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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

ENHANCING RADIOTHERAPY SAFETY IN HEAD AND NECK CANCER TREATMENT: A HYBRID DOUBLE-LAYERED ORTHODONTIC MOUTH GUARD

YOJANA SHARMA, AYUSH AWASTHI, MOHIT PANT, PARNIKA SHRIVASTAVA

Radiotherapy is a widely used method in the treatment of head-and-neck cancers; however, irradiation of surrounding oral structures often results in clinical complications such as dental caries, oral mucositis, osteoradionecrosis, dysphagia, dysgeusia, xerostomia and trismus. To address such issues, a patient-specific hybrid double-layer orthodontic mouthguard has been proposed to simultaneously enhance the radiation shielding and biomechanical comfort in treatments. The customized device integrates radiation-shiel …

28.08.2026journal-article

Clinical Cancer Research

Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

Jennifer Y. Sheng, Marianna L. Zahurak, Faith Too, Amanda Montanari, Jennifer Trost, Mengyang Lu, Young Lee, Sheetal Parida, Amanda L. Blackford, Dipali Sharma, Marci Laudenslager, Claire Snyder, Janelle W. Coughlin, Vered Stearns

Abstract Purpose: Behavioral weight loss (BWL) interventions consisting of remote coaching and self-monitoring have limited effectiveness in breast cancer survivors. We conducted a single-arm phase II study evaluating the addition of Contrave for <5% weight loss (%WL) after 2 months of BWL. Patients and Methods: Women with prior stage 0 to III breast cancer and a body mass index ≥27 kg/m2 were eligible and initiated BWL. We collected weight, patient-reported outcomes, and labs at baseline, 2 months, and 6 months …

28.08.2026journal-article

Veterinary Medicine and Science

Medicinal Plants in Poultry During Post‐Antibiotic Era in One‐Health Approach: An Extensive Review

Alireza Talebi, Arman Savari

ABSTRACT Background Increasing drug resistance, together with possible transmission of these phenomena to other pathogenic agents, as well as the dissemination of resistant microbes and drug residues to the environment, poses existing challenges for human health. The journey in history of medicine indicates that the post‐antibiotic era has been initiated and the application of medicinal plants is a promising alternative to antibiotics. Objectives The aim of this review was to have a glance at available medicinal pl …

28.08.2026journal-article

Behavioral Interventions

A Survey of Clinical Practices for Prompt Dependency

Kimberly R. Ford, Catia Cividini‐Motta

ABSTRACT Prompt‐dependent behavior, more colloquially known as “prompt dependency,” has been minimally studied in the literature. However, it remains a problem in clinical practice. This survey study was conducted to gain insight into clinical practices related to prompt‐dependent behavior, including the assessments and interventions clinicians currently employ. Participants were individuals who, within the last year, provided services to at least one individual with autism who displayed prompt‐dependent behavior a …

28.08.2026journal-article

Spartan Medical Research Journal

Device and Patient-Related Complications of Renal Denervation for Uncontrolled Hypertension: A Post-Marketing Analysis of the FDA MAUDE Database

Sai Tharun Reddy Gopannagari, Kesava Manikanta Achuta, Divya Ganisetti, Shravya Pingili, Towfiqul Chowdhury, Chadi Saad

Introduction Renal denervation (RDN) has re-emerged as an adjunctive therapy for uncontrolled hypertension following recent U.S. Food and Drug Administration (FDA) approvals of ultrasound- and radiofrequency-based systems. Although randomized trials report a favorable safety profile, post-marketing data may reveal additional safety signals in real-world settings. Methods We performed a retrospective descriptive observational study of reports in the FDA Manufacturer and User Facility Device Experience (MAUDE) databa …

28.08.2026journal-article

Healthcare

Within-Person Longitudinal Associations Between Obesity-Related Eating Behaviors and Physical Activity Among Older Adults: A Three-Wave Random-Intercept Cross-Lagged Study

Shi Luo, Bin Chen, Xianxiong Li, Joston Gary

Objectives: This study examined the within-person longitudinal associations between obesity-related eating behaviors and physical activity among community-dwelling Chinese older adults. Methods: Three waves of data were collected at three-month intervals from 1256 adults aged 65 years or older across 17 urban and rural communities. Physical activity was measured using the Physical Activity Rating Scale-3, and obesity-related eating behaviors were assessed using the seven-item Sakata Eating Behavior Scale Short Form …

