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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical Orthopaedics & Related Research

Is Femoral Head Decentration Reversible After Periacetabular Osteotomy for the Treatment of Developmental Dysplasia of the Hip?

Florian Schmaranzer, Alexander F. Heimann, Michael B. Millis, Ata M. Kiapour, David Liu, Young-Jo Kim, Eduardo N. Novais

Background Femoral head decentration, seen on MRI as a fluid gap between the femoral head and acetabulum, has recently been introduced as a sign of hip instability. Although periacetabular osteotomy (PAO) effectively corrects bony morphology in developmental dysplasia of the hip (DDH), it is unknown whether femoral head decentration is reversible after acetabular reorientation or whether it persists because of factors such as femoral version or intraarticular degeneration. Questions/purposes (1) Does femoral head d …

27.08.2026journal-article

Bioinformatics Advances

A FAIR gold-standard benchmark for geographic entity recognition in cancer genomics literature for biomedical NLP

Maricel G Kann, Karen O’Connor, Petra Tembei, Graciela Gonzalez Hernandez

Abstract Motivation Geographic biases in cancer genomics research limit precision oncology’s global applicability. Major consortia represent only 16 countries and sample less than 1% of 1.4 million publications worldwide. While automated literature mining could address these biases, the lack of benchmark datasets prevents rigorous development and validation of extraction models. We present a FAIR-compliant gold-standard benchmark of 129 manually curated cancer genomics studies spanning 46 countries, tripling geogra …

27.08.2026journal-article

Frontiers in Plant Science

Genome-wide identification of the superoxide dismutase gene family in Lycium barbarum and their expression profiles under abiotic stress and phytohormone treatment

Xiaoyu Cao, Xiaorong Bai, Yingwu Li, Xuedong Hui, Jinfeng Niu, Xiaojie Liang, Yue Yin, Wei An

Background Superoxide dismutases (SODs) are crucial metalloenzymes that constitute the first line of defense against reactive oxygen species in plants under abiotic stress. Wolfberry ( Lycium barbarum ) is an economically important medicinal plant with notable stress tolerance, however, a comprehensive genome-wide analysis of its SOD gene family has not yet been performed. Results We identified ten wolfberry SOD genes ( LbaSODs ) and classified them into three subfamilies: iron-SODs (Fe-SODs), manganese-SODs (Mn-SO …

27.08.2026journal-article

JAMA Network Open

Rates of Never Receiving Cervical Cancer Screening Among US Women, 2005-2023

Kalyani Sonawane, Haluk Damgacioglu, Trisha L. Amboree, Marvella E. Ford, Ketki N. Borse, Brian Orr, Gweneth Lazenby, Ana Patrica Ortiz, Ashish A. Deshmukh

This cross-sectional study examines trends in the prevalence of never having been screened for cervical cancer from 2005 to 2023 and assesses trends in cervical cancer incidence by age and stage at diagnosis to determine whether incidence patterns correspond with trends in nonscreening.

27.08.2026journal-article

Supportive Care in Cancer

Coordination of care in the context of primary brain tumors: Australian healthcare professionals’ exploration of the unspoken impact and clinical implications

Megan S. Jeon, Hannah Isaac, Joanne Shaw, Dianne M. Legge, Sharon He, Thomas Carlick, Eng-Siew Koh, Georgia K. B. Halkett, Brian Kelly, Mark B. Pinkham, Raymond J. Chan, Tamara Ownsworth, Haryana M. Dhillon, for the BRAINS Investigator Group, Meera Agar, Thea Blackler, Helen Haydon, Robyn Leonard, Anna Nowak, Kerryn Pike, Nicole Rankin, Ursula Sansom-Daly, Joel Rhee, Annie Miller, Kristi Milley, Mona Faris, Rachel Campbell, Katarzyna Lion, Jill Chen, Tiffany Fazon, Melinda Lyne, Sian Virtue-Griffiths, Jessica Buster, Emma McDougall

