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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Frontiers in Oncology

Circulating tumor DNA in neoadjuvant therapy for solid tumors

Xueqin Huang, Yu Deng, Yi Shen

Circulating tumor DNA (ctDNA), a core component of liquid biopsy, demonstrates significant potential in the field of neoadjuvant therapy for solid tumors. This review systematically examines the role of ctDNA across the pre-, intra-, and post-neoadjuvant treatment phases, with a focus on its value in predicting therapeutic efficacy, assessing early treatment response, detecting minimal residual disease (MRD), and monitoring for recurrence. By synthesizing the latest clinical research data and advancements in molecu …

26.08.2026journal-article

Molecular Cancer Therapeutics

Potent antitumor efficacy of datopotamab deruxtecan compared with sacituzumab govitecan in an intracranial tumor model of triple-negative breast cancer

Chikako Funasaka, Hiroki Takashima, Daisuke Okajima, Takanori Maejima, Satoru Yasuda, Tsuyoshi Karibe, Shuichi Mitsunaga, Toru Mukohara, Toshihiko Doi, Masahiro Yasunaga

Abstract Metastatic brain tumors are common in patients with triple-negative breast cancer (TNBC) and often lead to a poor prognosis. Trophoblast cell surface antigen 2 (TROP2) is overexpressed in TNBC cells and an attractive target molecule in breast cancer. Datopotamab deruxtecan (Dato-DXd) is an antibody-drug conjugate targeting TROP2 that selectively releases payloads in tumors. We evaluated the efficacy and tumor concentration of payload of Dato-DXd and sacituzumab govitecan (SG), another TROP2-directed antibo …

26.08.2026journal-article

Cancer Research

Single-Cell Analysis of Residual Esophageal Squamous Cell Carcinoma after Neoadjuvant Immunochemotherapy Reveals TFAM-Mediated Immunoregulation in Dendritic Cells

Linyan Chen, Tang Feng, Jianfeng Zhou, Hao Zeng, Yutian Lai, Xiafei Gu, Tianqi Lu, Pingxin Han, Ting Liu, Wenjun Meng, Zijian Lu, Jiumei Wu, Yushang Yang, Yong Yuan, Zhenyu Ding, Qing Li

Abstract Neoadjuvant immunochemotherapy (nICT) has emerged as a promising neoadjuvant strategy for esophageal squamous cell carcinoma (ESCC). Identification of the factors affecting responsiveness to nICT could help further improve treatment efficacy. In this study, we performed single-cell analysis on 14 patients with ESCC undergoing nICT and revealed tumor microenvironment (TME) features associated with differential treatment responses. Nonnegative matrix factorization (NMF) identified five coordinated cellular p …

26.08.2026journal-article

Diseases of the Colon & Rectum

A Novel Hybrid Retroperitoneal Approach and Natural Orifice Specimen Extraction Surgery II for Surgical Treatment of Rectosigmoid Cancer

Sergey K. Efetov, Niloofar Rouzy, Marina Y. Krylova, Denis I. Khlusov, Yaroslav P. Krasnov, Polina D. Panova

BACKGROUND: The retroperitoneal approach and natural orifice specimen extraction surgery are emerging minimally invasive techniques in colorectal surgery. Each technique independently aims to reduce operative trauma and enhance postoperative recovery. This report presents the first known case combining these 2 minimally invasive strategies for the surgical treatment of rectosigmoid cancer. IMPACT OF INNOVATION: This combined approach has the potential to minimize both peritoneal and abdominal wall trauma. By perfor …

26.08.2026journal-article

Radiation Sciences in Oncology

Outcomes of definitive chemoradiotherapy for laryngeal squamous cell carcinoma: A single-center experience

Asma Daneshvar, Candan Abakay, Meral Kurt, Sibel Çetintaş

Objective: Definitive chemoradiotherapy (CRT) is an established organ-preservation strategy for laryngeal squamous cell carcinoma (LSCC). However, real-world data regarding long-term survival and prognostic factors remain limited. This study evaluated survival outcomes, prognostic factors in LSCC patients treated with definitive nonsurgical therapy. Materials and Methods: In this retrospective study, 68 patients with pathologically confirmed stage II–IVA LSCC treated with definitive CRT between 2010 and 2022 were a …

26.08.2026journal-article

Biomedicines

The Galectin Family in Colorectal Cancer: Integrating Molecular Mechanisms with Diagnostic, Prognostic, and Therapeutic Perspectives

