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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

JMIR Research Protocols

Effect of Remote Vital Signs Monitoring in People Receiving Long-Term Oxygen Therapy: Protocol for a Randomized Controlled Trial

Elinny Raissa Moreira dos Reis, Gabriela Martins Alencar, Amanda Maria Schneider, Mari Claussen Tani Fernandes, Juliana de Melo Batista dos Santos, Celso Ricardo Fernandes Carvalho

Background Individuals receiving long-term oxygen therapy (LTOT) are often confined to their homes and have impaired health-related quality of life (HRQoL). Despite technological advances, monitoring these individuals remains a challenge. Objective This study aims to evaluate the impact of remote monitoring on HRQoL, dyspnea, health status, symptoms of anxiety and depression, and adherence to data entry via a mobile app in individuals receiving LTOT. Methods This randomized controlled trial will recruit 60 particip …

21.08.2026journal-article

Frontiers in Public Health

Latent profile analysis and determinants of social isolation among older adults in China

Xiaoxing Lai, Zhiyuan Zhang, Yonghua Cai, Yang Li, Rui Sun, Shuai Zhang, Kexin Zhang, Hongdi Du, Shuxian Li, Jingwei Hao, Xiaopeng Huo

Objective This study aimed to identify social isolation profiles among older adults in China using latent profile analysis and to explore their associations with demographic and health factors. Methods A cross-sectional study was conducted between July and December 2023 in the Chaoyang and Dongcheng districts of Beijing, China. Participants aged 60 years or older were recruited through convenience sampling from six communities. Latent profile analysis was used to classify social isolation patterns, and multivariate …

21.08.2026journal-article

Nutrients

Prevalence of Sarcopenia and Its Association with Nutrition Risk in Community-Dwelling Older Adults with Subjective Cognitive Impairment or Living in Retirement Homes

Raksha Aravind, Heather H. Keller

Background: Sarcopenia is an age-related condition characterized by declines in muscle strength and muscle mass associated with adverse health outcomes in older adults. Nutrition risk may contribute to sarcopenia development; however, its relationship with sarcopenia among community-dwelling older adults, especially those living in retirement homes or with subjective cognitive impairment, remains unclear. This study aimed to determine the prevalence of sarcopenia and its indicators using the EWGSOP2 criteria in com …

21.08.2026journal-article

Research on Aging

The Weight of Care: Examining the Relationship Between Grandchild Caregiving and Adiposity in Later Life

Ting-Syuan Lin, Wen-Hua Lai, Seung-won Emily Choi

Grandchild caregiving is an increasingly common later-life family role, yet its association with older adults’ adiposity remains unclear. Using five waves of the Health and Retirement Study (2010–2018), this study examines associations between grandchild caregiving arrangements and four adiposity indicators: BMI based on self-reported height and weight, physically measured BMI, waist circumference, and relative fat mass. Linear panel models, including random-effects and fixed-effects models, assess whether adiposit …

21.08.2026journal-article

Asia-Pacific Journal of Business Administration

The role of technology in facilitating accessible tourism: a systematic literature review of service access for people with disabilities

Giannis Theofanous, Alkis Thrassou, Yioula Melanthiou

Purpose Accessible tourism has become increasingly identified as a right, aligned with the global commitment for inclusion outlined in the 2030 Sustainable Development Goals. However, there are still significant barriers preventing people with disabilities from having smooth and inclusive tourism experiences. While technology has much potential to bridge these barriers, there is still a limited understanding of how technology currently develops access to services in accessible tourism. This study aims to conduct a …

21.08.2026journal-article

Obstetric Anesthesia Digest

Time-restricted Eating and Exercise Training Before and During Pregnancy for People With Increased Risk of Gestational Diabetes: Single Center Randomized Controlled Trial (Before the Beginning)

MJ Sujan, HM Skarstad, G Rosvold, SL Fougner, T Follestad, KA Salvesen, T Moholdt

( BMJ 2025;390:e083398. doi: 10.1136/bmj-2024-083398) Gestational diabetes mellitus (GDM) is a condition that affects about 1 of 7 live births globally and is characterized by hyperglycemia during pregnancy. There are several risk factors for GDM, including older age, a high body mass index, gaining excessive weight while pregnant, having a prior history of GDM or diabetes, and non-European ethnicity. Studies show that hyperglycemia typically resolves after delivery, and GDM is linked to many negative outcomes in l …

21.08.2026journal-article

Frontiers in Nutrition

Associations of dietary diversity trajectories with depressive symptoms among Chinese older adults: a 10-year longitudinal study

