into the Diagnosis and Management of Hereditary Angioedema

Margarita Paulauskiene, Laura Tamasauskiene, Brigita Gradauskiene

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of severe, non-pitting edema, most commonly caused by a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), resulting in excessive bradykinin production. HAE subtypes differ according to C1-INH levels, functional activity, underlying genetic variants, and increasingly recognized molecular mechanisms. Awareness of HAE outside specialized medical fields remains limited, and recurrent angioedema may arise through differ …

27.08.2026journal-article

International Journal of Molecular Sciences

Anti-Tumor Potential of Selective L-Type Amino Acid Transporter (LAT1) Inhibitor, JPH203, in Patient-Derived Canine Bladder Cancer Organoids

Ting-Wei Yu, Minami Kawahashi, Fumiya Goda, Ami Kanaya, Mohamed Elbadawy, Hitoshi Endou, Shoichiro Ide, Hideyuki Yamawaki, Masahiro Kaneda, Amira Abugomaa, Tsuyoshi Uchide, Tatsuya Usui, Kazuaki Sasaki

L-type amino acid transporter 1 (LAT1), which controls the neutral amino acid uptake across the cell membranes, has been frequently overexpressed in various human cancers. Overexpression of LAT1 is associated with higher proliferation and shorter patient survival in tumors. Here, upregulated LAT1 expression was observed in patient-derived canine bladder cancers (BCs), and a small-molecule LAT1 inhibitor (JPH203) successfully reduced BC tumor growth both in vitro and in vivo. Patient-derived cancer cells were collec …

27.08.2026journal-article

Physiotherapy Research International

Shared Decision‐Making and Patient Enablement in Outpatient Rehabilitation: An Observational Study

Naoto Iwasawa, Shota Hori, Hitoshi Fujita, Takuya Yamada, Hirono Ishikawa

ABSTRACT Objectives To examine the association between shared decision‐making (SDM) and patient enablement in outpatient rehabilitation consultations. Methods In this observational cross‐sectional study, 158 patients attending outpatient rehabilitation at four facilities in Japan were assessed, of whom 93 were included in the final analyses. Sociodemographic data, disease severity (modified Rankin Scale), treatment expectations, control preferences, and health literacy were collected via self‐administered questionn …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Neuroimaging Abnormalities and Genotype-Phenotype Correlations in Noonan Syndrome: A Multicenter Cohort Study

Giuseppa Patti, Nadia Gabriella Maiorano, Francesca Piccoli, Alice Zucconi, Maria Grazia Calevo, Federica Tamburrino, Emanuela Scarano, Concetta Schiavariello, Cesare Rossi, Laura Mazzanti, Eleonora Orlandini, Gabriella Pozzobon, Martina Finamore, Cristina Baldoli, Anna Grandone, Mario Cirillo, Francesca Aiello, Domenico Corica, Malgorzata Wasniewska, Alessandro Cattoni, Paolo Remida, Donatella Capalbo, Fabio Tortora, Maria Carolina Salerno, Sara Azzolini, Mariam Mansour, Maria Felicia Faienza, Stefano Palladino, Domenico Tortora, Giulia Rosti, Francesca Faravelli, Cristina Venturino, Pasquale Capuozzo, Letizia De Mori, Paola Maietta, Anna Elsa Maria Allegri, Chiara Morreale, Alessia Angelelli, Flavia Napoli, Natascia Di Iorgi

Abstract Context Neuroradiological findings in Noonan syndrome (NS) remain insufficiently characterized Objective To characterize neuroimaging abnormalities in children with genetically confirmed NS and evaluate their associations with clinical phenotype Design, Setting, and Participants In this multicenter retrospective study, brain MRI scans and longitudinal clinical and genetic data were reviewed from children with genetically confirmed NS evaluated between 2008 and 2023 at seven pediatric endocrinology centers …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Microsurgical Aspects of Middle Cerebral Artery Variations: Clinical and Anatomo-radiological Implications

Mustafa Eren Yüncü, Berra Bilgin, Yeliz Pekçevik, Ali Karadag, Necmettin Tanrıöver

