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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Medicine

Severe recurrent hypernatremia and probable lithium-associated nephrogenic diabetes insipidus following pancreatectomy in a patient with schizophrenia: a case report

Yanfei He, Liuyin Jin, Xiaolei Xu, Qing Xia

Background Nephrogenic diabetes insipidus (NDI) is characterized by impaired renal responsiveness to arginine vasopressin, causing defective urinary concentration and large volumes of dilute urine. Long-term lithium exposure is an important acquired cause. Perioperative fasting, restricted free-water intake, and ongoing fluid losses may unmask compensated lithium-associated urinary concentrating dysfunction and precipitate severe hypernatremia. Case presentation A 61-year-old man underwent laparoscopic resection of …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Monitoring Cholera Transmission in Zambia Using the Cholera Elimination Scorecard

Caroline C. Chisenga, Lilian Lamba, Charlie C. Luchen, Ashley Duncan, Nyuma Mbewe, Masuzyo Zyambo, Maisa Kasanga, Fraser Liswaniso, Harriet Ng’ombe, Michelo Simuyandi, Amanda K. Debes, Roma Chilengi, David A. Sack

ABSTRACT. We used the cholera elimination scorecard to better understand the changing cholera patterns in Zambia. The method used surveillance data from the Zambia National Public Health Institute to identify districts that had eliminated cholera or continued to be endemic between 2015 and 2024. Between 2017 and 2022 the number of cholera-endemic districts decreased from 27 to 6; however, in 2023 and 2024, a severe outbreak occurred in Lusaka and expanded to neighboring districts. Concurrently, a separate outbreak …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Neuroimaging Abnormalities and Genotype-Phenotype Correlations in Noonan Syndrome: A Multicenter Cohort Study

Giuseppa Patti, Nadia Gabriella Maiorano, Francesca Piccoli, Alice Zucconi, Maria Grazia Calevo, Federica Tamburrino, Emanuela Scarano, Concetta Schiavariello, Cesare Rossi, Laura Mazzanti, Eleonora Orlandini, Gabriella Pozzobon, Martina Finamore, Cristina Baldoli, Anna Grandone, Mario Cirillo, Francesca Aiello, Domenico Corica, Malgorzata Wasniewska, Alessandro Cattoni, Paolo Remida, Donatella Capalbo, Fabio Tortora, Maria Carolina Salerno, Sara Azzolini, Mariam Mansour, Maria Felicia Faienza, Stefano Palladino, Domenico Tortora, Giulia Rosti, Francesca Faravelli, Cristina Venturino, Pasquale Capuozzo, Letizia De Mori, Paola Maietta, Anna Elsa Maria Allegri, Chiara Morreale, Alessia Angelelli, Flavia Napoli, Natascia Di Iorgi

Abstract Context Neuroradiological findings in Noonan syndrome (NS) remain insufficiently characterized Objective To characterize neuroimaging abnormalities in children with genetically confirmed NS and evaluate their associations with clinical phenotype Design, Setting, and Participants In this multicenter retrospective study, brain MRI scans and longitudinal clinical and genetic data were reviewed from children with genetically confirmed NS evaluated between 2008 and 2023 at seven pediatric endocrinology centers …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Microsurgical Aspects of Middle Cerebral Artery Variations: Clinical and Anatomo-radiological Implications

Mustafa Eren Yüncü, Berra Bilgin, Yeliz Pekçevik, Ali Karadag, Necmettin Tanrıöver

The middle cerebral artery is the largest branch of the internal carotid artery and supplies extensive cortical and deep cerebral territories. Variations in its branching pattern are of considerable importance in microsurgical planning and may influence aneurysm development. This study aimed to evaluate the prevalence of middle cerebral artery variations, their microsurgical anatomy, and their relationship with anterior circulation aneurysms. Computed tomography angiography images of 500 patients were retrospective …

27.08.2026journal-article

BMC Oral Health

Parental knowledge, attitude, and practice on oral complications of leukemia treatment: a cross-sectional study

Nosrat Nourbakhsh, Ailar Adib Haji Bagheri, Maryam Torkian, Sheida Bagheri, Sahar Talebi

Abstract Background Leukemia is among the most common childhood cancers, and treatments such as chemotherapy and radiotherapy often lead to oral and dental complications. With rising survival rates, attention to oral health and its impact on quality of life has become increasingly important. Parental knowledge and practice play a vital role in preventing and managing these complications. Therefore, this study assessed the knowledge, attitude, and practice (KAP) of parents of children with leukemia regarding oral sy …

27.08.2026journal-article

Academia Nutrition and Dietetics

Beyond glycemia: clinical nutrition in type 2 diabetes and cardiometabolic risk

Antonio Maria Labate, Provvidenza Villari

Type 2 diabetes (T2D) is a multifactorial cardiometabolic disorder in which dysglycemia coexists with visceral adiposity, insulin resistance, atherogenic dyslipidemia, hypertension, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this setting, clinical nutrition should be considered a therapeutic intervention rather than a generic lifestyle add-on. This mini-review summarizes how nutritional strategies can modify major cardiometabolic domains in adults with T2D, with a practical focus on Me …

