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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Frontiers in Public Health

Factors influencing self-care among older patients with heart failure and spouses in China: a mixed methods study

Xiaoyan Wu, Yiyu Zhuang, Manjun Wang, Jinhua Jin, Yuting Ke

Objective This study aimed to investigate the factors influencing self-care among older patients with heart failure (HF) and their spouses from a dyadic perspective. Methods An explanatory sequential mixed-methods design was employed. In the quantitative phase, 145 dyads of older HF patients and their spouses were recruited from a tertiary hospital in Zhejiang, China. Validated instruments were used to measure patient self-care, spouse contribution to self-care, disease-specific health literacy, mutuality, and soci …

21.08.2026journal-article

The Oncologist

IUC26682-89 Efficacy and tolerability of immune checkpoint inhibitors in older versus younger patients with metastatic renal cell carcinoma: a real-world Asian cohort

R Kanesvaran, H S Tan, J W K Chan, W C Tan, D J M Ang, J J X Tan, H X Tan, A Roy Chowdhury

Abstract Background Older adults are underrepresented in pivotal immune checkpoint inhibitor (ICI) trials for metastatic renal cell carcinoma (mRCC), resulting in uncertainty regarding treatment effectiveness and tolerability in routine clinical practice. We compared clinical outcomes and treatment-related toxicities between younger and older patients with mRCC receiving ICIs in a real-world Asian cohort. Methods We conducted a retrospective study of 171 patients with mRCC treated with ICIs at the National Cancer C …

21.08.2026journal-article

Healthcare

Perceived Barriers to Home-Based Telemedicine and Facilitators of Public Health Center-Based Telemedicine Among Digitally Capable Community-Dwelling Older Adults: A Cross-Sectional Scenario-Based Survey

Seung-Kwon Ji, Wonseuk Jang

Background/Objectives: Home-based telemedicine requires patients to perform technical tasks independently, whereas assisted public health center (PHC)-based telemedicine transfers some of these tasks to on-site personnel. This study describes model-specific perceptions and estimates the difference in intention to use between the two scenarios among relatively digitally capable, community-dwelling older adults. Methods: A cross-sectional, fixed-order, scenario-based online survey was completed by 300 adults aged 65 …

21.08.2026journal-article

Aging Cell

RICTOR Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating FoxO1 Nuclear Export

Yifeng Lin, Jiwei Sun, Yue Ying, Dan Li, Yuewen Ying, Xilin Shen, Xiao Sun, Dan Zhang, Yiqing Wu, Runju Zhang

ABSTRACT Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase. As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders; however, its role in regulating age‐related decidualization disorders remains unreported. In this study, we identified pronounced decidualization defects in AMA foster mice, accompanied by a …

21.08.2026journal-article

Frontiers in Medicine

Declining yet persistent asthma mortality among U.S. adults aged 65 years and older (1999–2020)

Tong Feng, Pengcheng Zheng, Yue Cao, Ding Han, Ran Duan

Background Asthma in older adults (≥65 years) represents a growing yet understudied public health burden. Comprehensive spatiotemporal trends and future projections of asthma mortality in this population remain incompletely characterized. This study aimed to characterize the temporal, demographic, and geographic patterns of asthma mortality among U.S. adults aged ≥65 years, project future mortality trends through 2030, and evaluate state-level disparities relative to an empirical mortality frontier. Methods Using t …

21.08.2026journal-article

Healthcare

Effects of Traditional Chinese Mind–Body Exercise on Physical Function in Older Adults with Sarcopenia and Frailty: A Meta-Analysis of Randomized Controlled Trials

Jingtao Zhou, Wi-Young So, Minhye Shin

Background and Objectives: Sarcopenia and frailty are associated with falls, disability, and functional decline in older adults. This review evaluated traditional Chinese mind–body exercise (TCMBE), including Tai Chi and Health Qigong, in adults aged 60 years or older with clinically defined sarcopenia or frailty. Materials and Methods: Randomized controlled trials identified through December 2024 from six English- and Chinese-language databases were synthesized. The analyses included physical performance and secon …

21.08.2026journal-article

Applied Sciences

Effects of an Eight-Week Combined Isometric and Elastic-Resistance Training Program on Body Composition and Functional Fitness in Older Women

Sanghyun Lee, Byungkwan Kim

This exploratory randomized trial evaluated an eight-week combined isometric and elastic-resistance program in community-dwelling women aged 70 years or older. Forty-nine participants were randomized to exercise (EG; n = 24) or control (CG; n = 25). Twenty-two EG participants completed the intervention and follow-up; two had no post-intervention measurements because of scheduling conflicts. All randomized participants were included in the intention-to-treat analysis using 50 data sets generated by predictive mean m …

