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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Phenobarbital Versus Benzodiazepine‐Based Pathways for Alcohol Withdrawal Syndrome in Critically Ill Adults: A Systematic Review and Meta‐Analysis

Zeeshan M. Rizwan, Diane Brown, Simone Barry, Kern Guppy, Dana J. Gerberi, Ognjen Gajic, Svetlana Herasevich

ABSTRACT Objective To compare outcomes of phenobarbital‐based versus benzodiazepine‐based pathways for alcohol withdrawal syndrome (AWS) in critically ill adults and evaluate whether pathway design and timing of phenobarbital use affect treatment outcomes. Data Sources A librarian‐led search of MEDLINE, Embase, Cochrane Central, CINAHL, Web of Science, Scopus, ClinicalTrials.gov , and the World Health Organization International Clinical Trials Registry Platform was conducted through July 2024, with updates in Decem …

23.08.2026journal-article

British Journal of Occupational Therapy

An exploration into how people living in secure hospitals experience work

Joshua Ige, Jacqueline Parkes, Tracey Redwood

Introduction: This study examines how people living in secure hospitals experience work. Work is widely recognised as a vital element in mental health rehabilitation, providing structure, purpose, and opportunities for personal growth. However, engaging in work within secure hospital settings is often more complex due to environmental restrictions and their diverse needs. Methodology: Using a descriptive phenomenological approach, the study explored the lived experiences of seven individuals in secure hospitals who …

23.08.2026journal-article

Arthritis & Rheumatology

Expert Perspective: Low Dose Radiation Therapy and Osteoarthritis Pain

Joel A. Block

Despite revolutionary advances in therapeutics for many of the inflammatory rheumatic diseases, osteoarthritis (OA) has not been one of the diseases for which therapy has advanced dramatically, and OA pain frequently remains incompletely controlled. Low dose radiation therapy was commonly used to treat arthritis in the early twentieth century, but it lost currency in the latter years of that century and was not considered to be useful. However there has been a resurgence of interest in its potential utility for the …

23.08.2026journal-article

Journal of Child and Adolescent Psychopharmacology

Families’ Neighborhood Resources Predict Treatment Response for Regulating Together, a Group Therapy for Emotion Dysregulation in Autistic Youth

Walker S. McKinney, Lauren M. Schmitt, Jennifer R. Ruberg, Marika Coffman, Debra Reisinger, Rebecca C. Shaffer

Introduction: Autistic youth often face difficulties with emotion dysregulation (ED) and associated challenging behaviors. The Regulating Together (RT) group therapy was developed to treat ED in autistic youth ages 8–18 years and has been shown to be feasible, acceptable, and efficacious at reducing ED. Results from other clinical trials suggest the efficacy of behavioral therapies may vary based on family- or neighborhood-level social determinants of health (SDOH: “the conditions in the environments where people a …

23.08.2026journal-article

Occupational Medicine

Evaluation of Homocysteine Levels and Body Composition Indices Following Aerobic Exercise in Adults With and Without Chronic Disease: A Systematic Review and Meta-Analysis

O Zafarmand, A Saremi

Introduction: Homocysteine (HCY) is an important risk factor for chronic diseases and is associated with an unfavorable body composition status. Aerobic exercise can serve as a non-pharmacological intervention affecting these indicators; however, the available evidence is limited and inconsistent. The aim of this study was to conduct a systematic review and meta-analysis of the effects of aerobic exercise on HCY levels and body composition indices in adults with and without chronic disease. Materials and Methods: T …

23.08.2026journal-article

Journal of Nursing, Midwifery and Allied Health Sciences

Birth Spacing Practices among Postnatal Women Attending Primary Healthcare Facilities in Rivers State, Nigeria

Patience Ndidi Amadi, Folorunso Dipo Omisakin, Tamunotonye W. Jacks, Helen Wama, Mercy Mgbere

Background: Birth spacing is an important reproductive health practice with implications for maternal, neonatal, and child health. Short birth intervals may increase the risk of adverse pregnancy and child health outcomes, yet evidence on birth spacing practices among postnatal women in Rivers State, Nigeria, remains limited. This study assessed birth spacing practices and examined their association with selected sociodemographic characteristics among postnatal women attending primary healthcare facilities in River …

