Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 42

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Techniques in Coloproctology

Salvage surgery after total neoadjuvant therapy and watch-and-wait in rectal cancer: a systematic review and proposed minimum outcome set

J. R. Burke, I. Samuel, R. Clifford, P. Sutton, C. Arthur, A. G. Renehan

Abstract Background Salvage surgery for local regrowth following watch-and-wait (W&W) after total neoadjuvant therapy (TNT) is perceived to be technically more difficult than immediate surgery after treatment. However, surgical difficulty lacks standardised definition and reporting. This methodological review proposes a structured minimum outcome set (MOS) to distinguish intra-operative technical complexity from surgery-related morbidity and evaluates current reporting against this framework. Methods A predefined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Ning Zhao

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-PD-1 antibody can overcome immunosuppression and improve therapeutic outcomes by remodeling the tumor microenvironment (TME). Methods We constructed second-generation CAR-T cells targeting mesothelin, an antigen overexpressed in ESCC. Using …

22.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Prenatal molecular diagnosis and allogeneic hematopoietic stem cell transplantation in an infant with RAG2 deficiency

Maria Laura Herrera Andino, Milagros López Orozco, María Victoria Suen, Carlos Hernán Hollmann, Lucía Spossito, Arjan Lankester, María Emilia Mas, Ana Lisa Basquiera

RAG2 deficiency is a cause of severe combined immunodeficiency (SCID), characterized by a defect in the development of T and B lymphocytes that predisposes patients to life-threatening infections during the first months of life. We present the case of an infant with a prenatal molecular diagnosis of SCID secondary to RAG2 deficiency who underwent allogeneic hematopoietic stem cell transplantation (HSCT) using a human leukocyte antigen-identical sibling donor at 3 months old. The subsequent clinical course was favor …

22.08.2026journal-article

Cells

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Jiani Dai, Yufei Wang, Chunna Jin, Liuguang Song, Yao Xie, Liangliang Jia, Meixiang Xiang

Advances in anticancer therapies have substantially improved cancer survival but have also highlighted the growing challenge of cancer therapy-related cardiac dysfunction. Ferroptosis, an iron-dependent form of regulated cell death characterized by iron dysregulation, lipid peroxidation, and impaired antioxidant defense, has emerged as a promising strategy for eliminating therapy-resistant tumors. However, the lack of tissue specificity in ferroptosis regulation raises concerns regarding its potential contribution …

22.08.2026journal-article

International Journal of Innovative Science and Research Technology

Occupational Health and Safety of Employees in Wood Processing Industries in Cameroon

Ateba François René, Oum René, Ngongo Isidore Seraphins

Workers safety in Africa faces significant challenges, marked by the high number of workplace accidents, inadequate support from employers, a general shortage of personal protective equipment across all industries, insufficient controls, and unequal legal frameworks across countries. This article provides some answers both to help reverse the trend of occupational accidents and to raise awareness among decision-makers in African countries.

22.08.2026journal-article

Journal of Endovascular Therapy

Concurrent Peripheral Arterial Disease Predicts Re-Intervention Following Abdominal Aortic Aneurysm Repair: A Single-Centre Propensity Matched Retrospective Study

Navanith Murali, Angela Lee, Lukschana Senathirajah, Eman Otify, Jing Zhou, Tariq Ali, Philip Stather

Purpose: Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) share common risk factors and may co-exist in patients undergoing AAA repair. The impact of concomitant PAD on clinical outcomes post AAA repair remains unclear. This study aims to evaluate whether concurrent PAD is associated with adverse clinical outcomes following AAA repair. Materials and Methods: This was a single-centre retrospective propensity matched analysis involving patients undergoing infrarenal AAA repair at a single UK cent …

22.08.2026journal-article

Journal of Medicine and Health Research

Electronic Waste Exposure and Public Health Risks among Informal Recycling Workers: A Critical Narrative Review of Occupational Mixtures, Health Effects and Prevention

Hameedat Titilade Sanusi, Ogunyemi Joel, George-Oloja Nkechinyere, Elona Erezi

Electronic waste recycling sustains livelihoods and recovers valuable materials, yet informal processing can transfer a substantial fraction of the environmental and occupational costs of the digital economy to workers with limited access to engineering controls, occupational health services and social protection. This critical narrative review evaluates the evidence linking informal electronic waste work with hazardous exposures and adverse health outcomes, with emphasis on worker-specific studies rather than comm …