28.08.2026journal-article

Recent Patents on Nanotechnology

Chitosan-functionalized PLGA Nanoparticles: Exploring Recent Patents, Advanced Strategies for Controlled and Targeted Anticancer Therapy

Madhusudan Maity, Niranjan Panda, Subas Chandra Dinda, Bikash Ranjan Jena, Parameswar Patra, Chinmaya Keshari Sahoo

Introduction: Recent advances in the field of nanotechnology have accelerated the development of polymeric nanocarriers for cancer therapy, enabling high precision and improved therapeutic efficiency. Among these, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have gained significant attention, as PLGA is a U.S. FDA-approved polymer for various biomedical applications. Methods: PLGA has several important properties, including biodegradability, biocompatibility, sustained drug-release properties, and minim …

28.08.2026journal-article

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale

18 | Active breaks for health promotion in the classroom: the experience of I.C. “Abba Alighieri”

A. Li Puma, A. Di Benedetto, E. Modica, G. Ripoli, D. Lipari, B. Ferrante, F. Di Marco, A. Firenze

Background. Physical activity represents one of the main determinants of health and contributes significantly to the psychophysical well-being of the individual. Data from the "OKKIO alla Salute" surveillance system highlight a high prevalence of excess weight among Sicilian children, which is also associated with the prolonged use of smartphones and devices. Active breaks are an educational strategy designed to reduce sedentary behavior and promote psychophysical and relational well-being, thereby improving health …

28.08.2026journal-article

Frontiers in Pharmacology

Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization

Yuan Zhang, Tingting Li, Jie Chen, Huanhuan Ba, Jiajia Li, Jinling Yin, Kangxiao Ma, Huanqing Liu, Juan Jin

Background Human immunodeficiency virus (HIV) infection remains a global health challenge, necessitating personalized treatment strategies to optimize patient outcomes. Digital twin technology—synchronized with real-world entities—offers a pathway to precision medicine in HIV care. Methods We analyzed 5,436 HIV patients (2016–2024) with demographic, immunologic, and antiretroviral therapy (ART) information. Core algorithms comprised gradient boosting and random forest ensembles; deep architectures (LSTM and Transfo …

28.08.2026journal-article

Frontiers in Veterinary Science

Embedding laboratory animal welfare- and ethics-related techniques into a comparative medicine laboratory course: an educational reform study

Jian Zhang, Lingyan Zhang, Xingtao Zhang, Gang Yao

Background Animal welfare and ethics education is essential for laboratory animal science training, but students often struggle to translate ethical principles into practical experimental procedures. This study explored an embedded teaching approach that integrated animal welfare- and ethics-related techniques into a comparative medicine laboratory course using the bilateral ovariectomy (OVX) mouse model as an authentic teaching scenario. Methods A pre–post educational intervention design was adopted. Students firs …

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

Clinical and Translational Discovery

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Emmanuel Ifeanyi Obeagu, Yaregal Asres

Abstract Background Estrogen receptor‐positive (ER+) breast cancer represents the most common molecular subtype of breast cancer and remains highly responsive to endocrine therapy. However, therapeutic efficacy is frequently compromised by acquired or intrinsic endocrine resistance, particularly through ESR1 mutations, altered receptor conformation, co‐regulatory mechanisms, and activation of compensatory signaling pathways such as PI3K/AKT/mTOR. Conventional drug‐discovery approaches are often slow, resource‐inten …

28.08.2026journal-article

American Journal of Physical Education and Health Science

Effect of Maitland Mobilization Combined with Kendall Corrective Exercise on Pain and Postural Alignment of Patients with Upper Cross Syndrome: Pilot Study

Naeem Ullah, Fatima Amjad, Qamar Jan, Wagma Wajid, Aamir Niaz, Komal Hameed

Upper Cross Syndrome (UCS) is a prevalent postural dysfunction resulting from muscle imbalances that causes forward head posture, rounded shoulders and thoracic kyphosis. Although manual therapy and corrective exercises are frequently performed, studies comparing the two have not been conducted extensively.To determine the feasibility and effectiveness of Maitland mobilizations alongside Kendall exercises in patients with UCS.A pilot single-blinded randomized controlled trial was performed involving 28 subjects (14 …

28.08.2026journal-article

Research Involvement and Engagement

Building meaningful partnerships: engaging and co-developing a patient advisory council to inform the implementation of person-centred quality indicators in Alberta primary care

