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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Journal of Agricultural and Food Chemistry

Identification of Key Aging-Related Aroma Compounds in Sesame-Flavor Baijiu via Chemometrics and Molecular Docking: Insights into Flavor Formation Mechanisms

Xiaotong Lyu, Keen Wang, Meiyi Zhou, Yuchen Dong, Rebecca C. Deed, Liangcai Lin, Guoming Wang, Yanke Li, Changcheng Ren, Yan Zhu, Chunhui Wei, Cuiying Zhang

Abstract On the basis of 12 sesame-flavor Baijiu spanning multiple vintages, this study systematically revealed aging patterns through chemometrics, sensory, physicochemical, and molecular docking analyses. Sensory profiling showed that aging enhanced sesame and aged aromas while weakening fruity and alcoholic notes. Physically, prolonged aging increased the particle size, regularized the morphology, and intensified yellowing. Gas chromatography–olfactometry–mass spectrometry and omission tests confirmed 21 key aro …

19.08.2026journal-article

Healthcare

Ignoring the Older Person’s Voice: Dignity, Ageism, and Epistemic Injustice in Geriatric Nursing Practice—A Nursing-Oriented Conceptual Review and Practice Framework

Georgios Manomenidis, Charikleia Orfanidou, Christos Kleisiaris, Savvato Karavasileiadou, Panagiota Kazakou, Areti Nikiforou, Vasiliki Georgousopoulou

Background/Objectives: Older adults may experience healthcare encounters in which their voices are discounted, redirected through family members, or interpreted through age-related assumptions about cognitive decline. Although such problems are often discussed through dignity, communication, ageism, person-centred care, or shared decision-making, this conceptual review argues that they also involve epistemic harms: harms that occur when older adults are not recognized as credible knowers of their own bodies, needs, …

19.08.2026journal-article

Frontiers in Public Health

Prevalence and associated factors of tuberculosis/HIV coinfection among people living with HIV in Almaty, Kazakhstan: a cross-sectional study

Alfiya Y. Denebayeva, Elizabeth J. King, Zhamilya S. Nugmanova, Ulyana A. Gubareva, Marat S. Tukeyev, Anarkhan K. Nurkerimova, Aigerim B. Alimbekova, Elena Y. Ushanskaya, Roberta Z. Horth, Alexander J. Millman, Dilyara A. Nabirova

Introduction Tuberculosis (TB) is the leading cause of death among people living with HIV (PLHIV). Kazakhstan faces a growing number of new HIV diagnoses alongside a high incidence of multidrug-resistant TB. This study aimed to determine the prevalence and risk factors for TB among PLHIV in Almaty, Kazakhstan. Methods We conducted a cross-sectional study of adult PLHIV receiving care at the Almaty AIDS City Center by 2022. Participants were randomly selected from the HIV registry. TB/HIV coinfection was defined as …

19.08.2026journal-article

Frontiers in Immunology

Anti-inflammatory diet, physical activity, and risk of all-cause mortality in older adults: a prospective cohort study

Minghui Sun, Tian Li, Ling Cong, Xinyan Ma, Mengdi Hou, Hao Ai, Zhiyun Wu, Chao Huang

Background Anti-inflammatory dietary patterns are associated with a lower risk of several chronic diseases, but their association with all-cause mortality in Chinese older adults is unknown. In this first study of a Chinese population, we investigated this association and its joint effects with physical activity, to inform strategies for healthy longevity. Methods This analysis included 6,468 participants aged ≥65 years from the Chinese Longitudinal Healthy Longevity Survey. Anti-inflammatory diet was assessed usin …

19.08.2026journal-article

Experimental & Molecular Medicine

Hematopoietic stem cell aging: a review of transcriptional and multi-omics insights and potential paths for AI integration

Bongsoo Park, Hagai Yanai, Jun Ding, Isabel Beerman

Abstract Hematopoietic stem cell (HSC) aging underlies age-related immune decline, anemia and increased risk of hematologic malignancies, including clonal hematopoiesis and leukemia. Many available microarray and bulk RNA sequencing studies have elucidated conserved transcriptional hallmarks, such as myeloid bias, inflammation dysregulation, and self-renewal reinforcement in aged HSCs across mouse and human models. Here, we review key publicly available transcriptome and epigenome datasets from landmark studies, hi …

19.08.2026journal-article

Frontiers in Pharmacology

Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review

Sisi Yin, Huilan Zheng, Qingjing Yang, Xingyu Chen, Qianqian Yang, Qifeng Yang, Hongbin Cheng, Jingping Wu

