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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Cancers

Long-Term Outcomes and Prognostic Factors in Metastatic ALK-Rearranged Non-Small Cell Lung Cancer Treated with ALK Tyrosine Kinase Inhibitors: Real-World Evidence from a High-Volume Thoracic Diseases Center

Abdülkadir Koçanoğlu, Oktay Ünsal, Fatih Kuş, Nesrin Gürçay, Esra Zeynelgil, Yakup Düzköprü, Serdar Karakaya

Background/Objectives: ALK tyrosine kinase inhibitors (TKIs) have improved outcomes in patients with metastatic ALK-rearranged non-small cell lung cancer (NSCLC). However, real-world data on long-term outcomes, prognostic factors, and treatment sequencing remain limited. This study aimed to evaluate treatment outcomes, prognostic factors, and lorlatinib efficacy in different treatment settings. Methods: We retrospectively analyzed 83 patients with metastatic ALK-rearranged NSCLC treated with ALK TKIs at a tertiary …

26.08.2026journal-article

Nano LIFE

Protein Nanomedicine in Breast Cancer Therapy: Targeting Strategies, Clinical Applications and Future Perspectives

Samah Hamed Almurisi, Chua Hsuan Kai, Foo Yoong Kitt, Seow Wen En, Ngeow Qing Lun, Wee Hooi Yee, Bernice Chan Wen Jing, Annie Ling Hsiang Lan, Khater AL-Japairai, Dinesh Kumar Chellappan, Rana M. F. Sammour, Thiagarajan Madheswaran

The challenges of breast cancer treatment still exist despite significant progress. The challenges include tumor heterogeneity, drug resistance and systemic toxicity. However, the development of protein nanomedicine provides a good option to address these. The present review examines the possibilities of using protein-based nanomedicine in breast cancer treatment. It looks at targeted drug delivery, immune modulation and the mechanism of enhanced permeability and retention (EPR) for the precise targeting of the tum …

26.08.2026journal-article

Asia Pacific Journal of Clinical Medical Research

Machine Learning-Based Prediction of Fear of Cancer Recurrence in Gastrointestinal Cancer Survivors: A Cross-Sectional Study

Meijuan Wu, Qin Li, Weixin Xiong

Aims: To explore the current status of fear of cancer recurrence (FCR) in gastrointestinal (GI) cancer survivors, and analyze its influencing factors based on random forest algorithms. Design: A cross-sectional study design. Method: A convenient sampling method was used to select GI cancer survivors who were hospitalized in a tertiary Grade A hospital in Guangdong Province from April 2024 to May 2025. Patients were surveyed using the General Information Questionnaire, Fear of Progression Questionnaire-Short Form (F …

26.08.2026journal-article

Journal of Cancer Research and Therapeutics

Accurate differentiation of metastatic and ultrasound-atypical reactive hyperplastic lymph nodes using a fusion model integrating ultrasound radiomics and habitatomics: A multicenter study

Jiafei Shen, Zhiyan Jin, Xiaoxian Li, Jincao Yao, Yang Zhang, Tian Jiang, Ke Zhang, Lujiao Lv, Bin Li, Jianhua Zhou, Liping Wang, Dong Xu, Liyu Chen

ABSTRACT Background: The significant sonographic overlap between metastatic and ultrasound-atypical reactive hyperplastic lymph nodes remains a challenge in subjective, experience-based ultrasound diagnosis. Consequently, clinicians rely on biopsy, which is an invasive procedure associated with complications such as bleeding and infection, as well as the risk of false-negatives that exacerbate patient anxiety. Materials and Methods: In this multicenter retrospective study, patients with suspicious lymph nodes from …

26.08.2026journal-article

Medicina

Thoracic Epidural Analgesia in Major Cancer Surgery: An Update

Cyrus Motamed, Marie Josée Caballero

Background and Objectives: Postoperative pain after major cancer surgery contributes to pulmonary, cardiovascular, metabolic, and functional complications. Thoracic epidural analgesia [TEA] has traditionally been considered the standard analgesic technique for open thoracic and upper abdominal oncologic surgery, although minimally invasive techniques and ERAS pathways have prompted a re-evaluation of its role. Methods: This narrative review summarizes evidence from PubMed and MEDLINE published between 1995 and June …