23.08.2026journal-article

NED University Journal of Research

IMPLEMENTATION AND VALIDATION OF A PID-CONTROLLED MASTER-SLAVE EXOSKELETON ARM FOR PRECISION ELBOW REHABILITATION

Muhammad Zulhilmi Hussin, Jamaludin Jalani, Wan Ahmad Khairuddin Wan Zakaria, Amirul Syafiq Saadun

Weakness in the arm after a stroke often makes everyday tasks hard to manage. Because robotic sleeves can guide repeated motions, they may help regain movement over time. A new approach is presented in which one limb takes charge and the second follows, tied together by a digital twin that adjusts motion with rapid response control. Instead of operating independently, the stronger side sets the movement while the weaker side copies it, with real-time corrections. Trials were conducted twice—first in simulation, the …

23.08.2026journal-article

Quality in Sport

Companion animal-associated bacterial pathogens and surgical site infections following orthopaedic procedures: implications for rehabilitation and return to physical activity – a narrative review

Hubert Lurka, Piotr Ziajka, Agnieszka Zwolińska, Aleksandra Gaudynek-Sowała, Monika Łapot, Gabriela Szczepanek, Anna Matyas, Anna Zyskowska, Michał Starczewski, Adam Tomczyk, Karolina Krukowska

Background. Surgical site infections (SSIs) remain among the most serious complications of orthopaedic procedures, resulting in prolonged treatment, impaired functional recovery, delayed rehabilitation, and increased healthcare costs. Although most orthopaedic SSIs are caused by endogenous microorganisms, increasing evidence indicates that companion animal-associated bacterial pathogens, including Pasteurella multocida, Capnocytophaga canimorsus, and Staphylococcus pseudintermedius, may occasionally cause postopera …

23.08.2026journal-article

Occupational Medicine

Redesign and Development of a Biosampler and Evaluation of Its Collection Efficiency

M Hashemi, R Yarmohammadi, S Yousefinejad, M Gholampour, S Jafari

Introduction: Understanding the nature and concentration of airborne viruses such as SARS-CoV-2, influenza, and the common cold is essential for assessing transmission risk and developing preventive measures. This study aimed to evaluate the efficiency of BioSampler and impinger samplers in detecting these viruses in indoor air of healthcare centers in a southern city of Iran. In addition, the redesign and fabrication process of the BioSampler are presented. Methods and Materials: The biosampler was redesigned base …

23.08.2026journal-article

Occupational Medicine

A System-Level Investigation of Human and Organizational Failures in Mining Control Rooms

F Laal, R Fallah Madvari, B Abedi, V Sarsangi

Introduction: In high-risk industries, particularly mining, accidents frequently arise from complex interactions between human elements and organizational structures. The control room, as the operational command center, plays a critical role in maintaining safety and ensuring the continuity of production processes. Therefore, identifying and analyzing potential errors in this environment is of paramount importance. Methods: In this study, the Human Factors Analysis and Classification System was applied to systemati …

22.08.2026journal-article

MedComm

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao

ABSTRACT The fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling, primarily comprising FGFs, FGFRs, and the co‐receptor Klotho, regulates key physiological processes, including embryogenesis, tissue homeostasis, metabolism, and neurodevelopment. Dysregulation of FGF/FGFR signaling, whether resulting from pathological hyperactivation or loss‐of‐function, is implicated in multiple diseases such as skeletal dysplasia, metabolic disorders, cancers, and neurological disorders. Consequently, correction of causat …

22.08.2026journal-article

Diseases of the Esophagus

P1.128. Talaporfin Sodium Photodynamic Therapy for Locally Recurrent Esophageal Squamous Cell Carcinoma After Chemoradiotherapy

Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Takaya Shimura, Eiji Kubota, Hiromi Kataoka

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Local recurrence after chemoradiotherapy remains a major challenge in esophageal squamous cell carcinoma. Salvage surgery is invasive and often unsuitable for elderly or high-risk patients. Talaporfin sodium photodynamic therapy offers a minimally invasive alternative. This study evaluated its clinical efficacy and safety in locally recurrent or residual disease. Methods A retrospective analysis was performed on 29 patients with histologically …

