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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (<4 weeks duration) underwent clinical, psychometric, and functional mag …

27.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Systematic evaluation of foundation models for organ-level classification on CT scans

Jan Tagscherer, Sarah de Boer, Fennie van der Graaf, Lena Philipp, Colin Jacobs, Ewoud J. Smit, Alessa Hering

Abstract Purpose Foundation models are increasingly used as frozen feature extractors for CT classification tasks, yet the determinants of their downstream performance remain unclear. We assess how foundation model choice, feature aggregation strategy, and abnormality type are associated with performance in organ-level abnormality classification. We further evaluate whether more expressive aggregation strategies outperform simple pooling, and whether performance varies by abnormality type. Methods We evaluate five …

27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

Clinical and Translational Medicine

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

Danyi Yang, Yinyin Chen, Hao Li, Guoyong Liu, Yang Gao, Liyu He

Abstract Background NOP2/Sun RNA methyltransferase family member 4 (NSUN4)‐mediated 5‐methylcytosine (m5C) modification has been implicated in diabetes‐related diseases. However, its role and molecular mechanism in diabetic nephropathy (DN) remain unclear. Methods DN mouse model was constructed by injecting with streptozotocin (STZ). High glucose (HG)‐induced HK‐2 cells were used to establish a cellular model of DN. The levels of NSUN4, SMAD ubiquitination regulatory factor 1 (SMURF1), calcium/calmodulin‐dependent …

27.08.2026journal-article

Journal of NeuroInterventional Surgery

Millipede Aspiration for Revascularization in Stroke (MARRS): prospective trial of a novel 0.088 inch corrugated catheter

Raul G Nogueira, Manuel Requena, Jaydevsinh Dolia, Syed Zaidi, Pedro Navia, Gaultier Marnat, Tarun Bhalla, Alhamza R Al-Bayati, Michael Nahhas, Osama O Zaidat, Ryan Priest, Romain Bourcier, Waldo R Guerrero, Reza Dashti, Gregory Gascou, Raoul Pop, Tareq Kass-Hout, Nitin Goyal, Amin Aghaebrahim, Adnan I Qureshi, Sameer A Ansari, Guilherme Dabus, Jose I Suarez, Levansri D Makalanda, Alberto Alvarez-Muelas, Xavier Barreau, Matthew T Bender, Mouhammad Jumaa, Eugene Lin, Guillaume Bellanger, Francesco Diana, Ryan Hebert, Sunil A Sheth, Richard Burgess, Diogo C Haussen, Charles Matouk, Christophe Cognard, Ameer E Hassan, Ricardo A Hanel, Benjamin Gory

Background The Millipede AspiRation for Revascularization in Stroke (MARRS) pivotal study was a prospective, multicenter, single arm trial evaluating the safety and efficacy of the corrugated Millipede catheter system in patients with acute ischemic stroke due to large vessel occlusion. Methods Patients aged 18–85 years with internal carotid artery, M1, M2, or basilar artery occlusions treatable within 8 hours were eligible. Catheter selection was based on target vessel diameter (Millipede88 >2.7 mm; Millipede70 >2 …

27.08.2026journal-article

Cancers

Trends in Treatment and Survival Among Patients with Glioblastoma in the United States from 2000 to 2020

Jianan Chen, Catherine M. Boldig, Qiong Wu, Hannah M. Cardenas, Kaitlyn N. Bernard, Kwadwo Darko, Patrick T. Grogan, Yu Sun, Robert J. Macaulay, Ekokobe Fonkem, Arnold B. Etame

Background: Population-level patterns in the real-world use of initial treatment combinations for glioblastoma (GBM) remain poorly characterized. Materials and Methods: We assessed temporal trends in treatment and survival among patients with GBM in the SEER registry. Guideline-concordant multimodal therapy was defined as cancer-directed surgery combined with radiotherapy and chemotherapy. Outcomes were further stratified by extent of resection, including gross total resection (GTR) versus subtotal resection. Resul …

27.08.2026journal-article

Head & Neck

Symptom‐to‐Diagnosis Interval, Treating‐Center Context, and Survival in Nasopharyngeal Carcinoma in Nonendemic Northern China: A Multicenter Real‐World Cohort Study