Krystian Kozak, Monika Zajkowska

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Increasing evidence indicates that alterations in glycosylation and glycan-binding proteins, such as galectins, contribute substantially to colorectal carcinogenesis. We review the current knowledge on the role of known human galectins in CRC to provide up-to-date summaries, focusing on their involvement in tumor initiation, progression, invasion, angiogenesis, immune evasion, and treatment res …

26.08.2026journal-article

Frontiers in Oncology

Risk-adapted use of thoracic radiotherapy in stage IV non-small cell lung cancer: a multicenter prognostic model study

Jiaxing Guo, Guangqian Ji, Jiao Zhang, Tao Zhang, Xuehua Wei, Yu Lin, Lujun Zhao

Background Survival benefit of thoracic radiotherapy (TRT) in patients with stage IV non-small cell lung cancer (NSCLC) receiving first-line chemo-immunotherapy remains uncertain. This study developed and validated an overall survival (OS) prediction model and assessed whether TRT benefit varied across risk strata. Methods Patients with stage IV NSCLC treated with first-line chemo-immunotherapy were enrolled. A nomogram was developed using baseline clinical variables to calculate individual risk scores. Patients we …

26.08.2026journal-article

Scientific Reports

UQCRH promoter methylation limits apoptosis and drug sensitivity in ovarian cancer cells

Mizuki Nishikawa, Masako Nakanishi, Ibu Matsuzaki, Takashi Nouchi, Yo-Taro Shirai, Kosuke Miyakuni, Shin-ichi Murata, Shogo Ehata

Abstract Overcoming chemoresistance is a major challenge in ovarian cancer, where impaired apoptosis and mitochondrial dysfunction play key roles. Ubiquinol-cytochrome c reductase hinge protein (UQCRH), a component of mitochondrial complex III, is involved in intrinsic apoptosis, but its role in ovarian cancer remains unclear. We investigated UQCRH expression, regulation, and function in ovarian cancer. Pan-cancer analyses showed UQCRH downregulation across multiple malignancies, with particularly low expression in …

26.08.2026journal-article

Materials

Optimization of Bonding Behavior of Crumb Rubber-Modified (CRM) Asphalt for Sustainable High-Friction Surface Treatment (HFST) Applications

Abdallah Aboelela, Magdy Abdelrahman

Binder bonding strength (BBS) is critical to aggregate retention and friction performance in high-friction surface treatment (HFST). Although epoxy resin is traditionally used, asphalt-based binders offer a sustainable alternative; however, their bonding behavior and influence on polishing performance remain insufficiently understood. This study investigated the evolution and optimization of BBS in crumb rubber-modified (CRM) asphalt for rhyolite-based HFSTs. BBS was measured under dry and wet-conditioned states fo …

26.08.2026journal-article

Indian Dermatology Online Journal

Comparative Efficacy of Terbinafine, Itraconazole, and Griseofulvin in Treatment of Steroid-Modified Tinea

K. Sneha, Seema Jain, Deepika Pandhi, Shukla Das, Sumita Halder

Abstract Background: Steroid-modified tinea or tinea incognito has emerged as a significant challenge in India due to the widespread misuse of topical corticosteroids, leading to chronic, treatment-resistant dermatophytosis. Aim and Objectives: This study was performed to compare the efficacy and safety of antifungal drugs: oral terbinafine, itraconazole, and griseofulvin in the treatment of steroid-modified tinea. In addition, patient awareness about steroid misuse and consequent impact on quality of life were als …

26.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

MiR-326 targets ETS1 to activate PI3K/Akt signaling and promote malignant phenotypes in gastric cancer cells

Kai Liang

Abstract: Background: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide and effective therapeutic targets remain limited. Objectives: This study aimed to investigate the expression and functional role of miR-326 in gastric cancer, identify its direct target gene and elucidate the underlying molecular mechanisms involving the PI3K/Akt signaling pathway and the regulation of inflammatory cytokines. Methods: miR-326 expression was detected by qRT-PCR in 56 paired GC tissues and adjacent …

26.08.2026journal-article

Frontiers in Oncology

Utidelone-associated chemotherapy-induced peripheral neuropathy: an evidence-stratified narrative review of mechanisms, risk identification, and management strategies

Sili Li, Lifeng Lei, Yi Luo

Utidelone is a genetically engineered epothilone analog and microtubule-stabilizing agent developed in China. It demonstrates antitumor activity in recurrent or metastatic breast cancer after anthracycline and taxane failure. In the pivotal phase III BG01-1323L trial, utidelone plus capecitabine improved progression-free and overall survival versus capecitabine alone; however, peripheral neuropathy occurred in 59% of combination patients, including grade 3 in 22%, versus 8% and less than 1%, respectively, with cape …

