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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Education in Medicine Journal

Fostering Excellence in English Academic Writing Among Health Profession Students and Lecturers: An Action Research

Izzudeen Ayub, Megat Mustaqim Megat Iskandar, Siti Yusrina Nadihah Jamaludin, Yasrul Izad Abu Bakar, Mohd Salami Ibrahim

Academic writing is a critical skill for researchers and educators. However, many, especially in nonnative English-speaking contexts, face challenges in mastering it. This study employed action research (AR) involving 27 participants to address these challenges through the design and implementation of an academic writing workshop for postgraduate students and lecturers from the Facultiesof Medicine, Health Sciences, and Pharmacy. The AR workshop integrated hands-on learning, structured guidance, and innovative tool …

28.08.2026journal-article

Journal of Clinical Medicine

The Three Faces of IgA Nephropathy: Clinicopathological Heterogeneity and Urinary Albumin-to-Protein Ratio in a Case Series

Anna Masajtis-Zagajewska, Blazej Kieszek, Michał Nowicki

Background/Objectives: IgA nephropathy (IgAN) is a highly heterogeneous glomerular disease with variable clinical presentation and response to therapy. Standard histopathology provides a static assessment and may not fully reflect dynamic podocyte injury. The objective of this case series was to characterize distinct clinical phenotypes of IgAN and explore the relationship between urinary protein composition assessed by the urine albumin-to-protein ratio (uAPR) and ultrastructural glomerular injury. Methods: We ret …

28.08.2026journal-article

Tropical Medicine and Infectious Disease

Application of Genomics to Prevent and Combat Emerging Infectious Disease Threats in Latin America: Perspectives from an Overseas U.S. Navy Research Command

Hugo O. Valdivia, Maria Silva, Cristopher D. Cruz, Paul Rios, Marisa E. Lozano, Julia S. Ampuero, Yeny Tinoco, Jeffrey Spiro, Yuliya S. Johnson, Alden S. Estep, Steev Loyola, Carmen Flores-Mendoza, Gissella M. Vasquez, Jose A. Garcia-Rivera, Henju Marjuki

Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of these diseases. High-throughput sequencing technologies have become a critical resource for the field of infectious disease monitoring, specifically for tracking pathogen evolution, antimicrobial resistance, and transmission. This review prov …

28.08.2026journal-article

Hippocrates Medical Journal

When Artificial Intelligence Speaks For The Obstetrician: Multilingual Accuracy On Real Patient Questions

Alihan Tığlı, Yakup Baykuş, Rulin Deniz, Sefer Üstebay, Muammer Hayri Bektaş, Çağdaş Çöllüoğlu

BackgroundThe use of generative large language models (LLMs) in healthcare is rapidly increasing, offering easier access to medical information. However, comprehensive data on their multilingual accuracy and the reliability of cited scientific references remain limited. This study aimed to compare the response accuracy and reference quality of three free LLMs (ChatGPT, Google Gemini, DeepSeek) in Turkish and English using common pregnancy-related questions.MethodsIn this comparative observational study, 14 frequent …

28.08.2026journal-article

Gynecology Obstetrics & Reproductive Medicine

Longitudinal Assessment of Fetal Ductus Arteriosus Morphometry: Establishing Gestational Age-Specific Reference Values

Murat Cagan, Umutcan Kayikci, Erdem Fadiloglu, Ayse Cigdem Bayrak, Edip Alptug Kir, Hayrettin Hakan Aykan, Ozgur Deren

OBJECTIVES: To longitudinally evaluate fetal ductus arteriosus (DA) morphometric changes and establish normative reference values between 18 and 36 weeks of gestation. STUDY DESIGN: This prospective cohort study included 29 pregnant women with structurally normal singleton fetuses and confirmed gestational ages. Each participant underwent serial standardized ultrasound examinations to evaluate DA length and proximal, mid, and distal diameters. We defined weekly growth trends using regression analyses and assessed c …