26.08.2026journal-article

Psycho-Oncology

Enhancing Self Care Among Oral Cancer Survivors Using a Digital Approach: The Empowered Survivor Trial

Sharon L. Manne, Shawna V. Hudson, Janet H. Van Cleave, Marissa Grosso, Sara Frederick, Morgan Pesanelli, Neetu Singh, Justin Solleder, Denalee M. O'Malley, Elizabeth Handorf, Shou‐En Lu

ABSTRACT Background Oral and oropharyngeal cancer survivors experience debilitating physical and psychosocial challenges. Little knowledge exists on the efficacy of interventions to enhance self‐efficacy in managing these challenges, increase survivorship preparedness, and improve health‐related quality of life (HRQoL). Methods Individuals ( n = 643) diagnosed with oral or oropharyngeal cancer diagnosed within past 3 years were randomized to a digital intervention, Empowered Survivor (ES) or a Generic Online Interv …

26.08.2026journal-article

Journal of Minimal Access Surgery

Surgical management of rectal cancer: Analysis of procedural patterns and perioperative outcomes in 510 patients

Amir Zaffar Lone, Mehraj Ul Islam Teeli, Fazl-Ul-Qadir Parray, Anna Batool, Imran Salam Teeli, Qadar Un Nisaa, Zubair Gani

Abstract Introduction: Effective surgical therapy of rectal cancer necessitates meticulous selection of suitable surgical procedures contingent upon tumour location, stage and patient characteristics. This research examines surgical procedural trends and results in a tertiary care facility in Kashmir. Patients and Methods: A 7-year retrospective–prospective research examined 510 rectal cancer patients who had surgical treatment at SKIMS. Surgical interventions were classified as local excision, low anterior resecti …

26.08.2026journal-article

Biomass

Treatment of Real Wastewater in a Dual-Chamber Microbial Fuel Cell: Comparison of Scenedesmus acutus and a Native Microbial Consortium

Sandryd Ochoa Cruz, Yordan Rodríguez Pinzón, Juan Miguel García Méndez, Gabriel Andrés Quintero Niño, Jeniffer Katerine Carrillo Gómez, Cristhian Manuel Durán Acevedo, Alba Lucía Roa Parra

The growing deterioration of water resources and the energy requirements of conventional wastewater treatment technologies have increased interest in systems that combine organic matter removal with bioelectrochemical conversion. This study evaluated a laboratory-scale dual-chamber microbial fuel cell (MFC) operated with real wastewater using Scenedesmus acutus (S. acutus) and a native microbial consortium as anodic biocatalysts at 25 and 30 °C. The system was assessed through continuous monitoring of voltage, pH, …

26.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Agreement to Referral for Consultation and Utilization of Reproductive Endocrinology and Infertility Services among Female Childhood Cancer Survivors from a Regional Childhood Cancer Survivorship Clinic

Madhumitha Saravanan, Sophia E. Kujawski, Jaime L. Rotatori, Leah Hirschman, Lyn M. Balsamo, Claudia Auerbach, Sonia de Assis, Nagi G. Ayad, Gary M. Kupfer, Nina S. Kadan-Lottick, Rozalyn L. Rodwin

Counseling on infertility risk and fertility preservation (FP) is recommended for childhood cancer survivors (CCS). We describe agreement to and receipt of reproductive endocrinology and infertility (REI) services after counseling during survivorship clinic among female CCS 16–40 years old exposed to gonadotoxic therapy. Of 80 eligible CCS without prior FP or post-therapy REI referrals, 7 (9%) agreed to REI referrals, 1 (1%) attended REI consults, and 0 underwent FP. Survivors who agreed and did not agree to REI re …