Abstract Aim People with primary brain tumor (PBT) and their families experience high distress and face challenges navigating their disease and treatment, healthcare systems, and/or survivorship. Quality brain tumor care coordination (BTCC) enables continuous, timely care according to the individual care needs of patients. We aimed to explore healthcare professionals’ (HCPs) practices and perceptions of BTCC. Methods We conducted semi-structured interviews with 12 HCPs (92% female) working with people with PBT from …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Human epidermal growth factor receptor 2-directed therapeutics and their role in changing the natural course of breast cancer

Mark Sliwkowski

Abstract ErbB/EGFR (erythroblastosis B/epidermal growth factor receptor) family members play a role in driving the growth of various solid tumours. Therapeutic agents directed against two receptor family members, EGFR and human epidermal growth factor receptor 2 (HER2/ErbB2), show meaningful clinical benefit in solid tumours, including breast, lung, colorectal, gastric, head and neck. Clinically approved agents can be divided into three general categories: small-molecule tyrosine kinase inhibitors, monoclonal antib …

27.08.2026journal-article

Journal of Eating Disorders

Improvements in sleep, weight, and eating-disorder symptoms following off-label leptin treatment in an adolescent with chronic anorexia nervosa and insomnia: a case report

Alexander Dück, Hang Zhu, Judith Melinat, Monika Kruzer, Christoph Berger, Michael Kölch, Martin Reinhardt, Hannes Brehme, Annelie Zimmermann, Linda Frintrop, Olaf Reis

Abstract We report off-label administration of human recombinant leptin (metreleptin) over a 12-day period in a 17-year-old female adolescent with chronic anorexia nervosa (AN) and clinically significant insomnia. Two observation windows are distinguished throughout: a short-term window between day 1 (pre) and day 12 (post) of dosing, and a longer-term window between day 12 and the two-month follow-up (d + 60), capturing both changes temporally associated with leptin administration and the course of continued weigh …

27.08.2026journal-article

Neuro-Oncology

68 Adjuvant chemotherapy in WHO Grade 2 Astrocytoma: Retrospective Analysis at NNUH to Inform a Multicentre Comparative Study

Clare Hannon, Rebecca Brooks, Pinelopi Gkogkou, Andrew Ho

Abstract Background The optimal adjuvant chemotherapy for WHO grade 2 astrocytoma remains uncertain. UK NICE guidance recommends radiotherapy followed by PCV chemotherapy in higher-risk patients; however, temozolomide (TMZ) is sometimes used due to efficacy data in grade 3 astrocytoma as well as its favourable tolerability and ease of administration. No randomised trials directly compare PCV and TMZ in this population, and real-world data on toxicity, treatment adherence, and outcomes remain limited. Retrospective …

27.08.2026journal-article

Neuro-Oncology

145 Implementing Vorasidenib in Clinical Practice: A Single-Centre Real-World Service Evaluation

Brooke Smart, Lorna Raymond, Antonia Creak, Liam Welsh, Ella Nicklin, Matteo Isolani, Ozofu Omuemu, Francesca Solda, Nicola Rosenfelder

Abstract Introduction The phase 3 INDIGO trial demonstrated significantly improved progression-free survival with Vorasidenib in patients with residual/recurrent IDH-mutant grade 2 oligodendroglioma and astrocytoma, supporting its integration into routine neuro-oncology practice. We undertook a real-world service evaluation at the Royal Marsden Hospital to assess toxicity, monitoring burden, and implications for wider UK implementation ahead of the anticipated appraisal by the National Institute for Health and Care …

27.08.2026journal-article

Neuro-Oncology

101 Independent replication and validation of nanopore-based long read sequencing and methylome classification for rapid brain tumour diagnosis

Vassili Crispi, Luke Ames, Joanne Stockton, Sana Manan, Nicola Chadderton, Lisa James, Sahar Sanai, Tracy Bright, Rajwinder Rai, Santosh Nagaraju, Ute Pohl, Philipe Taniere, Andrew Beggs, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological-molecular analysis is essential to diagnose and guide precision therapies in brain tumours. Whilst standard of care (SoC) diagnostics takes weeks, long read sequencing (LRS) on Oxford Nanopore Technology (ONT) platform and bioinformatics research tools provide rapid diagnosis within hours/days. We independently replicated ONT-LRS diagnostic assay within the NHS. Methods Patients undergoing brain tumour surgery were prospectively consented for surplus tissue samplin …