26.08.2026journal-article

Discover Health Systems

A mixed methods exploration of mental health pathways and treatment as usual for young people experiencing depression in the United Kingdom

Siobhan B. Mitchell, Vashti Berry, Juliette Westbrook, Emma Grace Carey, Alice Wickersham, Alice Garrood, Rachel Hayes, Julieta Galante, Husna Hassan Basri, Kristin Liabo, Tamsin Ford

Abstract Epidemiological data indicate that the prevalence of depression among young people (YP) is increasing. Although evidence-based interventions are effective for many, 20 to 40% fail, and relapse is common. This study focused on second-line treatments. Modifying psychological processes that predispose individuals to treatment failure or relapse necessitates the development of interventions, but their evaluation depends on a clear understanding of current practice to enable meaningful comparison and assessment …

26.08.2026journal-article

Frontiers in Endocrinology

IVF outcomes in cancer survivors: lower ovarian response and early embryo development but comparable success in frozen embryo transfer cycles — a retrospective cohort study

Xiaoqian Zhou, Zhijie Hu, Yijun Zhang, Qiuju Chen, Chengrui Ye, Yuqi Zhang, Yanping Kuang, Xuefeng Lu

Objective To evaluate whether women who have undergone cancer chemotherapy or radiotherapy achieve assisted reproductive technology (ART) outcomes comparable to those of non-cancer patients with equivalent ovarian reserve, and to explore the association between ART outcomes and the interval after chemotherapy or radiotherapy. Design Retrospective cohort study. Patients 32 cancer survivors who had received chemotherapy or radiotherapy and 160 matched control women had similar ovarian functions without malignancy. Ma …

26.08.2026journal-article

Journal of Clinical Medicine

Cardio-Oncology in Older Adults: Evidence Gaps, Geriatric Considerations, and Future Directions

Vasiliki Katsi, Lefki Nikolopoulou, Christos Fragoulis, Vasilios Kordalis, Konstantinos Tsioufis, Konstantinos Toutouzas

Cardio-oncology has emerged as a critical discipline addressing cardiovascular toxicities from cancer therapies, yet substantial evidence gaps persist for elderly patients, who represent over 60% of new cancer diagnoses. This narrative review synthesizes the current literature on cardio-oncology challenges in older adults (≥65 years), highlighting underrepresentation in clinical trials, compounded risks from frailty, multimorbidity, and polypharmacy, and the paucity of geriatric-specific guidelines. Older adults ex …

26.08.2026journal-article

BMC Cancer

Deciphering the mechanisms of transcriptome remodeling in residual HCC recurrence post-radiofrequency ablation via long-read sequencing

Junhui Li, Panpan Wu, Zhicheng Nie, Jianbang Li, Yeermaike Ahati, Peng Gu

Abstract Background Insufficient radiofrequency ablation (IRFA) remains a major clinical challenge in hepatocellular carcinoma (HCC) treatment, often leading to rapid tumor recurrence. However, the full-length transcriptome landscape and the role of alternative polyadenylation (APA) in post-IRFA recurrence remain poorly understood. Methods We performed Oxford Nanopore Technologies long-read RNA sequencing (ONT-lrRNA-seq) on paired HCC and adjacent non-tumor tissues from five patients, categorized into four groups: …

26.08.2026journal-article

Frontiers in Pharmacology

Dynamic remodeling of the tumor immune microenvironment: immunometabolic regulatory networks of astragalus polysaccharides and astragaloside IV

Ziming Xu, Lijie Wang, Xin Zhang, Yue Qi

The highly heterogeneous tumor immune microenvironment (TIME) remains a major obstacle to effective cancer immunotherapy. This review systematically elucidates the immunometabolic regulatory networks of the primary active constituents of Astragalus membranaceus—Astragalus polysaccharides (APS) and Astragaloside IV (AS-IV)—within the TIME. Synthesizing preclinical evidence up to January 2026, we focus on immune cell modulation, metabolic interventions, and advanced translational strategies. Evidence indicates that A …

26.08.2026journal-article

International Breastfeeding Journal

Milk donor perceptions of the acceptability of breastmilk as a tool in breast cancer research: a qualitative study

Sophia D’Alessandro, Samantha Griffin, Gillian Weaver, James M. Flanagan, Amy Brown

Abstract Breastmilk is a highly complex biofluid, essential for early infant nutrition. The benefits of breastfeeding for maternal and infant health are extensive and well established. In addition to this, breastmilk holds potential as a biomedical research tool, providing a window of opportunity to study maternal health and diseases, such as breast cancer, through investigation of breastmilk components, immune factors, microbiome and live cells that can harbour precancerous changes. However, the prospect of using …