22.08.2026journal-article

International Journal of Computer Trends and Technology

A Distilbert Case-Based Deep Learning Model for Part-of-Speech Tagging for Under-Resourced Kenyan Language: A Case of Dholuo

Maureen Otieno, Lilian Wanzare, Calvins Otieno

One of the basic Natural Language Processing (NLP) tasks is Part-of-Speech (POS) tagging, which helps in various applications like sentiment analysis and information retrieval. However, creating accurate POS taggers for low-resource African languages continues to be difficult due to the scarcity of linguistic resources that are annotated. Its contribution is a deep learning method for POS tagging of Dholuo, a less-resourced Western Nilotic language, spoken by about four million people in Kenya and Tanzania. The sug …

22.08.2026journal-article

Journal of Web Engineering

Immersive Web Virtual Environment for Language Learning: Multimodal Interaction and Error Correction Based on Speech, Gesture and Eye Tracking

Shuwen Yu

In order to solve the problems of existing Web language learning tools, such as single interaction dimension, lagging error correction feedback and insufficient attention perception, this paper designs and verifies a multimodal immersive Web virtual environment optimization scheme which integrates voice, gesture and eye tracking. The core breakthroughs are as follows: (1) a dual-mechanism adaptive fusion algorithm of “attention weight+dynamic threshold” is proposed, which solves the problem of error correction fail …

22.08.2026journal-article

Lasers in Medical Science

Photobiomodulation therapy and postoperative recovery after abdominoplasty: a non-randomized pilot study

Carmen Lucia Kretiska Araujo, Graziele Silveira Fardin, Ana Paula Bernardi, Joane Severo Ribeiro, Ricardo Vitiello Schramm, Isadora Frois Ourique, Maria Luiza Santos, Betina Vescovi, Tássio Fernando Crusius, Flávia Marafon, Denis Valente, Níveo Steffen, Patricia Viana da Rosa, Alessandra Peres

Abstract Photobiomodulation (PBM) has been proposed as a non-invasive therapeutic strategy to support wound healing and modulate oxidative and inflammatory responses. However, clinical data evaluating its effects in the postoperative period of abdominoplasty remain limited. This non-randomized clinical trial included 31 female patients undergoing abdominoplasty, divided into two groups: PBM intervention ( n = 15) and control ( n = 16). Salivary samples were collected at three time points: preoperative (T0), 48 h po …

22.08.2026journal-article

ShodhKosh: Journal of Visual and Performing Arts

EFFECTIVENESS OF TRAUMA-INFORMED ART THERAPY IN REDUCING PTSD SYMPTOMS AMONG WOMEN SURVIVORS OF DOMESTIC VIOLENCE IN ERNAKULAM, KERALA

Tanya Filbert

Domestic violence is associated with substantial psychological consequences, including post-traumatic stress disorder (PTSD), anxiety, depression, impaired self-esteem and difficulties in interpersonal functioning. Although psychological, legal and social-support services are available to survivors, access to sustained and culturally responsive trauma-focused interventions remains a concern. The present study examines the potential effectiveness of an eight-week trauma-informed art-therapy intervention among women …

22.08.2026journal-article

Renal Replacement Therapy

Antioxidant assessment of vitamin E-coated hemodialysis membranes: mechanistic context and implications for novelty

Francesco Galli

Abstract Vitamin E-coated polysulfone (VE-PS) dialysis membranes were developed to enhance both antioxidant performance and biocompatibility of conventional dialyzers and have been investigated for more than three decades both in experimental models and clinical studies. Tange et al. recently reported that VE-PS membranes retain greater antioxidant capacity than conventional polysulfone following exposure to Fenton’s reagent and proposed their assay as a new standardized in vitro method. Although the experimental a …

22.08.2026journal-article

Diseases of the Esophagus

P1.145. The pCR Paradox: Unmasking Systemic Failure in Esophageal Cancer Following Neoadjuvant CROSS Therapy

