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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

International Journal of Molecular Sciences

Targeting PKM2 Enhances the Anti-Tumor Function of CD8+ T Cells Through Metabolic Reprogramming

Junxiu Zhang, Shuyi Wu, Qin Yin, Yanglin Liu, Shuguo Zheng, Peiwei Yang

The efficacy of adoptive cell transfer (ACT) therapy in solid tumors is often limited by the functional exhaustion and insufficient persistence of infused CD8+ T cells within the tumor microenvironment. Through the integrated analysis of single-cell transcriptomic data, this study identified enolase 1 (ENO1), a key rate-limiting enzyme in glycolysis, as a core gene highly correlated with the superior anti-tumor phenotype of tumor-infiltrating lymphocytes (TILs). However, in vitro functional validation demonstrated …

27.08.2026journal-article

Neuro-Oncology

52 Access to non-standard treatments: Insights from a UK-wide review of adult brain tumour services (2024-2026)

Joanne Lewis, Andrew Wright, Eloise Lines, Camille Goetz, Nicky Huskens

Abstract Introduction Patients with high grade primary brain tumours often face poor outcomes and limited treatment options. Access to non-standard treatments - interventions not routinely available or funded for this patient group - may offer opportunities to improve survival and quality of life. Access routes include individual funding requests (IFRs), clinical trials, and early/managed access programmes. We aimed to examine variation in access to non-standard treatments across UK adult brain tumour services. Met …

27.08.2026journal-article

Neuro-Oncology

29 Repetitive Transcranial Magnetic Stimulation (rTMS) for Motor Rehabilitation in Neuro-Oncology: the impact of the Orpington Prognostic Score (OPS)

Katie Mirocha, Amy Jones, Jose Lavrador, Keyoumars Ashkan, Ranj Bhangoo, Francesco Vergani

Abstract Introduction rTMS is well-evidenced in the stroke population. Its therapeutic use is increasing in post-operative neuro-oncology patients. Functional outcomes using the OPS, a prognostic indicator for onwards rehabilitation needs, are yet to be explored. This is an exploratory study assessing the feasibility of the OPS to monitor functional outcomes and guide rehabilitation streams in post-operative neuro-oncology patients receiving the rTMS motor rehabilitation protocol for new motor deficit. Method Over …

27.08.2026journal-article

Biomedicines

UCHL1 Expression in Colorectal Cancer: Clinicopathological Significance, Prognostic Value, and Implications for Immunotherapy Response

Jiming Gu, Suhua Xia, Tongguo Shi, Dongming Zhu

Background/Objectives: Ubiquitin C-terminal hydrolase L1 (UCHL1) exhibits context-dependent roles in various cancers, but its clinical significance and biological functions specifically in colorectal cancer (CRC) remain incompletely understood. Methods: We systematically evaluated UCHL1 expression, clinicopathological associations, prognostic value, and immunological role in CRC using multiple public databases (TCGA, GTEx, UALCAN, GEPIA2, GSCA, and ENCORI) combined with immunohistochemical validation on a tissue mi …

27.08.2026journal-article

JCO Oncology Practice

Immune Checkpoint Inhibitor–Associated Acute Kidney Injury

Sree Manasa Puttamreddy, Yumna Khalid, Ketki Tendulkar, Apar Kishor Ganti

Immune checkpoint inhibitors (ICIs) have reshaped modern oncology by improving outcomes in multiple cancers. They function by enhancing T-cell–mediated antitumor immunity through the blockade of inhibitory pathways, such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4), the PD-1 receptor and its ligand PD-L1, and lymphocyte-activation gene 3. Despite their clinical benefits, ICIs are associated with immune-related adverse events that can involve any organ system. Renal toxicity, although less common, represe …

27.08.2026journal-article

Neuro-Oncology

98 Barriers and opportunities in the integrated histopathological-molecular diagnosis of adult diffuse gliomas: a national survey of neuropathology units in UK&I

Vassili Crispi, Ute Pohl, Federico Roncaroli, Kathereena Kurian, Ashiward Merve, Peter Auguste, Arabella Scantlebury, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological–molecular diagnosis is central to the contemporary classification and management of adult diffuse gliomas. The delivery of timely integrated diagnosis remains operationally complex, resource-intensive, and variably implemented across healthcare systems. Methods We conducted an online cross-sectional national survey of all 23 neuropathology units covering 34 adult neurosurgical units across the United Kingdom and Ireland to characterise current diagnostic pathways f …