26.08.2026journal-article

Frontiers in Immunology

Sequential conditioning in hematopoietic stem cell transplantation in elderly high-risk myeloid blood cancer patients: long-term survival, disease control, and immune recovery across donor types in a matched-pair analysis

Sarah Haebe, Elena Stauffer, Heidrun Drolle, Dusan Prevalsek, Moritz Schmidt, Quentin Fichaux, Michael Weigand, Alessia Fraccaroli, Johanna Tischer

Background Sequential conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) regimens might offer improved disease control in high-risk myeloid patients. But concerns remain regarding toxicity, infection risk and delayed immune reconstitution (IR), particularly in older and HLA-haploidentical transplant recipients. To address these concerns, we comprehensively compared safety, feasibility and clinical outcome across HLA-matched related (MRD), matched unrelated (MUD) and haploidentical donor (Ha …

26.08.2026journal-article

Neuro-Oncology

GABA shunt metabolism drives smoking-related peri-neuronal brain metastasis by hijacking synaptic signaling

Shih-Ying Wu, Abhishek Tyagi, Eleanor C Smith, Jung‑Shun Lee, Pang‑Shuo Perng, Yu-Min Kuo, Tzu-Feng Wang, Hui-Fang Chen, Ravindra Pramod Deshpande, Jee Won Kim, Michael D Chan, Kounosuke Watabe

Abstract Background Brain metastases are a major clinical challenge with poor prognosis, particularly in patients with a history of smoking. While neurons are abundant in the brain and capable of synaptic interaction with tumor cells, their role in brain metastasis remains poorly understood. Emerging evidence suggests that neuronal activity may contribute to metastatic progression, yet the mechanisms by which smoking alters the brain microenvironment to promote tumor growth are unclear. Methods We examined the impa …

26.08.2026journal-article

International Journal of Clinical Oncology

Real-world safety and effectiveness of nivolumab in patients with cancer of unknown primary: results from a nationwide post-marketing surveillance in Japan

Akira Kawasaki, Akito Kakuuchi, Ayumi Akamatsu, Misato Nakanishi, Chikara Honda

Abstract Background Cancer of unknown primary (CUP) is associated with poor prognosis. In December 2021, nivolumab was approved in Japan for the treatment of CUP based on a small phase II trial. This post-marketing surveillance (PMS) evaluated the real-world safety and effectiveness of nivolumab in Japanese patients with CUP. Methods This prospective, observational, PMS enrolled patients with CUP who initiated nivolumab between April 2022 and June 2023 at 66 institutions. Patients were observed for 6 months. Safety …

26.08.2026journal-article

BJU International

Sexual function after prostate cancer surgery or radiotherapy in an international registry

Y. Hess‐Busch, C. Darr, L. Püllen, M. Al‐Nader, M. Wahl, A. V. Bailey, H. Wilhalme, J. Lee, B. Hadaschik, J. Hess, the TrueNTH Global Registry

Objectives Our objective was to evaluate patient‐reported sexual function (SF) outcomes and sexual aid use 12 months after curative treatment for prostate cancer (PC). Patients & Methods This prospective registry‐based cohort study analysed men with localized or locally advanced PC enrolled in the TrueNTH Global Registry. Patients with baseline and 12‐month patient‐reported outcome measures after radical prostatectomy (RP), external beam radiotherapy (EBRT) ± androgen‐deprivation therapy (ADT), or brachytherapy (BT …

26.08.2026journal-article

American Journal of Health Promotion

Bringing Cancer Prevention to Schools: Evaluation of a Novel Teaching Toolkit

Ana A. Gomes, Nuno Ribeiro, Pedro Oliveira, Pedro Ribeiro, Nuno T. Marcos

Purpose cancer prevention is key to reduce disease burden, but is often dependent on individual behavioral choices, many of which are adopted early on during adolescence. A novel cancer prevention teaching toolkit, designed for this audience and the educational context, was evaluated for its adequacy and impact. Design Three complementary methods were used: a students’ evaluation study, a teachers’ survey, and website metrics analysis. Setting Schools and online. Sample 316 high school students (15-21yo), 79 teache …