Matthew Luzentales-Simpson, Ingrid Nielssen, Fakhriyya Aghabayli, Sadia Ahmed, Kalpana Thapa Bajgain, Ifrah Anjum, Veronika Kiryanova, Safa Ahmed, Kim Giroux, D’Arcy Duquette, Eleanor Benterud, Paul Fairie, Maria J. Santana

Abstract Background Effective primary care improves patient outcomes by providing comprehensive, continuous, and person-centred care. The Patient’s Medical Home vision positions primary care as the central entry point to high-quality health care in Canada. In Alberta, Person-centred Care Quality Indicators (PC-QIs) were developed with patients and health system stakeholders, are being implemented across the province to assess and report patient experiences in primary care. To ensure that patients are central to thi …

28.08.2026journal-article

Palliative Medicine

Palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia: A mixed methods systematic review

Jingjing Li, Ping Guo, Hao Liu, Nikolaos Efstathiou

Background: The high prevalence of heart failure in Asia highlights the growing need for palliative care. However, access to palliative care remains limited. Understanding the palliative care needs and experiences of patients with heart failure and families is essential to inform policy and service development in diverse Asian contexts. Aims: To identify, appraise and synthesise recent evidence on palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia. Design: Mi …

28.08.2026journal-article

JAMA

Cardiovascular Magnetic Resonance to Guide Defibrillator Implantation for LVEF of 36% to 50%

Joseph B. Selvanayagam, John G. F. Cleland, Graham S. Hillis, Sivabaskari Pasupathy, Laurent Billot, Katherine E. George, John J. Atherton, Colin Berry, Ivaylo Tonchev, Chris Gianacas, Werner Jung, Sanjay K. Prasad, Carmine G. De Pasquale, Johannes Brachmann, Anand Ganesan, Cardiovascular Magnetic Resonance–Guided Management of Mild to Moderate Left Ventricular Systolic Dysfunction Trial Investigators, Rajiv Ananthakrishna, Margaret Arstall, Niall Campbell, Derek T Connelly, David Ferreira, Daniel Garofalo, Jemima Gore, Suchi Grover, John Hill, Nicola Johnston, Alamgir Kabir, David Kaye, Sau Lee, Tina Lin, Scott Lorensini, Jakob Lüker, Paul D MacIntyre, Christian Mahnkopf, Andrew Martin, Gerry P McCann, Ashley Nisbet, Gaetano Nucifora, Bhupesh Pathik, Andreas Pflaumer

Importance Current guidelines do not recommend primary prevention implantable cardioverter-defibrillators (ICDs) unless a patient’s left ventricular ejection fraction (LVEF) is 35% or less. Many sudden cardiac deaths (SCD) occur when LVEF is 36% to 50%. Myocardial scar (a key arrhythmic substrate) can be assessed by late gadolinium enhancement on cardiovascular magnetic resonance (CMR), but robust evidence is lacking regarding a scar-based approach to ICD insertion. Objective To determine whether implantation of IC …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Personalization of therapy for infections caused by N. gonorrhoeae, C. trachomatis, M. genitalium and T. vaginalis. Part II. Evaluation of the clinical effectiveness of personalized therapy

E.S. Negasheva, N.V. Frigo, A.E. Guschin, A.Yu. Khachaturyan, I.R. Baskakova, O.V. Zhukova

Background. Currently used antimicrobial agents, their doses, and treatment durations are clearly defined by standards and clinical guidelines. Nevertheless, treating patients with sexually transmitted infections presents significant challenges despite the availability of highly effective drugs. In this connection, the transition to personalized treatment is relevant, which is consistent with the provisions of the Strategy for Research and Technological Development of the Russian Federation adopted in 2024. Objecti …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Drug-induced sarcoid-like reaction during BRAF/MEK inhibitor therapy for metastatic melanoma

A.N. Khlebnikova, V.E. Shikina, A.V. Semenkov, A.I. Zotov, G.R. Setdikova

In recent years, targeted therapy with BRAF/MEK inhibitors has been successfully used for treating metastatic melanoma. Although generally well tolerated, it may lead to the development of both systemic and cutaneous side effects. The most frequently reported adverse events include nausea, vomiting, diarrhea, pyrexia, chills, and hypertension. Cutaneous side effects manifest as alopecia, acneiform rash, maculopapular rash, dry skin, and photosensitivity reactions. Cases of squamous cell carcinoma and keratoacanthom …