27.08.2026journal-article

Neuro-Oncology

172 Transforming the National Genomic Test Directory to Improve Genomic Testing for CNS Tumours

Jane Starczynski, Maricica Zabrautanu, Peter Street, Thomas Jacques, Kathreena Kurian, Ross Finnegan

Abstract Introduction The National Genomic Test Directory (NGTD), introduced in 2019, defines NHS commissioned genomic tests in England and outlines their clinical eligibility. In cancers of the central nervous system (CNS), neuropathologists routinely integrate genomic analysis into diagnostic workflows to support tumour classification and clinical patient management. However, the existing Excel based NGTD is difficult to navigate and lacks the flexibility required, highlighting the need for a modernised, digital …

27.08.2026journal-article

Cellular Oncology

Epigenetic memory of epithelial–mesenchymal transition: linking transient plasticity to metastasis, therapy resistance, and immune evasion

Dominika Denisz, Magdalena Fabian, Jan Olszewski, Karolina Bajdak-Rusinek

Abstract Epithelial–mesenchymal transition (EMT) is increasingly recognized as a dynamic, plastic process that equips tumor cells with invasive capacity, stress tolerance, stem-like features, and adaptability, contributing to metastasis, therapeutic failure, and immune escape. Accumulating evidence indicates that these effects can outlast the inducing signal: tumor cells may retain molecular and functional traces of prior EMT exposure, biasing future cell-state behavior. This Review terms this phenomenon EMT memory …

27.08.2026journal-article

European Journal of Cancer Prevention

Impact of screening compliance on gastric cancer risk and eligibility for endoscopic treatment: a nationwide population-based cohort study

Jinju Choi, Joo Hyun Lim, Kyungdo Han, Cheol Min Shin, Byung-Ha Jeon, Ho-Kyoung Lee, Eun Hyo Jin, Seung Joo Kang

To evaluate the association between compliance with the Korean national gastric cancer screening program and both gastric cancer incidence and eligibility for endoscopic treatment. Using the Korean National Health Insurance Service database, we conducted a nationwide cohort study of individuals who underwent screening endoscopy in 2012 and 2014 without prior gastric cancer. Participants were classified as high compliance, moderate compliance, or low compliance according to screening history from 2008 to 2014. Gastr …

27.08.2026journal-article

Data

A Breast Cancer Histology and Immunohistochemistry Image Dataset with Linked Clinicopathological Metadata

Oleh Berezsky, Grygoriy Melnyk, Petro Selskyy, Andrii Slyva, Oleh Pitsun

Digital pathology and computational analysis of breast cancer require datasets that connect microscopic images with clinically meaningful diagnostic, morphological and immunohistochemical information. But images are often provided separately from pathomorphological reports, tumour profiles, biomarker assessments and segmentation masks, which limits their use for interpretable machine learning. This data descriptor presents a structured dataset of de-identified breast cancer cases that integrates H&E images, immunoh …

27.08.2026journal-article

Recycling

Life Cycle Assessment of Anaerobic Digestion Pathways for Winery Residues: Influence of Functional Unit Selection on Wastewater Treatment and Grape Pomace Valorization

Mara Silva, Vitor Coelho Barroso, José Pereira, Ana Catarina Faria

Winery activities generate large amounts of residues requiring sustainable management. Anaerobic digestion offers opportunities for resource recovery while reducing the environmental burdens associated with these residues. This study presents a gate-to-gate Life Cycle Assessment (LCA) of two anaerobic digestion pathways: winery wastewater treatment (Scenario A) and grape pomace valorization (Scenario B). Inventory data were obtained from pilot-scale operation and complemented with the Ecoinvent 3.10 database. Envir …

27.08.2026journal-article

Tijdschrift voor Urologie

Klinische kenmerken en chirurgische behandeling van urogenitale endometriose: een retrospectief cohortonderzoek

