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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

PD04.01. Multimodal Treatment Strategies Incorporating Conversion Therapy for Thoracic Esophageal Cancer With Adjacent Organ Invasion

Kohei Kanamori, Rie Nakashima, Kohei Tajima, Mika Ogimi, Yamato Ninomiya, Yoshiaki Shoji, Akihito Kazuno, Miho Yamamoto, Takayuki Nishi, Kazuo Koyanagi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Management of thoracic esophageal cancer with suspected adjacent organ invasion remains challenging because of diagnostic uncertainty and limited curative options. Recent advances in induction chemotherapy, including DCF and immune checkpoint inhibitors, have enabled downstaging and subsequent conversion to curative-intent treatment in selected patients. Methods We retrospectively reviewed 57 patients with locally advanced, initial …

22.08.2026journal-article

International Urogynecology Journal

Stem Cell Therapy for Stress Urinary Incontinence: Why Has Clinical Success Remained Limited?

Rodrigo A. Castro

Abstract Introduction and Hypothesis Stem cell therapy for stress urinary incontinence (SUI) has been pursued for more than a decade, supported by a compelling regenerative rationale and reassuring early-phase safety data. Yet clinical efficacy has remained modest, complete continence uncommon, and durability uncertain. Method In this Clinical Opinion, we argue that translation has stalled for reasons that are both biological and conceptual: heterogeneous cell products and manufacturing variability undermine reprod …

22.08.2026journal-article

International Journal of Molecular Sciences

Protease-Activated Receptor-2 as a Proteolytic Rheostat in Colorectal and Pancreatic Cancer: From Mechanism to Biomarker-Guided Therapy

Hodasadat Tabatabaei Yeganeh, Malak Sellat, Zayd Anis, Reine Chiri, Rajashree Patnaik, Shloka Gambhir, Yajnavalka Banerjee

Protease-activated receptor-2 (PAR-2; encoded by F2RL1) is emerging as a context-dependent driver of gastrointestinal cancer. Activated by irreversible N-terminal cleavage, its signalling output is not fixed but is calibrated by the identity and source of the activating protease, the receptor cleavage state, cellular context and biased coupling to G-protein αq (Gαq), G-protein α12/13 (Gα12/13) and β-arrestin. PAR-2 is best understood not as a simple inflammatory receptor but as a proteolytic rheostat that converts …

22.08.2026journal-article

Diseases of the Esophagus

P1.038. Minimising the Systemic Effects of an Oesophageal Leak Following High Risk Myotomy Repair Using Prophylactic Endoluminal Vacuum Therapy (EVT) – Time for a Change?

Unaiza Waheed, Alexander Ribbits, Vijayendran Sujendran, Ayesha Noorani, Andrew Hindmarsh

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Case Submission An 80 year old frail lady (ASA 2, BMI 22) was referred with progressive dysphagia, regurgitation, and unintentional weight loss. Endoscopy demonstrated a dilated oesophagus and tight lower oesophageal sphincter without mucosal lesions. Computed Tomography confirmed a patulous lower oesophagus with no malignancy. Barium swallow showed a dilated, aperistaltic oesophagus with severe tertiary contrac …

22.08.2026journal-article

Diseases of the Esophagus

S24.0.1. Integrating Anti-CTLA4 Salvage With Locoregional Therapy After Anti-PD-1 in Liver-Dominant Metastatic ESCC

Chien-Huai Chuang, Huai-Cheng Huang, Jhe-Cyuan Guo, Chih-Hung Hsu

Abstract Submission Category Esophageal Cancer: Management of Metastatic Cancer Case Submission The 70-year-old man was diagnosed with squamous cell carcinoma of the mid-esophagus and underwent endoscopic submucosal dissection (ESD) in November 2022. Pathology demonstrated pT1b disease with negative margins but lymphovascular invasion (LVI) present. Given the adverse pathologic feature, he underwent additional lymph node dissection, which confirmed pN0 disease. He was followed with surveillance until September 2024 …