Qi An, Qingxin Wang, Yubing Qian, Minghan Qiu, Shenglin Zhang, Xinyu Zhao, Xiaoyan Chen, Rui Jian, Zhongjie Chen, Wei Wang, Peiguo Wang, Zhongqiu Wang

ABSTRACT Background In nonendemic northern China, symptom recognition prompts diagnostic evaluation for nasopharyngeal carcinoma. Methods We analyzed 1022 patients with nonmetastatic nasopharyngeal carcinoma treated with definitive‐intent intensity‐modulated radiotherapy. The symptom‐to‐diagnosis interval extended from first symptom onset to pathological diagnosis. Logistic and Cox models assessed stage and survival; treating‐center analyses used a 2016–2022 common‐window cohort. Results Stages III–IVA disease occu …

27.08.2026journal-article

Pigment International

The divergent management of melasma: a 2026 clinical review comparing traditional standards in lighter photo types to novel athermal and biological modalities in Fitzpatrick IV–VI

Dalitso Namutowe, Yun Xu, Jin Gong

Melasma (historically chloasma) remains a complex, recalcitrant pigmentary disorder affecting millions worldwide. This article elucidates the paradigm shift in management strategies observed in early 2026 for Fitzpatrick III-VI, its comparison with Fitzpatrick I–III, and the transition from aggressive mono-therapies to a multi-layered, synergistic approach. To locate, select, and extract relevant data, a comprehensive search of recent clinical protocols and emerging technological studies was conducted. This literat …

27.08.2026journal-article

International Journal of Molecular Sciences

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Andressa Oliveira Peixoto, Larissa Ferreira Selicani, Camila Bento Safi, Daniela Souza Paiva Borgli, Adyléia Aparecida Dalbo Contrera Toro, Nathália Mariana Santos Sansone, Andrea de Melo Alexandre Fraga, Fernando Augusto Lima Marson, José Dirceu Ribeiro

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This retrospective study aimed to clinically characterize individuals with cystic fibrosis who developed HHMA, characterize their CFTR genetic profile and compare it with that of other individuals with cystic fibrosis followed at a Brazilian te …

27.08.2026journal-article

European Journal of Therapeutics

Associations of the February 2023 Earthquakes with Semen and Serum Parameters in Men Undergoing Infertility Evaluation, Stratified by Psychiatric Diagnosis: a Retrospective Cross-Sectional Study

Emrah Zayman, Feyza İnceoğlu, Muhammet Serdar Buğday, Kübra Orman

Objective: To compare semen and serum parameters between the pre- and post-earthquake periods among men undergoing infertility evaluation and to examine whether the observed patterns differed according to recorded psychiatric diagnosis. Methods: This retrospective comparative cross-sectional study used hospital records from before (January 1, 2021-February 5, 2023) and after (February 6, 2023-December 31, 2024) the February 6, 2023 earthquakes, which affected 11 provinces in Türkiye. Participants were selected by s …

27.08.2026journal-article

Research in Veterinary Science and Medicine

Effects of Room Temperature Storage Duration on the Quality of Cauda Epididymal Spermatozoa Recovered from Red Sokoto Bucks

Linda Ijeoma Okoro, Philip Makama Dawuda, Gbemi Olatunde Fanaiye, Hope Mhohe Agama, Mlumun Love Ayila

Objectives: The conservation of valuable genetic resources in livestock is essential for sustainable breeding programs, particularly when superior breeding males die unexpectedly before semen collection. This study evaluated the quality of cauda epididymal spermatozoa recovered from Red Sokoto Bucks immediately after slaughter and following storage of testes-epididymides at room temperature. Material and Methods: Forty pairs of testes-epididymides were collected from apparently healthy mature Red Sokoto Bucks and r …

27.08.2026journal-article

Plastic & Reconstructive Surgery

“A Split-Muscle Support Technique for Direct-To-Implant Breast Reconstruction”

Michelle Park, Brittany M. Lala, Alexandra N. Townsend, Melissa Rony, Pedro S. Piccinini

