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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Bioengineering

Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions

Lijin Liu, Changfa Huang, Zhongyin Ji, Yujie Zhou, Zihua Li, Xueyi Zhang, Zhihong Wu

Wearable technologies are reshaping gait rehabilitation by shifting assessment and therapy from intermittent, clinic-based observation to continuous, data-driven, and adaptive care. This narrative review synthesizes the biomechanical basis of gait instability, the architecture and classification of wearable rehabilitation systems, and the clinical evidence for motion sensors, smart insoles, biofeedback devices, robotic and orthotic wearables, neuromodulatory systems, immersive platforms, and artificial intelligence …

28.08.2026journal-article

Small

Phage‐Derived Protein‐Guided Nanozymes for the Treatment of MRSA‐Infected Acute Otitis Media

Bin Hong, Jie Wang, Bing Hu, Gongxi Qiao, Qun Ma, Ming Yang, Zhaoyang Ke, Xiyun Yan, Daji Wang

ABSTRACT Nanozymes with peroxidase‐like activity have been identified as promising nanomaterials against antimicrobial resistance. However, their in vivo efficacy is significantly limited due to the lack of bacterial targeting ability. Furthermore, the substantial accumulation of nanozymes in nontarget tissues raises concerns of potential nanotoxicity. Here, we report a single‐atom nanozyme (mFeP‑gCBD) by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Stap …

28.08.2026journal-article

The International Journal of Tuberculosis and Lung Disease

Peer-led education on treatment success and patient-reported outcomes in drug-susceptible pulmonary TB

M.G. Workie, F. Ambaw, M.A. Asemahegn

<sec><title>BACKGROUND</title>Peer-led education has shown effectiveness in improving adherence and psychosocial outcomes for HIV and chronic disease through shared experience and social learning. Despite its potential, peer involvement remains underutilised in TB care, particularly in low-income settings. Existing studies primarily focus on microbiological cure and treatment completion with minimal attention to patient-reported outcomes such as quality of life, disability, and mental health.</sec><sec><title>OBJEC …

28.08.2026journal-article

Clinical Case Reports

Management of Infective Endocarditis Complicated by Ruptured Cerebral Mycotic Aneurysm: A Case Report

Shogo Oyama, Junpei Yamauchi, Satoshi Arimura, Kosuke Saku, Tomomitsu Takagi, Satoshi Hoshino, Takayuki Abe, Yoko Matsumura, Michio Yoshitake, Ryuichi Nagahori, Ko Bando, Takashi Kunihara, Gota Nagayama, Yuichi Murayama

ABSTRACT This case highlights multidisciplinary decision‐making and the timing of staged surgical intervention in infective endocarditis complicated by intracranial hemorrhage. Early cardiac surgery following neurosurgical treatment may be considered in carefully selected patients.

27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Systematic evaluation of foundation models for organ-level classification on CT scans

Jan Tagscherer, Sarah de Boer, Fennie van der Graaf, Lena Philipp, Colin Jacobs, Ewoud J. Smit, Alessa Hering

Abstract Purpose Foundation models are increasingly used as frozen feature extractors for CT classification tasks, yet the determinants of their downstream performance remain unclear. We assess how foundation model choice, feature aggregation strategy, and abnormality type are associated with performance in organ-level abnormality classification. We further evaluate whether more expressive aggregation strategies outperform simple pooling, and whether performance varies by abnormality type. Methods We evaluate five …

27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (&lt;4 weeks duration) underwent clinical, psychometric, and functional mag …

27.08.2026journal-article

International Journal of Molecular Sciences

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Andressa Oliveira Peixoto, Larissa Ferreira Selicani, Camila Bento Safi, Daniela Souza Paiva Borgli, Adyléia Aparecida Dalbo Contrera Toro, Nathália Mariana Santos Sansone, Andrea de Melo Alexandre Fraga, Fernando Augusto Lima Marson, José Dirceu Ribeiro

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This retrospective study aimed to clinically characterize individuals with cystic fibrosis who developed HHMA, characterize their CFTR genetic profile and compare it with that of other individuals with cystic fibrosis followed at a Brazilian te …

27.08.2026journal-article

Cancers

Trends in Treatment and Survival Among Patients with Glioblastoma in the United States from 2000 to 2020

Jianan Chen, Catherine M. Boldig, Qiong Wu, Hannah M. Cardenas, Kaitlyn N. Bernard, Kwadwo Darko, Patrick T. Grogan, Yu Sun, Robert J. Macaulay, Ekokobe Fonkem, Arnold B. Etame

Background: Population-level patterns in the real-world use of initial treatment combinations for glioblastoma (GBM) remain poorly characterized. Materials and Methods: We assessed temporal trends in treatment and survival among patients with GBM in the SEER registry. Guideline-concordant multimodal therapy was defined as cancer-directed surgery combined with radiotherapy and chemotherapy. Outcomes were further stratified by extent of resection, including gross total resection (GTR) versus subtotal resection. Resul …