22.08.2026journal-article

Diseases of the Esophagus

PD02.03. Proximal Resection Margin and Survival in Esophageal Adenocarcinoma Surgery Following Neoadjuvant Therapy

Laser Arif Bazancir, Andreas Weise Mucha, Thomas Baastrup Piper, Trygve Ulvund Solstad, Gustav Holm Schæbel, Mette Kjoelhede Nedergaard, Rajendra Singh Garbyal, Michael Patrick Achiam

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Achieving an adequate proximal resection margin is considered essential for oncologic control in esophageal adenocarcinoma. However, the prognostic significance of margin length following neoadjuvant therapy remains uncertain, particularly in patients who don't complete adjuvant chemotherapy. This study evaluates the clinical impact of proximal margin distance and adherence to national guidelines. Methods This retrospective single- …

22.08.2026journal-article

Advanced Functional Materials

Membrane Protein‐Instructed Peptide Self‐Assembly for Cancer Therapy

Jiaying Zhang, Yanyan Zhou, Ruo‐Chen Guo, Junyan Du, Wenjun Zhan, Gaolin Liang

ABSTRACT Abnormal membrane proteins often play a crucial role in the development and progression of cancer, making them ideal targets for cancer treatment. However, traditional membrane protein inhibitor‐based therapies only benefit a small part of patients and suffer from notorious drug resistance due to their occupation‐driven pharmacology. Recently, membrane protein‐instructed peptide self‐assembly has emerged as a powerful tool in precision cancer treatment. Due to its unique merits such as high tumor targeting …

22.08.2026journal-article

Diseases of the Esophagus

PD01.02. Renin–Angiotensin System Blockade During Neoadjuvant Therapy is Associated With Enhanced Tumor Regression and Survival in Esophageal Squamous Cell Carcinoma

Maohui Chen, Yizhou Huang, Zhenyuan Yang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Beyond blood pressure regulation, the renin–angiotensin system (RAS) has been implicated in tumor angiogenesis, stromal remodeling, and immune modulation. Pharmacologic blockade of this pathway through angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has demonstrated potential antineoplastic properties in several malignancies. Whether exposure to these agents during neoadjuvant treatment influences pathological response or long-term outcome …

22.08.2026journal-article

Diseases of the Esophagus

P1.081. The Effect of Pre-Rehabilitation During Neoadjuvant Chemotherapy in Esophageal Cancer

Ryoma Haneda, Eisuke Booka, Takahiro Kuroda, Shuhei Yasumoto, Keita Misu, Yuki Sakai, Kenichi Sekimori, Shunta Nakamura, Wataru Soneda, Tomohiro Murakami, Tomohiro Matsumoto, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The standard treatment for resectable advanced esophageal squamous cell carcinoma is neoadjuvant chemotherapy (NAC) followed by surgery. Rehabilitation is recommended during NAC; however several adverse events often hinder its completion. This study examined the impact of rehabilitation completion rates during NAC on postoperative complications. Methods We retrospectively analyzed 111 patients who had esophagectomy after NAC for thorac …

22.08.2026journal-article

Diseases of the Esophagus

P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC

Feng Su, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference with apoptosis and alterations in proliferative signaling, however, clinical evidence remains inconsistent and may depend on tumor histology and treatment modality.Whether CCB exposure influences outcomes in esophageal squamous cell carcino …

22.08.2026journal-article

Diseases of the Esophagus

P1.045. Management of a Large Esophagojejunostomy Defect After Laparoscopic Total Gastrectomy Using Endoscopic Vacuum Therapy and Adjunctive Stenting

Jeong Ju NOH, Ji Yeon Park, Ki Bum Park, Hyun Wook Shin, Oh Kyoung Kwon

Abstract Topic Benign Disease: Other Background Esophagojejunostomy (EJ) leakage after total gastrectomy remains a life-threatening complication. While endoscopic vacuum therapy (EVT) has emerged as an effective treatment option, management of large anastomotic disruption and subsequent stenosis remains challenging. We report a case successfully managed with repeated EVT and subsequent stent placement. Methods An 80-year-old woman with antral gastric cancer underwent planned totally laparoscopic distal gastrectomy. …