27.08.2026journal-article

Physiotherapy Research International

Shared Decision‐Making and Patient Enablement in Outpatient Rehabilitation: An Observational Study

Naoto Iwasawa, Shota Hori, Hitoshi Fujita, Takuya Yamada, Hirono Ishikawa

ABSTRACT Objectives To examine the association between shared decision‐making (SDM) and patient enablement in outpatient rehabilitation consultations. Methods In this observational cross‐sectional study, 158 patients attending outpatient rehabilitation at four facilities in Japan were assessed, of whom 93 were included in the final analyses. Sociodemographic data, disease severity (modified Rankin Scale), treatment expectations, control preferences, and health literacy were collected via self‐administered questionn …

27.08.2026journal-article

Clinical and Translational Medicine

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen

Abstract Background All‐trans retinoic acid (ATRA) exerts its biological functions primarily through nuclear receptors, but its therapeutic efficacy in solid tumours remains limited. This study aimed to elucidate the regulatory role of the cancer‐testis antigen PRAME in posttranslational modifications (PTMs) of the ATRA receptor RARα, and to assess its consequent impact on tumour progression in salivary adenoid cystic carcinoma (SACC). Methods Transcriptome sequencing was performed on public datasets from the Gene …

27.08.2026journal-article

Pregnancy

Society for Maternal‐Fetal Medicine Special Statement: Quality metrics to assess prenatal detection of congenital heart defects—Updated 2026

Society for Maternal‐Fetal Medicine (SMFM), Adina Kern‐Goldberger, C. Andrew Combs, Afshan B. Hameed, Iffath Abbasi Hoskins, SMFM Patient Safety and Quality Committee

Abstract Congenital heart defects (CHDs) are a leading cause of neonatal morbidity and mortality. Accurate prenatal diagnosis of CHDs can reduce morbidity and mortality by improving prenatal care, facilitating predelivery pediatric cardiology consultation, and directing delivery to facilities with resources to manage the complex medical and surgical needs of newborns with CHD. Unfortunately, fewer than half of CHD cases are detected prenatally, resulting in lost opportunities for counseling, shared decision‐making, …

27.08.2026journal-article

Frontiers in Medicine

Skin phenotype diversity across populations: from skin morphology to molecular phenotype

Xiaoqian Yu, Meiting Yi, Jiayuan Shi, Yan Jia, Liya Song, Huaming He

The considerable range of phenotypic variation observed in human populations may partly reflect distinct processes of natural selection and adaptation to variable environmental conditions. Differences in physiological indices, structure, molecular phenotypes and metabolic mechanisms of the skin across populations with varying skin phototypes are also a reflection of this unique process. These differences are reflected in skin color, pH, moisture content, water loss, sebum secretion, and skin elasticity. The differe …

27.08.2026journal-article

BMC Medical Education

Impact of clinical case discussions in anatomy on national exam performance: a 10-year longitudinal cohort study

Fang Fang, Lan Yu, Yetao Ou, Si Zhou, Jun Ma, Yuntao Peng, Fang Liu, Junfeng Wang, Chunbo Xia, Houzhong Li, Weishan Zhang, Tan Cheng, Yu Chen, Yi Huang, Xin Li, Heng Guan

Abstract Background Traditional anatomy instruction often prioritizes structural memorization over clinical application. Although case-based learning is widely endorsed to bridge this theory-practice gap, longitudinal evidence regarding its sustained impact in foundational sciences remains limited, particularly concerning its performance over a decade amid massive enrollment expansion. Methods This 10-year longitudinal retrospective cohort study tracked seven clinical medicine cohorts (2015-2021). To maintain teach …

27.08.2026journal-article

Plant Health Progress

Current Status of Ceratobasidium theobromae Affecting Cacao and Cassava: Diagnosis and Management

Cansu Oksel, Fulya Baysal-Gurel

Ceratobasidium theobromae, the causal agent of vascular streak dieback in cacao, has recently been associated with cassava witches’ broom disease, expanding its known host range and increasing its importance in crop production systems. This review summarizes disease development, diagnosis, and management of C. theobromae in cacao and cassava. Diagnosis remains challenging due to difficulties in pathogen isolation and confirmation of pathogenicity, although molecular tools have improved detection and identification. …

27.08.2026journal-article

Journal of Clinical Medicine

Late-Course Lactate/Albumin Ratio and In-Hospital Mortality in CRRT-Treated Critically Ill Patients: A Retrospective Severity-Adjusted Analysis

Hasan Şenay, Mehmet Kürşad Orhan, Mahmut Sami Tutar, Munise Yıldız, Ece Ünüvar Şenay, Muhammed Halit Satıcı, Ahmet Erarkadaş, Betul Kozanhan

Background/Objectives: The lactate/albumin ratio (LAR) integrates tissue hypoperfusion and nutritional reserve into a single dimensionless index. As a late-course measurement (last available value before the primary outcome), it may reflect terminal metabolic deterioration rather than early prognostic signal. We examined the association of the final LAR with in-hospital mortality after adjustment for validated severity scores (APACHE II, SOFA) in critically ill patients receiving CRRT, and evaluated its incremental …

