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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Advances in Research

Current Evidence and Clinical Outcomes of Neuro-oncology Rehabilitation: A Systematic Review

Jagmohan Lal Meena, Madho Singh Mehra, Prakash Kumar, Arun Balaji, Bhumika Rathod, Nandinee P. Jena

Background: Adults with brain tumours can experience motor, cognitive, psychological and participation limitations across surgery, active treatment and survivorship, but rehabilitation evidence is heterogeneous. Objective: To synthesise clinical outcomes, harms and implementation results of structured adult neuro-oncology rehabilitation without statistical meta-analysis. Methods: Openly accessible PubMed/PMC record pages, ClinicalTrials.gov records, backward citations and related reports were searched through 30 Ju …

26.08.2026journal-article

Journal of Mid-life Health

Cancer Risk in Premature Ovarian Insufficiency: Current Evidence and Clinical Implications

Vinoth Gnana Chellaiyan Devanbu, Jennifer Britto John, K. Vidya Karpagam

A BSTRACT Premature ovarian insufficiency (POI), defined as loss of ovarian function before 40 years with elevated gonadotropins and oligo/amenorrhea, is increasingly recognized as a systemic condition with long-term health consequences. While cardiovascular, skeletal, and neurocognitive risks are well established, the relationship between POI and cancer risk remains less clearly understood. This mini-review summarizes current evidence on site-specific malignancy risks in women with POI and evaluates the influence …

26.08.2026journal-article

Indian Journal of Pain

Impact of Implementing a Structured Nurse-led Pain Reassessment Protocol on Pain Outcomes among Hospitalized Cancer Patients: A Before-and-after Interventional Study

Sapna Arun More, Somya Vishwakarma, Shubham Gadaria, Aman Kumar Singh Rajan

Abstract Background: Pain reassessment after analgesic administration is essential for effective cancer pain management, yet reassessment practices remain inconsistent in routine clinical settings. Nurses are well positioned to facilitate timely pain reassessment and appropriate escalation of care. Objectives: To evaluate the impact of implementing a structured nurse-led pain reassessment protocol on pain outcomes among hospitalized cancer patients. Methods: A quasi-experimental before-and-after interventional stud …

26.08.2026journal-article

Clinical nutrition and metabolism

Efficiency of a semi-elemental mixture as part of complex therapy for chronic diarrhea in patients with gastric cancer after completion of treatment

Olga A. Obukhova, Ildar A. Kurmukov

BACKGROUND: Radical antitumor treatment for gastric cancer (GC) can lead to chronic diarrhea. Therefore, the choice of enteral formula for nutritional support becomes important. AIM: To compare the effectiveness of using semi-elemental and standard polymer mixtures in the post discharge period in patients after gastrectomy. METHODS: A retrospective, non-randomized, single-center study included patients with gastric cancer over 18 years old after gastrectomy, completed anticancer treatment, had no progression of the …

26.08.2026journal-article

International Journal of Urology

Cathepsin V ( CTSV ) Shapes the Epigenetic–Immune Landscape of Bladder Cancer and Emerges as a Noninvasive Biomarker

Wallax Augusto Silva Ferreira, Fabio Albuquerque Marchi, Glauco Akelinghton Freire Vitiello, Rolando André Rios Villacis, Ana Paula Drummond Rodrigues, Edivaldo Herculano Correa de Oliveira

ABSTRACT Objective The aim of this study was to perform a comprehensive characterization of CTSV regulation in bladder cancer (BC) and its association with clinicopathological features, prognosis, and tumor stroma modulation using multi‐omics databases. Methods We used integrative bioinformatics approaches with publicly available multi‐omics datasets. CTSV expression was evaluated across BC cohorts using TIMER2.0, GEPIA, GENT2, and GEO databases, while protein expression was examined with the Human Protein Atlas. G …

26.08.2026journal-article

PeerJ

Heterogeneity and associated factors of palliative care core competency among oncology nurses: a latent profile analysis

Yang Yu, Fangxin Luoye, Danhui You, Zhenhong Xu, Yuping Liu, Li Wu, Qian Deng, Yanting Ning, Liqiong Liu

Background Global cancer incidence is expected to rise by 60% by 2040, intensifying the burden experienced by patients and their families. Palliative care improves quality of life in advanced disease and depends on oncology nurses’ competencies in ethical decision-making, symptom management, and psychological resilience. Despite moderate overall proficiency, psychosocial shortcomings and heterogeneity in competency remain insufficiently characterized. This study utilized latent profile analysis (LPA), guided by sha …

26.08.2026journal-article

Frontiers in Psychiatry

Personality characteristics, alexithymia and anxiety/depression in breast cancer patients undergoing radiotherapy: a cross-sectional mediation analysis