Jiafa Yang, Yuxia Xie, Fengting Hu, Jin Peng, Weiran Wang, Lin Shen

Background Depression is one of the most prevalent mental health conditions among older adults in China, profoundly impairing quality of life and impeding healthy aging. Dietary diversity, as a comprehensive indicator of overall diet quality, has been associated with various chronic diseases and mental health outcomes. However, the association between longitudinal trajectories of the Dietary Diversity Score (DDS) and depressive symptoms among older adults remains poorly understood. Methods Using four waves of longi …

20.08.2026journal-article

ACS Applied Materials & Interfaces

An Adiponectin Receptor Agonist Dispersed via Nonencapsulative Exosomes Alleviates Aging-Associated Cardiac Dysfunction

Yin Zhou, Xue Li, Lilei Wang, Penghui Zeng, Yuxiao Zhang, Qi Zhu, Rui Wang, Cong Wang, Xifei Yang, Qi Zhao, Yushuo Feng, Ming Dong

Abstract Aging-related cardiac dysfunction constitutes a major and growing global health challenge with limited effective treatment options. While adiponectin receptor activation has demonstrated cardioprotective potential, its translation into a viable therapy for the senescent heart remains unrealized. In this study, we developed CardiAdip (CAD), an agonist with improved predicted binding affinity for adiponectin receptors. In d-galactose (d-gal)-induced senescent H9c2 cardiomyocytes, CAD attenuated senescence-as …

20.08.2026journal-article

International Journal of Disaster Risk Science

Unequal Access to Emergency Facilities for Older Adults: A Spatial Analysis in Shanghai, China

Xi Chen, Xiaogang Zhu, Wuxiao Teng

Abstract Increasingly frequent disasters and the heightened vulnerability of older adults highlight the need for equitable access to lifesaving resources such as evacuation shelters and emergency supply storage. This study evaluates whether the spatial accessibility of these facilities aligns with the distribution of older residents in core and non-core areas of Pudong New Area, Shanghai Municipality. We develop a spatial equity framework employing bivariate local Moran’s I, Lorenz curves, and Gini coefficients to …

20.08.2026journal-article

The Singapore Economic Review

Advances in Medical Technology, Population Aging, and Healthcare Expenditure in Japan

Takeyuki Hirai, Hisashi Okamoto

Using annual data from 1960 to 2023, we estimate autoregressive distributed lag models to examine the effects of population aging and technological advances in high-cost areas of medical care, such as cancer treatment, on Japan’s public healthcare insurance finances in the long-run. Results show that while population aging and technological advances increase healthcare expenditure and public burden, their effects on insurance premiums and out-of-pocket payments differ. An increase in public burden will further dete …

20.08.2026journal-article

Journal of the American Heart Association

Associations of Cardiovascular–Kidney–Metabolic Syndrome With All‐Cause and Cardiovascular Death and the Progression of Cardiovascular–Kidney–Metabolic Syndrome Among Hong Kong Chinese People Over 2 Decades

Lanlan Li, David Tak‐Wai Lui, Carol Ho‐Yi Fong, Jimmy Ho‐Cheung Mak, Chloe Yu‐Yan Cheung, Aimin Xu, Kathryn Choon‐Beng Tan, Hung‐Fat Tse, Jean Woo, Tai‐Hing Lam, Yu‐Cho Woo, Bernard Man‐Yung Cheung, Karen Siu‐Ling Lam, Chi‐Ho Lee

Background In 2023, the American Heart Association established the cardiovascular–kidney–metabolic (CKM) syndrome and defined its different stages. Here, we analyzed the prospective associations of CKM stages with mortality outcomes and how CKM syndrome progresses over time. Methods This observational study used data from the Hong Kong CRISPS (Cardiovascular Risk Factor Prevalence Study) 2, a population‐based cohort involving community‐dwelling Chinese participants who underwent comprehensive health assessment betw …

20.08.2026journal-article

Aging Cell

The Thymic Microenvironment Shapes Age‐Related Qualitative Changes in the TCR Repertoire

Jasmine Rowell, Diana C. Yanez, Susan Ross, Ching‐In Lau, Eden Zhang, Amir Monfared, Oscar A. Peña, Benny Chain, Tessa Crompton

ABSTRACT Ageing impairs immune function, increasing susceptibility to infection, autoimmunity and inflammation. The thymus undergoes involution during childhood, and thymocyte and thymic epithelial cell (TEC) numbers decline. Given that adaptive immunity depends on T‐cells recognising diverse antigens via their unique T‐cell receptor (TCR), the precise age‐related changes in TCR repertoire composition are key to understand immunity. To investigate the influence of age on the thymic TCR repertoire we sequenced TCRα …