21.08.2026journal-article

Perspectiva XXI

Autoestima, depresión y preocupación sexual y su relación con las actitudes hacia el uso del condón en personas que viven con VIH en Villavicencio, Colombia

Diego Alejandro Garcés Rojas, David Mauricio Rodríguez Machado

Las personas que viven con VIH pueden experimentar dificultades emocionales e interpersonales vinculadas con su sexualidad, las cuales podrían estar asociadas con sus actitudes hacia las prácticas preventivas. El objetivo de este estudio fue analizar la relación entre las dimensiones de la sexualidad y las actitudes hacia el uso del condón en personas que viven con VIH en Villavicencio, Colombia. Se desarrolló una investigación cuantitativa, no experimental, transversal, descriptiva y correlacional. Participaron 15 …

21.08.2026journal-article

PLOS One

Integrated liver transcriptomic data reveal differences in aging-associated regulation between metabolic dysfunction-associated steatotic liver disease and normal liver aging

Tanchun Wang, Qin Huang, Yan Wang, Cong Li, Juan Ni, Fang Xie

Background Age-related molecular trajectories of metabolic dysfunction-associated steatotic liver disease (MASLD) remain insufficiently characterized, limiting age-stratified risk assessment and intervention. Objective To test whether MASLD-related molecular changes with age merely reflect accelerated physiological aging or represent a disease-specific divergence. Methods We utilized public transcriptomic data from normal liver and MASLD samples to identify differential transcriptomic signals. We employed Spearman …

21.08.2026journal-article

The Oncologist

IUC26589-95 First-Line or Maintenance Immune Checkpoint Inhibitors in Older Patients with Advanced Urothelial Carcinoma: A Systematic Review and Meta-Analysis

D Incognito, A D'arienzo, C Barraco, A Nicastro, S Facchini, G Facchini

Abstract Background Evidence on immune-based treatment in older patients with advanced urothelial carcinoma are limited because age-specific outcomes are usually exploratory. We assessed the efficacy of first-line and maintenance immune-based strategies in patients aged ≥65 years. Methods PubMed/MEDLINE, Embase, Cochrane and major oncology congresses were searched from Jan 2015 to May 2026 for randomized trials reporting age-specific hazard ratios (HRs) for overall survival (OS) or progression-free survival (PFS). …

21.08.2026journal-article

Frontiers in Public Health

Models for identifying cognitive frailty in hospitalized older adults with chronic heart failure in China: a systematic review

Yue Mou, Longyun Li, Qian Geng, Yao Li, Tingjia Zhang, Fang Cao, Yuanyuan Li, Ting Zhang

Objective To systematically evaluate models for identifying cognitive frailty (CF) among hospitalized older adults with chronic heart failure (CHF) in China and assess their intended use, performance, and methodological quality. Methods A systematic search was conducted in PubMed, Web of Science Core Collection, Embase, the Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and the Chinese Biomedical Literature Database from inception to March 31, 2026. Two reviewers independently screened the …

21.08.2026journal-article

Forum for Health Economics and Policy

Valuing Dementia Interventions Under Uncertainty: A Comparison of Generalized and Risk-Adjusted Cost Effectiveness to Traditional Cost-Effectiveness Analyses

Jason Shafrin, Jaehong Kim, Jacob Fajnor, Kyi-Sin Than, Elizabeth S. Mearns, Stacey L. Kowal, Thomas Majda, Jakub P. Hlávka

Abstract Traditional cost-effectiveness analysis (TCEA) overlooks nonlinear patient health preferences, potentially under-valuing health gains for severe diseases and overvaluing health gains for less severe diseases. Generalized and risk-adjusted cost effectiveness (GRACE) can address this limitation by incorporating patient risk preferences and disease severity, but its implication for valuing treatments for neurodegenerative diseases is unclear. A five-state Markov model was developed to estimate the health econ …

21.08.2026journal-article

Acta Odontologica Scandinavica

Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging

Hanlu Xiao, Yajun Zhao, Yishu Wang, Yuhan Wang, Dingxin Zhang, Rongzeng Huang, Chengwu Song, Shan Cao, Shuna Jin