28.08.2026journal-article

Global Spine Journal

Association of Postoperative Slip Reduction With Patient-Reported Outcomes at Two Years After Fusion Surgery for Low-Grade Degenerative Spondylolisthesis: A Single-Center Study

Tom Folkerts, Julia Wimmer, Lukas Schönnagel, Anna-Maria Mielke, Bruno Verna, Pedro Rocha Torres, Paul Köhli, Jiaqi Zhu, Jennifer Shue, Rolando Duculan, Andrew A. Sama, Federico P. Girardi, Frank P. Cammisa, Carol A. Mancuso, Marco D. Burkhard, Alexander P. Hughes

Study Design Retrospective cohort study of prospectively enrolled patients. Objectives To evaluate the association between postoperative slip reduction and improvement in disability and low back pain (LBP) after lumbar fusion for low-grade degenerative spondylolisthesis (DLS), and to determine whether outcomes are independently associated with slip reduction or with sagittal alignment changes. Methods 160 patients undergoing lumbar fusion for low-grade DLS were analyzed. Slip reduction was quantified on lateral rad …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

An Analysis of Graduate Theses Based on Watson’s Human Caring Model in Nursing

Cemal Özalp

Objectives: The aim of this review is to examine the postgraduate theses based on Watson's Human Care Model in the field of nursing in Türkiye.Materials and Methods: Within the scope of the review, theses registered in the National Thesis Centre were scanned with the keywords ‘Watson’ and ‘human care’ in Türkiye between 1-15 December 2024. The theses were analyzed in terms of application group, sample, method, research type and results.Results: It was determined that 28 theses in the field of nursing in Türkiye inc …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

University Students' Experiences During COVID-19: Insights from Online/Distance Education

Rabia Kıvanç, Çiğdem Aytekin

Objectives: The COVID-19 pandemic caused unprecedented disruptions in higher education, compelling a rapid transition to distance learning and altering students’ academic and psychosocial functioning. This study aimed to examine perceived stress levels among university students enrolled in Child Development departments and to identify the educational deprivations they experienced during pandemic-related remote instruction. Materials and Methods: A convergent mixed-methods design was employed. Data were collected fr …

28.08.2026journal-article

Revista chilena de nutrición

Vitamin D fortification of dairy products: strategies, technologies, and health impacts

Macarena Ortiz, Andrés Bustamante, Francisco Perez-Bravo, Rodrigo Valenzuela, Catalina Espejo, Lissette Duarte

Vitamin D deficiency is a widespread global health concern driven by limited dietary sources, reduced sun exposure, and lifestyle changes. This narrative review synthesizes current evidence on the rationale, technologies, efficacy, and public health implications of vitamin D fortification of dairy products. A literature search was conducted in PubMed, Web of Science, and Scopus for English-language studies, including original research, randomized controlled trials, systematic reviews, meta-analyses, and relevant re …

28.08.2026journal-article

Pharmaceuticals

Precision Pharmacotherapy for Obstructive Sleep Apnea: Matching Targeted Drugs to Patient Endophenotypes

Jayoung Oh, Ji Ho Choi

Background: Obstructive sleep apnea (OSA) remains under-treated because continuous positive airway pressure, though efficacious, is frequently limited by poor tolerance and adherence. Long considered a purely anatomical disease refractory to drugs, OSA is now understood as the shared endpoint of four measurable endotypes—a collapsible upper airway, poor pharyngeal dilator-muscle responsiveness, high loop gain, and a low arousal threshold—each a distinct pharmacological target. This review synthesizes the mechanisti …

28.08.2026journal-article

Medicine

Association of serum, follicular fluid, and embryo culture media homocysteine levels with embryo quality and pregnancy rates in assisted reproductive techniques

Xuxin Zhan, Xiaoting Wang, Jinxia Xie, Jing Zhao, Hongli Zhu

Homocysteine (Hcy) is involved in reproductive metabolism, but the associations of Hcy levels in different reproductive microenvironments with embryo development and pregnancy outcomes remain unclear. This study investigated these associations in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). This prospective study included 66 women undergoing IVF/ICSI treatment. Serum and follicular fluid (FF) samples were collected on the day of oocyte pick-up, and Hcy concentrations were mea …