20.08.2026journal-article

JDR Clinical & Translational Research

Nonlinear Association between Density of Dental Clinics and Dental Visits among Older Japanese

K. Honda, S. Kiuchi, K. Takeuchi, T. Kusama, K. Osaka, J. Aida

Objectives: Correcting clinic maldistribution is key to universal health care. The imbalance in dental clinic supply, characterized by both oversupply and undersupply, remains underexplored, and few studies link geographic distribution with patient utilization patterns. This study examined the association between the density of dental clinics and dental visits among the older Japanese population. Method: This repeated cross-sectional study used data from 3 waves (2016, 2019, and 2022) of the Japan Gerontological Ev …

20.08.2026journal-article

Biological Research For Nursing

Association Between Serum BDNF and S100 B Levels in Community-Dwelling Older Adults

Ryuzo Orihashi, Takumi Shiraishi, Toru Murakawa-Hirachi, Hiroshi Tateishi, Yutaka Kunitake, Hiroko Kunitake, Yoshito Mizoguchi

Population aging has made the maintenance of cognitive function and mental health in older adults a major public health priority. Brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100 B) are biomarkers of brain health, reflecting neurotrophic support and neuroinflammatory activity, respectively. The objectives of this study were to examine the association (a) between serum BDNF and S100 B levels and (b) between these biomarkers and cognitive function and depression in community-dwelling …

20.08.2026journal-article

International Journal of Environmental Research and Public Health

Facing Dementia in Primary Care: A Process Evaluation of a Multicomponent Practice Change Intervention to Improve Dementia Diagnosis in General Practice

Mark Yates, Caroline Gibson, Constance Dimity Pond, Stephanie Daly, Jessica Jebramek, Sharon Daniel, Lyn Phillipson, Kate Laver, Meredith Gresham, Edwin Tan, Henry Brodaty, Jamie Swann, Shahana Ferdousi, Annica Barcenilla-Wong, Nora Wong, Lee-Fay Low

Dementia is a leading cause of disability and death worldwide, yet diagnosis in primary care remains substantially lower than expected, delaying access to treatment, support and future care planning. The Facing Dementia Together Practice Change Program was developed as a co-designed, multicomponent intervention to improve dementia diagnosis in Australian general practice. A mixed-methods process evaluation used the RE-AIM framework with the addition of Appropriateness. The intervention included Primary Health Netwo …

20.08.2026journal-article

ACS Applied Energy Materials

Mechanism of Capacity Loss of Zinc Anodes during Calendar Aging

Ze Chen, Qiang Fu, Congxin Xie, Xianfeng Li

Abstract Zinc-based flow batteries (ZBFBs) hold significant promise for low-cost and safe large-scale energy storage; however, there has been a lack of focus on calendar aging and the corresponding strategies to mitigate capacity decay. Herein, we systematically examined the factors affecting the calendar aging of zinc anodes, identifying current density and dissolved oxygen (DO) as key contributors to capacity loss. Low interfacial impedance and deposition overpotential in oxygen-free electrolytes, especially at l …

20.08.2026journal-article

Frontiers in Medicine

Sarcopenia in older adults admitted to acute medical unit: a prospective observational study of feasibility and clinical outcomes

Vicky Kamwa, Zaki Hassan-Smith, Thomas Jackson, Elizabeth Sapey

Background Sarcopenia, the loss of skeletal muscle mass and function, has recently emerged as a significant health concern. It is common in older adults and linked to poor outcomes. It is dynamic and can improve or deteriorate over short periods of time. We aimed to determine its prevalence and changes during hospital admission and explore associations with clinical outcomes. Methods This was a Prospective, Observational Cohort, Feasibility Study. Older Adults (>65 years old) with an unplanned admission to an AM …

20.08.2026journal-article

Frontiers in Public Health

Cancer prevention and screening for people with intellectual disabilities in Europe: a systematic review and recommendations for policy and practice

Vladimir Vukovic, Peter Knapp, Kate Sykes, Margaret Denny, Oliwia Kowalczyk, Suzanne Denieffe, John Wells, Maarten Cuypers, Barrie Tyner, Kálya Yasmine Lima, Adela Elena Popa, Dalia Ismail Ibrahim, Rebecca Hansford, Trine Allerslev Horsbøl, Dragana Milutinović, Bilge Güvenç Tuna, Eda Başustaoğlu Şahin, Ayşegül Ilgaz, Amina Banda, Elif Sarac, Soner Doğan, Seda Cansu Yeniğün Akbulut, Bahar Aksoy, Dušanka Tadić, Mohammed A. Merzah, Pınar Soylar, Aysenur Doğan, Dragana Simin, Jasmin Mušanović, Damla Altin, Merve Sena Topkaya, Fatima Kassymbekova, Vladimir Trajkovski, Edanur Tar Bolacali, Louise Lynch, Eilish Burke, Martin McMahon