26.08.2026journal-article

Journal of Clinical Medicine

Perioperative NT-proBNP in Lung Cancer Surgery: A Narrative Review of Mechanisms, Predictive Value, and Clinical Implications

Mădălina Butaș, Sonia Elena Popovici, Stelian Adrian Ritiu, Gabriel Veniamin Cozma, Vasile Gaborean, Iulia Najette Crintea, Maria Sala-Cirtog, Alina Ramona Buzatu, Roxana Buzas, Marilena Dinuți

Background: NT-proBNP is a mechanistically grounded biomarker of ventricular wall stress with established prognostic value in cardiac surgery, but its perioperative role in lung cancer resection remains incompletely characterised. Pulmonary resection imposes unique haemodynamic stressors—including one-lung ventilation-induced right ventricular afterload increase, permanent pulmonary vascular bed reduction, and ischaemia–reperfusion injury—that create a distinct biological context for natriuretic peptide elevation n …

26.08.2026journal-article

Research on Social Work Practice

An Initial Outcome Evaluation of Assisted Outpatient Treatment Under Tim's Law in Kentucky

Aubrey E. Jones, Aaron R. Brown, Opeyemi Daramola, Olivia Raley, Tara Brewer, David T. Susman, Sheila Barnhart, Justin “Jay” Miller

Purpose The purpose of this study was to assess four outcomes among participants in Kentucky's assisted outpatient treatment (AOT) program, which was created under Tim's Law, enacted in 2017. AOT is a court-ordered, community-based treatment approach for individuals living with serious mental illness. Method Quantitative data were collected for 220 AOT participants in Kentucky from July 2020 through December 2025 using administrative data, provider-completed administrative interviews, and structured interviews with …

26.08.2026journal-article

Diagnostics

Genotyping and Cytology Co-Testing for Anal Cancer Screening: Exploratory Evaluation of Cumulative HPV Genotype Burden as a New Potential Marker for Risk Stratification

Cristina Sani, Claudia Giachini, Giampaolo Pompeo, Alessandra Mongia, Irene Paganini, Stephanie Pacella, Sara Galastri, Serena Giunti, Ornella Cutaia, Luigi Pisano, Giuseppe Gorini, Alessandro Senape, Martina Turco, Jacopo Farini, Filippo Caminati, Claudio Elbetti, Iacopo Giani, Nicola Pimpinelli, Stefania Cannistrà, Simonetta Bisanzi

Background/Objectives: Anal squamous cell carcinoma (SCCA) is a rare Human Papillomavirus (HPV)-related disease in the general population but its incidence is increasing among high-risk populations, i.e., men who have sex with men (MSM), HIV+ patients and women with a history of cervical/vulvar dysplasia. The objectives of this study were: (i) to investigate the prevalence of high-risk (HR) and low-risk (LR) anal HPV infections in a high-risk cohort; (ii) to correlate specific HPV genotypes with cytological and his …

26.08.2026journal-article

Frontiers in Oncology

Clinical stratification utility of HER2, PD-L1, MSI/MMR, and CLDN18.2 in conversion therapy for gastric cancer: narrative review

Tao Ding, Peiqiang Chen, Huajiong Yu

Most patients with gastric cancer considered for conversion therapy present with locally advanced or metastatic disease, where surgery alone or conventional chemotherapy often provides limited benefit. Conversion therapy aims to reduce tumor burden through systemic treatment, reassess treatment response over time, and create an opportunity for radical surgery with complete tumor removal. This approach is mainly considered for patients with initially unresectable, borderline resectable, or limited metastatic disease …

26.08.2026journal-article

Neurosurgery

Systemic Adverse Effects of Intensive Blood Pressure Treatment After Craniotomy for Tumor Resection

Fatima Gauhar, Breanne Reisen, Jaiden Sutaria, Nick De Oliviera, Zhiguo Zhao, Fei Ye, Patrick D. Kelly

BACKGROUND AND OBJECTIVES: Postcraniotomy hypertension is commonly treated with intravenous (IV) antihypertensives to reduce hemorrhage risk. Intensive systolic blood pressure (SBP) control has been associated with adverse effects in hospitalized patients, but its impact after craniotomy is unclear. This study evaluated whether IV nicardipine use to achieve an SBP target <140 mm Hg is associated with hypoperfusion and other adverse outcomes after craniotomy. METHODS: We retrospectively reviewed 1997 adult craniotom …