Skin aging involves complex endogenous and extrinsic mechanisms, driving oxidative stress, cellular senescence, DNA damage, and extracellular matrix degradation. This narrative review synthesizes preclinical evidence on traditional Chinese medicine (TCM)-derived botanical drugs and formulae targeting these pathways. We identified 19 single-botanical drug and 17 formula studies. The most consistently reported effects include Nrf2/ARE activation, reduced reactive oxygen species (ROS) and malondialdehyde (MDA), increa …

19.08.2026journal-article

Frontiers in Medicine

Comparative efficacy of non-pharmacological interventions on fatigue in people undergoing hemodialysis: a systematic review and network meta-analysis

Juncai Li, Zhe Meng, Jing Yang, Longjie Wei, Qirui Zhang, Yijia Lin, Bonolo William, Xiuling Zhou

Background Fatigue is a prevalent and debilitating symptom among people undergoing maintenance hemodialysis (MHD). Pharmacological options for fatigue are limited, and treatment may be complicated by altered pharmacokinetics, polypharmacy, and adverse effects. Non-pharmacological interventions have therefore received increasing attention, but their comparative efficacy remains uncertain. This study aimed to compare and rank their efficacy for fatigue relief in people undergoing MHD. Methods PubMed, Embase, the Coch …

19.08.2026journal-article

Humanity & Society

The Rights of Indigenous Deaf People to Language, Education, and Culture in the United States

Britnee Nguyen, Melanie McKay-Cody

Individuals who are Indigenous and Deaf have a unique experience walking in multiple cultural and linguistic worlds. This requires a formal recognition of their rights that support their way of being, doing, and knowing. Indigenous Deaf people have rights to language acquisition, Indigenous cultural engagement, educational attainment, and community involvement. Communication is the essential foundation for the lives of Indigenous Deaf people, as it is necessary for realizing all of their rights. This includes the r …

19.08.2026journal-article

Frontiers in Aging Neuroscience

Cell-type-dependent decline of IGF1 and IGF1R in the prefrontal cortex contributes to age-related behavioral changes

Shuwen Yue, Christian Young, Arushi Garg, Tyler Sarovich, Lu Chen, Kendall Dickerson, Zi-Jun Wang

Insulin-like growth factor 1 (IGF1) signaling plays a critical role in brain function and declines significantly with aging. However, how these changes occur across different brain regions and cell types, and how they contribute to behavioral dysfunction, remains poorly understood. The prefrontal cortex (PFC), a key regulator of cognitive, emotional, and social behaviors, is particularly vulnerable to age-related changes. Here, we investigated age-associated changes in IGF1 and its receptor (IGF1R) in major neurona …

19.08.2026journal-article

Frontiers in Education

Older visitors’ acceptance of augmented-reality heritage interpretation: an extended technology acceptance model for informal cultural heritage learning

Xuejia Zhu, Suebsiri Saelee, Quan Wen

Augmented-reality (AR) interpretation is increasingly used to explain heritage buildings, yet its educational value depends on more than interface acceptance. This Hypothesis and Theory article proposes an extended technology acceptance model (TAM) for studying older visitors’ acceptance of AR heritage interpretation as an informal cultural heritage learning experience. The manuscript does not report a survey, experiment, interview, observation, usage log analysis, or any human participant dataset. Instead, it spec …

19.08.2026journal-article

International Journal For Multidisciplinary Research

The Influence of Artificial Aging on the Color Stability of Light Cure and Dual Cure Luting Cement

Ranveer Chauhan, Rajesh Kumar, Sunil MV, Manvendra Singh

Background: The long-term esthetic success of ceramic laminate veneer restorations largely depends on the color stability of the resin luting cement used for their cementation. Because ceramic veneers are thin and highly translucent, any discoloration of the underlying luting cement may become visible over time and compromise the final appearance of the restoration. Several factors, including the composition of the resin matrix, the type of polymerization, and water-related degradation, can influence the color stab …

19.08.2026journal-article

People and Nature

Spatio‐temporal patterns, associated factors and mitigation of tiger and leopard attacks on people in western Himalayas

Aman Deep Rathi, Keshab Gogoi, Rajiv Bhartari, Yadvendradev V. Jhala

Abstract Coexistence with large carnivores becomes extremely difficult in areas where there are large number of attacks on humans. An understanding of the factors that explain the spatio‐temporal context of such attacks would guide policy and management to mitigate conflict, conserve carnivores and assist coexistence. We use spatial locations of attacks by tigers ( n = 132) and leopards ( n = 1914) between 2000 and 2019 in the Himalayan state of Uttarakhand, India, to understand their seasonality, vulnerability of …

