Therapie & Reha: neue Gesundheitspublikationen – Seite 40

22.08.2026journal-article

Diseases of the Esophagus

P1.116. Comparison Between Nivolumab + Ipilimumab, FOLFOX, and Nivolumab + FOLFOX Therapy as First-Line Therapy for Cisplatin-Unfit Advanced Esophageal Squamous Cell Carcinoma

Nozomu Ogura, Shun Yamamoto, Ryuichi Morita, Hiroshi Imazeki, Hideaki Takahashi, Yoshitaka Honma, Daisuke Kurita, Koshiro Ishiyama, Hiroyuki Daiko, Yasuyuki Seto, Ken Kato

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Nivolumab plus platinum-based chemotherapy and nivolumab plus ipilimumab (Nivo+Ipi) therapy are standard first-line treatments for advanced esophageal squamous cell carcinoma (ESCC). However, patients with renal or cardiac dysfunction and elderly patients might be unfit for cisplatin-containing regimens. Therefore, leucovorin, 5-FU, and oxaliplatin (FOLFOX), Nivo+Ipi, and nivolumab plus FOLFOX (Nivo+FOLFOX) therapy might be alt …

22.08.2026journal-article

BMC Urology

The double-decking method for rezūm water vapor therapy in benign prostatic hyperplasia: volumetric, functional, and dosimetric outcomes

Ming-Jui Tseng, Ka-Lun Lo, Chi-Hsiang Wu, Shih-Ying Lin, Chih-Jen Wang, Chen-Yueh Wen

Abstract Background Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) significantly impact quality of life in aging men. Conventional Rezūm water vapor therapy consistently achieves only a modest 25–30% prostate volume reduction, leaving a clinically meaningful therapeutic gap—particularly for larger glands where single-plane periurethral injection fails to achieve adequate thermal coverage of the entire transition zone. Objectives To evaluate the efficacy and safety of a dual-laye …

22.08.2026journal-article

International Journal of Language and Literary Studies

Language Choice, Mixed Inner Speech, and Code-Switching in Putonghua-Dialect Speakers

Ran Qiao

Inner speech is usually treated as private cognition, yet its language may reflect socially organized repertoires. This mixed-methods study examined language choice, mixed inner speech, and within-episode code-switching among Putonghua–dialect users in China. Phase 1 involved 360 adults completing a fully crossed 2 × 3 × 2 vignette task manipulating formality, imagined interlocutor, and emotional intensity; 90 entered a seven-day experience-sampling phase, 79 met the confirmatory compliance threshold, and 30 comple …

22.08.2026journal-article

Bioconjugate Chemistry

Development of a Homogeneous Trastuzumab-Triptolide Conjugate for Targeted Therapy of HER2-Overexpressing Ovarian Cancer

Idowu E. Fadayomi, Maria Jangan, Dilna Varghese, Elisabete Pires, James McCullagh, Alan Richardson, Adrian Murray Brunt, Wen-Wu Li

Abstract Ovarian cancer remains a lethal malignancy due to chemoresistance and toxicity, which limits the dose of chemotherapy that can be used, necessitating the development of more targeted therapies such as antibody-drug conjugates (ADCs). However, conventional ADCs suffer from heterogeneity. This study aimed to develop a stable, homogeneous ADC by utilizing a bifunctional dibromomaleimide (DBM) linker to cross-link antibody cysteine residues via disulfide-bridging. A DBM linker was synthesized from 3,4-dibromof …

22.08.2026journal-article

International Journal of Translational Medicine

Changes in ANA/ENA and Anti-dsDNA Autoantibodies During Adalimumab Therapy in Patients with Psoriasis: A Single-Centre Retrospective Study

Anna Sardiko, Ilze Upeniece, Ilvija Vasiljeva

Background and Objectives: Tumour necrosis factor alpha (TNF-α) inhibitors are widely used for moderate-to-severe psoriasis and are known to induce autoantibody formation in a proportion of treated patients. This study evaluated changes in ANA/ENA and anti-dsDNA antibody levels in psoriasis patients receiving adalimumab therapy during the first 12 months of treatment. Materials and Methods: A retrospective single-centre study was conducted at the Dermatology and Sexually Transmitted Diseases Clinic of Riga 1st Hosp …