Manish Jethani, Ganesh Jadhav, Rajesh Mistry, Imran Shaikh, Pranav Chadha

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background While neoadjuvant chemoradiotherapy (nCTRT) followed by esophagectomy has established itself as the global standard for locally advanced esophageal cancer - predominant squamous histology, the "Achilles' heel" remains disease recurrence. Although achieving a pathological complete response (pCR) suggests a favourable prognosis, it does not guarantee a cure. We aimed to characterize the specific timing and patter …

21.08.2026journal-article

Frontiers in Medicine

Pharmacist-led medication therapy management improving medication adherence in a patient with type 2 diabetes: case report

Hong Jiang, Jing Liu, Yin Ying, Mingwan Zhang, Lu Zhao

Background Poor medication adherence is a major challenge in healthcare for patients with type 2 diabetes mellitus (T2DM), particularly those with long disease duration, multiple comorbidities, and complex therapeutic regimens. This case report describes the application of pharmacist-led MTM (medication therapy management) in a patient with T2DM presenting complex therapeutic regimens and poor adherence. Patients and methods A 76-year-old female with a 30-year history of T2DM complicated by diabetic peripheral neur …

21.08.2026journal-article

Journal of Clinical Medicine

More than Rehabilitation: The Role of Contextual Factors in Pain Perception and Recovery: What the Physiotherapy Literature Reports—A Narrative Review with a Systematic Search Strategy

Giulia Leonardi, Francesco Bonanno, Angelo Alito, Francesca Cucinotta, Clara Lombardo, Antonio Di Dio, Francesca Sposito, Carmen Cucinotta, Alfio Garofalo, Simona Portaro

Background: Pain is a multidimensional experience shaped not only by nociceptive input but also by cognitive, emotional, and social processes. In musculoskeletal (MSK) rehabilitation, outcome variability among patients with similar clinical presentations suggests that determinants beyond tissue pathology may influence pain perception and recovery. Contextual factors (CFs)—communication, therapeutic relationship, patient expectations, and environmental cues—are increasingly recognized yet remain inconsistently integ …

21.08.2026journal-article

Advanced Functional Materials

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang

ABSTRACT Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infrared region II fluorescent dye (FD1080), and PD‐1 inhibitor (TFA) through a simple extrusion method and further modified them with DSPE‐PEG2000‐cRGD to enhance their tumor‐targeting ability. The …

21.08.2026journal-article

eJournal Kedokteran Indonesia

Rehabilitation in Juvenile Myasthenia Gravis: Strategies and Challenges in Enhancing Pediatric Patient Quality of Life

zulfahmidah zulfahmidah, Nila Mayasari

Juvenile Myasthenia Gravis (JMG) is a rare autoimmune disorder characterized by impaired neuromuscular transmission, resulting in fatigable weakness and significant functional limitations in pediatric patients. Despite growing recognition of rehabilitation's importance in JMG management, there remains a critical need to synthesize current evidence and establish standardized approaches. This comprehensive review examines the pathophysiology of JMG, focusing on autoantibody-mediated disruption of acetylcholine recept …

21.08.2026journal-article

The Oncologist

IUC26672-88 Treatment beyond progression in primary refractory mRCC during 1L systemic therapy (Meet-Uro 33)

D Aspden, D Bimbatti, A Dalla Volta, G Roviello, R Iacovelli, G Bozza, M G Vitale, E Fantinel, A Guida, F M Deppieri, C Nasso, S Scagliarini, E Cocorocchio, B Maiorano, C Caserta, A Cavo, F Paolieri, F La Russa, L Fratino, S E Rebuzzi

Abstract Background The optimal management of metastatic renal cell carcinoma (mRCC) patients (pts) experiencing progressive disease (PD) at the 1st radiological assessment during 1st line therapy (primary refractory pts) remains undefined. While treatment beyond progression (TBP) may be appropriate for selected pts with clinical benefit, evidence on pts selection and survival outcomes in this setting is limited. Methods Meet-Uro 33 is an ongoing Italian multicenter retrospective/prospective observational study of …

21.08.2026journal-article

Future Health

Yoga therapy for mental resilience in technology professionals: From mechanisms to practice

Santosh Kumar Sahu, Ajit Kumar Pradhan, Prasanta Kumar Sahoo, Mohammad Zaki Ahmad