27.08.2026journal-article

Pigment International

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Dalitso Namutowe, Yun Xu, Jin Gong

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the transition from aggressive mono-therapies to a multi-layered, synergistic approach. To locate, select, and extract relevant data, a comprehensive search of recent clinical protocols and emerging technological studies was conducted. This literat …

27.08.2026journal-article

European Journal of Therapeutics

Associations of the February 2023 Earthquakes with Semen and Serum Parameters in Men Undergoing Infertility Evaluation, Stratified by Psychiatric Diagnosis: a Retrospective Cross-Sectional Study

Emrah Zayman, Feyza İnceoğlu, Muhammet Serdar Buğday, Kübra Orman

Objective: To compare semen and serum parameters between the pre- and post-earthquake periods among men undergoing infertility evaluation and to examine whether the observed patterns differed according to recorded psychiatric diagnosis. Methods: This retrospective comparative cross-sectional study used hospital records from before (January 1, 2021-February 5, 2023) and after (February 6, 2023-December 31, 2024) the February 6, 2023 earthquakes, which affected 11 provinces in Türkiye. Participants were selected by s …

27.08.2026journal-article

Head & Neck

Symptom‐to‐Diagnosis Interval, Treating‐Center Context, and Survival in Nasopharyngeal Carcinoma in Nonendemic Northern China: A Multicenter Real‐World Cohort Study

Qi An, Qingxin Wang, Yubing Qian, Minghan Qiu, Shenglin Zhang, Xinyu Zhao, Xiaoyan Chen, Rui Jian, Zhongjie Chen, Wei Wang, Peiguo Wang, Zhongqiu Wang

ABSTRACT Background In nonendemic northern China, symptom recognition prompts diagnostic evaluation for nasopharyngeal carcinoma. Methods We analyzed 1022 patients with nonmetastatic nasopharyngeal carcinoma treated with definitive‐intent intensity‐modulated radiotherapy. The symptom‐to‐diagnosis interval extended from first symptom onset to pathological diagnosis. Logistic and Cox models assessed stage and survival; treating‐center analyses used a 2016–2022 common‐window cohort. Results Stages III–IVA disease occu …

27.08.2026journal-article

Research in Veterinary Science and Medicine

Effects of Room Temperature Storage Duration on the Quality of Cauda Epididymal Spermatozoa Recovered from Red Sokoto Bucks

Linda Ijeoma Okoro, Philip Makama Dawuda, Gbemi Olatunde Fanaiye, Hope Mhohe Agama, Mlumun Love Ayila

Objectives: The conservation of valuable genetic resources in livestock is essential for sustainable breeding programs, particularly when superior breeding males die unexpectedly before semen collection. This study evaluated the quality of cauda epididymal spermatozoa recovered from Red Sokoto Bucks immediately after slaughter and following storage of testes-epididymides at room temperature. Material and Methods: Forty pairs of testes-epididymides were collected from apparently healthy mature Red Sokoto Bucks and r …

27.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

The spiral evolution of techniques for the laboratory diagnosis of microbial infections

Yi-Wei Tang, Nahed Ismail, Rodolfo García-Contreras

The laboratory diagnosis of microbial infections has undergone a profound transformation over the past century, evolving from classical phenotypic methods to molecular genetic approaches and now toward ultra-sensitive molecular phenotyping. While this progression is often described as linear, a closer examination reveals a cyclical pattern: an initial reliance on observable biological function, followed by a shift toward genetic abstraction, and, more recently, a return to phenotypic measurement at unprecedented mo …

27.08.2026journal-article

Frontiers in Medicine

Focusing on persistent hypoxemia during VV-ECMO secondary to traumatic tricuspid valve injury: a case report

Yunpeng Zhao, Jing Liu, Kun Chen

Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving salvage therapy for treating severe respiratory failure. We present a case of trauma-related hypoxemia with severe tricuspid chordae tendinae rupture managed with VV-ECMO. Case presentation We report the successful use of VV-ECMO in a 29-year-old patient with severe acute respiratory distress syndrome (ARDS). Refractory hypoxemia persisted despite maximal conventional therapy during the course of treatment at the outside hospital. …

27.08.2026journal-article

Frontiers in Neuroinformatics

Interpretable AI for neural signal decoding in dementia: an EEG ensemble approach to differential diagnosis

Fawad Muhammad, Irfan Ahmed Usmani, Muhammad Aamir, Mai Alduailij, Mehrez Marzougui, Rab Nawaz

Introduction The differential diagnosis between Alzheimer’s disease (AD) and frontotemporal dementia (FTD) presents a significant clinical challenge due to overlapping early-stage symptom profiles. Conventional resting-state EEG provides limited sensitivity to the impaired neural plasticity and lateralized cortical degeneration frequently observed in FTD. Methods We developed a domain-informed heterogeneous ensemble framework incorporating dynamic neural reactivity and hemispheric asymmetry metrics from 19-channel …