The middle cerebral artery is the largest branch of the internal carotid artery and supplies extensive cortical and deep cerebral territories. Variations in its branching pattern are of considerable importance in microsurgical planning and may influence aneurysm development. This study aimed to evaluate the prevalence of middle cerebral artery variations, their microsurgical anatomy, and their relationship with anterior circulation aneurysms. Computed tomography angiography images of 500 patients were retrospective …

27.08.2026journal-article

BMC Oral Health

Parental knowledge, attitude, and practice on oral complications of leukemia treatment: a cross-sectional study

Nosrat Nourbakhsh, Ailar Adib Haji Bagheri, Maryam Torkian, Sheida Bagheri, Sahar Talebi

Abstract Background Leukemia is among the most common childhood cancers, and treatments such as chemotherapy and radiotherapy often lead to oral and dental complications. With rising survival rates, attention to oral health and its impact on quality of life has become increasingly important. Parental knowledge and practice play a vital role in preventing and managing these complications. Therefore, this study assessed the knowledge, attitude, and practice (KAP) of parents of children with leukemia regarding oral sy …

27.08.2026journal-article

Academia Nutrition and Dietetics

Beyond glycemia: clinical nutrition in type 2 diabetes and cardiometabolic risk

Antonio Maria Labate, Provvidenza Villari

Type 2 diabetes (T2D) is a multifactorial cardiometabolic disorder in which dysglycemia coexists with visceral adiposity, insulin resistance, atherogenic dyslipidemia, hypertension, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this setting, clinical nutrition should be considered a therapeutic intervention rather than a generic lifestyle add-on. This mini-review summarizes how nutritional strategies can modify major cardiometabolic domains in adults with T2D, with a practical focus on Me …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Monitoring Cholera Transmission in Zambia Using the Cholera Elimination Scorecard

Caroline C. Chisenga, Lilian Lamba, Charlie C. Luchen, Ashley Duncan, Nyuma Mbewe, Masuzyo Zyambo, Maisa Kasanga, Fraser Liswaniso, Harriet Ng’ombe, Michelo Simuyandi, Amanda K. Debes, Roma Chilengi, David A. Sack

ABSTRACT. We used the cholera elimination scorecard to better understand the changing cholera patterns in Zambia. The method used surveillance data from the Zambia National Public Health Institute to identify districts that had eliminated cholera or continued to be endemic between 2015 and 2024. Between 2017 and 2022 the number of cholera-endemic districts decreased from 27 to 6; however, in 2023 and 2024, a severe outbreak occurred in Lusaka and expanded to neighboring districts. Concurrently, a separate outbreak …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Application of enhanced recovery after surgery in the perioperative period of pediatric enterostomy closure

Kai Zhu, Feng Zhang, Wang-Wang Ou, Yan Ke, Zhen-Ying Zhu, Xiao-Man Tan, Hui Wang, Chuan-Cheng Sun, Heng-Fei Gao, Yi-Lin Su

BACKGROUND Enhanced recovery after surgery (ERAS) protocols have improved perioperative outcomes in adults. However, we know less about their use in pediatric enterostomy closure and this area still has no specific guidelines. AIM To see how well ERAS pathways, when adjusted for children, work during the whole perioperative period of enterostomy closure surgery. METHODS This is a single-center retrospective analysis conducted in a tertiary pediatric surgery department. It included 61 children who received enterosto …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Application of a three-dimensional-printed endoscopic retrograde cholangiopancreatography simulation operation model in surgical training and teaching

Wen-Jun Zhou, Jia-Wei Qin, Cheng Li, Xiao-Feng Li

BACKGROUND Three-dimensional (3D)-printed models have been widely applied in the medical field and play roles in preoperative simulation, surgical training, and education for young doctors. Compared with traditional imaging data, 3D-printed models are more intuitive, more accurate, and more operable, providing valuable support for clinical and educational purposes. AIM To create an endoscopic retrograde cholangiopancreatography training model for the diagnosis and treatment of common bile duct stones. The model inc …