The technology sector involves sustained cognitive load, high-performance demands, prolonged screen exposure, and sedentary patterns, all of which contribute to stress, anxiety, and burnout, impairing well-being and productivity. Yoga therapy (YT), a multimodal mind-body practice that combines breath regulation, mindful movement, and meditative attention, offers a promising strategy for enhancing mental resilience in such contexts. Evidence indicates that YT may modulate stress physiology by improving heart rate va …

21.08.2026journal-article

Frontiers in Drug Delivery

Harnessing liposomal delivery to boost polyphenols’ potential in chronic wound therapy

Lisa Myrseth Hemmingsen, Marte Kristensen, Cecilie Thanh Loan Dang, Mari Salamonsen, Elizabeth G. Aarag Fredheim, Nataša Škalko-Basnet

Introduction Chronic wounds pose a significant clinical challenge due to impaired healing, persistent inflammation, and susceptibility to infection, often by antimicrobial-resistant bacteria. Therefore, active compounds should ideally act both as antimicrobials with limited potential for resistance development and offer other beneficial wound-healing properties. Polyphenols, such as chlorogenic acid (CGA) and quercetin (QCT), exhibit those properties, but are limited by poor stability or low bioavailability. Method …

21.08.2026journal-article

Behavioral Sciences

A Non-Controlled Study of Cognitive Behavior Therapy for Panic Disorder in Veterans

Daniel F. Gros, Jeffrey M. Pavlacic

Panic disorder is a highly prevalent and impairing diagnosis in veterans. Despite consistent efficacy findings in community samples, few studies have investigated evidence-based psychotherapies in veterans with panic disorder, limiting the understanding of their utility and deployment in Veterans Affairs (VA) settings. The present study preliminarily investigated cognitive behavioral therapy (CBT) for panic disorder via a non-controlled design in a treatment-seeking veteran sample with panic disorder at the VA. Of …

21.08.2026journal-article

Genes

4-Phenylbutyrate Plus Wildtype GAT-1 Augmentation: A Dual Therapy to Rescue SLC6A1 Variant-Associated Developmental and Epileptic Encephalopathy

Aiden James Delahanty, Kaitlin James, Emma Grace Carter, Ziang Debbie Song, Juexin Wang, Melissa Bassette, Jing-Qiong Kang

Background: Pathogenic variants in SLC6A1, which encodes the γ-aminobutyric acid (GABA) transporter GAT-1, cause developmental and epileptic encephalopathies (DEEs) through reduced GABA uptake, impaired transporter trafficking, and functional haploinsufficiency. 4-phenylbutyrate (PBA) is a clinically available small molecule with chemical-chaperone and histone-deacetylase-inhibitor activities that can rescue misfolded GABAergic proteins, but variant-level rescue data are needed to guide precision treatment. Methods …

21.08.2026journal-article

Journal of Artificial Organs

Clinical differences between destination therapy and bridge-to-transplant left ventricular assist device implantation: a 17-year single-center experience in Japan

Koichi Inoue, Daisuke Yoshioka, Yusuke Misumi, Ai Kawamura, Shin Yajima, Takuji Kawamura, Shunsuke Saito, Takashi Yamauchi, Shigeru Miyagawa

Abstract The use of left ventricular assist device (LVAD) implantation for destination therapy (DT) has been recently increased worldwide. In 2021, DT was also approved in Japan. Here, we report a single-institution experience of LVAD implantation for DT. This retrospective observational study was conducted at Osaka University Medical Hospital in Japan. Forty patients who underwent LVAD implantation for DT were included. The primary endpoint was on-device survival, and the secondary endpoint was the incidence of LV …

21.08.2026journal-article

Renal Replacement Therapy

The NF-κB/miR-378c/IRG1 axis drives tubular injury in septic AKI by suppressing immunometabolic protection

Lu Zhou, Xiang Zhou, Hongmei Deng, Miaoyuan Zhang, Zheng Li

Abstract Background Septic acute kidney injury (AKI) is a life-threatening complication with high morbidity and mortality. Despite decades of research, therapeutic options remain limited to supportive care, underscoring the urgent need to decipher the molecular drivers that govern septic AKI. Methods We used a murine LPS-induced septic AKI model and cultured BUMPT cells. miR-378c expression was assessed by qPCR and fluorescence in situ hybridization. Gain- and loss-of-function studies were performed using miR-378c …