27.08.2026journal-article

Neuro-Oncology

42 The case for rapid molecular diagnosis; The power of PPIE

Simon Newman, Rachel Roberts, Helen Bulbeck, Lillie Pakzad-Shahabi, Ameeta Retzer, Stuart Smith, Matt Loose, Victoria Wykes

Abstract Introduction With over a hundred distinct molecular diagnostic entities, timely and accurate diagnosis is essential. A Network of Excellence (NoE) is being proposed to deliver rapid (<3 days) molecular diagnosis. To inform the funding application for the NoE, a PPIE survey was developed as a joint initiative between The Brain Tumour Charity, Brainstrust, BERTI-West Midlands and Imperial College London. Methods The survey ran between 13-19 January 2026 and was shared through major brain tumour patient an …

27.08.2026journal-article

European Journal of Heart Failure

Treatment effects of dapagliflozin in patients with aortic stenosis undergoing transcatheter aortic valve implantation across left ventricular ejection fraction

Sergio Raposeiras Roubín, Rafael Gonzalez-Manzanares, Ignacio Amat-Santos, María Melendo Viu, David Dobarro, Diego López Otero, Luis Nombela Franco, Livia Gheorge, Jorge Sanz-Sánchez, Baladrón Zorita Carlos, Soledad Ojeda, Andrés Iñiguez Romo, Antonio Jesús Muñoz García, Victoria Vilalta, Gabriela Veiga Fernández, Juan Gabriel Córdoba Soriano, Ander Regueiro, Miriam Sandín Rollán, Xacobe Flores Ríos, Aitor Uribarri, Roberto Martín Reyes, Rafael Romaguera, Pablo Avanzas, Sergio García Blas, Juan A Franco-Peláez, Javier Martín Moreiras, José Ramón Gonzalez Juanatey, Gabriela Tirado, German Calle, José Luis Díez, Sandra Santos-Martínez, Rocío González Ferreiro, Erika Muñoz García, Xavier Carrillo Suarez, Xoan Sanmartín, Nieves Gonzalo, Alejandro Gutierrez Barri, Lluis Asmarats, Felipe Díaz Del Hoyo, Santiago Camacho Freire

Abstract Aims Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in heart failure (HF) across the left ventricular ejection fraction (LVEF) spectrum, but patients with severe valvular heart disease have been excluded from pivotal trials. We investigated the efficacy and safety of dapagliflozin across the full range of baseline LVEF in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Methods and results DapaTAVI was a pragmatic, multicentre, randomized, open-label trial wit …

27.08.2026journal-article

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Moh. Khairul Hassan

Drug-sensitive tuberculosis (TB) treatment success in low- and middle-income countries (LMICs) has historically fallen short of the WHO's 85% benchmark. Predictors of treatment success are well described, but newer adherence-focused interventions, including digital tools introduced since 2018, have not been synthesized alongside contemporary evidence on predictors. Methods. A systematic review and meta-analysis followed PRISMA guidelines and covered the period from January 2018 to April 2023 across PubMed, ScienceD …

27.08.2026journal-article

Clinical Cancer Research

Adrenergic regulation of cancer immunity

Jingjing Zhu, Pierre-Hubert Desimpel, Constance Gérard, Benoit J. Van den Eynde

Abstract The nervous and immune systems engage in extensive bidirectional crosstalk that shapes tumor progression and therapeutic response. Among the neuro-immune pathways involved in cancer, adrenergic receptor signaling has emerged as a key regulator of the tumor microenvironment. In this review, we summarize current understanding of the distinct roles of β- and α2-adrenergic receptor signaling in cancer immunity and their therapeutic implications. β2-adrenergic receptor signaling promotes immune suppression by i …

27.08.2026journal-article

Neuro-Oncology Practice

Interventions Addressing Informational Needs of Adults with Primary Malignant Brain Tumors: A Systematic Review