19.08.2026journal-article

Frontiers in Medicine

Comparative effectiveness of daytime versus nighttime paravertebral block analgesia on intraoperative hemodynamics in older lung cancer patients: a target trial emulation study

Qiang Wang, Lin Zhuo, Yue Zhang, Bowen Zhang, Kaibing Yang, Shijing Wei, Jingchao Yang, Xinwei Ma, Xiaolin Han, Hui Zheng, Yang Xu

Surgery remains the mainstay treatment for older patients with lung cancer, and paravertebral block (PVB) is recommended for perioperative analgesia. With the increasing surgical demand, a growing proportion of elective thoracic procedures in China are scheduled at night. Circadian variation, prolonged fasting, and resource limitations may affect intraoperative hemodynamics. However, the comparative hemodynamic safety of daytime versus nighttime PVB has not been systematically investigated. We emulated a target tri …

19.08.2026journal-article

Frontiers in Pharmacology

Multi-omics integration identifies a gut-microbiota-associated plasma metabolite signature for alzheimer disease diagnosis and metabolic pathway targeting

Jiao Chen, Xuhui Chen, Weiwei Yu, Ting Chen, Zhigang Liu, Jun Hu

Background Alzheimer’s disease (AD) is the leading cause of dementia, with early diagnosis remaining constrained by the invasiveness and limited accessibility of current biomarkers. The gut–brain axis has emerged as a critical communication network linking intestinal homeostasis with central nervous system function, yet the diagnostic utility of gut-microbiota-associated circulating metabolites in AD remains largely unexplored. Methods In this case-control study, 85 participants (37 AD patients and 48 cognitively n …

19.08.2026journal-article

Polymers

PEEK in Harsh Oil and Gas Environments: Applications and Chemical Aging Response

Wael Badeghaish, Ahmed Wagih, G. Lubineau

The oil and gas (O&G) industry is increasingly adopting non-metallic materials for pipelines and downhole components to mitigate corrosion, reduce maintenance costs, and improve performance in harsh service environments. Among high-performance polymers, polyether-ether-ketone (PEEK) has attracted significant attention owing to its excellent mechanical properties, thermal stability, and chemical resistance, making it a promising candidate for aggressive downhole applications. However, exposure to acids, hydrocarbons …

19.08.2026journal-article

Bioscience, Biotechnology, and Biochemistry

Azelaic Acid delays aging and prolongs lifespan via resisting oxidation stress mediated by IIS pathway coupling hsf-1 in C. elegans

Yang Chen, Liangliang Wang, Zixian Zhu, Beibei Pan, Juan Bai

Abstract Azelaic acid (AzA), an antioxidant and anti-inflammatory compound from cereals used in food preservatives and cosmetics, was investigated for anti-aging effects in Caenorhabditis elegans. AzA improved locomotive activities and muscle morphology during aging, extended lifespan under both normal and oxidative stress conditions, and reduced paralysis in neurodegenerative models. It decreased reactive oxygen species levels and enhanced superoxide dismutase (SOD) activity and SOD-3 protein expression. Quantitat …

19.08.2026journal-article

International Journal of Medical Science and Clinical Research Studies

Thirty-Day Functional Ambulation After Hip Fracture Surgery in Older Adults: A Single-Centre Retrospective Cohort Study

Michele Bisaccia, Francesco Bronzini, Marco Siragusano, Giuseppe Rinonapoli

Background: Regaining walking ability is a central patient-relevant outcome after hip fracture, but early recovery estimates are difficult to interpret when death and missing functional assessments are not reported separately. Objective: To describe 30-day functional ambulation, survival, and completeness of follow-up in older adults treated surgically for hip fracture at a single trauma centre. Methods: This retrospective cohort included 96 patients aged 65 years or older who underwent surgery for an intracapsular …

19.08.2026journal-article

JMIR Aging

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial

John Grosser, Sophie Pauge, Birthe Aufenberg, Wolfgang Greiner, Miriam Hertwig, Jenny Unterkofler, David Brücken, Christian Hübel, Optimal@NRW Research Group, Jörg Christian Brokmann

Abstract Background The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we d …

19.08.2026journal-article

AIDS

LDL-C target achievement in people living with HIV: impact of combination lipid-lowering therapy. A retrospective cohort analysis

Marcella Manicardi, Jovana Milic, Giuseppe Esposito, Marianna Menozzi, Giuseppe Mancini, Gian Luca Cuomo, Lorenzo Benassi, Elisabetta Delmonte, Severino Ambrosio, Cristina Mussini, Giuseppe Boriani, Giovanni Guaraldi