22.08.2026journal-article

Georgian Medical Journal

Methodological considerations in evaluating Tskaltubo low-radon nitrogen mineral bath therapy for osteoarthritis

Areesha Sajjad

This Letter to the Editor discusses methodological considerations in the evaluation of Tskaltubo low-radon nitrogen mineral bath therapy for osteoarthritis, with particular attention to study design, control groups, blinding, outcome selection, disease-severity stratification, and long-term follow-up. It comments on the article by Shavianidze et al. published in Georgian Medical Journal (2026) 1(1):99–114. Keywords: osteoarthritis; balneotherapy; Tskaltubo; low-radon mineral baths; methodology; clinical research; L …

22.08.2026journal-article

Diseases of the Esophagus

P1.103. Evaluation of the Efficacy of Local Therapy for Postoperative Oligo-Recurrence in Esophageal Squamous Cell Carcinoma

Ryo Shibayama, Kentoku Fujisawa, Yusuke Ogawa, Hayato Shimoyama, Shusuke Haruta, Masaki Ueno

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Postoperative recurrence of esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis. Among recurrent patterns, oligo-recurrence (OR) has attracted attention because long-term survival may be achieved by combining systemic therapy with local treatments. However, the optimal treatment strategy for OR remains controversial. Methods We retrospectively analyzed patients with postoperative OR of ESCC who underwent curative es …

22.08.2026journal-article

Journalism and Media

Don’t Believe the Hype: Methodological Approaches for Applying LLM-Assisted Content Analysis to Reported Speech in Journalism

Jessy de Cooker

To better understand how journalists represent sources, it is necessary to systematically study the use of reported speech in news coverage. This paper presents a method for LLM-assisted content analysis to identify and classify reported speech in Dutch newspapers automatically. The study evaluates a three-step procedure utilising role-based instructions to prompt the model as a professional journalist. First, a codebook for identifying citation structures and source types was developed with LLM support and then ma …

22.08.2026journal-article

Advanced Materials

Hydrogel‐Interfaced Active Rehabilitation System: From Materials Design and Architecture to Applications

Haofeng Chen, Ranzi Si, Yibing Luo, Yiqun Gu, Bo‐Ru Yang, Qiuhua Yu, Kai Tao, Chuhuai Wang, Fengwei Huo, Jin Wu

ABSTRACT Driven by the pursuit of superior therapeutic efficacy and patient autonomy, healthcare is shifting toward proactive “active rehabilitation”. Conductive composite hydrogels, featuring tissue‐mimetic mechanics and multi‐modal sensing capabilities, have emerged as ideal bio‐electronic interfaces for these systems. This review systematically provides a comprehensive overview of hydrogel‐interfaced active rehabilitation systems, progressing from fundamental material design and system architecture to applicatio …

22.08.2026journal-article

International Journal of Stroke

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Meret Branscheidt, Wala Jaser Mahmoud, Christoph Bauer, Juan Camillo Cortes Ramirez, Ronald Cotton, Steven C Cramer, Sebastian Gallegos Berrios, Gert Kwakkel, Olivier Lambercy, Kate Laver, Alessandro Picelli, Nancy Margaret Salbach, John M. Solomon, Robert Teasell, Tamaya Van Criekinge, Vivian Weerdesteyn, John W Krakauer

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological plausibility and clinical rationale for HDHI are well established. The fourth Stroke Recovery and Rehabilitation Roundtable convened to identify principal barriers to wider HDHI uptake and derive actionable solutions. Methods: Sixteen inter …

22.08.2026journal-article

Diseases of the Esophagus

OA01.1. Invited Lecture: Organ-Preserving Therapy for Higher Stage Esophageal Cancer Using Endoscopic Submucosal Dissection (ESD): Endoscopic Outcomes From OPERA-RADIO Phase 1 Clinical Trial

Professor Biniam Kidane, Dr Julian Kim, Dr Vivian Lu, Dr Stephen Gowing, Jasvir Dhaliwal, Dr Shantanu Banerji