Ying Li, Yue Luo, Zheng Li, Dan Wang, Lu Yang, Yan He, Qinglian Wen

Objective This study aims to explore the relationship between personality characteristics and both anxiety and depression in breast cancer patients undergoing radiotherapy after surgery, and to assess the indirect effects of alexithymia. Methods This cross-sectional study was conducted in the Department of Radiation Oncology from January 2024 to May 2024. A convenient sampling method was used to recruit breast cancer patients receiving radiotherapy after surgery. Participants completed the survey during the last tw …

26.08.2026journal-article

Veterinary Record Case Reports

Surgical treatment and 3D‐printed modelling of humeral intracondylar fissure and humeral condylar fracture in an Asiatic black bear ( Ursus Thibetanus )

Mandala Hunter‐Ishikawa, Yi‐Kwan Lee, Emily Drayton, Alane Kosanovich Cahalane

Abstract An adult Asiatic black bear ( Ursus thibetanus ) presented with a history of chronic intermittent bilateral forelimb lameness followed by an acute worsening lameness on the right forelimb. Based on radiography and computed tomography, bilateral incomplete ossification of the humeral condyle or humeral intracondylar fissure with a secondary right humeral condylar fracture were suspected. The condylar fracture of the right limb was stabilised with a transcondylar screw and a titanium locking plate. Surgical …

26.08.2026journal-article

Revista Enfermagem Atual In Derme

FORMULAÇÃO LDT-PPH (PTERODON PUBESCENS) NO TRATAMENTO TÓPICO DE LESÃO POR PRESSÃO

Fernanda De Souza Silva, Priscilla Roberta Silva Rocha, Luiz Antonio Soares Romeiro

As lesões por pressão são eventos adversos de notificação obrigatória e constituem importantes indicadores da qualidade da assistência em saúde. Seu manejo representa um desafio clínico e organizacional significativo devido à complexidade do tratamento e às demandas associadas sobre os recursos do sistema de saúde. Este estudo descreve o processo de cicatrização de uma lesão por pressão sacral em estágio IV tratada com uma solução a 1% do extrato hexânico do óleo fixo de Pterodon pubescens (LDT-PPH), diluída no pro …

26.08.2026journal-article

Science Translational Medicine

LTBP4 deficiency induces MRC1 + /CD44 + macrophages to drive cancer progression in preclinical colorectal cancer models

Songtao Ji, Shuya Du, Ge Miao, Xiaohua Yang, Haojia Wang, Xuemei Li, Wanqi Ma, Dan Wei, Tianyu Cao, Mingzhen Zhou, Jianing Yu, Xiangshu Cheng, Yuanci Zhang, Hua Han, Yongzhan Nie, Jipeng Li, Hongyan Qin, Liang Wang, Xin Wang, Yuanyuan Lu, Xiaodi Zhao

The tumor microenvironment is crucial for cancer progression, but the mechanisms underlying the tumor-immune cell interactions in it remain poorly understood. Here, we identified latent transforming growth factor–β (TGFβ) binding protein 4 (LTBP4) deficiency in colorectal cancer (CRC) as a critical driver that reprogrammed tumor-associated macrophages (TAMs) and induced a distinct subset, which promoted tumor progression by coordinating immune evasion and extracellular matrix (ECM) remodeling. Clinically, LTBP4 def …

26.08.2026journal-article

NMR in Biomedicine

A Machine Learning Approach That Measures Extracellular pH Within an In Vivo Tumor Model Using acidoCEST MRI

Alia Khaled, Chetan B. Dhakan, Lucas B. McCullum, Jorge de la Cerda, F. William Schuler, Tianzhe Li, Mark D. Pagel

ABSTRACT Quantitative mapping of extracellular tumor pH (pHe) using acidoCEST MRI offers a method to characterize the tumor microenvironment. Conventional analysis of acidoCEST MRI relies on fitting the Bloch–McConnell equations to experimental CEST spectra. However, this “Bloch fitting” method is computationally intensive. Recent work has demonstrated that machine learning can accurately predict pH from CEST spectra of phantoms containing iopamidol, providing an alternative to Bloch fitting for acidoCEST MRI analy …

26.08.2026journal-article

Journal of Cancer Education

Development of a Responsive Digital Intervention to Support Sexual Health Self-management and Quality of Life in Women with Breast Cancer

Calinca Eliotério Oliveira, Patrícia Brito Ribeiro de Oliveira, Camila Rangel Santos, Izabel Almeida Alves

Abstract Breast cancer is one of the most prevalent malignancies among women, and despite improved survival associated with endocrine therapy, treatment-related adverse effects significantly affect quality of life, particularly sexual health. This study aimed to describe the development of the responsive website “Cancer and My Life” , a digital self-management intervention designed to support the sexual health and well-being of women receiving oral endocrine therapy for hormone receptor-positive breast cancer. The …