22.08.2026journal-article

Journal of Clinical Medicine

The Safety of Pre-Filter Heparin for Circuit Clotting Prevention in Continuous Renal Replacement Therapy: A Retrospective Evaluation

Thomas Diaz, Traci Grucz, Stephanie Davis, John Lindsley, Kathryn E. Dane, Hailey Burns, Samir Gautam, Gianna Iantosca

Background: Circuit clotting is a common complication of continuous renal replacement therapy (CRRT). Pre-filter unfractionated heparin (UFH) is widely used to maintain circuit patency, but real-world data describing its safety and efficacy are limited. Methods: This retrospective, single-health-system study evaluated critically ill adults receiving pre-filter UFH for CRRT clotting prevention between 2021 and 2025. The primary outcome was clinically relevant major bleeding, adapted from International Society on Thr …

22.08.2026journal-article

Small

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

Jingmei Li, Jin Zhang, Xiayu Chen, Shan Wu, Jieping Wu, Xizi Fu, Yan Gao, Lixia Guo, Xingmei Duan, Ke Men

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumor immunogene therapy. Here reported the collaboration of two types of CMNPs using a double‐layered spherical scaffold. This scaffold was prepared by stacking photosensitive hydrogels with two concentrations. After implantation, the two laye …

22.08.2026journal-article

Klinik Psikoloji Dergisi

The effects of a child-parent relationship therapy based psycho-education program on children and parents in single-parent families

Gülçin Güler Öztekin, Başaran Gençdoğan

Single-parent families, one of the common family structures in society, experience some challenges as well as advantages. One way to deal with these challenges is to strengthen the child-parent relationship. The aim of this study was to reduce problematic behaviors in single-parent children and increase parental empathy and acceptance levels of their parents by implementing a psycho-education program based on Child-Parent Relationship Therapy. The study employed a pre-test-post-test control group experimental desig …

22.08.2026journal-article

Diseases of the Esophagus

P1.101. Treatment Selection and Real-World Outcomes of First-Line ICI-Based Therapy for Unresectable or Recurrent Esophageal Cancer in a Regional Hospital

Tomonari Suetsugu, Narutoshi Nagao, Kazuo Yamamoto, Shinya Ohno, Shunya Kiriyama, Kakeru Tawada, Yoshinori Iwata, Chihiro Tanaka, Masahiko Kawai

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Based on pivotal clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated efficacy in patients with unresectable advanced or recurrent esophageal cancer and are now incorporated as standard treatment in the Japanese clinical practice guidelines. Although expanded therapeutic options are expected to improve survival outcomes, real-world data remain limited. Our institution is a regional hospital where a large proportion of pat …

22.08.2026journal-article

Diseases of the Esophagus

PD01.07. Surgery Timing After Neoadjuvant Therapy for Esophageal Carcinoma: A Meta-Analysis of 7,544 Patients

Jianfeng Zhou, Pinhao Fang, Yong Yuan, Zewen Wang

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In treating locally advanced esophageal carcinoma, neoadjuvant therapy followed by surgery represents a key approach. However, the timing of surgery following neoadjuvant therapy in esophageal carcinoma remains controversial. Methods We conducted a systematic search of PubMed, EMBASE, Web of Science, and Cochrane Library for studies published up to August 1, 2024. Studies that compared delayed versus early surgery for locally advanced …

22.08.2026journal-article

Pharmaceuticals

Neurofilament Light Chain (NfL) in Neurodegenerative Diseases: Biological and Clinical Significance, Multi-Omics Integration, and AI-Driven Biomarker Modeling for Precision Therapy