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Esophagectomy is the mainstay of curative for esophageal cancer but comes with high risk for complications, especially in comorbid and frail patients. The OPERA RADIO trial aimed to assess the feasibility and safety of organ-preserving therapy with combining endoscopic submucosal dissection (ESD) and chemoradiotherapy. We report here the endoscopic/surgical outcomes of this trial. Methods OPERA-RADIO (NCT05667298) is a phase I …

22.08.2026journal-article

Diseases of the Esophagus

P1.218. Early Results of Shifting From CROSS to FLOT for Neoadjuvant Therapy Before Esophagectomy

Rishindra M Reddy, Margaret Lasonde, Meganne Ferrel, Njikem Fomengia, Dani Ahmetovic, Tejas Godbole, Daniel Lee, Jules Lin, Chigozirim Ekeke, David D Odell, Andrew C Chang, Samantha Savitch, Kiran Lagisetty

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background There has been a shift from CROSS (C) neoadjuvant chemoradiation to FLOT (F) perioperative chemotherapy for esophageal and gastro-esophageal junction adenocarcinomas. We hypothesized that the shift to FLOT would be associated with higher pathologic complete response rates and potentially lower rates of post-operative anastomotic leak. Methods Data for patients receiving esophagectomy for esophagea …

22.08.2026journal-article

Diseases of the Esophagus

P1.066. Prognostic Equivalence of ypN and pN Staging in Esophageal Cancer After Neoadjuvant Therapy: A Multicenter Cohort Study of 2,545 Patients

Simiao Lu, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Current staging systems apply ypN and pN categories interchangeably after neoadjuvant therapy plus esophagectomy; however, their prognostic equivalence has not been rigorously established. We investigated whether ypN0–3 confers equivalent disease-free survival (DFS) to pN0–3. Methods We analyzed 2,545 consecutive esophagectomy patients from three high-volume centers with complete DFS data. Patients were stratified by treatment type …

22.08.2026journal-article

Angewandte Chemie

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Yu‐Hui Guo, Yao‐Hui Shi, Pei‐Min Huang, Gui‐Xue Tang, Shu‐Min Xu, Mao‐Lin Li, Jia‐Hao Yuan, Xiu‐Cai Chen, Zhi‐Shu Huang, Yi‐Yong Yan, Jia‐Heng Tan, Jin‐Wu Yan, Shuo‐Bin Chen

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target toxicity. Here, we introduce the mitoGPS (mitochondrial G‐quadruplex–targeting photosensitizer) strategy, a rational design framework for developing photosensitizers (PSs) with prolonged intratumoral retention through targeting mitochondrial …

22.08.2026journal-article

Cancers

Biomaterial Techniques for Enhancing CAR-T Cell Therapy of Solid Tumours

Kai Chilvers, John Maher

Background/Objectives: Chimeric antigen receptor (CAR)-T cell therapy has achieved substantial clinical success in haematological malignancies but has shown limited efficacy against solid tumours. Key barriers include inadequate tumour trafficking, immunosuppressive tumour microenvironments, poor selectivity and heterogeneity of antigen expression, and challenges related to safety and manufacturing. Biomaterial-based technologies have emerged as a potential strategy to address many of these limitations. This review …

22.08.2026journal-article

International Journal of Innovative Science and Research Technology

Beyond the Steering Wheel: Occupational Stress, Organizational Well-Being and Workforce Resilience Among Employees of the Telangana State Road Transport Corporation

Aluvala Ravi, Md. Rafi

Stress at work has become an important organizational and public health problem, and can affect employee health, organizational performance and service quality in public transportation. The current study provides a detailed conceptual discussion on occupational stress of employees in Telangana State Road Transport Corporation (TGSRTC) amidst growing complexities of operations, technologization and changing demands of the work environment. The main aim of the study is to synthesize the current theories and research …

22.08.2026journal-article

Journal of Applied Physiology

Cardiometabolic Benefits and Risks for Transgender Youth with the Initiation of Gender-Affirming Hormone Therapy: a case series