26.08.2026journal-article

American Journal of Gastroenterology

Absolute Risk of Malignancy by Treatment in Patients With Crohn's Disease Compared with the General Population: A Nationwide Population-Based Cohort Study

Åsa H. Everhov, Julia Eriksson, Jonas Söderling, Johan Askling, Jonas Halfvarson, SWIBREG Study Group, Karin E. Smedby, Jonas F. Ludvigsson, Henrik Toft Sørensen, Ola Olén

INTRODUCTION: Real-world data quantifying absolute cancer risk in Crohn's disease (CD) by treatment status are lacking but are essential for patient counselling. METHODS: We linked nationwide Swedish register data and assessed incident cancers overall and by type in patients with CD 2007–2023. We estimated age-stratified incidence rate (IR) differences compared with the general population in a once-exposed-always-exposed design. Treatment cohorts comprised new users of thiopurine, tumor necrosis factor inhibitors ( …

26.08.2026journal-article

Frontiers in Surgery

Hypophosphatemic osteomalacia secondary to jaw phosphaturic mesenchymal tumor: a case report with literature review

Wuxiao Cui, Ting Liu, Shuqian Mo, Chaofeng Yang, Wei Deng

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, resulting in hypophosphatemia and altered bone turnover. It is most frequently caused by phosphaturic mesenchymal tumors (PMTs), a rare and distinct group of neoplasms. Patients with TIO exhibit clinical features of osteomalacia, including bone and muscle pain, severe muscle weakness, gait disturbance, and increased susceptibility to fracture. PMTs exhibit pananatomic distribution, in soft tissue or bones, b …

26.08.2026journal-article

Vision

Discordance Between Eye-Specific Clinical Outcomes and Patient-Reported Visual Function After Faricimab Treatment for Neovascular Age-Related Macular Degeneration: A Two-Case Report

Tereza Pařilová, Libor Hejsek, Lenka Hodačová

Neovascular age-related macular degeneration is a retinal disease of older adults causing central vision loss associated with macular neovascularization. Treatment response is commonly evaluated using visual acuity and retinal morphology. These measures may not fully reflect patient-perceived benefit. We report two older adults with neovascular age-related macular degeneration treated with faricimab who demonstrated discordance between clinical and patient-reported outcomes. In the first case, best-corrected visual …

26.08.2026journal-article

Environments

Non-Target Profiling of the Wastewater Metabolome Using a Suite of HRMS Tools: A Study Across Diverse Treatment Plants

Ester Sánchez-Jiménez, Joaquin Abian, Antoni Ginebreda, Damià Barceló, Montserrat Carrascal

Wastewater analysis has emerged as a powerful tool for wastewater-based epidemiology, environmental surveillance, and monitoring of emerging contaminants. While most studies rely on targeted approaches focusing on predefined compound lists, untargeted metabolomics offers potential to capture a broader and less biased chemical snapshot. However, the complexity of wastewater matrices and the chemical diversity of small molecules pose analytical challenges. In this study, we apply a multi-platform, untargeted metabolo …

26.08.2026journal-article

Cancer Imaging

Heterogeneous treatment response in metastatic breast cancer: discordance between FDG-PET and CT classification

Vilma Landfors Andersson, Kristin Johnson, Ida Skarping

Abstract Background Heterogeneous treatment response, characterized by simultaneous regression of some lesions and progression of others within the same patient, is increasingly recognized in metastatic breast cancer (mBC) and may reflect biological heterogeneity. However, this response pattern is not captured by current response assessment frameworks. We aimed to determine the prevalence of heterogeneous treatment response on FDG-PET and mixed response on CT during mBC systemic therapy. Methods This retrospective …

26.08.2026journal-article

Frontiers in Oncology

ULBP1 is a prognostic biomarker associated with immune suppression in breast cancer

Qixin Mao, Yu Zheng, Shanqing Liu, Yong Li, Yan Shen, Hao Zhuang

Background Breast cancer (BC) is the most common malignant tumor among women worldwide. ULBP1 (UL16 binding protein 1), as a ligand of NKG2D, has been associated with poor prognosis in multiple cancers; however, its role in BC remains unclear. Methods TCGA and GEO datasets (TCGA-BRCA, GSE36295, and GSE1379) were used to evaluate the expression characteristics of ULBP1 and its association with prognosis. Functional enrichment analyses were subsequently performed to identify key biological pathways. The CIBERSORT and …

26.08.2026journal-article

Frontiers in Oncology

Romiplostim for cancer treatment-induced thrombocytopenia in acute promyelocytic leukemia: a case report

Xiaoye Yuan, Qixin Guo, Zewen Zhang

Background All-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) is a first-line treatment regimen for acute promyelocytic leukemia (APL), with generally milder myelosuppressive effects compared with conventional chemotherapy. Although standard-dose ATO is not typically considered a major risk factor for cancer treatment-induced thrombocytopenia (CTIT), severe and persistent thrombocytopenia may still occur during ATO maintenance therapy, and its clinical characteristics and therapeutic strategies rem …