28.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/ G3BP1 Axis

Ke Li, MeiXia Li, XueQiang Pan, JiaWen Xu, Rui Jiang

ABSTRACT Background and Objective Brucea javanica oil emulsion (BJOE), a traditional Chinese medicine extract, has been demonstrated to possess antitumor activity in multiple cancers. However, its molecular mechanisms in breast cancer, particularly those involving circRNAs, remain unclear. This study investigates whether BJOE exerts its anti‐breast cancer effects by inducing autophagy and apoptosis through regulating hsa_circ_0001589/G3BP1/PAX6 signalling axis. Methods After BJOE treatment of MCF‐7 cells, cell viab …

28.08.2026journal-article

European Journal of Plastic Surgery

A novel indication of Glyaderm®: its use as a nerve wrap in the treatment of compression neuropathies

Milly van de Warenburg, Claire van Houdt, Stefan Hummelink, Till Wagner

Abstract Background Fibrotic changes following surgical decompression of nerve entrapment can restrict nerve regeneration, and exert pressure on the nerve, leading to symptoms of recurring entrapment. This case series reports on the outcomes of using Glyaderm® (ETB-BISLIFE Multi Tissue Center, The Netherlands) as a low-cost, customizable, and biocompatible nerve wrap in patients with recurrent or post-traumatic compression neuropathies, highlighting its potential benefits as a neuroprotective shield. Methods We rev …

28.08.2026journal-article

Journal of Innovations in Materials and Manufacturing Engineering

Influence of Heat Treatment and Thermal Aging on the Fatigue Performance of LPBF Fabricated AlSi10Mg Alloy

Edel Arrieta, Luis A. Marquez, Lawrence E. Murr, Diego A. Ariza, Mark Benedict, Jason Thomas, James Carney, Francisco Medina

This investigation explores fatigue performance of laser powder bed fusion (LPBF)-fabricated AlSi10Mg alloy subjected to various post-processing treatments: stress relief (SR), Hot Isostatic Pressing (HIP), and HIP + T6, all followed by prolonged thermal aging at 177 °C for up to 1000 h. Microstructural evolution, hardness, density, and uniaxial fatigue performance, including SEM fractography, were examined to recommend practical service life thresholds. Microstructural analysis confirmed that HIP and HIP + T6 trea …

28.08.2026journal-article

Bioengineering

Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions

Lijin Liu, Changfa Huang, Zhongyin Ji, Yujie Zhou, Zihua Li, Xueyi Zhang, Zhihong Wu

Wearable technologies are reshaping gait rehabilitation by shifting assessment and therapy from intermittent, clinic-based observation to continuous, data-driven, and adaptive care. This narrative review synthesizes the biomechanical basis of gait instability, the architecture and classification of wearable rehabilitation systems, and the clinical evidence for motion sensors, smart insoles, biofeedback devices, robotic and orthotic wearables, neuromodulatory systems, immersive platforms, and artificial intelligence …

28.08.2026journal-article

Measurement Science and Technology

An event-based machinery fault diagnosis method via incremental retention and condition-aware alignment

Linfei Ji, Siyuan Liu, Gangzhu Qiao, Li Wang

Abstract An event camera,as an emerging dynamic visual sensor,provides a new test method for non-contact fault diagnosis in complex industrial environments.However,most existing studies follow the offline static assumption.Aiming at the continual learning challenges brought by the constant change of operating conditions and dynamic evolution of fault categories in industrial online monitoring,this paper proposes a continual learning framework based on event-based dynamic vision.Specifically,a Condition-aware MixSty …

28.08.2026journal-article

Medicine

Network analysis of symptoms and psychological distress in patients with sudden sensorineural hearing loss

Jiemei Wang, Yifang Li, Wei Song, Li Xie, Changju Tao

Sudden sensorineural hearing loss (SSNHL) is characterized by rapid-onset, unexplained hearing impairment, frequently accompanied by symptoms such as tinnitus, dizziness, and nausea. Patients with SSNHL often experience psychological distress, including anxiety and depression, which are interconnected, offering insights for holistic management. This study aims to elucidate these connections, with a focus on anxiety and depression, using network analysis to inform holistic management strategies. Network analysis was …