Nina S. Stachenfeld, Cheryl A. Leone, Stuart A. Weinzimer

Background. Interventions for transgender youth include puberty suppression and gender affirming hormone therapy (GAHT). Studies have begun to show changes in cardiometabolic outcomes in adolescent transgender males (TGM) and females (TGF). We hypothesized that in TGM and TGF youth, GAHT would increase total cholesterol (TC), LDL cholesterol (LDL-C), insulin resistance (IR) and adiposity, while decreasing HDL cholesterol (HDL-C) and endothelium-dependent vasodilation. Methods. We measured IR (oral glucose tolerance …

22.08.2026journal-article

Diseases of the Esophagus

P1.079. Real-World Adoption of Adjuvant Immunotherapy Following Trimodality Therapy for Esophageal Cancer: A National Cancer Database Analysis

Zamaan Hooda, Ana McCracken, Antonio Luna, Mara Antonoff, Arlene Correa, Jenny Li, Steven Lin, Reza Mehran, David Rice, Stephen Swisher, Ara Vaporciyan, Garrett Walsh, Wayne Hofstetter, Ravi Rajaram, Kyle Mitchell

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Following CheckMate 577 (CM577, 2021), adjuvant nivolumab was approved for patients with esophageal cancer (EC) and residual disease following trimodality therapy. As perioperative paradigms continue to evolve, early adoption patterns may inform implementation of future multimodality strategies. We evaluated adoption trends and factors associated with receipt of guideline-concordant adjuvant immunotherapy. Methods The National Cancer D …

22.08.2026journal-article

Diseases of the Esophagus

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Feng Su, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heterogeneous across tumor histologies and treatment contexts.Angiotensin system inhibitors (ASIs) are widely used for cardiovascular indications and represent a plausible, readily implementable adjunct if associated with improved oncologic outcome …

22.08.2026journal-article

Journal of Functional Biomaterials

Glucose-Responsive Nanomedicine in Diabetes Therapy: Emerging Advances and Clinical Prospects

Adnan Alsaei, Ayah Binrajab, Shahd Alsaei, Fatema Rahimi, Ahmad Zarwi, Helen N. Zarwi, Renad Alansari, G. Roshan Deen

Diabetes mellitus continues to impose a substantial global health burden, underscoring the need for therapeutic systems capable of achieving precise, adaptive, and patient-friendly glycemic control. Conventional diabetes treatments, including repeated insulin injections and oral hypoglycemic agents, are often constrained by non-physiological drug release, poor adherence, systemic side effects, and the persistent risk of hypoglycemia. In this context, glucose-responsive nanomedicine has emerged as a promising platfo …

22.08.2026journal-article

South African Journal of Communication Disorders

Clinical characteristics and outcomes of referrals for speech and language delay to the Speech Therapy and Audiology department at a district hospital in Gauteng, South Africa

Lucie B.L. Graca, Renate Strehlau, Jacqueline K. Bezuidenhout

Background: Speech and language skills are essential for effective communication. Speech and language delays may have far-reaching consequences on a child’s development; their early identification and intervention are paramount to a child reaching their full potential. Objectives: To describe the referral process, clinical characteristics, risk factors and outcomes of paediatric referrals to a Speech Therapy and Audiology (STA) department at a district-level hospital in Gauteng, South Africa. Method: A retrospectiv …

22.08.2026journal-article

Diseases of the Esophagus

P1.052. Photodynamic Therapy (PDT) in the Treatment of Gastroesophageal Reflux Disease (GERD) Complicated by Metaplasia of the Esophageal Mucosa in Children

Sofya Sosnova, Dmitry Khaspekov, Dmitry Morozov, Arthur Sar

Abstract Topic Benign Disease: Pediatric Esophageal Disorders Background GERD is common among children. Conservative treatment methods and surgical interventions for GERD complicated by esophageal mucosal metaplasia, do not always lead to reversal of the metaplasia or a reduction in the risk of esophageal adenocarcinoma. In some cases, PDT is used after antireflux surgery to target the metaplastic mucosa. Methods Five patients with a diagnosis of esophageal mucosal metaplasia were treated in the Thoracic Surgery De …

22.08.2026journal-article

Respiratory Care

Year in Review: Cystic Fibrosis Modulator Therapy—Efficacy, Access, and Evolution