26.08.2026journal-article

Cancer Immunology, Immunotherapy

Immune checkpoint blockade facilitates primary tumor rejection in a cDC1-independent manner without immunological memory acquisition

Hitoki Arisato, Takuro Noguchi, Akihiko Shiiya, Yuta Toji, Masahiro Kashima, Jun Taguchi, Satoshi Takeuchi, Yasushi Shimizu, Hidenori Kitai, Kaoru Murakami, Jun Sakakibara-Konishi, Ichiro Kinoshita, Masaaki Murakami, Hirotoshi Dosaka-Akita, Satoshi Konno

Abstract Immune checkpoint blockade (ICB) provides durable therapeutic responses across multiple cancer types. Although crosstalk between T cells and conventional type 1 dendritic cells (cDC1s) is essential, the contribution of other antigen-presenting cells (APCs) to ICB-induced tumor rejection remains unclear. To address this, we show that while the majority of wild type (WT) mice rejected an immunogenic clone of Lewis lung carcinoma (LLC) following ICB, 35.7% of Batf3 –/– mice, which lack the cDC1 subset, also r …

26.08.2026journal-article

Cancer Immunology, Immunotherapy

Integration of a severe immune-related adverse events predictive model with efficacy biomarkers enables precise stratification in NSCLC immunotherapy: insights from the phase 3 ORIENT-11 study

Yue Peng, Ling Wen, Jiayi Shen, Jianhua Zhan, Huaqiang Zhou, Jiaqing Liu, Gang Chen, Yaxiong Zhang, Shen Zhao, Yuanyuan Zhao, Yan Huang, Wenfeng Fang, Yunpeng Yang, Haishuang Sun, Li Zhang, Dongchen Sun

Abstract Background Severe immune-related adverse events (irAEs) compromise the outcomes of immune checkpoint inhibitors (ICIs). However, in routine practice, clinicians still lack biomarkers that can prospectively disentangle antitumor efficacy from the risk of severe irAEs, resulting in largely empirical, one-size-fits-all use of ICIs. Methods In this post hoc analysis of the randomized phase III ORIENT-11 trial, we analyzed RNA-sequencing data from baseline tumor samples of patients with advanced NSCLC receiving …

26.08.2026journal-article

Frontiers in Oncology

Circulating tumor DNA in neoadjuvant therapy for solid tumors

Xueqin Huang, Yu Deng, Yi Shen

Circulating tumor DNA (ctDNA), a core component of liquid biopsy, demonstrates significant potential in the field of neoadjuvant therapy for solid tumors. This review systematically examines the role of ctDNA across the pre-, intra-, and post-neoadjuvant treatment phases, with a focus on its value in predicting therapeutic efficacy, assessing early treatment response, detecting minimal residual disease (MRD), and monitoring for recurrence. By synthesizing the latest clinical research data and advancements in molecu …

26.08.2026journal-article

Molecular Cancer Therapeutics

Potent antitumor efficacy of datopotamab deruxtecan compared with sacituzumab govitecan in an intracranial tumor model of triple-negative breast cancer

Chikako Funasaka, Hiroki Takashima, Daisuke Okajima, Takanori Maejima, Satoru Yasuda, Tsuyoshi Karibe, Shuichi Mitsunaga, Toru Mukohara, Toshihiko Doi, Masahiro Yasunaga

Abstract Metastatic brain tumors are common in patients with triple-negative breast cancer (TNBC) and often lead to a poor prognosis. Trophoblast cell surface antigen 2 (TROP2) is overexpressed in TNBC cells and an attractive target molecule in breast cancer. Datopotamab deruxtecan (Dato-DXd) is an antibody-drug conjugate targeting TROP2 that selectively releases payloads in tumors. We evaluated the efficacy and tumor concentration of payload of Dato-DXd and sacituzumab govitecan (SG), another TROP2-directed antibo …

26.08.2026journal-article

Frontiers in Oncology

Risk-adapted use of thoracic radiotherapy in stage IV non-small cell lung cancer: a multicenter prognostic model study

Jiaxing Guo, Guangqian Ji, Jiao Zhang, Tao Zhang, Xuehua Wei, Yu Lin, Lujun Zhao

Background Survival benefit of thoracic radiotherapy (TRT) in patients with stage IV non-small cell lung cancer (NSCLC) receiving first-line chemo-immunotherapy remains uncertain. This study developed and validated an overall survival (OS) prediction model and assessed whether TRT benefit varied across risk strata. Methods Patients with stage IV NSCLC treated with first-line chemo-immunotherapy were enrolled. A nomogram was developed using baseline clinical variables to calculate individual risk scores. Patients we …