Many patients who undergo direct-to-implant breast reconstruction with subpectoral implant placement experience animation deformity, where implants move up toward the axilla with contraction of the pectoralis muscle. The deformity affects quality of life and prompts patients to seek revisionary surgery. 1 Prepectoral implant placement has gained popularity over the past decade as an alternative. However, prepectoral placement may increase implant visibility and rippling, and provide inadequate coverage. Additionall …

27.08.2026journal-article

Frontiers in Surgery

3D accurate osteotomy for pediatric cubitus varus deformity using a custom-matched surgical osteotomy template combined with a reduction template via a limited lateral incision: a case report and literature review

Jiang-Long Guo, Xiao Zeng, Jian-Hao Guan, Hai-Yun Chen, Kui Zhao, Mei-Ren Zhang

Background Cubitus varus deformity is a common complication following supracondylar fractures of the humeri in children. Due to the limited capacity of the distal humeral epiphysis to spontaneously correct existing varus deformity, the deformity typically persists into adulthood without improvement. Accurate correction of this deformity is essential to prevent late complications and significantly improve cosmetic appearance. However, achieving precise correction through a limited incision remains technically emandi …

27.08.2026journal-article

JAMA Ophthalmology

Digital Defocus Vision Training Using Virtual Reality for Myopia Control

Jing Zhong, Yu Liu, Tianli Peng, Jing Ma, Ziting Huang, Xiao Yang, Shi-Ming Li, Jin Yuan

Importance Virtual reality–based digital defocus vision training (DDVT) may offer a home-based strategy to slow myopia progression in children, but evidence is limited. Objective To evaluate efficacy and safety of a head-mounted virtual reality–based DDVT system on myopia progression. Design, Setting, and Participants This randomized clinical trial was conducted among children aged 6 to 12 years with myopia enrolled in July 2024, with follow-up completed in September 2025. The trial was conducted at a single center …

27.08.2026journal-article

Journal of Clinical Medicine

Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea: Clinical Applications, Classification Systems, and Anesthetic Considerations

Patryk Oskar Manycz, Monika Morawska-Kochman, Jakub Zieliński

Background/Objectives: Drug-induced sleep endoscopy (DISE) enables dynamic, real-time visualization of the level, severity, and configuration of upper airway collapse during pharmacologically induced sleep, providing anatomical information that polysomnography cannot. It is increasingly used to guide individualized surgical planning in obstructive sleep apnea (OSA), particularly in children with persistent OSA after adenotonsillectomy or at elevated risk of surgical failure. However, the absence of a universally ac …

27.08.2026journal-article

Bioengineering

Preliminary Clinical Outcomes of an Alternating-Current-Assisted Implant Surface Decontamination Protocol: A Prospective Case Series with 12-Month Follow-Up

Dorian Kostandini, Antonella Mattei, Giovanni Falisi, Arianna Viarchi, Davide Gerardi, Angelo Bruni, Edra Qorri, Lia A. Hoz-Rodriguez, Eduardo Basañes Rivera, Sofia Rastelli, Roberto Gatto, Marco Severino, Gianluca Botticelli

Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clinical trial, in which short-term clinical outcomes following use of a multimodal protocol to decontaminate the titanium implant surface were obtained; consequently, the independent contribution of the Ximplant® device to the observed outcomes …

27.08.2026journal-article

Seminars in Respiratory and Critical Care Medicine

Use of Oxygen in the Emergency Department

Riccardo Guglielmi, Antonio Campanella, Jesús Villar, Carlos Ferrando

ABSTRACT Oxygen is one of the most frequently used treatments in the emergency department (ED), but it should be prescribed and reassessed as an active therapy rather than left as a harmless default. Acute hypoxemia may reflect ventilation-perfusion mismatch, shunt, hypoventilation, impaired oxygen transport, circulatory failure, or a combination of these mechanisms. For this reason, the response to oxygen, the choice of device, and the need for escalation depend less on the SpO2 value alone than on the physiology …

27.08.2026journal-article

Scientific and Technical Journal of Information Technologies, Mechanics and Optics