Dawn Selhorst, Elena Stekolchik

The introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators has transformed the therapeutic landscape of cystic fibrosis. CFTR modulators target specific functional defects in the CFTR protein, improving its folding, trafficking, gating, or conductance depending on mutation class. As CFTR modulators become the standard of care, emerging data highlight not only their transformative benefits but also knowledge gaps regarding long-term outcomes, variability in therapeutic response, effect …

22.08.2026journal-article

Diseases of the Esophagus

P1.078. Long-Term Follow-Up of Tislelizumab Combined With Chemotherapy or Radiotherapy as Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma (TINES)

Yong Zhang, Shaomin Che, Nanzheng Chen, Xinju Li, Tuotuo Gong, Junke Fu, Chenao Yu, Tianren Wang, Runjia Liang, Haozhen Xu, Aoran Liu, JiangTao You, Xiaohai Cui, AL-AMEERWAILHUSSEIN AHMED

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive malignancy with limited treatment options. Neoadjuvant therapy has shown promise in improving surgical outcomes and overall survival. This study focuses on long-term follow-up results of tislelizumab combined with chemotherapy or radiotherapy as neoadjuvant treatment for resectable ESCC. Methods Patients with resectable ESCC (T2-4aNanyM0) were randomized into two a …

Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

P1.116. Comparison Between Nivolumab + Ipilimumab, FOLFOX, and Nivolumab + FOLFOX Therapy as First-Line Therapy for Cisplatin-Unfit Advanced Esophageal Squamous Cell Carcinoma

The double-decking method for rezūm water vapor therapy in benign prostatic hyperplasia: volumetric, functional, and dosimetric outcomes

Language Choice, Mixed Inner Speech, and Code-Switching in Putonghua-Dialect Speakers

Development of a Homogeneous Trastuzumab-Triptolide Conjugate for Targeted Therapy of HER2-Overexpressing Ovarian Cancer

Changes in ANA/ENA and Anti-dsDNA Autoantibodies During Adalimumab Therapy in Patients with Psoriasis: A Single-Centre Retrospective Study

Methodological considerations in evaluating Tskaltubo low-radon nitrogen mineral bath therapy for osteoarthritis

P1.103. Evaluation of the Efficacy of Local Therapy for Postoperative Oligo-Recurrence in Esophageal Squamous Cell Carcinoma

Don’t Believe the Hype: Methodological Approaches for Applying LLM-Assisted Content Analysis to Reported Speech in Journalism

Hydrogel‐Interfaced Active Rehabilitation System: From Materials Design and Architecture to Applications

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

OA01.1. Invited Lecture: Organ-Preserving Therapy for Higher Stage Esophageal Cancer Using Endoscopic Submucosal Dissection (ESD): Endoscopic Outcomes From OPERA-RADIO Phase 1 Clinical Trial

P1.218. Early Results of Shifting From CROSS to FLOT for Neoadjuvant Therapy Before Esophagectomy

P1.066. Prognostic Equivalence of ypN and pN Staging in Esophageal Cancer After Neoadjuvant Therapy: A Multicenter Cohort Study of 2,545 Patients

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

Biomaterial Techniques for Enhancing CAR-T Cell Therapy of Solid Tumours

Beyond the Steering Wheel: Occupational Stress, Organizational Well-Being and Workforce Resilience Among Employees of the Telangana State Road Transport Corporation

Cardiometabolic Benefits and Risks for Transgender Youth with the Initiation of Gender-Affirming Hormone Therapy: a case series

P1.079. Real-World Adoption of Adjuvant Immunotherapy Following Trimodality Therapy for Esophageal Cancer: A National Cancer Database Analysis

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Glucose-Responsive Nanomedicine in Diabetes Therapy: Emerging Advances and Clinical Prospects

Clinical characteristics and outcomes of referrals for speech and language delay to the Speech Therapy and Audiology department at a district hospital in Gauteng, South Africa

P1.052. Photodynamic Therapy (PDT) in the Treatment of Gastroesophageal Reflux Disease (GERD) Complicated by Metaplasia of the Esophageal Mucosa in Children

Year in Review: Cystic Fibrosis Modulator Therapy—Efficacy, Access, and Evolution

P1.078. Long-Term Follow-Up of Tislelizumab Combined With Chemotherapy or Radiotherapy as Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma (TINES)