Background: Real-world low-density lipoprotein cholesterol (LDL-C) target attainment remains low in people with HIV (PWH). Updated ESC/EAS 2025 guidelines underscore the need to reassess treatment patterns in clinical practice. Methods: Retrospective observational longitudinal study including PWH ≥40 years, evaluated twice between 2020 and 2025 at the Modena HIV Metabolic Clinic, with complete laboratory and clinical follow-up data. Objective was to evaluate the real-world use and effectiveness of different lipid-l …

19.08.2026journal-article

JAMA Surgery

Clinician Considerations Regarding Surgical Decision-Making in the Context of Dementia

Rachel R. Adler, Richard E. Chunga, Joely A. Centracchio, Zeba N. Ahmad, Karen R. Sepucha, Christina Sheu, Samir K. Shah, Clancy Clark, Dae Kim, Susan L. Mitchell, Emily Finlayson, Zara Cooper, John Hsu, Kellie L. Flood, Stephen Ryan, Tamara Flys, Adolph J. Yates, Sarah A. Wingfield, Anupama Gangavati, Joel S. Weissman, Lara Traeger

Importance Clinicians, people living with dementia (PLWD), and their caregivers face clinical, ethical, and psychosocial challenges when making surgical decisions. Objective To explore clinician experiences with surgical decision-making when a patient has dementia. Design, Setting, and Participants This qualitative study uses case studies compiled from interviews, surveys, and resource review across 12 sites and 178 clinicians. Interviews were conducted between November 2021 and May 2023, while analysis of intervie …

19.08.2026journal-article

Journal of Advanced Nursing

Surrogate Medical Decision‐Making in Dementia: A Theory‐Informed Integrative Review

Claire McGowan, Rick Zoucha, Melissa Kalarchian

ABSTRACT Aim To synthesize empirical evidence on decision‐making factors and emotional outcomes among surrogate medical decision‐makers for people with dementia. Design Integrative review. Methods A comprehensive search was conducted following Whittemore and Knafl's integrative review methodology. Eligible studies were appraised using the Mixed Methods Appraisal Tool and synthesized through inductive content analysis, guided by the Transactional Model of Stress and Coping. Data Sources PubMed, CINAHL, Embase, Scopu …

19.08.2026journal-article

Healthcare

Association Between Oral Function Limitation and Frailty-Related Functional Impairment in Older Koreans: An Analysis of KNHANES 2024

Mi Ra Lee

Background/Objectives: Oral function limitation (OFL) may be associated with functional decline in older adults, but evidence from nationally representative data remains limited. This study examined the association between OFL and frailty-related functional impairment among older Korean adults using data from the 2024 Korea National Health and Nutrition Examination Survey (KNHANES). Methods: This cross-sectional study included 1247 adults aged 65 years or older with complete data on chewing discomfort, speech disco …

19.08.2026journal-article

Environmental Toxicology

Comparing the Effects of Microplastics From Conventional Cigarette Butts and Heated Tobacco Device: The Role of UV ‐Induced Aging

Andraž Dolar, Veno Kononenko, Valentina Perc, Damjana Drobne, Gabriela Kalčíková, Jernej Imperl, Tina Skalar, Ula Rozman, Branka Mušič, Anita Jemec Kokalj

ABSTRACT Despite the widespread presence of cigarette butts in the environment, the potential toxicological effects posed by microplastics (MPs) derived from them remain poorly understood. In this study, we compared the effects of MPs from conventional cigarette butts (cellulose acetate) and heated tobacco devices (cellulose acetate and polylactic acid film), the latter being under‐investigated. We also compared their effects before and after UV‐accelerated aging. The most notable change in chemical properties of M …

19.08.2026journal-article

Endocrinology, Diabetes & Metabolism

Qualitative and Quantitative Health‐Related Quality‐of‐Life Outcomes From an 8‐year Follow‐Up After Gastric Bypass Surgery in People With Type 2 Diabetes

Giovanni Fanni, Petros Katsogiannos, Magnus Sundbom, Janeth Leksell, Eva Randell

ABSTRACT Background Obesity and Type 2 diabetes (T2D) impair health‐related quality of life (HRQoL) across metabolic, mechanical and mental domains. Gastric bypass surgery improves HRQoL in the short term, but long‐term trajectories remain insufficiently understood. This study evaluated HRQoL 8 years after gastric bypass in a cohort with T2D, integrating quantitative assessments with qualitative exploration of lived experiences. Methods Eleven individuals with obesity and T2D who underwent gastric bypass participat …