Combined feature selection in machine learning for disease diagnosis in medicine

K. S. Dyomin, I. V. Germashev

Often, the initial data sets for machine learning contain an excessive number of features, among which there may be highly informative and insignificant, correlating or even noise variables. Solving the feature selection problem not only optimizes machine learning processes, but also opens up new opportunities for implementing machine learning in practice-oriented areas that require high accuracy and trust in algorithms. This phenomenon leads to a number of critical problems: distorted training of the model based o …

27.08.2026journal-article

International Journal of Clinical and Experimental Medical Sciences

Biofilm Formation and Detection of the icaA Gene in Staphylococcus Aureus Isolates from Ocular Infections

Karar Abdulkhuder, Mahmood Awad

Background: Staphylococcus aureus is a major opportunistic pathogen implicated in various infections, including ocular infections. One of its key virulence factors is the ability to form biofilms, which are structured bacterial communities embedded in a self-produced extracellular matrix. Biofilm formation enhances bacterial survival under adverse conditions, including antibiotic exposure and host immune defenses, thereby contributing to chronic and recurrent infections. Aim: This study aimed to evaluate the biofil …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Prevalence of Parosmia Among Coronavirus Disease 2019 Patients in a Tertiary Center: A Retrospective Cross Sectional Study

Amani Algouhi, Maha A. Aljrayed, Sara F. Alhuwairini, Ghadi A. Almohaisen, Shmokh M. Alsalamah, Riyadh Alhedaithy

Abstract Background: After the COVID pandemic, many people experience a long-term symptom of olfactory dysfunction. Most of the affected cases recovered within weeks to a few months, while minority had persistent parosmia. This study aims to investigate the prevalence and factors associated with parosmia in patients who were diagnosed with COVID-19. Methods: A retrospective cross-sectional study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. Adult COVID-19 patients diagnosed between January 2 …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Value of serum procalcitonin levels and intraabdominal pressure in prognosis of severe acute pancreatitis course

Efstathios T Pavlidis, Christina Mouratidou, Alexandra G Marneri, Kalliopi E Stavrati, Theodoros E Pavlidis

Severe acute pancreatitis is associated with significant morbidity and mortality, primarily due to infected pancreatic necrosis, systemic inflammatory response syndrome, and multiple organ dysfunction, which can result in poor clinical outcomes. The identification of early prognostic biomarkers is essential for facilitating prompt and effective multidisciplinary intervention. Serum procalcitonin, which is recognized as a biomarker indicative of bacterial infection and systemic inflammation, and intra-abdominal pres …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Cutting seton as salvage strategy for complex or recurrent anal fistula: Single-tertiary center 10-year experience with 207 patients

Mohammed A Widinly, Mahmood H Aljohani, Abdullah Alrebdi, Mohammed Basem Beyari, Saleh Husam Aldeligan, Aisha M Abdulrahman, Abdullah Alkassim, Hadi Almohsen, Rasha Eidah Althebaity, Eman Almotairi, Reem A Alharbi, Asim M Almughamsi, Nasser Alsanea

BACKGROUND An ideal treatment for complex anal fistula that achieves a high success rate, low recurrence, and minimal risk of fecal incontinence has yet to be established. The cutting seton technique remains one surgical option for managing complex anal fistula. However, concerns persist regarding postoperative pain, recurrence, and sphincter-related complications. AIM To evaluate cure rate and clinical outcomes of cutting seton in the treatment of complex or recurrent anal fistula. METHODS A retrospective chart re …

27.08.2026journal-article

Clinical Kidney Journal

Managing hyponatremia: fast or slow? why, when, how, and controversies

Kamel S Kamel, Ziv Harel, Martin Schreiber

Abstract Hyponatremia is the most common electrolyte disorder encountered in clinical practice. Its management is challenging because treatment must balance the risk of cerebral edema in acute hyponatremia against the risk of osmotic demyelination syndrome (ODS) from overly rapid correction of chronic hyponatremia. Recent observational studies have questioned current correction limits, prompting renewed debate regarding optimal management. This narrative review presents a physiology-based approach to the evaluation …