28.08.2026journal-article

Medicine

Association between serum antibodies against oral microorganisms and vitamin D deficiency among US adults

Li Tan, Si-qun Xu

Vitamin D deficiency is common and may contribute to periodontal disease by affecting periodontal pathogens. Most studies analyzing this association have focused mainly on a specific periodontal bacterium ( P gingivalis ) and have involved relatively small study populations (tens or hundreds of individuals). To address this gap, a sizable, nationally representative adult population was utilized to investigate the association between the prevalence of Vitamin D deficiency and immunoglobulin G (IgG) antibodies to 19 …

28.08.2026journal-article

Medicine

Sex‑specific associations between multiple hormone axes and dynapenic obesity in middle‑aged and older patients with type 2 diabetes

Di Yu, Qin Ou, Bo Xie, Yinghao Li, Kun Liao, Rong Li, Mei Mei, Bo Zhou

Accumulating evidence indicates that hormones play a critical role in the pathogenesis of dynapenic obesity (DO), although the precise relationships and underlying mechanisms remain elusive. This study aimed to investigate sex-stratified associations between multiple hormones and prevalence of DO in type 2 diabetes mellitus (T2DM) populations. In this cross-sectional study of 557 T2DM patients, body composition was assessed by dual-energy X-ray absorptiometry, and hormones from pituitary-target gland axes and the v …

28.08.2026journal-article

Small

Phage‐Derived Protein‐Guided Nanozymes for the Treatment of MRSA‐Infected Acute Otitis Media

Bin Hong, Jie Wang, Bing Hu, Gongxi Qiao, Qun Ma, Ming Yang, Zhaoyang Ke, Xiyun Yan, Daji Wang

ABSTRACT Nanozymes with peroxidase‐like activity have been identified as promising nanomaterials against antimicrobial resistance. However, their in vivo efficacy is significantly limited due to the lack of bacterial targeting ability. Furthermore, the substantial accumulation of nanozymes in nontarget tissues raises concerns of potential nanotoxicity. Here, we report a single‐atom nanozyme (mFeP‑gCBD) by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Stap …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

The spiral evolution of techniques for the laboratory diagnosis of microbial infections

Yi-Wei Tang, Nahed Ismail, Rodolfo García-Contreras

The laboratory diagnosis of microbial infections has undergone a profound transformation over the past century, evolving from classical phenotypic methods to molecular genetic approaches and now toward ultra-sensitive molecular phenotyping. While this progression is often described as linear, a closer examination reveals a cyclical pattern: an initial reliance on observable biological function, followed by a shift toward genetic abstraction, and, more recently, a return to phenotypic measurement at unprecedented mo …

27.08.2026journal-article

Frontiers in Medicine

Focusing on persistent hypoxemia during VV-ECMO secondary to traumatic tricuspid valve injury: a case report

Yunpeng Zhao, Jing Liu, Kun Chen

Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving salvage therapy for treating severe respiratory failure. We present a case of trauma-related hypoxemia with severe tricuspid chordae tendinae rupture managed with VV-ECMO. Case presentation We report the successful use of VV-ECMO in a 29-year-old patient with severe acute respiratory distress syndrome (ARDS). Refractory hypoxemia persisted despite maximal conventional therapy during the course of treatment at the outside hospital. …

27.08.2026journal-article

Frontiers in Neuroinformatics

Interpretable AI for neural signal decoding in dementia: an EEG ensemble approach to differential diagnosis

Fawad Muhammad, Irfan Ahmed Usmani, Muhammad Aamir, Mai Alduailij, Mehrez Marzougui, Rab Nawaz

Introduction The differential diagnosis between Alzheimer’s disease (AD) and frontotemporal dementia (FTD) presents a significant clinical challenge due to overlapping early-stage symptom profiles. Conventional resting-state EEG provides limited sensitivity to the impaired neural plasticity and lateralized cortical degeneration frequently observed in FTD. Methods We developed a domain-informed heterogeneous ensemble framework incorporating dynamic neural reactivity and hemispheric asymmetry metrics from 19-channel …

