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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Artificial intelligence-empowered echocardiography: an updated review of clinical management in hypertrophic cardiomyopathy

Miao Zhang, Shanshan Yuan, Hongyan Dai, Guoan Wang

Hypertrophic cardiomyopathy (HCM) is a common and highly heterogeneous inherited cardiomyopathy characterized by complex clinical phenotypes and diverse disease trajectories, posing significant challenges for early diagnosis, precise phenotypic classification, and risk stratification. Owing to its noninvasive nature, repeatability, and wide availability, echocardiography remains the cornerstone imaging modality for the diagnosis and longitudinal management of HCM. However, conventional echocardiographic analysis re …

27.08.2026journal-article

International Journal of Molecular Sciences

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Magdalena Grześk-Kaczyńska, Szymon Kaczyński, Bernadetta Kosztulska, Magdalena Rydzyńska, Tomasz Rosada, Natalia Ukleja-Sokołowska

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signaling and has demonstrated efficacy across multiple type 2 inflammatory diseases. This systematic review aimed to evaluate the effects of dupilumab on food allergy outcomes in pediatric and adult patients. Across studies, dupilumab treatment w …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case–Control Study

Neval Kızıl, Masum Öztürk, Fatma Subaşı Turgut, Yağmur Soysal, Ayfer Gözü Pirinççioğlu

ABSTRACT Objective Cannabis is among the most commonly used substances by adolescents and is frequently associated with the development of addiction. Various individual, environmental and psychological factors are associated with the onset and maintenance of cannabis use disorder (CUD). Our study aimed to compare levels of depression, anxiety, stress, perceived cognitive flexibility and metacognitive beliefs in adolescents diagnosed with CUD with those in a healthy control (HC) group. Another objective was to inves …

27.08.2026journal-article

Exploration of Asthma & Allergy

Lessons from rheumatoid arthritis and inflammatory bowel disease: The importance of patient-centred outcomes in severe asthma

Joseph W. Lanario, Matthew Masoli, Michael E. Hyland

Biologic therapies have transformed care for people with severe asthma, yet treatment response has traditionally been assessed using clinician-derived measures, including lung function, exacerbation rates, and oral corticosteroid use. These metrics, while clinically important, frequently fail to capture what matters most to patients: their ability to participate in daily life, maintain relationships, and sustain work and social roles. The publication of the Core Outcome Measures Set for Severe Asthma (COMSA) and th …

27.08.2026journal-article

Revista Goiana de Medicina

Teratoma ovariano maduro gigante em gestante de primeiro trimestre

Nayane Peixoto Soares, Gabriela Mesquita Pontes, Fernanda Mendonça Salles Ghannam, Henri Naves e Siqueira, Daniel Fernandes Correia Júnior, Waldemar Naves do Amaral

Introduction: Mature cystic teratoma is the most frequent ovarian neoplasm in reproductive-aged women, posing maternal and fetal risks when diagnosed during pregnancy. Objectives: To report the diagnosis and surgical management of a giant ovarian teratoma in a first-trimester pregnant patient. Methods: A descriptive case report study of a 17-year-old primigravida with a 30 cm adnexal mass concomitant with a 12-week intrauterine pregnancy. Results: Exploratory laparotomy with partial drainage of the contents was per …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Transjugular intrahepatic portosystemic shunt via the caudate lobe portal vein due to anatomic variation: Two case reports

Tao Xu, Xiao-Huan Lai, Qiao-Xia Ye, Li-Guan Liu, Zheng-Ju Xu

BACKGROUND The target sites for transjugular intrahepatic portosystemic shunt (TIPS) treatment of esophageal and gastric varices are typically the left and right branches of the portal vein and its confluence. In clinical practice, the puncture needle may inadvertently puncture secondary branches or other smaller branches of the portal vein. It was observed that when the caudate lobe portal vein (CLPV) was successfully targeted, a covered stent can be effectively placed. CASE SUMMARY This study reports two patients …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Incidence and risk factors of poor wound healing following emergency surgery for intestinal tuberculosis

Qian He, Juan-Min Xue, Jian-Feng Weng, Xia-Nan Li, Cai-Xia Zhang

BACKGROUND Intestinal tuberculosis accounts for 11%-16% of extrapulmonary tuberculosis cases and frequently mimics Crohn’s disease or intestinal neoplasms due to nonspecific clinical presentations. When complicated by obstruction, perforation, or hemorrhage, emergency surgery becomes necessary. These patients often present with malnutrition, anemia, and immune dysfunction, substantially increasing the risk of poor postoperative wound healing a complication that prolongs hospitalization and predisposes patients to i …