Nawaf Alshammari, Reyaz Hassan, Mitesh Patel, Mohd Adnan

Neurodegenerative diseases represent a major cause of disability and death, but early diagnosis, prognosis, and therapeutic monitoring are challenging due to biological heterogeneity and the absence of disease-specific biomarkers. Neurofilament light chain (NfL) is a highly sensitive fluid biomarker of neuroaxonal injury with well-established clinical utility in selected neurological disorders, especially in disease monitoring and prognostic evaluation. However, since NfL is not disease-specific, the interpretation …

22.08.2026journal-article

Techniques in Coloproctology

Salvage surgery after total neoadjuvant therapy and watch-and-wait in rectal cancer: a systematic review and proposed minimum outcome set

J. R. Burke, I. Samuel, R. Clifford, P. Sutton, C. Arthur, A. G. Renehan

Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporting. This methodological review proposes a structured minimum outcome set (MOS) to distinguish intra-operative technical complexity from surgery-related morbidity and evaluates current reporting against this framework. Methods A predefined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Prenatal molecular diagnosis and allogeneic hematopoietic stem cell transplantation in an infant with RAG2 deficiency

Maria Laura Herrera Andino, Milagros López Orozco, María Victoria Suen, Carlos Hernán Hollmann, Lucía Spossito, Arjan Lankester, María Emilia Mas, Ana Lisa Basquiera

RAG2 deficiency is a cause of severe combined immunodeficiency (SCID), characterized by a defect in the development of T and B lymphocytes that predisposes patients to life-threatening infections during the first months of life. We present the case of an infant with a prenatal molecular diagnosis of SCID secondary to RAG2 deficiency who underwent allogeneic hematopoietic stem cell transplantation (HSCT) using a human leukocyte antigen-identical sibling donor at 3 months old. The subsequent clinical course was favor …

22.08.2026journal-article

Cells

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Jiani Dai, Yufei Wang, Chunna Jin, Liuguang Song, Yao Xie, Liangliang Jia, Meixiang Xiang

Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution …

22.08.2026journal-article

International Journal of Innovative Science and Research Technology

Occupational Health and Safety of Employees in Wood Processing Industries in Cameroon

Ateba François René, Oum René, Ngongo Isidore Seraphins

Workers safety in Africa faces significant challenges, marked by the high number of workplace accidents, inadequate support from employers, a general shortage of personal protective equipment across all industries, insufficient controls, and unequal legal frameworks across countries. This article provides some answers both to help reverse the trend of occupational accidents and to raise awareness among decision-makers in African countries.

22.08.2026journal-article

Journal of Endovascular Therapy

Concurrent Peripheral Arterial Disease Predicts Re-Intervention Following Abdominal Aortic Aneurysm Repair: A Single-Centre Propensity Matched Retrospective Study

Navanith Murali, Angela Lee, Lukschana Senathirajah, Eman Otify, Jing Zhou, Tariq Ali, Philip Stather

Purpose: Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) share common risk factors and may co-exist in patients undergoing AAA repair. The impact of concomitant PAD on clinical outcomes post AAA repair remains unclear. This study aims to evaluate whether concurrent PAD is associated with adverse clinical outcomes following AAA repair. Materials and Methods: This was a single-centre retrospective propensity matched analysis involving patients undergoing infrarenal AAA repair at a single UK cent …

22.08.2026journal-article

Journal of Medicine and Health Research

Electronic Waste Exposure and Public Health Risks among Informal Recycling Workers: A Critical Narrative Review of Occupational Mixtures, Health Effects and Prevention

Hameedat Titilade Sanusi, Ogunyemi Joel, George-Oloja Nkechinyere, Elona Erezi

Electronic waste recycling sustains livelihoods and recovers valuable materials, yet informal processing can transfer a substantial fraction of the environmental and occupational costs of the digital economy to workers with limited access to engineering controls, occupational health services and social protection. This critical narrative review evaluates the evidence linking informal electronic waste work with hazardous exposures and adverse health outcomes, with emphasis on worker-specific studies rather than comm …