22.08.2026journal-article

Burns & Trauma

Root-System-Inspired Core–Shell Microneedles Enable Spatiotemporal Sequential Therapy via ROS Scavenging, Angiogenesis, and Capillary-Driven Lipid Removal for Enhanced Fat Graft Survival

Hengyu Wu, Ganghua Yang, Yuanzheng Zhu, Yanglong Zhu, HaoWen Kang, Jiahui Wu, Minchen Zhang, Xinghong Zeng, Yangyan Yi

Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therapeutic strategies generally focus on single-stage regulation and lack temporal coordination with the dynamic pathological evolution of transplanted adipose tissue. Here, we developed a root system-inspired core–shell microneedle platform capa …

22.08.2026journal-article

Diseases of the Esophagus

P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC

Feng Su, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A clinically important subset experiences early recurrence (ER), which is often followed by rapid deterioration and limited opportunities for effective salvage therapy. Identifying patients at high risk of ER and understanding the dominant f …

22.08.2026journal-article

Diseases of the Esophagus

P1.177. Supracarinal Lymph Nodal Dissection in Esophageal Squamous Cell Carcinoma Following Neoadjuvant Therapy

Caleb Harris, Sandeep Ghosh, Vikas Jagtap, Biswajit Dey, Nari Lyngdoh

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Accurate mediastinal staging remains pivotal to the management of esophageal carcinoma. While subcarinal and perigastric nodal basins are routinely evaluated, the prognostic and staging implications of supracarinal nodal involvement are less clearly defined. This study evaluates the incidence of metastasis to these stations in a contemporary esophagectomy cohort. Methods An audit of a prospective database of esophagogastric cancers …

22.08.2026journal-article

Diseases of the Esophagus

P04.5. Repurposing Cholesterol-Lowering Statins to Overcome Esophageal Cancer Therapy Resistance, From Bench to Bedside

Luis Castro, Sanjima Pal, Megan Sperry, Yi Fei Yan, Shuyuan Wang, Mingyang Kong, Ruo Y Ma, Qian Qiu, Nicholas Bertos, Mehrnoush Dehghani, Andrew Meng, Carmen Mueller, Jonathan Cools-Lartigue, Mathieu Rousseau, Sara Najmeh, Jonathan Spicer, Donald Ingber, Lorenzo Ferri

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal cancer is the seventh cause of cancer mortality worldwide. Despite recent advances in the perioperative management of esophageal adenocarcinoma with systemic and immunotherapy, significant therapy resistance persists. New approaches are in demand, and repurposing approved drugs for other indications is an attractive and low-cost approach to address this issue. Interfering with the adaptive metabolism of cancer cells holds pr …

22.08.2026journal-article

Diseases of the Esophagus

PD04.04. Prognostic Significance of B7-H3 Expression in High-Risk Locally Advanced ESCC After Trimodality Therapy and Adjuvant Pembrolizumab: Post-Hoc Analysis

Chien-Huai Chuang, Jhe-Cyuan Guo, Ta-Chen Huang, Yen-Lin Huang, Hung-Yang Kuo, Chia-Chi Lin, Tsung-Che Wu, Pei-Ming Huang, Jang-Ming Lee, Chih-Hung Hsu

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background B7-H3 (CD276) is an immunoregulatory molecule and emerging therapeutic target. The prognostic value of B7-H3 expression in locally advanced esophageal squamous cell carcinoma (ESCC) treated with multimodality therapy plus adjuvant pembrolizumab was unclear. We performed a post-hoc analysis of a single-arm phase II ESCC patient cohort (NCT03322267) treated with protocol-specified adjuvant cisplatin-based chemoradiotherapy (CRT) followed by pemb …

22.08.2026journal-article

Journal of the American Chemical Society

In Situ Construction of a Reticulated Peptide Scaffold via Responsive Self-Assembly and Proximal Covalent Labeling for Enhanced Tumor Imaging and Therapy

Ruxin Feng, Yunfeng Qiu, Yang Zhao, Rixin Wang, Weilu Xu, Jinhui Ning, Yumin Li, Juyue Zhou, Dingqing Feng, Suying Xu, Leyu Wang