26.08.2026journal-article

International Surgery Journal

Overlapping symptoms of pelvic metastasis and degenerative spine disease in colorectal cancer: a challenge in early diagnosis

Muhammad Adib Fajar Anwar, Siti Roisya Aga Maydiana, Budhi Ida Bagus, Anung Noto Nugroho

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. 90% of CRC-related deaths are due to metastasis. One of the rarer CRC metastases is bone metastasis, especially pelvic metastasis, with minor symptoms that frequently overlap with other degenerative diseases. The 85-year-old woman with CRC experienced progressive lower back pain radiating to both legs. CT scan showed degenerative spine disease. Further bone scan revealed lytic lesions on the superior pubic ramus, prompting a rare dia …

26.08.2026journal-article

World Journal of Clinical Cases

Oxidative stress and inflammation in breast cancer: Mechanistic interactions and clinical implications

Şeyma Tutar, Kezban Uçar Çifçi, Yusuf Tutar

The development and progression of breast cancer (BC) are influenced by genetic, hormonal, and metabolic factors, as well as by signals within the tumor microenvironment. A review of studies on BC biology and treatment outcomes was undertaken. The studies were experimental, translational, and clinical, and were indexed in PubMed and Web of Science. The focus was on the connection between oxidative and inflammatory markers and clinical endpoints, as well as intervention strategies that modify these pathways. Oxidati …

26.08.2026journal-article

Otolaryngology–Head and Neck Surgery

Preoperative Visualization of the Intraparotid Facial Nerve–Tumor Relationship in Parotidectomy

Yoko Murayama, Kenya Kobayashi, Shiori Amemiya, Yusuke Ito, Koji Yamamura, Kenji Kondo, Yuki Saito

Abstract Preoperative visualization of the intraparotid facial nerve remains challenging with conventional imaging. This retrospective case series evaluated the feasibility of three‐dimensional double‐echo steady‐state with water excitation magnetic resonance imaging for identifying the intraparotid facial nerve and its relationship to parotid tumors. Fifteen lesions in 14 patients who underwent parotidectomy with preoperative imaging using this sequence were analyzed. The main trunk and major divisions were identi …

26.08.2026journal-article

Frontiers in Oncology

A two-phase low-dose ACD-A strategy overcomes hypocalcemia during peripheral blood stem cell collection: a randomized controlled study

Zhangbiao Long, Yutong Jin, Dinghui Zhao, Yuxin Li, Zhengfeng Hou, Min Ruan, Jian Hong, Jifei Dai, Xinglin Liang, Qingsheng Li, Jian Ge

Background Citrate anticoagulation during peripheral blood stem cell (PBSC) collection frequently causes hypocalcemia. Conventional fixed-ratio protocols frequently employ prophylactic calcium supplementation in many centers; however, they are associated with a high citrate burden and have been linked to platelet aggregation in some reports. This randomized controlled study evaluated a two-phase low-dose Acid Citrate Dextrose formula A (ACD-A) strategy designed to reduce hypocalcemia without compromising collection …

26.08.2026journal-article

Frontiers in Oncology

The unusual first sign of presentation of hepatocellular carcinoma: a rare case report

Rocco Morra, Anna Nappi, Nicoletta Zanaletti, Mauro Piccirillo, Luca Tarotto, Salvatore Stilo, Francesco Fiore, Francesco Izzo, Antonio Avallone

Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, characterized by aggressive biological behavior and a high propensity for extrahepatic spread. The most common sites of metastasis are the lungs, regional lymph nodes, bones, adrenal glands, and peritoneum. In contrast, the paranasal sinuses are an unusual site for metastatic HCC, and involvement of the sphenoid sinus represents an even rarer event. Case description We report the case of a 67-year-old male patient who presented w …