27.08.2026journal-article

AIDS Research and Therapy

Long-term survival analysis of HIV patients receiving antiretroviral treatment in Congo: a 14-year retrospective analysis, 2003–2017

Gilbert Ndziessi, Ange Clauvel Niama, Arkadit Jeandria Nkodia, Merlin Diafouka

Abstract Background Long-term survival of people living with HIV (PLHIV) on antiretroviral therapy (ART) is poorly documented in the Republic of Congo. Methods We conducted a retrospective cohort study of 2,309 adults initiating ART between 2003 and 2017. Survival was estimated using the Kaplan-Meier method, and determinants were assessed using Cox regression. Results The median age of participants was 49 years (IQR 42–57), and women represented 68.6% of the cohort. The 14-year overall survival probability was 83% …

27.08.2026journal-article

Plastic & Reconstructive Surgery

“A Split-Muscle Support Technique for Direct-To-Implant Breast Reconstruction”

Michelle Park, Brittany M. Lala, Alexandra N. Townsend, Melissa Rony, Pedro S. Piccinini

Many patients who undergo direct-to-implant breast reconstruction with subpectoral implant placement experience animation deformity, where implants move up toward the axilla with contraction of the pectoralis muscle. The deformity affects quality of life and prompts patients to seek revisionary surgery. 1 Prepectoral implant placement has gained popularity over the past decade as an alternative. However, prepectoral placement may increase implant visibility and rippling, and provide inadequate coverage. Additionall …

27.08.2026journal-article

JAMA Ophthalmology

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Jing Zhong, Yu Liu, Tianli Peng, Jing Ma, Ziting Huang, Xiao Yang, Shi-Ming Li, Jin Yuan

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progression. Design, Setting, and Participants This randomized clinical trial was conducted among children aged 6 to 12 years with myopia enrolled in July 2024, with follow-up completed in September 2025. The trial was conducted at a single center …

27.08.2026journal-article

Frontiers in Surgery

3D accurate osteotomy for pediatric cubitus varus deformity using a custom-matched surgical osteotomy template combined with a reduction template via a limited lateral incision: a case report and literature review

Jiang-Long Guo, Xiao Zeng, Jian-Hao Guan, Hai-Yun Chen, Kui Zhao, Mei-Ren Zhang

Background Cubitus varus deformity is a common complication following supracondylar fractures of the humeri in children. Due to the limited capacity of the distal humeral epiphysis to spontaneously correct existing varus deformity, the deformity typically persists into adulthood without improvement. Accurate correction of this deformity is essential to prevent late complications and significantly improve cosmetic appearance. However, achieving precise correction through a limited incision remains technically emandi …

27.08.2026journal-article

Journal of Clinical Medicine

Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea: Clinical Applications, Classification Systems, and Anesthetic Considerations

Patryk Oskar Manycz, Monika Morawska-Kochman, Jakub Zieliński

Background/Objectives: Drug-induced sleep endoscopy (DISE) enables dynamic, real-time visualization of the level, severity, and configuration of upper airway collapse during pharmacologically induced sleep, providing anatomical information that polysomnography cannot. It is increasingly used to guide individualized surgical planning in obstructive sleep apnea (OSA), particularly in children with persistent OSA after adenotonsillectomy or at elevated risk of surgical failure. However, the absence of a universally ac …

27.08.2026journal-article

Bioengineering

Preliminary Clinical Outcomes of an Alternating-Current-Assisted Implant Surface Decontamination Protocol: A Prospective Case Series with 12-Month Follow-Up

Dorian Kostandini, Antonella Mattei, Giovanni Falisi, Arianna Viarchi, Davide Gerardi, Angelo Bruni, Edra Qorri, Lia A. Hoz-Rodriguez, Eduardo Basañes Rivera, Sofia Rastelli, Roberto Gatto, Marco Severino, Gianluca Botticelli

Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clinical trial, in which short-term clinical outcomes following use of a multimodal protocol to decontaminate the titanium implant surface were obtained; consequently, the independent contribution of the Ximplant® device to the observed outcomes …

27.08.2026journal-article

International Journal of Innovative Technologies in Social Science

ARTIFICIAL INTELLIGENCE IN MODERN MEDICINE: A COMPREHENSIVE REVIEW OF CURRENT APPLICATIONS, CHALLENGES, AND FUTURE PERSPECTIVES

Aleksandra Stańczyk, Kinga Haduch, Zuzanna Michalska, Anna Łęczycka, Nicole Aleksandra Ordyczyńska-Mardyła, Izabela Zuzanna Stranz, Olga Chorąży, Joanna Strzelczyk, Iga Suchta, Amelia Kędziora

Introduction: The digital transformation of healthcare is accelerating, driven by unprecedented advancements in Artificial Intelligence (AI). From large language models (LLMs) to biomolecular structure prediction, AI is redefining modern diagnostic and therapeutic standards. Aim: This review evaluates the current state of AI applications in medicine, focusing on clinical knowledge encoding, molecular drug discovery, and administrative workflow optimization, while critically addressing the technical, ethical, and sy …