Abstract Precise imaging and specific retention of therapeutic agents at solid tumors were particularly desirable yet hindered by limited specificity and fast diffusion. Herein, we established a dual-trigger-mediated synergistic strategy to form a reticulated peptide network in situ by functional peptide (CL-YPFG) through responsive self-assembly and covalent labeling for prolonged imaging and boosted accumulation of drugs. Specifically, the CL-YPFG underwent morphology transformation from nanoparticles to nanofibe …

22.08.2026journal-article

Angewandte Chemie International Edition

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

Diagnostics

Ultrasound-Visible 3D Nickel–Titanium Clip for Tumor Localization After Neoadjuvant Therapy in Early Breast Cancer: A Prospective Multicenter Real-World Study

Mattea Reinisch, Efstathia Cremer, Kilian Pankert, Diana Weber, Volker Hanf, Katja Engellandt, Sebastian Hentsch, Cordula Müller, Peter Dall, Matthias Losch, Petra Deuschle, Alexander Traut, Satyen Shenoy, Anita Engel, Dorothea Schindowski, Sherko Kuemmel, Simona Gipe

Background: Neoadjuvant systemic therapy (NST) enables tumor downsizing and increases the feasibility of breast-conserving surgery (BCS) in patients with early breast cancer (EBC). Reliable tumor localization after NST remains challenging, particularly in patients with a complete clinical response. If clips are not visible on ultrasound, stereotactic mammography-guided wire localization is required, which involves additional radiation exposure and may increase patient discomfort and procedural complexity. The 3D-sh …

22.08.2026journal-article

International Journal of Therapy and Rehabilitation

The Outstretched Arm Test: comparison of arm dominance and intersession reliability for a new shoulder endurance test

Paul F Greene

Background/Aims Stability at the shoulder is critical for functional use of the upper extremity. Shoulder pain is highly prevalent, and many daily and occupational tasks require sustained arm elevation where the glenohumeral joint is less stable and more vulnerable. Previous tests have explored shoulder endurance dynamically, isometrically, and isokinetically; however, there appears to be a need for a more focused test of sustained endurance at an elevated position. This study aims to explore a test, the Outstretch …

22.08.2026journal-article

Cancers

Myeloid-Mediated Immunoregulation and Resistance to Immune Checkpoint Inhibitor Therapy Across Squamous Cell Carcinomas: Mechanisms and Reprogramming Strategies

Jaafar A. Hadi, Zohra N. Nizami, Ahmed Tajmim Noor, Abdullah A. Osman, Jeffrey N. Myers

Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 have improved outcomes across squamous cell carcinomas (SCCs) of the head and neck, lung, esophagus, and skin, yet durable responses remain confined to a subset of patients in every subtype. Objective response rates vary substantially across SCCs despite overlapping genomic alterations, comparable tumor mutational burden, and high PD-L1 expression, indicating that tumor-intrinsic biomarkers alone do not explain this variability. Growing evidence points to the …

22.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

TENS with proprioceptive-visual training on gait parameters in children with spastic diplegic cerebral palsy: A randomized controlled trial

Mostafa S Ali, Mahmoud Usama

Objective This study aimed to evaluate the effect of TENS with proprioceptive—visual training on gait parameters in children with spastic diplegic cerebral palsy. Methods Two groups of thirty diplegic CP children, ages 4 to 6, were randomly assigned to receive proprioceptive-visual training as the control group and TENS with proprioceptive—visual training as the research group. For eight weeks, both groups received therapy three times a week. Prior to and during the intervention period, each participant had an eval …

22.08.2026journal-article

American Journal of Occupational Therapy

Co-Occupational Participation and Musculoskeletal Health in Mothers: A 7-Day Diary Study

Gamze Ayas, Esra Akı

Importance Postpartum musculoskeletal disorders are prevalent, yet ergonomic approaches often overlook the temporal organization of mother–infant co-occupations. Examining weekly care patterns may help identify patterns relevant to occupational therapy assessment and future intervention research. Objective To examine associations between weekly co-occupational exposure patterns and musculoskeletal disability among postpartum women. Design Cross-sectional study using a 7-day co-occupational participation log. Settin …