Objective: The interplay between periodontitis (PD) and rheumatoid arthritis (RA) is well recognized, with aging being a central risk factor for both. However, the shared aging-related molecular mechanisms remain unclear. We aimed to identify common aging-related hub genes linking PD and RA and elucidate their underlying functional mechanisms. Material and methods: PD and RA gene expression profiles were obtained from Gene Expression Omnibus database. Crosstalk genes were identified via differential expression anal …

21.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

A ENFERMAGEM NO CUIDADO À PESSOA COM ANEMIA FALCIFORME: PRÁTICAS, DESAFIOS E EVIDÊNCIAS CIENTÍFICAS

Antonieta Benvinda Cassinda Cachipa, Kemelândua Sebastião Ngando, Maria Daniela Alves Martins, Vladson Gouveia Ferreira, Stella Maia Barbosa, Gabriela Silva Cruz, Erika Helena Salles de Brito, Ana Caroline Rocha de Melo Leite

A anemia falciforme é uma doença genética crônica de elevada morbidade, predominante na população negra, que ocasiona importantes repercussões clínicas e sociais. Nesse contexto, a enfermagem desempenha papel essencial no manejo da dor, prevenção de complicações e promoção do autocuidado. Objetivo: Sintetizar as evidências científicas sobre a atuação da enfermagem no cuidado de pacientes com anemia falciforme. Método: Revisão integrativa da literatura, baseada na estratégia PCC: População (pacientes com anemia falc …

21.08.2026journal-article

BMC Psychiatry

Encounters between people with mental health and/or substance use problems and ambulance clinicians: a qualitative interview study in Norway

Lin Eik Ulvøy, Jorun Rugkåsa, Trine Møgster Jørgensen, Solveig H. H. Kjus, Kristin Häikiö

Abstract Background Interactions between ambulance clinicians and people with mental health and/or substance use problems are frequent, and international studies show that these encounters are often shaped by stigma, power dynamics and challenges to patient autonomy. However, there is limited research exploring patients’ experiences of ambulance services in the Norwegian context. This study addresses this knowledge gap. Methods This qualitative study was based on in-depth, semi-structured interviews with 23 people …

21.08.2026journal-article

Child Development

Peer victimization, school belonging, and epigenetic aging among children of Latino immigrants

Rebeca Alvarado-Harris, Krista M Perreira

Abstract U.S.-born children of Latino immigrants often begin life with health advantages, yet the developmental conditions that ­sustain or erode these advantages remain unclear. Drawing on socioecological and sociocultural perspectives, this study examined whether peer victimization and school belonging in middle childhood predicted changes in epigenetic aging from childhood to adolescence. These associations were compared between children of immigrant and U.S.-born Latina mothers. Future of Families and Child Wel …

21.08.2026journal-article

Aging Cell

Aging Alters Hair Cell Physiological Properties in Mice With Late‐Onset Age‐Related Hearing Loss

Piece Yen, Adam J. Carlton, Andrew O'Connor, Niovi Voulgari, Stuart L. Johnson, Jing‐Yi Jeng

ABSTRACT Mammalian cochlear hair cells convert acoustic stimuli into electrical signals, which are relayed to the central auditory pathway via auditory neurons. Progressive loss of hair cells and their synapses is a characteristic of age‐related hearing loss (ARHL), but the underlying mechanisms remain poorly understood. In this study, we tested the hypothesis that hair cell physiological properties change with age in CBA/CaJ mice, a strain known for its slow ARHL progression. We found that hair cell size began to …

21.08.2026journal-article

Aging Cell

LivAge : An Online Aging Clock for Murine Transcriptomic Age Estimation

Víctor Celemín‐Capaldi, Guillermina Bea, David Roiz‐Valle, Alejandro P. Ugalde, Clea Bárcena, Pedro M. Quirós, José M. P. Freije

ABSTRACT The increase in life expectancy over the past century has been accompanied by the recognition of age as the primary risk factor for a wide range of pathologies, including cardiovascular and neurodegenerative diseases, as well as cancer. Thus, the development of interventions that slow the underlying biological processes of aging could have beneficial effects on the prevention or progression of these diseases. To evaluate such geroprotective interventions, quantifying biological damage via aging clocks—part …

21.08.2026journal-article

Administration and Policy in Mental Health and Mental Health Services Research

A Qualitative Investigation of Managers’ Experiences and Views of Early Support Hubs for Children and Young People