Maria Camilla Mathiasen, Florien Boele, Georgia K B Halkett, Anders Overby Sjøstrøm, Dorte Schou Nørøxe, Helle Pappot, Karin Piil

Abstract Background Patients with primary malignant brain tumors (PMBT) and their caregivers face informational challenges due to cognitive impairment, emotional distress, and complex treatment trajectories. Although informational interventions have been developed, effectiveness and scope remain unclear. This systematic review aimed to synthesise evidence on interventions addressing informational needs in this population. Methods Five databases (MEDLINE, Embase, Cochrane Library, CINAHL, PsycINFO) were searched for …

27.08.2026journal-article

Frontiers in Public Health

Lung cancer screening in occupational settings: a scoping review

Edelqueen Ijeoma Okoro, Helena Keller, Felix Greiner, Jan Heidrich, Volker Harth

Background Lung cancer is the leading cause of cancer-related mortality worldwide. It is often asymptomatic until advanced stages, resulting in delayed diagnosis and poor survival. Screening enables early detection and reduces mortality. Multiple occupational and environmental exposures have been linked to lung cancer, and some guidelines recommend their inclusion in risk assessment. This review aims to map the existing evidence on lung cancer screening (LCS) in occupational settings. Methods This review followed J …

27.08.2026journal-article

Canadian Liver Journal

Impact of direct-acting antiviral treatment on time and out-of-pocket costs for hepatitis C patients

Yasmin A Saeed, Arcturus Phoon, Josephine F Wong, Kate Mason, Seff Pinch, Valérie Martel-Laferrière, Julie Bruneau, Jordan J Feld, Zeny Feng, Samuel S Lee, Jeff Powis, Beate Sander, William WL Wong

Abstract Background: Direct-acting antiviral (DAA) therapies have transformed care for chronic hepatitis C (CHC); however, the effect of DAA therapy on patient-borne costs is unclear. These costs can pose a substantial burden for patients and their families—even in a publicly funded health system. We estimated the patient-borne costs associated with CHC and the impact of DAA therapy on these costs. Methods: We recruited patients with CHC who were prescribed DAA therapy at two specialized liver clinics and five low- …

27.08.2026journal-article

Endocrine-Related Cancer

PSIP1::TBL1X : a recurrent gene fusion in pancreatic neuroendocrine tumors

Daniel Ackerman, Elisabeth R. Seyferth, Wuyan Li, Julia E. Youngman, Jelsia N. Cottone, Cecilia A. Wright, Robyn T. Sussman, Abashai A. Woodard, David C. Metz, Bryson W. Katona, Michael C. Soulen, Daniel M. DePietro, Jennifer R. Eads, Terence P. Gade

Abstract Effective treatment of metastatic neuroendocrine tumors (NETs) is limited by a lack of targeted therapies and clinically useful predictive biomarkers. We applied complementary genomic profiling technologies, including optical genome mapping (OGM) and whole exome sequencing (WES), to 70 liver metastases of NETs from multiple anatomical primary sites to identify actionable genomic alterations. We detected recurrent fusions involving TBL1X (PSIP1::TBL1X) and BEND2 (CHD7::BEND2 and NEO1::BEND2) by OGM in pancr …

27.08.2026journal-article

Cancers

Beyond Thrombus Level: Increased Surgical Complexity, Nutritional Status, and Postoperative Complications Shape Outcomes in Renal Cell Carcinoma with Venous Tumor Thrombus—A 14-Year Single-Center Experience

Zuzanna Korbecka, Beata Jabłońska, Michał Serafin, Wiktoria Kuczmik, Bartosz Pomianowski, Karolina Blady, Robert Król

Background: Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) (RCC-VTT) represents a surgically challenging entity with heterogeneous prognosis. While the level of thrombus has traditionally been considered a key prognostic factor, its independent impact remains controversial. Aim: The aim of the study was to evaluate perioperative and oncological outcomes in patients with RCC-VTT, as well as to assess the impact of VTT level on the surgical and oncological outcomes, and identify predictors of postoperati …