27.08.2026journal-article

Frontiers in Oral Health

Comparative effectiveness of therapeutic ultrasound and pharmacotherapy in the management of muscular temporomandibular disorders: a randomized clinical trial

M. Subhikshaa, Prathima Shetty, K. M. Veena, Prashanth Shenoy, Rachana Prabhu, Laxmikanth Chatra

Introduction Temporomandibular disorders (TMDs) of muscular origin are a common cause of chronic orofacial pain and functional limitation. Conservative management includes pharmacotherapy and physiotherapeutic modalities such as therapeutic ultrasound. However, evidence directly comparing their effectiveness remains limited. This randomized clinical trial compared therapeutic ultrasound and pharmacotherapy in reducing pain intensity and improving mandibular function in patients with muscular TMDs. Materials and met …

27.08.2026journal-article

Frontiers in Neurology

“Internal carotid artery-type cervical spondylosis” is not supported as an independent subtype: a perspective on diagnostic classification and clinical differentiation

Tianjun Zhai, Yeping Chen, Wei Feng, Hui Zhang

Cervical spondylosis is a common degenerative disorder, yet its diagnostic boundaries may be inappropriately expanded when nonspecific symptoms such as dizziness coexist with age-related cervical imaging changes. This Perspective evaluates the hypothetical concept of “internal carotid artery-type cervical spondylosis” and whether it qualifies as an independent clinical subtype. Using an adapted validity–utility framework, the proposed entity was assessed according to five criteria: a specific anatomical relationshi …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Mediating Role of Rumination in the Relationship Between University Students' Attachment Dimensions and Future Anxiety

İlayda Üçer, Manolya Çalışır

The purpose of this study is to examine the mediating role of ruminative thought processes in the relationship between attachment dimensions and future anxiety among college students. To this end, 420 participants were included in the study. Participants completed the Sociodemographic Information Form, the Experiences in Close Relationships Inventory II, the Rumination Response Scale, and the Future Anxiety Scale for College Students online. According to the study results, there are positive correlations between th …

27.08.2026journal-article

Veterinary Medicine and Science

Clinical Case and Follow‐Up of Babesia banethi Infection in a Red Fox

Mariaelisa Carbonara, Michela Prioletti, Antonio Camarda, Stefano Castellana, Giuseppe Menga, Giovanna Girardi, Gad Baneth, Domenico Otranto

ABSTRACT Background Red foxes play an important role in the circulation of ticks and tick‐borne pathogens, including Babesia spp. While for Babesia vulpes many studies are available on its epidemiology in fox populations as well as pathogenicity in dogs, no data are reported for the recently described Babesia banethi infecting red foxes. Objective Here we describe the clinical and parasitological follow‐up of a naturally occurring B. banethi infection in a red fox from southern Italy. Case presentation An adult mal …

27.08.2026journal-article

Journal of Clinical Medicine

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Haoruo Zhang, Yanfeng Tian, Songqing Yang, Rui Cao, Haoran Jing, Chunlin Gong, Jiaoyue Zhong, Yuran Chen, Siting Hong, Zhaojun Wang

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibility and short-term outcomes of percutaneous endocardial septal pulsed field ablation in patients with symptomatic hypertrophic obstructive cardiomyopathy. Methods: Five patients with symptomatic hypertrophic obstructive cardiomyopathy and …

27.08.2026journal-article

International Journal of Translational Medicine

Efficacy of Doxycycline as Monotherapy or in Combination with Levofloxacin in Treating Late-Stage Systemic Anthrax in Non-Human Primates

Amir Ben-Shmuel, Assa Sittner, Itai Glinert, Elad Bar-David, Josef Schlomovitz, Haim Levy, Shay Weiss

Background: Bacillus anthracis spores pose a major biosecurity threat, in light of their use in several documented bioterror attacks and the fact that it was weaponized. The absence of specific and accurate treatment instructions in the 2001 anthrax letter attacks and the poor prognosis of patients receiving ineffective treatment emphasized the need for reliable guidelines for treating exposed (prophylaxis) or symptomatic populations. The recent 2023 CDC guidelines for treating systemic anthrax recommend a combined …

27.08.2026journal-article

Visualization in Medicine

Галерея истории лучевой диагностики

Татьяна Николаевна Трофимова, Наталия Александровна Карлова, Марина Геннадьевна Бойцова, Ярослав Петрович Зорин, Ирина Григорьевна Камышанская

Первая в мире виртуальная Галерея истории лучевой диагностики открылась в октябре 2025 г. в Санкт-Петербургском государственном университете (СПбГУ). Мультимедийный ресурс посвящен развитию рентгенологии в России и охватывает все направления лучевой визуализации от момента открытия рентгеновского излучения до наших дней. В основу виртуальной Галереи истории лучевой диагностики была положена концепция сохранения исторических материалов, фотографий, воспоминаний врачей, ученых, персонала отделений лучевой диагностики …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Role of Anima-Animus Balance in Relationships and Its Psychopathological Reflections: A Review within the Framework of Analytical and Clinical Psychology