Kylee Trevillion, Rebecca Appleton, Gilda Spaducci, Emma Maynard, Felicity Allman, Jessica L Griffiths, Connor Clarke, Hannah K Lewis, Sadiya Begum, Anam Bhutta, Nima Cas Hunt, Eva Driskell, Lizzie Mitchell, Phoebe Barnett, Rob Saunders, Julian Edbrooke-Childs, Isabel Hanson, Polly Waite, Brynmor Lloyd-Evans, Sonia Johnson

Abstract Early Support Hubs are an emerging model of youth mental health provision, designed to offer holistic, open-access support for young people whose needs often fall below the threshold for specialist services. Despite increased expansion in many countries, little is known about how these Hubs are implemented in practice or the challenges faced by those responsible for delivering them. This paper presents a qualitative interview study with 19 managers of Early Support Hubs in England. A codebook thematic anal …

21.08.2026journal-article

Alzheimer's & Dementia: Behavior & Socioeconomics of Aging

Social frailty as a predictor of new onset dementia in older adults

Claire Wang, Sofia Liu, Rendong He, Katherine Ornstein, Anna Beeber, Thomas K. M. Cudjoe, Subhash Aryal, Yunxiang Sun, Junxin Li

Abstract Introduction Social frailty, defined as the loss of essential social resources, has been linked to cognitive impairment. Yet, few studies have examined whether changes in social frailty influence dementia risk or transitions along the cognitive decline continuum. Methods We included 13,207 community‐dwelling adults aged ≥ 65 from the National Health and Aging Trends Study (2011–2024), a nationally representative sample of US Medicare beneficiaries. Social frailty was measured using a 5‐item index (social f …

21.08.2026journal-article

Medicine

Linking probable respiratory sarcopenia to frailty in older adults

Mingqi Wu, Feiyan Cao, Yidan Huang, Kangkang Chen, Pingfei Ding

Frailty is a common geriatric syndrome linked to disability and mortality. Respiratory sarcopenia (RS), recently conceptualized as concurrent decline in muscle and respiratory function, may contribute to frailty, but evidence is scarce. We analyzed data from the nationally representative China Health and Retirement Longitudinal Study. Probable RS was defined, following the 2023 consensus, as low peak expiratory flow rate (PEFR) plus low appendicular skeletal muscle (ASM) mass. Frailty was assessed using the Fried f …

21.08.2026journal-article

Dietetics

Perceived Genetic Risk and Dietary Prevention Beliefs Among Offspring of People Living with Dementia: A Mixed-Methods Study Guided by the Health Belief Model

Vaios Svolos, Dimitra Eleftheria Strongylou, Elli Zoupa, Anastasia Triantafyllou, Maria Katsama, Konstantinos Michas, Rena Kosti, Olympia Bogiatzidou, Vasileios Siokas, Ioannis Liampas, Efthimios Dardiotis, Odysseas Androutsos

Background: Given the rising global prevalence of dementia and its complex etiology, involving genetic and environmental risk factors, the aim of the present exploratory study was to investigate how offspring of individuals with dementia perceive genetic risk and the role of diet in dementia prevention. Methods: A mixed-methods study was conducted in Greece. Overall, 118 offspring completed an online questionnaire assessing demographics, risk perceptions, and dietary beliefs and practices in dementia risk reduction …

21.08.2026journal-article

Journal of Dementia and Alzheimer's Disease

A Systematic Review on the Effects of Speech and Language Therapy in Patients with Dementia

Ioanna Rodaki, Despina Moraitou, Theodora Papamitsou, Effrosyni Koutsouraki

Background/Objectives: Dementia is a progressive neurocognitive disorder characterized by decline in cognitive, communicative, and functional abilities. Speech and language therapists (SLTs) play a role in managing communication and cognitive–linguistic impairments while supporting families and caregivers. However, evidence regarding the effectiveness of speech and language therapy interventions remains heterogeneous, and evidence has not integrated cognitive–linguistic and caregiver-related outcomes. This systemat …

21.08.2026journal-article

Frontiers in Public Health

Latent profile analysis and determinants of social isolation among older adults in China

Xiaoxing Lai, Zhiyuan Zhang, Yonghua Cai, Yang Li, Rui Sun, Shuai Zhang, Kexin Zhang, Hongdi Du, Shuxian Li, Jingwei Hao, Xiaopeng Huo

Objective This study aimed to identify social isolation profiles among older adults in China using latent profile analysis and to explore their associations with demographic and health factors. Methods A cross-sectional study was conducted between July and December 2023 in the Chaoyang and Dongcheng districts of Beijing, China. Participants aged 60 years or older were recruited through convenience sampling from six communities. Latent profile analysis was used to classify social isolation patterns, and multivariate …