Hanzhe Dong, Eefje Oude Lohuis, Johanna M. A de Bruin, Bob Theodoor Merks

Samenvatting Endometriose kan verscheidene orgaansystemen aantasten. Urogenitale endometriose (UGE) is een zeldzame vorm van diepe endometriose met betrokkenheid van blaas en/of ureters. In dit retrospectieve cohortonderzoek werden 80 vrouwen met UGE geïdentificeerd onder 1.568 geopereerde patiënten met diepe endometriose (2018–2024), overeenkomend met een prevalentie van 5,1 %. Blaasendometriose kwam voor bij 34 patiënten, ureterbetrokkenheid bij 32 en gecombineerde ziekte bij 14. Dysurie trad vaker op bij blaasbe …

27.08.2026journal-article

International Journal of Molecular Sciences

Repurposing Disulfiram for Cancer Therapy: Mechanistic Insights and Translational Challenges

Anna Bilska-Wilkosz, Magdalena Górny, Małgorzata Iciek

Disulfiram (DSF), long used as an aversive agent in alcohol dependence therapy, has recently regained attention as a promising candidate for oncological drug repurposing. After administration, DSF is rapidly reduced to diethyldithiocarbamate (DDC), which, in the presence of Cu2+, forms the complex Cu(DDC)2. This compound acts as a strong inducer of oxidative stress, an inhibitor of the ubiquitin–proteasome system, and a suppressor of endogenous hydrogen sulfide (H2S) synthesis. DSF also modifies protein and non-pro …

27.08.2026journal-article

Small

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Judun Zheng, Miaomiao Kang, Minghai Zhao, Shuang Guo, Qihu Xie, Zhijin Fan, Sitong Zhou, Zhijun Zhang, Qin Zeng, Zeyu Liu, Yinghui Liu, Jialin Huang, Xu Chen, Bowen Shu, Bin Li, Kexiang Rao, Hongfang Liu, Xiaoping Zhong, Ronghua Yang, Yunxia Wu, Dong Wang, Yuhui Liao

ABSTRACT Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re‐epithelialization. Herein, we propose a sequential integrating microenvironment regulation and re‐epithelialization promotion (SIMREP) strategy based on zinc‐doped glycyrrhizinate carbon dots loaded with aggregation‐induced emission luminoge …

27.08.2026journal-article

JAMA Network Open

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Kirsten A. Jorgensen, Nuria Agusti, Tara Coffin, Karla Barajas, Maria D. Iniesta, Erica M. Bednar, Alexa Kanbergs, Roni Nitecki Wilke, Isabel Beshar, Sara Pirzadeh-Miller, Sayoni Lahiri, Kathy Pratt, Kristofer Jennings, Heidy Bosch, Charles A. Leath, Beth Karlan, Melissa Frey, Ravi Sharaf, Karen Lu, J. Alejandro Rauh-Hain

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved populations where structural and informational barriers limit access to genetic services. Objective To evaluate the feasibility and preliminary effects of IGNITE-TX (Identifying Individuals for Genetic Testing and Treatment), a scalable, bilingu …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Discover Oncology

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Barbora Vavrušáková, Renata Bartošová, Michal Hendrych, Tomáš Kazda, Lukáš Moráň, Marek Svoboda

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1 in 70 women in developed countries over their lifetimes. Tumor development and progression are orchestrated within the tumor immune microenvironment, a dynamic and complex structural niche that supports malignant transformation and immune …

27.08.2026journal-article

Medicina

Prognostic Significance of Oxidative Stress Biomarkers and Novel Hematological Inflammatory Indices in Colorectal Cancer: A Prospective Observational Study

Răzvan Alexandru Marinescu, Daniela Marinescu, Ana-Maria Ciurea, Lidia Boldeanu, Marius Bică, Ștefan Pătrașcu, Victor Dan Eugen Strâmbu, Petru Adrian Radu, Petrica Popa, Mihail Virgil Boldeanu, Styliani Laskou, Valeriu Șurlin

Background and Objectives: Oxidative stress and chronic inflammation are closely interconnected processes involved in colorectal cancer (CRC) development and progression. However, the relationships between oxidative stress biomarkers, emerging hematological inflammatory indices, clinicopathological characteristics, and survival outcomes remain insufficiently characterized. This study evaluated circulating levels of 8-epi-prostaglandin F2α (8-epi-PGF2α), malondialdehyde (MDA), and superoxide dismutase 1 (SOD1), toge …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Long-term outcomes following successful treatment of acute mesenteric ischemic event: A population-based observational study