Gamze Küçükaslan, Reşat Güven, Buse Odabaşı, Deniz Ergün

This study is a systematic review examining the role of anima and animus archetypes in the spiritual integration processes of individuals, their effects on interpersonal relationships, and their psychopathological manifestations within the framework of Carl Gustav Jung’s analytical psychology theory. Anima and animus are defined as opposite-sex archetypes located in the unconscious of the individual and play a decisive role in the individuation process. In this context, the effects of anima and animus on the indivi …

27.08.2026journal-article

Medical Sciences

Clinical Remission Trajectories Beyond 12 Months in Severe Asthma Patients Continuing a Single Biologic: A Real-World Single SANI Center Cohort

Simone Negrini, Stefania Nicola, Francesco Sardanapoli, Rocco Francesco Rinaldo, Marco Russo, Iuliana Badiu, Anna Quinternetto, Luca Lo Sardo, Francesco Blasi, Pierluigi Paggiaro, Enrico Heffler, Giovanni Rolla, Caterina Bucca, Giorgio Walter Canonica, Fulvia Ribolla, Paolo Solidoro, Luisa Brussino

Background: Clinical remission is an emerging therapeutic goal in severe asthma treated with biologics. However, remission may evolve beyond the conventional 12-month assessment, and limited real-world data are available on patients who continue the same biologic after incomplete remission at 12 months. We evaluated longitudinal remission trajectories in patients with severe T2-high asthma continuing the same biologic therapy. Methods: This retrospective real-world single-center SANI cohort included adults with sev …

27.08.2026journal-article

Archiv Euromedica

SOCIAL MEDIA AND MENTAL HEALTH SELF-DIAGNOSIS: RISKS, BENEFITS, AND CLINICAL IMPLICATIONS FOR ADOLESCENTS AND YOUNG PEOPLE

Bogna Błachowska, Wojciech Frączyk, Agata Świątek, Kamil Andruszkiewicz, Bartosz Machnio, Natalia Jasińska, Mateusz Krysiak, Natalia Turzyńska, Katarzyna Mania, Julia Bąk, Agnieszka Stankowska

Background Adolescents increasingly use social media platforms, including TikTok, Instagram, and Reddit, to obtain information about mental health and psychiatric disorders. Such content may facilitate mental health literacy, validation, and help seeking, but may also expose users to misinformation, oversimplified diagnostic narratives, and algorithmically reinforced content. Aim To examine the potential benefits and risks of mental health self-diagnosis through social media among adolescents and young people, with …

27.08.2026journal-article

Frontiers in Medicine

Treatment and clinical outcomes among stage II–IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA

Ci-ming Sun, Zhen Xu, Cheng-hao Li, Jun-xiang Chen, Xin-yi Su, Jing-xia Song, Shuang-hong Song, Qing-qing Xu, Yan-Ling Wu

Background This study analyzed the efficacy of multiple combined chemotherapy modalities on the long-term survival outcomes in stage II–IVA nasopharyngeal carcinoma (NPC) patients with undetectable pretreatment Epstein-Barr viral DNA (pre-DNA). Patients and methods We retrospectively analyzed 2,440 patients with stage II–IVA NPC with undetectable pre-DNA. Patients received any of the following treatment modalities: intensity-modulated radiotherapy (IMRT) alone; concurrent chemoradiotherapy (CCRT); induction chemoth …

27.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Plant‐Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection

Jindong Dai, Xue Xia, Xincheng Hu, Thangamani Kanagaraj, Kanagaraj Rajalakshmi, Mangirish Deshpande, Natarajan Kiruthiga, Dongwei Zhu, Yisun Fan

ABSTRACT Rheumatoid arthritis (RA) represents a persistent autoimmune disease that causes continuous joint inflammation and results in synovial tissue overgrowth and worsening cartilage breakdown together with degeneration of bones. The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant‐derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide …

27.08.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Recent advances in arterial spin labeling MRI for imaging brain tumors

Gabriel Hoffmann, Matthias J. P. van Osch

Abstract Perfusion MRI plays an important role in brain tumor assessment, especially for tumor grading and differentiation of tumor progression from pseudoprogression. Arterial spin labeling (ASL) MRI is a non-invasive method for measuring cerebral blood flow (CBF) using blood water as an endogenous tracer, which has great clinical potential for brain tumor imaging and might help to lower the use of gadolinium-based contrast agents. In this review, we discuss recent advances of the ASL method with a special focus o …