Introduction People with intellectual disability experience inequalities across the cancer care continuum, including lower screening participation, later-stage diagnosis, and higher cancer related mortality. Whether European cancer prevention and screening policies explicitly address this population has not been systematically mapped. Methods This review aimed to identify and synthesise European national and international policy frameworks, guidelines, and recommendations for cancer prevention and screening that ad …

20.08.2026journal-article

Working with Older People

Managing complex needs amidst limited formal care: informal support, reciprocity and loneliness among older adults in Vietnam

Anh Nu Nguyet Nguyen, Binh Huu Nguyen, Anh Xuan Nguyen

Purpose This study aims to examine how older adults in Vietnam manage complex care needs where formal care is limited and how informal support, reciprocity and loneliness intersect within these arrangements. Design/methodology/approach This paper draws on 90 semi-structured interviews with older adults, family carers and local stakeholders at urban and rural sites in southern Vietnam, conducted in 2024. Older-adult interviews formed the primary analytic data set, while carer and local-stakeholder accounts were used …

20.08.2026journal-article

Frontiers in Health Services

Supporting continuous glucose monitoring for people with serious mental illness and type 2 diabetes: a co-design study for a structured intervention

Jennifer V. E. Brown, Olivia Matthias, Jessica Hendon, Ramzi A. Ajjan, Najma Siddiqi, Ian Kellar, Peter A. Coventry

Introduction Individuals with serious mental illness (SMI), such as schizophrenia or bipolar disorder, are at a two- to threefold increased risk of developing type 2 diabetes and face significant health inequalities, including reduced life expectancy. Diabetes self-management in this population is challenging, and existing interventions are poorly suited to their needs. Continuous glucose monitoring (CGM) offers potential benefits but remains underused. This study aimed to co-design a logic model and programme theo …

20.08.2026journal-article

Frontiers in Aging Neuroscience

Acceptability and feasibility of an adapted Portuguese folk dance–based therapy in older adults with moderate-to-severe dementia and balance impairment

Ana Almeida, Vasco Caveirinha, Joana Felício, Rui Fontes, Patrícia João, Tânia Libório, Ana Piedade, Carlos Família, Catarina Godinho, Júlio Belo Fernandes

Introduction Population ageing has increased the prevalence of dementia, often accompanied by mobility impairments. It is essential to develop effective interventions and promote adherence among people with dementia. Culturally meaningful activities may enhance motivation, engagement, and rehabilitation outcomes. Methods A mixed-methods pilot study was developed to evaluate the acceptability and feasibility of an adapted Portuguese folk dance–based intervention among older adults with moderate to severe dementia an …

20.08.2026journal-article

Drug and Alcohol Review

High Awareness, Low Clarity: Knowledge of the Australian Capital Territory's Multi‐Drug Decriminalisation Reform Among People Who Use Illicit Drugs

Rachel Sutherland, Connor Graham, Caitlin Elizabeth Hughes, Anna Olsen, Chris Gough, Cate King, Amy Peacock

ABSTRACT Introduction In October 2023, the Australian Capital Territory became the first Australian jurisdiction to decriminalise possession of small quantities of multiple illicit drugs by law, introducing an alternative, legislated pathway enabling police to divert individuals to a health education and information session or issue a $100 expiation fine. This study examined awareness and understanding of this reform among two populations of people who regularly use illicit drugs in Canberra. Methods Cross‐sectiona …

20.08.2026journal-article

Healthcare

Effects of a Fully Immersive Virtual Reality Exercise Game on Fear of Movement, Pain, and Disability in People with Chronic Non-Specific Low Back Pain: A Pilot Randomized Controlled Trial

Hana Alsobayel, Kholoud Almufaireej, Dalia Alimam, Hamad Alduaij, Afaf Shaheen, Hend Al-Khalifa

Background/Objectives: Low back pain (LBP) is a leading cause of disability worldwide, and exercise-based rehabilitation is recognized as an effective management strategy. However, adherence to exercise remains challenging. Fully immersive virtual reality (VR) exercise interventions may enhance engagement and clinical outcomes. This study aimed to examine the effect of a fully immersive VR exercise game on pain, fear-avoidance beliefs, and disability in individuals with chronic non-specific LBP. Methods: A single-b …