Karri Kase, Merli Koitmäe, Annika Reintam Blaser, Kadri Tamme, Peep Talving, Marko Murruste

BACKGROUND There is a lack of studies reporting long-term outcomes in patients surviving initial event of acute mesenteric ischemia (AMI). AIM To identify population-based outcomes and risk factors for mortality according to AMI subtypes. METHODS We performed overall survival analysis of all enrolled AMI patients and follow-up investigation on patients who survived beyond index admission. The demographics, diagnostic and management variables, in addition to causes of death, were accrued from the Estonian National E …

27.08.2026journal-article

Cellulose

Bioactive silver(I) complex delivered via bacterial cellulose and Zeolitic imidazolate framework-8 composites for skin cancer therapy

Silmara C. Lazarini Frajácomo, Augusto Henrique Piva, Hernane da Silva Barud, Eliane Trovatti, Tamires de Souza Nossa, Bernardo Castro-Dominguez, Regina Celia Galvão Frem, Bruna C. Lustri, Douglas H. Nakahata, Pedro P. Corbi, Wilton R. Lustri

Abstract Topical antimicrobial strategies that combine targeted drug delivery with selective cytotoxicity are critically needed for treating infected skin lesions, especially those complicated by multidrug-resistant bacteria. Here, we report the synthesis, characterization, and evaluation of a silver(I) complex with the sulfonamide probenecid (Ag–PROB) and its integration into a bacterial cellulose (BC) based composite with zeolitic imidazolate framework-8 (ZIF-8) for controlled release applications. We developed t …

27.08.2026journal-article

Light: Science & Applications

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Zhengyuan Pan, Naikun Song, Shanshan Cheng, Wen Pang, Hongen Liao, Yu Wang, Bobo Gu

Abstract Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature. A restoration method capable of distinguishing these signal voids from stochastic noise to render quantitative pathology is lacking. Here, we proposed a deep learning framework of AFN-DeSeg (Auto-Fluorescence Nuclei Denoising and S …

27.08.2026journal-article

Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

S. Martínez, M. J. Del Sole, L. Maté, S. Sánchez Bruni, A. Lifschitz, M. Ballent

ABSTRACT Canine demodicosis is an inflammatory skin disease caused by Demodex canis mites. While newer isoxazoline classes currently represent the standard of care where licensed and available, prolonged ivermectin treatment remains an effective and cost‐effective alternative under specific socioeconomic contexts or clinical challenges associated with specific presentations, such as refractory pododemodicosis. Prolonged ivermectin treatment remains the primary choice, especially in resource‐limited settings and cer …

27.08.2026journal-article

Environments

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Vanesa Benito, Naroa Lopez-Herguedas, Maite Cabañas, Santos Paunero, Ane Rivas-Macho, Iker Alvarez-Mora, Manu Soto, Felipe Goñi-de-Cerio

Wastewater treatment plants (WWTPs) are key nodes in the environmental dissemination of antimicrobial resistance (AMR), although their net role as sources or barriers of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG) under full-scale conditions remains insufficiently understood. This study evaluated the occurrence and dynamics of ARB and ARG in a full-scale urban WWTP and its receiving river over a two-year monitoring campaign. Samples were collected from the WWTP influent and effluent, a …

27.08.2026journal-article

Journal of Pharmaceutical Health Care and Sciences

Impact of interventions for adverse events by oncology pharmacists before versus after medical examination in outpatient chemotherapy: a retrospective, comparative study

Shinsaku Washinosu, Tatsuya Hayama, Akihiro Uchiike, Shinya Tsuboi, Katsuyuki Hazama, Sakae Fukushima, Kei Saito, Katsuhiro Miura

Abstract Background While pharmacist interventions improve clinical outcomes in cancer treatment, their optimal timing remains unclear. To address psychological barriers to modifying prescriptions during conventional post-examination interventions, we shifted to a proactive, pre-examination approach. This study evaluated the impact of this proactive management on clinical outcomes in outpatients receiving chemotherapy. Methods We conducted a retrospective, comparative study of pharmacist interventions for chemother …