27.08.2026journal-article

Cancers

Serum SAMD9 as a Potential Prognostic Biomarker for Pancreatic Cancer

Xingyu He, Ying Zheng, Xunjie Cao, Jianhao Zhang, Yang Yang, Qing Zhu

Background: Pancreatic cancer (PC) is one of the most aggressive malignancies and remains a leading cause of cancer-related mortality worldwide. Despite advances in diagnosis and treatment, reliable biomarkers for detection and prognostic assessment remain limited. Sterile alpha motif domain containing 9 (SAMD9) has been implicated in several human malignancies, but its clinical significance in PC has not been fully elucidated. Therefore, this study aimed to investigate the diagnostic and prognostic value of SAMD9 …

27.08.2026journal-article

Neuro-Oncology

15 Promoting the need for a dedicated Neuro‑Oncology Occupational Therapy Service at QEHB: A Quality Improvement Project

Megan Jones

Abstract Introduction This project highlights the role of Occupational Therapists (OTs) in supporting the neuro‑oncology patient population at the Queen Elizabeth Hospital Birmingham (QEHB). Although the OT service is well established, there is currently no structured pathway to ensure that patients with brain cancer receive optimal pre‑ and post‑operative management. This patient group is also at risk of inadequate follow‑up after discharge, re-affirming the need for service development and targeted investment. Me …

27.08.2026journal-article

Diagnostics

Toward AI-Assisted Precision Diagnostics in Breast Cancer: Source-Group-Preserving Evaluation of Class-Imbalance Strategies for Ordered ER-IHC Segmentation

Md Saiful Arefin, Mohammad Saiful Islam, Md Serajun Nabi, Rashadul Islam Sumon, Maria Lapina, Vitalii Lapin, Mohammed Muthanna

Background/Objectives: Estrogen receptor immunohistochemistry (ER-IHC) exhibits heterogeneous staining and substantial class imbalance, complicating segmentation of ordered expression categories. We evaluated whether class weighting, minority-focused crop sampling, adaptive minority curriculum (AMC), and Focal–Tversky optimization improved a common ResUNet-DS backbone for segmenting background/non-target pixels and C1 ER-negative, C2 weak-positive, C3 moderate-positive, and C4 strong-positive foreground categories. …

27.08.2026journal-article

Frontiers in Medicine

Advanced and underlying therapeutic strategies in transformed small cell lung cancer

Mingfeng Wei, Zheng Li, Kaiyuan Zhu, Shixiang Guo, Lefei Hu, Fuzhi Yang, Xiaoyu Chen, Xuelin Zhang, Shuai Jiang, Xunxia Zhu, Xiaoyong Shen

Transformed small-cell lung cancer (T-SCLC) is a clinically important form of histologic transformation and a mechanism of acquired resistance in non-small-cell lung cancer (NSCLC). It is associated with poor prognosis, with a median overall survival of only about 9–13 months. This review summarizes recent advances in the mechanisms, diagnosis, monitoring, and treatment of T-SCLC. Repeat biopsy remains the gold standard for confirming histologic transformation, whereas molecular profiling and liquid biopsy may faci …

27.08.2026journal-article

Cancer Immunology Research

CD4+ T Cells Play Distinct Roles during the Priming versus Effector Phases of Immune Checkpoint Therapy–Dependent Tumor Elimination by CD8+ T Cells

Samuel Ameh, Derek J. Theisen, Mahima Thapa, Jackson S. Turner, Abhinav Rangarajan, Christopher A. Nelson, Aaron J. Schmitz, Yuang Song, Ruan F. Vieira Medrano, Cora D. Arthur, J. Michael White, Kathleen C.F. Sheehan, Daved H. Fremont, Ali H. Ellebedy, Hussein Sultan, Robert D. Schreiber

Abstract It is well established that CD4+ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8+ T-cell priming has been well investigated, their requirement at the effector phase in the tumor is only now beginning to be appreciated. Herein, we used our major histocompatibility complex class II–negative (MHC-II−) sarcoma models to confirm that CD4+ T cells are essential not only during T-cell priming but also to maintain T-cell effector …