26.08.2026journal-article

Frontiers in Oncology

Immune checkpoint inhibitor–based combination therapy for platinum-resistant or platinum-refractory recurrent ovarian cancer: a systematic review and meta-analysis of prospective trials

Jing Xu, Lin Zhang, Wen-Ying Yang, Xiao-Jing Cai, Xiong Xiao

Background The clinical value of immune checkpoint inhibitor (ICI)-based combinations in platinum-resistant or platinum-refractory recurrent ovarian cancer remains regimen-dependent and uncertain. We updated the evidence base and separated nonrandomized response evidence from randomized comparative evidence. Methods PubMed/MEDLINE, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to 23 July 2026, supplemented by reference and citation searching. E …

26.08.2026journal-article

Endocrine Oncology

AGK::BRAF fusion activates MAPK signaling, promotes genomic instability, and reduces NIS expression in thyroid cancer cells

Luiza Sisdelli, Welbert Gomes Rocha, Débora Mota Dias Thomaz, Roxane Hatanaka, Renata Elen Costa da Silva, Guilherme Henrique, Caroline Serrano-Nascimento, Matheus Fabião, Aline Rangel-Pozzo, Sabine Mai, Janete M. Cerutti

Abstract The AGK::BRAF fusion is a recurrent oncogenic alteration in sporadic pediatric papillary thyroid carcinoma (PTC), frequently associated with multifocal disease and pulmonary metastasis. However, the molecular and cellular consequences of AGK::BRAF expression in thyroid follicular cells remain poorly defined. Here, we investigated the biological effects of AGK::BRAF in PCCL3 thyroid cells and compared them with those induced by clinically established pediatric PTC oncogenic drivers, including RET/PTC1, RET/ …

26.08.2026journal-article

Journal of the Egyptian National Cancer Institute

Nanomedicine strategies for overcoming multidrug resistance in breast cancer: recent advances and future perspectives

Mohit Kumar, Tejaswi, Rohit Bangwal, Manish Yadav, Rahul Singh

Abstract Multidrug resistance (MDR) remains a major challenge in the effective treatment of breast cancer, often leading to therapeutic failure, tumor recurrence, and poor clinical outcomes. Multiple mechanisms contribute to MDR, including overexpression of ATP-binding cassette (ABC) transporters, evasion of apoptosis, epithelial–mesenchymal transition (EMT), and the persistence of cancer stem cells (CSCs). In recent years, nanomedicine has emerged as a promising strategy to overcome these resistance pathways by en …

26.08.2026journal-article

Bulgarian Journal of Animal Husbandry

Water treatment technologies in poultry production: Mechanisms, effects, and limitations - A review

Pavlina Hristakieva, Nadya Mincheva, Ivelina Ivanova, Magdalena Oblakova, Mitko Lalev, Nedka Dimova, Krasimir Velikov

Various water treatment technologies - magnetic treatment, alkaline ionization, hydrogen enrichment, and reverse osmosis have been compared for their potential to improve water quality and enhance the physiological responses in birds. Data from multiple studies indicate that the use of treated water can increase growth performance, feed conversion efficiency, and antioxidant capacity by reducing oxidative stress and improving nutrient absorption. Magnetic (MW) and alkaline water (AW) have been shown to stimulate me …

26.08.2026journal-article

Advances in Research

Current Evidence and Clinical Outcomes of Neuro-oncology Rehabilitation: A Systematic Review

Jagmohan Lal Meena, Madho Singh Mehra, Prakash Kumar, Arun Balaji, Bhumika Rathod, Nandinee P. Jena

Background: Adults with brain tumours can experience motor, cognitive, psychological and participation limitations across surgery, active treatment and survivorship, but rehabilitation evidence is heterogeneous. Objective: To synthesise clinical outcomes, harms and implementation results of structured adult neuro-oncology rehabilitation without statistical meta-analysis. Methods: Openly accessible PubMed/PMC record pages, ClinicalTrials.gov records, backward citations and related reports were searched through 30 Ju …