27.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ARTIFICIAL INTELLIGENCE IN MODERN MEDICINE: A COMPREHENSIVE REVIEW OF CURRENT APPLICATIONS, CHALLENGES, AND FUTURE PERSPECTIVES

Aleksandra Stańczyk, Kinga Haduch, Zuzanna Michalska, Anna Łęczycka, Nicole Aleksandra Ordyczyńska-Mardyła, Izabela Zuzanna Stranz, Olga Chorąży, Joanna Strzelczyk, Iga Suchta, Amelia Kędziora

Introduction: The digital transformation of healthcare is accelerating, driven by unprecedented advancements in Artificial Intelligence (AI). From large language models (LLMs) to biomolecular structure prediction, AI is redefining modern diagnostic and therapeutic standards. Aim: This review evaluates the current state of AI applications in medicine, focusing on clinical knowledge encoding, molecular drug discovery, and administrative workflow optimization, while critically addressing the technical, ethical, and sy …

27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (<4 weeks duration) underwent clinical, psychometric, and functional mag …

27.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Systematic evaluation of foundation models for organ-level classification on CT scans

Jan Tagscherer, Sarah de Boer, Fennie van der Graaf, Lena Philipp, Colin Jacobs, Ewoud J. Smit, Alessa Hering

Abstract Purpose Foundation models are increasingly used as frozen feature extractors for CT classification tasks, yet the determinants of their downstream performance remain unclear. We assess how foundation model choice, feature aggregation strategy, and abnormality type are associated with performance in organ-level abnormality classification. We further evaluate whether more expressive aggregation strategies outperform simple pooling, and whether performance varies by abnormality type. Methods We evaluate five …

27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

Clinical and Translational Medicine

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

Danyi Yang, Yinyin Chen, Hao Li, Guoyong Liu, Yang Gao, Liyu He

Abstract Background NOP2/Sun RNA methyltransferase family member 4 (NSUN4)‐mediated 5‐methylcytosine (m5C) modification has been implicated in diabetes‐related diseases. However, its role and molecular mechanism in diabetic nephropathy (DN) remain unclear. Methods DN mouse model was constructed by injecting with streptozotocin (STZ). High glucose (HG)‐induced HK‐2 cells were used to establish a cellular model of DN. The levels of NSUN4, SMAD ubiquitination regulatory factor 1 (SMURF1), calcium/calmodulin‐dependent …

27.08.2026journal-article

Journal of NeuroInterventional Surgery

Millipede Aspiration for Revascularization in Stroke (MARRS): prospective trial of a novel 0.088 inch corrugated catheter

Raul G Nogueira, Manuel Requena, Jaydevsinh Dolia, Syed Zaidi, Pedro Navia, Gaultier Marnat, Tarun Bhalla, Alhamza R Al-Bayati, Michael Nahhas, Osama O Zaidat, Ryan Priest, Romain Bourcier, Waldo R Guerrero, Reza Dashti, Gregory Gascou, Raoul Pop, Tareq Kass-Hout, Nitin Goyal, Amin Aghaebrahim, Adnan I Qureshi, Sameer A Ansari, Guilherme Dabus, Jose I Suarez, Levansri D Makalanda, Alberto Alvarez-Muelas, Xavier Barreau, Matthew T Bender, Mouhammad Jumaa, Eugene Lin, Guillaume Bellanger, Francesco Diana, Ryan Hebert, Sunil A Sheth, Richard Burgess, Diogo C Haussen, Charles Matouk, Christophe Cognard, Ameer E Hassan, Ricardo A Hanel, Benjamin Gory

Background The Millipede AspiRation for Revascularization in Stroke (MARRS) pivotal study was a prospective, multicenter, single arm trial evaluating the safety and efficacy of the corrugated Millipede catheter system in patients with acute ischemic stroke due to large vessel occlusion. Methods Patients aged 18–85 years with internal carotid artery, M1, M2, or basilar artery occlusions treatable within 8 hours were eligible. Catheter selection was based on target vessel diameter (Millipede88 >2.7 mm; Millipede70 >2 …