27.08.2026journal-article

International Journal of Molecular Sciences

Beyond Swelling: Clinical Insights into the Diagnosis and Management of Hereditary Angioedema

Margarita Paulauskiene, Laura Tamasauskiene, Brigita Gradauskiene

Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of severe, non-pitting edema, most commonly caused by a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), resulting in excessive bradykinin production. HAE subtypes differ according to C1-INH levels, functional activity, underlying genetic variants, and increasingly recognized molecular mechanisms. Awareness of HAE outside specialized medical fields remains limited, and recurrent angioedema may arise through differ …

27.08.2026journal-article

International Journal of Molecular Sciences

Anti-Tumor Potential of Selective L-Type Amino Acid Transporter (LAT1) Inhibitor, JPH203, in Patient-Derived Canine Bladder Cancer Organoids

Ting-Wei Yu, Minami Kawahashi, Fumiya Goda, Ami Kanaya, Mohamed Elbadawy, Hitoshi Endou, Shoichiro Ide, Hideyuki Yamawaki, Masahiro Kaneda, Amira Abugomaa, Tsuyoshi Uchide, Tatsuya Usui, Kazuaki Sasaki

L-type amino acid transporter 1 (LAT1), which controls the neutral amino acid uptake across the cell membranes, has been frequently overexpressed in various human cancers. Overexpression of LAT1 is associated with higher proliferation and shorter patient survival in tumors. Here, upregulated LAT1 expression was observed in patient-derived canine bladder cancers (BCs), and a small-molecule LAT1 inhibitor (JPH203) successfully reduced BC tumor growth both in vitro and in vivo. Patient-derived cancer cells were collec …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Application of enhanced recovery after surgery in the perioperative period of pediatric enterostomy closure

Kai Zhu, Feng Zhang, Wang-Wang Ou, Yan Ke, Zhen-Ying Zhu, Xiao-Man Tan, Hui Wang, Chuan-Cheng Sun, Heng-Fei Gao, Yi-Lin Su

BACKGROUND Enhanced recovery after surgery (ERAS) protocols have improved perioperative outcomes in adults. However, we know less about their use in pediatric enterostomy closure and this area still has no specific guidelines. AIM To see how well ERAS pathways, when adjusted for children, work during the whole perioperative period of enterostomy closure surgery. METHODS This is a single-center retrospective analysis conducted in a tertiary pediatric surgery department. It included 61 children who received enterosto …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Application of a three-dimensional-printed endoscopic retrograde cholangiopancreatography simulation operation model in surgical training and teaching

Wen-Jun Zhou, Jia-Wei Qin, Cheng Li, Xiao-Feng Li

BACKGROUND Three-dimensional (3D)-printed models have been widely applied in the medical field and play roles in preoperative simulation, surgical training, and education for young doctors. Compared with traditional imaging data, 3D-printed models are more intuitive, more accurate, and more operable, providing valuable support for clinical and educational purposes. AIM To create an endoscopic retrograde cholangiopancreatography training model for the diagnosis and treatment of common bile duct stones. The model inc …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

Revista Goiana de Medicina

Teratoma ovariano maduro gigante em gestante de primeiro trimestre

Nayane Peixoto Soares, Gabriela Mesquita Pontes, Fernanda Mendonça Salles Ghannam, Henri Naves e Siqueira, Daniel Fernandes Correia Júnior, Waldemar Naves do Amaral

Introduction: Mature cystic teratoma is the most frequent ovarian neoplasm in reproductive-aged women, posing maternal and fetal risks when diagnosed during pregnancy. Objectives: To report the diagnosis and surgical management of a giant ovarian teratoma in a first-trimester pregnant patient. Methods: A descriptive case report study of a 17-year-old primigravida with a 30 cm adnexal mass concomitant with a 12-week intrauterine pregnancy. Results: Exploratory laparotomy with partial drainage of the contents was per …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Artificial intelligence-empowered echocardiography: an updated review of clinical management in hypertrophic cardiomyopathy

Miao Zhang, Shanshan Yuan, Hongyan Dai, Guoan Wang

Hypertrophic cardiomyopathy (HCM) is a common and highly heterogeneous inherited cardiomyopathy characterized by complex clinical phenotypes and diverse disease trajectories, posing significant challenges for early diagnosis, precise phenotypic classification, and risk stratification. Owing to its noninvasive nature, repeatability, and wide availability, echocardiography remains the cornerstone imaging modality for the diagnosis and longitudinal management of HCM. However, conventional echocardiographic analysis re …

27.08.2026journal-article

International Journal of Molecular Sciences

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Magdalena Grześk-Kaczyńska, Szymon Kaczyński, Bernadetta Kosztulska, Magdalena Rydzyńska, Tomasz Rosada, Natalia Ukleja-Sokołowska

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signaling and has demonstrated efficacy across multiple type 2 inflammatory diseases. This systematic review aimed to evaluate the effects of dupilumab on food allergy outcomes in pediatric and adult patients. Across studies, dupilumab treatment w …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …